Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P98063

Entry ID Method Resolution Chain Position Source
AF-P98063-F1 Predicted AlphaFoldDB

54 variants for P98063

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3405241410 29 P>T No EVA
rs3405244788 30 L>R No EVA
rs3389348316 58 A>P No EVA
rs30628397 74 Q>R No EVA
rs3389343597 92 K>N No EVA
rs3389262911 120 R>G No EVA
rs3389305066 134 V>M No EVA
rs13463177 151 S>R No EVA
rs3389262980 163 W>C No EVA
rs3389348332 163 W>R No EVA
rs3389343616 180 Y>* No EVA
rs3389331555 187 P>S No EVA
rs3389295105 192 S>F No EVA
rs3389338230 194 V>M No EVA
rs3389262990 221 G>S No EVA
rs3389331605 222 H>R No EVA
rs3389344772 228 H>Y No EVA
rs3389338216 234 D>G No EVA
rs3389348387 247 Q>* No EVA
rs3405014711 251 E>D No EVA
rs3405014694 256 K>N No EVA
rs3405337295 256 K>N No EVA
rs3389323707 315 I>N No EVA
rs3389357426 332 Q>H No EVA
rs3389339738 334 S>I No EVA
rs3389312771 343 Y>* No EVA
rs3389323649 345 N>K No EVA
rs3389337117 377 S>G No EVA
rs3389340847 397 L>F No EVA
rs3404547497 414 D>E No EVA
rs3405420932 414 D>H No EVA
rs3389295085 415 S>R No EVA
rs3389357474 440 C>Y No EVA
rs13463176 500 V>A No EVA
rs3389343590 533 K>N No EVA
rs3389586095 568 C>G No EVA
rs3389344846 595 A>T No EVA
rs3389303649 602 K>M No EVA
rs3389303650 632 Y>H No EVA
rs3389338281 673 S>A No EVA
rs3389312846 696 V>M No EVA
rs3405307093 753 E>* No EVA
rs3389303672 769 P>T No EVA
rs3389340819 773 P>S No EVA
rs3389262966 804 E>* No EVA
rs3389303621 807 Y>F No EVA
rs3389344838 849 D>N No EVA
rs3389343607 865 C>Y No EVA
rs243182314 900 V>M No EVA
rs3389295078 906 G>V No EVA
rs3389323653 911 F>L No EVA
rs3389262967 924 Y>* No EVA
rs3389262941 937 A>S No EVA
rs3389312836 985 D>E No EVA

No associated diseases with P98063

15 regional properties for P98063

Type Name Position InterPro Accession
ptm EGF-type aspartate/asparagine hydroxylation site 568 - 579 IPR000152
domain EGF-like domain 552 - 593 IPR000742-1
domain EGF-like domain 711 - 748 IPR000742-2
domain CUB domain 327 - 439 IPR000859-1
domain CUB domain 440 - 552 IPR000859-2
domain CUB domain 596 - 708 IPR000859-3
domain CUB domain 752 - 864 IPR000859-4
domain CUB domain 865 - 981 IPR000859-5
domain Peptidase M12A 126 - 325 IPR001506
domain EGF-like calcium-binding domain 552 - 593 IPR001881-1
domain EGF-like calcium-binding domain 708 - 748 IPR001881-2
domain Peptidase, metallopeptidase 131 - 273 IPR006026
conserved_site EGF-like calcium-binding, conserved site 552 - 577 IPR018097-1
conserved_site EGF-like calcium-binding, conserved site 708 - 732 IPR018097-2
domain Tolloid/BMP1 peptidase domain 126 - 325 IPR034036

Functions

Description
EC Number 3.4.24.19 Metalloendopeptidases
Subcellular Localization
  • Golgi apparatus, trans-Golgi network
  • Secreted, extracellular space, extracellular matrix
  • Secreted
  • Co-localizes with POSTN in the Golgi
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
collagen-containing extracellular matrix An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
vesicle Any small, fluid-filled, spherical organelle enclosed by membrane.

7 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
cytokine activity The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells.
growth factor activity The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
identical protein binding Binding to an identical protein or proteins.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
peptidase activity Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
zinc ion binding Binding to a zinc ion (Zn).

7 GO annotations of biological process

Name Definition
cartilage development The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
dorsal/ventral pattern formation The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
positive regulation of cartilage development Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

19 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9DER7 TLL1 Tolloid-like protein 1 Gallus gallus (Chicken) PR
P25723 tld Dorsal-ventral patterning protein tolloid Drosophila melanogaster (Fruit fly) PR
P98066 TNFAIP6 Tumor necrosis factor-inducible gene 6 protein Homo sapiens (Human) PR
O43897 TLL1 Tolloid-like protein 1 Homo sapiens (Human) PR
Q9Y6L7 TLL2 Tolloid-like protein 2 Homo sapiens (Human) PR
P13497 BMP1 Bone morphogenetic protein 1 Homo sapiens (Human) PR
O08859 Tnfaip6 Tumor necrosis factor-inducible gene 6 protein Mus musculus (Mouse) PR
Q9WVM6 Tll2 Tolloid-like protein 2 Mus musculus (Mouse) PR
Q6HA09 Astl Astacin-like metalloendopeptidase Mus musculus (Mouse) PR
Q62381 Tll1 Tolloid-like protein 1 Mus musculus (Mouse) PR
Q9U3S9 nas-6 Zinc metalloproteinase nas-6 Caenorhabditis elegans PR
P55112 nas-4 Zinc metalloproteinase nas-4 Caenorhabditis elegans PR
P55113 nas-7 Zinc metalloproteinase nas-7 Caenorhabditis elegans PR
Q18439 nas-8 Zinc metalloproteinase nas-8 Caenorhabditis elegans PR
Q20942 nas-38 Zinc metalloproteinase nas-38 Caenorhabditis elegans PR
Q21252 nas-3 Zinc metalloproteinase nas-3 Caenorhabditis elegans PR
P55115 nas-15 Zinc metalloproteinase nas-15 Caenorhabditis elegans PR
Q20176 nas-39 Zinc metalloproteinase nas-39 Caenorhabditis elegans PR
O57460 tll1 Dorsal-ventral patterning tolloid-like protein 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MPGVARPPLP LLSLPLLLLL LLLPRAGRPL DLADYTYDLG EEDAPELLNY KDPCKAAAFL
70 80 90 100 110 120
GDIALDEEDL RAFQVQQAAV LRQQTARRPS IKAAGNSSAL GGQGTSGQPQ RESRGRWRGR
130 140 150 160 170 180
PRSRRAATSR PERVWPDGVI PFVIGGNFTG SQRAVFRQAM RHWEKHTCVT FLERTDEDSY
190 200 210 220 230 240
IVFTYRPCGC CSYVGRRGGG PQAISIGKNC DKFGIVVHEL GHVIGFWHEH TRPDRDRHVS
250 260 270 280 290 300
IVRENIQPGQ EYNFLKMEVQ EVESLGETYD FDSIMHYARN TFSRGIFLDT IVPKYEVNGV
310 320 330 340 350 360
KPSIGQRTRL SKGDIAQARK LYKCPACGET LQDSTGNFSS PEYPNGYSAH MHCVWRISVT
370 380 390 400 410 420
PGEKIILNFT SMDLYRSRLC WYDYVEVRDG FWRKAPLRGR FCGGKLPEPI VSTDSRLWVE
430 440 450 460 470 480
FRSSSNWVGK GFFAVYEAIC GGDVKKDNGH IQSPNYPDDY RPSKVCIWRI QVSEGFHVGL
490 500 510 520 530 540
TFQSFEIERH DSCAYDYLEV RDGHSESSNL IGRYCGYEKP DDIKSTSSRL WLKFVSDGSI
550 560 570 580 590 600
NKAGFAVNFF KEVDECSRPN RGGCEQRCLN TLGSYKCSCD PGYELAPDKR RCEAACGGFL
610 620 630 640 650 660
TKLNGSITSP GWPKEYPPNK NCIWQLVAPT QYRISLQFDF FETEGNDVCK YDFVEVRSGL
670 680 690 700 710 720
TADSKLHGKF CGSEKPEVIT SQYNNMRVEF KSDNTVSKKG FKAHFFSDKD ECSKDNGGCQ
730 740 750 760 770 780
QDCVNTFGSY ECQCRSGFVL HDNKHDCKEA GCEHKVTSTS GTITSPNWPD KYPSKKECTW
790 800 810 820 830 840
AISSTPGHRV KLTFVEMDIE SQPECAYDHL EVFDGRDAKA PVLGRFCGSK KPEPVLATGN
850 860 870 880 890 900
RMFLRFYSDN SVQRKGFQAS HSTECGGQVR ADVKTKDLYS HAQFGDNNYP GGVDCEWVIV
910 920 930 940 950 960
AEEGYGVELV FQTFEVEEET DCGYDYIELF DGYDSTAPRL GRYCGSGPPE EVYSAGDSVL
970 980 990
VKFHSDDTIS KKGFHLRYTS TKFQDTLHSR K