P98199
PR
Gene name |
Atp8b2 |
Protein name |
Phospholipid-transporting ATPase ID |
Names |
ATPase class I type 8B member 2, P4-ATPase flippase complex alpha subunit ATP8B2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
|
EC number |
7.6.2.1: Linked to the hydrolysis of a nucleoside triphosphate |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P98199
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P98199-F1 | Predicted | AlphaFoldDB |
56 variants for P98199
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388644180 | 30 | E>V | No | EVA | |
| rs3388643317 | 31 | E>V | No | EVA | |
| rs3388640674 | 32 | E>V | No | EVA | |
| rs3388640701 | 33 | R>W | No | EVA | |
| rs3388636859 | 61 | V>L | No | EVA | |
| rs3388643329 | 81 | L>M | No | EVA | |
| rs3388640656 | 81 | L>P | No | EVA | |
| rs3388640337 | 85 | I>F | No | EVA | |
| rs3388640337 | 85 | I>V | No | EVA | |
| rs3388645362 | 95 | L>M | No | EVA | |
| rs3388645339 | 104 | L>W | No | EVA | |
| rs3388645363 | 117 | T>I | No | EVA | |
| rs3388646084 | 124 | K>N | No | EVA | |
| rs3388646661 | 139 | N>S | No | EVA | |
| rs3388646151 | 154 | D>V | No | EVA | |
| rs3388646702 | 271 | D>Y | No | EVA | |
| rs3388640693 | 299 | I>N | No | EVA | |
| rs3388646077 | 337 | S>N | No | EVA | |
| rs3388632642 | 395 | T>I | No | EVA | |
| rs3388646658 | 437 | F>C | No | EVA | |
| rs3388635293 | 437 | F>I | No | EVA | |
| rs3388640689 | 439 | V>G | No | EVA | |
| rs3388635212 | 442 | H>R | No | EVA | |
| rs3388644171 | 465 | F>L | No | EVA | |
| rs3388635282 | 486 | F>L | No | EVA | |
| rs3388624676 | 490 | L>P | No | EVA | |
| rs3388632625 | 523 | R>W | No | EVA | |
| rs3388640659 | 529 | F>S | No | EVA | |
| rs3388640654 | 572 | G>V | No | EVA | |
| rs3388635277 | 595 | E>* | No | EVA | |
| rs3388645345 | 600 | T>I | No | EVA | |
| rs3388624664 | 612 | L>M | No | EVA | |
| rs3393297693 | 636 | Q>E | No | EVA | |
| rs3393323142 | 645 | E>D | No | EVA | |
| rs3388636908 | 696 | K>* | No | EVA | |
| rs50714552 | 722 | G>S | No | EVA | |
| rs3388642947 | 741 | D>Y | No | EVA | |
| rs3393382769 | 769 | A>P | No | EVA | |
| rs3393115688 | 775 | V>I | No | EVA | |
| rs3388636909 | 783 | H>L | No | EVA | |
| rs3388624633 | 817 | V>M | No | EVA | |
| rs3388640716 | 819 | L>M | No | EVA | |
| rs3412824802 | 854 | E>K | No | EVA | |
| rs3393336536 | 999 | T>S | No | EVA | |
| rs3393373401 | 1000 | R>W | No | EVA | |
| rs3393336518 | 1006 | L>V | No | EVA | |
| rs3388643306 | 1017 | A>V | No | EVA | |
| rs3388640672 | 1077 | Q>R | No | EVA | |
| rs3388636890 | 1088 | T>I | No | EVA | |
| rs3388645324 | 1095 | V>I | No | EVA | |
| rs3388639143 | 1123 | L>V | No | EVA | |
| rs3388646667 | 1127 | K>E | No | EVA | |
| rs3388639166 | 1135 | M>I | No | EVA | |
| rs3393264329 | 1141 | T>I | No | EVA | |
| rs3388639135 | 1154 | E>* | No | EVA | |
| rs3388640747 | 1154 | E>DG* | No | EVA |
No associated diseases with P98199
4 regional properties for P98199
Functions
| Description | ||
|---|---|---|
| EC Number | 7.6.2.1 | Linked to the hydrolysis of a nucleoside triphosphate |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| phospholipid-translocating ATPase complex | A protein complex that functions as a phospholipid-translocating P-Type ATPase. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATPase-coupled intramembrane lipid transporter activity | Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| phosphatidylcholine flippase activity | Catalysis of the movement of phosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. |
| phosphatidylcholine floppase activity | Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| Golgi organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. |
| phospholipid translocation | The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9P241 | ATP10D | Phospholipid-transporting ATPase VD | Homo sapiens (Human) | PR |
| Q8TF62 | ATP8B4 | Probable phospholipid-transporting ATPase IM | Homo sapiens (Human) | PR |
| Q9Y2Q0 | ATP8A1 | Phospholipid-transporting ATPase IA | Homo sapiens (Human) | PR |
| O43520 | ATP8B1 | Phospholipid-transporting ATPase IC | Homo sapiens (Human) | EV |
| P98198 | ATP8B2 | Phospholipid-transporting ATPase ID | Homo sapiens (Human) | PR |
| Q148W0 | Atp8b1 | Phospholipid-transporting ATPase IC | Mus musculus (Mouse) | SS |
| P70704 | Atp8a1 | Phospholipid-transporting ATPase IA | Mus musculus (Mouse) | PR |
| D4AA47 | Atp8b1 | Phospholipid-transporting ATPase IC | Rattus norvegicus (Rat) | SS |
| Q9U280 | tat-1 | Phospholipid-transporting ATPase tat-1 | Caenorhabditis elegans | PR |
| Q5BL50 | atp8b1 | Phospholipid-transporting ATPase IC | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTVPKEIPEK | WARAGAPPSW | SQKKPSWGTE | EERRARANDR | EYNEKFQYAS | NCIKTSKYNI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VTFLPVNLFE | QFQEVANTYF | LFLLILQLIP | QISSLSWFTT | IVPLVLVLTI | TAVKDATDDY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FRHKSDNQVN | NRHSQVLING | VLQQEQWMNV | CVGDIIKLEN | NQFVAADLLL | LSSSEPHGLC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YIETAELDGE | TNMKVRQAIP | VTSELGDVSQ | LARFDGEVIC | EPPNNKLDKF | SGTLYWKENK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FPLSNQNMLL | RGCVLRNTEW | CFGLVIFAGP | DTKLMQNSGR | TKFKRTSIDR | LMNTLVLWIF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GFLVCMGVIL | AIGNAIWEHE | VGTRFQVYLP | WDEAVDSAFF | SGFLSFWSYI | IILNTVVPIS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LYVSVEVIRL | GHSYFINWDK | KMFCMKKRTP | AEARTTTLNE | ELGQVEYIFS | DKTGTLTQNI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MVFNKCSING | HSYGDVFDVL | GHKAELGERP | EPVDFSFNPL | ADKKFLFWDS | SLLEAVKMGD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PHTHEFFRLL | SLCHTVMSEE | KNEGELYYKA | QSPDEGALVT | AARNFGFVFR | SRTPKTITVH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ELGTAITYQL | LAILDFNNIR | KRMSVIVRNP | EGKIRLYCKG | ADTILLDRLH | PPTQELLSST |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TDHLNEYAGD | GLRTLVLAYK | DLDEEYYEEW | ARRRLQASLA | QDSREDRLAS | IYEEVESDMM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LLGATAIEDK | LQQGVPETIA | LLTLANIKIW | VLTGDKQETA | VNIGYSCKML | TDDMTEVFVV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TGHTVLEVRE | ELRKARKKMV | DSSHAVGNGF | TYQGNLSSSK | LTSVLEAVAG | EYALVINGHS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LAHALEADME | LEFLETACAC | KAVICCRVTP | LQKAQVVELV | KKYKKAVTLA | IGDGANDVSM |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IKTAHIGVGI | SGQEGIQAVL | ASDYSFSQFK | FLQRLLLVHG | RWSYLRMCKF | LCYFFYKNFA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| FTMVHFWFGF | FCGFSAQTVY | DQYFITLYNI | VYTSLPVLAM | GVFDQDVPEQ | RSMEYPKLYE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| PGQLNLLFNK | REFFICIAQG | IYTSVLMFFI | PYGVFAEATR | DDGTQLADYQ | SFAVTVATSL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| VIVVSVQIGL | DTGYWTAINH | FFIWGSLAVY | FAILFAMHSN | GLFDMFPNQF | RFVGNAQNTL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| AQPTVWLTIA | LTTAVCIMPV | VAFRFLRLSL | KPDLSDTVRY | TQLVRKKQKA | QHRCMRRVGR |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| TGSRRSGYAF | SHQEGFGELI | MSGKNMRLSS | LALSSFSTRS | SSSWIESLRR | KKSDSANSPS |
| GGAEKPLKG |