AiPD: Autoinhibited Protein Database

P98066

Gene name	TNFAIP6 (TSG6)
Protein name	Tumor necrosis factor-inducible gene 6 protein
Names	Hyaluronate-binding protein, TNF-stimulated gene 6 protein, TSG-6, Tumor necrosis factor alpha-induced protein 6, TNF alpha-induced protein 6
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7130
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

219-277 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

219-277 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

6 structures for P98066

Entry ID	Method	Resolution	Chain	Position	Source
1O7B	NMR	-	T	36-133	PDB
1O7C	NMR	-	T	36-133	PDB
2N40	NMR	-	A	36-133	PDB
2PF5	X-ray	190 A	A/B/C/D/E	36-133	PDB
2WNO	X-ray	230 A	A	129-277	PDB
AF-P98066-F1	Predicted				AlphaFoldDB

234 variants for P98066

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA1903375 rs144488091	2	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA1903374 rs78598479	2	I>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA348738551 rs1309741565	4	L>F		No	ClinGen gnomAD
CA57618185 rs906774524	5	I>T		No	ClinGen Ensembl
TCGA novel	5	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA57618186 rs938308191	8	F>L		No	ClinGen Ensembl
CA348738616 rs1227801594	9	L>I		No	ClinGen gnomAD
CA1903378 rs762941271 COSM354227	10	L>F	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs766282193 CA1903379	11	L>V		No	ClinGen ExAC TOPMed gnomAD
CA348738639 rs1377079307	12	W>*		No	ClinGen TOPMed
COSM1613478 rs1482130755 CA348738645	13	E>G	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
CA348738642 COSM1007334 rs1255173921	13	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA57618236 rs763386524	14	D>G		No	ClinGen Ensembl
CA348738701 rs1178900449	21	K>E		No	ClinGen gnomAD
CA348738726 rs1471980059	24	I>T		No	ClinGen gnomAD
rs1252375732 CA348738723	24	I>V		No	ClinGen gnomAD
CA348738736 rs1179380465	25	F>L		No	ClinGen gnomAD
TCGA novel	26	H>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1300954433 CA348738742	26	H>L		No	ClinGen TOPMed
CA348738743 rs1431045299	26	H>Q		No	ClinGen gnomAD
rs774170435 CA1903380	28	S>P		No	ClinGen ExAC gnomAD
rs767120411 CA1903382	29	I>M		No	ClinGen ExAC gnomAD
CA1903381 rs759370266	29	I>V		No	ClinGen ExAC TOPMed gnomAD
CA1903383 rs752372019	30	W>*		No	ClinGen ExAC gnomAD
rs755566605 CA1903384	32	E>*		No	ClinGen ExAC gnomAD
rs763712766 CA1903404	33	R>*		No	ClinGen ExAC gnomAD
rs763712766 CA1903403	33	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1903405 rs761269991	33	R>L		No	ClinGen ExAC TOPMed gnomAD
rs761269991 CA348739887	33	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1298030316 CA348739897	34	A>E		No	ClinGen gnomAD
CA348739904 rs1341413378	35	A>D		No	ClinGen TOPMed gnomAD
CA348739907 rs1341413378	35	A>V		No	ClinGen TOPMed gnomAD
CA348739910 rs750979012	36	G>C		No	ClinGen ExAC TOPMed gnomAD
rs750979012 CA57621576	36	G>R		No	ClinGen ExAC TOPMed gnomAD
rs750979012 CA1903407 COSM1528281	36	G>S	lung haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs758767494 CA1903408	39	H>Y		No	ClinGen ExAC gnomAD
CA348740009 rs1299889223	41	E>K		No	ClinGen TOPMed
CA348740030 rs1308388959	42	A>P		No	ClinGen gnomAD
rs566948911 CA1903410	43	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA57621590 rs201398199	44	S>P		No	ClinGen Ensembl
rs148912042 CA57621592	45	G>D		No	ClinGen ESP TOPMed
CA348740150 rs1426798974	47	Y>*		No	ClinGen TOPMed
CA348740144 rs1486636427	47	Y>C		No	ClinGen TOPMed gnomAD
CA57621598 rs375585000	48	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA348740163 rs1190964425	48	K>R		No	ClinGen gnomAD
rs75961064 CA1903412	50	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs75961064 CA348740178	50	T>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1903414 rs557940940	51	Y>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM241955 CA57621606 rs577924895	52	A>T	prostate [Cosmic]	No	ClinGen cosmic curated 1000Genomes TOPMed gnomAD
rs1264066329 CA348740208	52	A>V		No	ClinGen TOPMed
CA57621611 rs1046624496	53	E>D		No	ClinGen Ensembl
rs1206000077 CA348740229	54	A>P		No	ClinGen TOPMed
CA348740237 rs1321610042	54	A>V		No	ClinGen TOPMed
CA1903415 rs778767210	55	K>R		No	ClinGen ExAC gnomAD
CA348740249 COSM1528280 rs1321415465	56	A>E	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs372855249 CA348740247	56	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA1903416 rs372855249	56	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1007335 CA348740251 rs1321415465	56	A>V	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
TCGA novel	63	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760436617 CA1903419	63	G>S		No	ClinGen ExAC gnomAD
CA348740325 rs1356961459	64	H>R		No	ClinGen gnomAD
CA57621642 rs868652351	64	H>Y		No	ClinGen Ensembl
rs138376471 CA57621650	65	L>I		No	ClinGen ESP TOPMed gnomAD
rs138376471 CA57621657	65	L>V		No	ClinGen ESP TOPMed gnomAD
rs768323812 CA1903421	66	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	66	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776169770 CA1903422	67	T>I		No	ClinGen ExAC TOPMed gnomAD
rs776169770 CA1903423	67	T>S		No	ClinGen ExAC TOPMed gnomAD
CA1903426 rs763538732	68	Y>*		No	ClinGen ExAC gnomAD
rs150253672 CA1903424	68	Y>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1903425 rs750019197	68	Y>S		No	ClinGen ExAC gnomAD
rs767039176 CA1903427	69	K>Q		No	ClinGen ExAC gnomAD
CA1903428 rs373889474 COSM1528279	70	Q>K	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA348740415 rs1473397404	70	Q>R		No	ClinGen gnomAD
CA57621700 rs1002258799	73	A>T		No	ClinGen TOPMed gnomAD
TCGA novel	75	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1364961972 CA348740526	76	K>T		No	ClinGen TOPMed
rs1573779649 CA348740550	77	I>N		No	ClinGen Ensembl
CA57622908 rs965594926	85	G>R		No	ClinGen TOPMed gnomAD
rs1573780698 CA348741759 COSM1007336	86	W>C	endometrium [Cosmic]	No	ClinGen cosmic curated Ensembl
TCGA novel	87	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs149442878 CA1903448	87	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs766949017 CA1903449	88	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1487580979 CA348741834	89	K>R		No	ClinGen TOPMed
rs774746563 CA1903450	90	G>A		No	ClinGen ExAC gnomAD
CA57622914 rs774746563	90	G>D		No	ClinGen ExAC gnomAD
CA348741862 rs774746563	90	G>V		No	ClinGen ExAC gnomAD
rs1323821290 CA348741984	95	P>A		No	ClinGen TOPMed
rs759889961 CA1903451	95	P>L		No	ClinGen ExAC gnomAD
CA1903453 rs753174763	96	I>V		No	ClinGen ExAC gnomAD
CA348742048 rs1288176027	97	V>L		No	ClinGen TOPMed
CA1903454 rs756279797	99	P>S		No	ClinGen ExAC gnomAD
TCGA novel	101	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	101	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1573780739 CA348742188	102	N>K		No	ClinGen Ensembl
CA1903455 rs764349918	103	C>G		No	ClinGen ExAC TOPMed gnomAD
rs753884537 CA1903456	104	G>A		No	ClinGen ExAC gnomAD
CA348742324 rs1280150420	107	K>R		No	ClinGen TOPMed
CA1903457 rs757358858	108	T>I		No	ClinGen ExAC gnomAD
CA348742352 rs1398274437	108	T>S		No	ClinGen TOPMed
TCGA novel	109	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779908291 CA348742428	111	I>N		No	ClinGen ExAC gnomAD
rs779908291 CA1903458	111	I>T		No	ClinGen ExAC gnomAD
rs1277207727 CA348742468	112	D>V		No	ClinGen gnomAD
rs1558898867 CA348742507	113	Y>F		No	ClinGen Ensembl
CA348742497 rs1437120616	113	Y>H		No	ClinGen TOPMed
rs373227124 COSM1399889 CA1903460	116	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA1903461 rs200351871 COSM1399890	116	R>H	large_intestine Variant assessed as Somatic; 0.0002772 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs780835429 CA1903462	117	L>F		No	ClinGen ExAC gnomAD
rs1273287962 CA348742774	125	A>T		No	ClinGen gnomAD
rs1378365946 CA348742779	125	A>V		No	ClinGen gnomAD
CA348742789 rs1477613107	126	Y>N		No	ClinGen gnomAD
CA348742869 rs1558898879	130	P>L		No	ClinGen Ensembl
rs748020930 CA1903465	131	H>D		No	ClinGen ExAC gnomAD
rs748020930 CA1903464	131	H>Y		No	ClinGen ExAC gnomAD
rs79800957 CA1903467	132	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1558900019 CA348743811	133	K>E		No	ClinGen Ensembl
CA1903490 rs144393744	134	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs745433699 CA1903491	137	G>S		No	ClinGen ExAC TOPMed gnomAD
CA1903493 COSM206342 rs564029423	138	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA348743930 rs1411232696	140	T>I		No	ClinGen TOPMed
rs1208305017 CA348743919	140	T>S		No	ClinGen gnomAD
rs1250068848 CA348743932	141	D>N		No	ClinGen gnomAD
TCGA novel	142	P>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA57624752 rs899943634	143	K>Q		No	ClinGen TOPMed gnomAD
rs1046668 CA1903495 VAR_013005	144	Q>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA348743996 rs1425468247	145	I>S		No	ClinGen gnomAD
rs777047478 CA1903496	146	F>Y		No	ClinGen ExAC gnomAD
rs149968670 CA1903497	147	K>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs1465096752 CA348744014	148	S>P		No	ClinGen TOPMed
rs1249337236 CA348744015	148	S>Y		No	ClinGen TOPMed
rs750435263 CA1903499	149	P>S		No	ClinGen ExAC
CA1903501 rs140516340	150	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA1903500 rs140516340	150	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA348744023 rs1160947174	150	G>S		No	ClinGen gnomAD
TCGA novel	150	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1320279312 CA348744057	155	Y>H		No	ClinGen gnomAD
rs777710715 CA1903504	156	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA348744094 rs1339954648	157	D>E		No	ClinGen gnomAD
rs1313995402 CA348744082	157	D>N		No	ClinGen gnomAD
rs1436050926 CA348744148	161	C>S		No	ClinGen TOPMed
CA1903506 rs200453016	163	W>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs1330074240 CA348744183	163	W>C		No	ClinGen gnomAD
TCGA novel	165	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348744228 rs1434394866	167	L>F		No	ClinGen TOPMed
CA1903509 rs370598436	171	Q>L		No	ClinGen ESP ExAC gnomAD
CA57624813 COSM1669300 rs981707651	172	R>C	ovary [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA1903510 rs780367746 COSM1007338	172	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA348744310 rs1573783283	174	H>Q		No	ClinGen Ensembl
TCGA novel	176	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747510114 CA348744330	176	S>R		No	ClinGen ExAC gnomAD
rs1472041501 CA348744349	178	L>*		No	ClinGen TOPMed gnomAD
CA348744350 rs1472041501	178	L>S		No	ClinGen TOPMed gnomAD
rs958421084 CA57624845	179	D>A		No	ClinGen Ensembl
CA348744368 rs1156453547	179	D>E		No	ClinGen gnomAD
rs1449680419 CA348744375	180	F>S		No	ClinGen TOPMed
rs1028157279 CA57624847	181	D>Y		No	ClinGen TOPMed gnomAD
rs769208574 CA1903513	183	E>K		No	ClinGen ExAC gnomAD
CA348744439 rs1186283138	184	D>G		No	ClinGen TOPMed
CA1903514 rs776955823	184	D>N		No	ClinGen ExAC gnomAD
CA1903515 rs762203306	185	D>G		No	ClinGen ExAC gnomAD
CA1903516 rs769648795	186	P>R		No	ClinGen ExAC gnomAD
CA1903517 rs563382038	187	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs375122098 CA57624858	188	C>F		No	ClinGen ESP
TCGA novel	188	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348744537 rs1351383907	190	A>P		No	ClinGen gnomAD
CA57624864 rs866337628	191	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1305075536 CA348744569	192	Y>C		No	ClinGen gnomAD
CA1903518 rs762880468	192	Y>D		No	ClinGen ExAC gnomAD
rs766487949 CA1903519	194	E>Q		No	ClinGen ExAC gnomAD
rs1210482350 CA348744620	196	Y>H		No	ClinGen gnomAD
CA348744674 rs1484636494	198	S>G		No	ClinGen gnomAD
CA1903521 rs529021144	198	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs764178747 CA1903522	199	Y>D		No	ClinGen ExAC
rs757108830 CA1903524	200	D>N		No	ClinGen ExAC TOPMed gnomAD
rs143338696 CA1903525	201	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA1903526 rs140582548	203	H>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA1903527 rs140582548	203	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA348744841 rs1177222226	204	G>V		No	ClinGen gnomAD
TCGA novel	207	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749666169 CA1903555	209	Y>C		No	ClinGen ExAC gnomAD
CA348745790 rs1174607222	210	C>Y		No	ClinGen TOPMed
CA1903556 rs771155983	212	D>N		No	ClinGen ExAC TOPMed gnomAD
CA348745831 rs1321757669	214	L>F		No	ClinGen gnomAD
rs867593216 CA57626679	216	D>Y		No	ClinGen Ensembl
CA1903557 rs774746995	217	D>N		No	ClinGen ExAC gnomAD
rs75295519 CA1903578	225	M>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA348747767 rs1263829925	225	M>V		No	ClinGen Ensembl
CA348747817 rs1398683081	226	T>S		No	ClinGen gnomAD
CA1903580 rs769731044	228	K>R		No	ClinGen ExAC TOPMed gnomAD
CA1903581 rs773044528	229	F>V		No	ClinGen ExAC gnomAD
CA348748028 rs1286585291	231	S>R		No	ClinGen TOPMed
rs762748545 CA1903583	233	A>G		No	ClinGen ExAC
rs1386354888 CA348748116	235	V>E		No	ClinGen TOPMed
CA348748125 rs1165881610	236	T>A		No	ClinGen TOPMed
rs1443095164 CA348748157	238	G>E		No	ClinGen TOPMed
CA348748190 rs1558903194	239	G>D		No	ClinGen Ensembl
rs1043531162 CA57630914	240	F>L		No	ClinGen TOPMed gnomAD
CA1903584 rs770715241	241	Q>E		No	ClinGen ExAC gnomAD
CA57630942 rs903730413	241	Q>R		No	ClinGen TOPMed
CA1903585 rs774196085	247	M>V		No	ClinGen ExAC TOPMed gnomAD
rs767208447 CA1903587	249	P>H		No	ClinGen ExAC gnomAD
CA1903588 rs752224364	250	V>A		No	ClinGen ExAC TOPMed
rs1337129553 CA348748423	251	S>C		No	ClinGen TOPMed gnomAD
rs760138076 CA1903589	254	S>N		No	ClinGen ExAC gnomAD
rs1480030108 CA348748478	255	Q>E		No	ClinGen Ensembl
CA348748486 rs1183183577	255	Q>H		No	ClinGen gnomAD
rs764614306 CA1903590	255	Q>R		No	ClinGen ExAC gnomAD
rs754315587 CA1903591	256	G>E		No	ClinGen ExAC TOPMed gnomAD
rs759969484	258	N>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1468470122 CA348748550	259	T>I		No	ClinGen gnomAD
rs1363376468 CA348748542	259	T>S		No	ClinGen gnomAD
rs757631554 CA1903593	260	S>C		No	ClinGen ExAC gnomAD
rs757631554 CA348748555	260	S>G		No	ClinGen ExAC gnomAD
rs149283868 CA1903595	261	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA1903596 rs371407882	262	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs371407882 CA1903597	262	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA348748622 rs1327849249	264	T>N		No	ClinGen gnomAD
rs1333603367 CA348748659	267	K>R		No	ClinGen TOPMed gnomAD
CA348748654 rs1333603367	267	K>T		No	ClinGen TOPMed gnomAD
CA1903600 rs768628817	268	N>I		No	ClinGen ExAC gnomAD
rs777695934 CA1903601	269	F>V		No	ClinGen ExAC gnomAD
CA348748728 rs1278745392	271	A>G		No	ClinGen TOPMed gnomAD
rs1573788962 CA348748751	273	R>K		No	ClinGen Ensembl
CA348748820 rs1366742553	275	S>N		No	ClinGen TOPMed
rs1344419277 CA348748805	275	S>R		No	ClinGen gnomAD
CA1903602 rs749216110	276	H>P		No	ClinGen ExAC gnomAD
CA57631042 rs200515492	276	H>Q		No	ClinGen TOPMed gnomAD
CA57631061 rs866744420	278	L>K		No	ClinGen TOPMed
CA1903603 rs753076336	278	L>K		No	ClinGen ExAC TOPMed gnomAD
rs770909635 CA1903610	278	L>L		No	ClinGen ExAC TOPMed gnomAD
CA348748894 rs866744420	278	L>Q		No	ClinGen TOPMed
rs770909635 CA1903611	278	L>S		No	ClinGen ExAC TOPMed gnomAD
CA348748933 rs1453508269	278	L>Y		No	ClinGen gnomAD

No associated diseases with P98066

1 regional properties for P98066

Type	Name	Position	InterPro Accession
domain	Small GTP-binding protein domain	12 - 139	IPR005225

Functions

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
ficolin-1-rich granule lumen	Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
tertiary granule lumen	Any membrane-enclosed lumen that is part of a tertiary granule.

4 GO annotations of molecular function

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
carboxylic ester hydrolase activity	Catalysis of the hydrolysis of a carboxylic ester bond.
fibronectin binding	Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
hyaluronic acid binding	Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.

15 GO annotations of biological process

Name	Definition
cell adhesion	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cell-cell signaling	Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
fibronectin fibril organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a fibronectin fibril.
hyaluronan metabolic process	The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
negative regulation of BMP signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
negative regulation of inflammatory response	Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
negative regulation of neutrophil chemotaxis	Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
negative regulation of osteoblast differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.
negative regulation of osteoclast differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.
ovarian cumulus expansion	Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells.
ovulation	The release of a mature ovum/oocyte from an ovary.
positive regulation of cell migration	Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of receptor clustering	Any process that activates or increases the frequency, rate or extent of receptor clustering.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

23 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6UC88	LYVE1	Lymphatic vessel endothelial hyaluronic acid receptor 1	Bos taurus (Bovine)	PR
Q9DER7	TLL1	Tolloid-like protein 1	Gallus gallus (Chicken)	PR
P25723	tld	Dorsal-ventral patterning protein tolloid	Drosophila melanogaster (Fruit fly)	PR
O43897	TLL1	Tolloid-like protein 1	Homo sapiens (Human)	PR
P13497	BMP1	Bone morphogenetic protein 1	Homo sapiens (Human)	PR
Q9Y6L7	TLL2	Tolloid-like protein 2	Homo sapiens (Human)	PR
Q9Y5Y7	LYVE1	Lymphatic vessel endothelial hyaluronic acid receptor 1	Homo sapiens (Human)	PR
P98063	Bmp1	Bone morphogenetic protein 1	Mus musculus (Mouse)	PR
Q9WVM6	Tll2	Tolloid-like protein 2	Mus musculus (Mouse)	PR
Q6HA09	Astl	Astacin-like metalloendopeptidase	Mus musculus (Mouse)	PR
Q62381	Tll1	Tolloid-like protein 1	Mus musculus (Mouse)	PR
O08859	Tnfaip6	Tumor necrosis factor-inducible gene 6 protein	Mus musculus (Mouse)	PR
Q8BHC0	Lyve1	Lymphatic vessel endothelial hyaluronic acid receptor 1	Mus musculus (Mouse)	PR
P45442	lag-2	Protein lag-2	Caenorhabditis elegans	EV
Q9U3S9	nas-6	Zinc metalloproteinase nas-6	Caenorhabditis elegans	PR
P55112	nas-4	Zinc metalloproteinase nas-4	Caenorhabditis elegans	PR
P55113	nas-7	Zinc metalloproteinase nas-7	Caenorhabditis elegans	PR
Q18439	nas-8	Zinc metalloproteinase nas-8	Caenorhabditis elegans	PR
Q20176	nas-39	Zinc metalloproteinase nas-39	Caenorhabditis elegans	PR
Q20942	nas-38	Zinc metalloproteinase nas-38	Caenorhabditis elegans	PR
Q21252	nas-3	Zinc metalloproteinase nas-3	Caenorhabditis elegans	PR
P55115	nas-15	Zinc metalloproteinase nas-15	Caenorhabditis elegans	PR
O57460	tll1	Dorsal-ventral patterning tolloid-like protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MIILIYLFLL	LWEDTQGWGF	KDGIFHNSIW	LERAAGVYHR	EARSGKYKLT	YAEAKAVCEF
70	80	90	100	110	120
EGGHLATYKQ	LEAARKIGFH	VCAAGWMAKG	RVGYPIVKPG	PNCGFGKTGI	IDYGIRLNRS
130	140	150	160	170	180
ERWDAYCYNP	HAKECGGVFT	DPKQIFKSPG	FPNEYEDNQI	CYWHIRLKYG	QRIHLSFLDF
190	200	210	220	230	240
DLEDDPGCLA	DYVEIYDSYD	DVHGFVGRYC	GDELPDDIIS	TGNVMTLKFL	SDASVTAGGF
250	260	270
QIKYVAMDPV	SKSSQGKNTS	TTSTGNKNFL	AGRFSHL