P98063
Gene name |
Bmp1 |
Protein name |
Bone morphogenetic protein 1 |
Names |
BMP-1, Mammalian tolloid protein, mTld, Procollagen C-proteinase, PCP |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12153 |
EC number |
3.4.24.19: Metalloendopeptidases |
Protein Class |
|

Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure

Activated structure

1 structures for P98063
Entry ID | Method | Resolution | Chain | Position | Source |
---|---|---|---|---|---|
AF-P98063-F1 | Predicted | AlphaFoldDB |
54 variants for P98063
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
rs3405241410 | 29 | P>T | No | EVA | |
rs3405244788 | 30 | L>R | No | EVA | |
rs3389348316 | 58 | A>P | No | EVA | |
rs30628397 | 74 | Q>R | No | EVA | |
rs3389343597 | 92 | K>N | No | EVA | |
rs3389262911 | 120 | R>G | No | EVA | |
rs3389305066 | 134 | V>M | No | EVA | |
rs13463177 | 151 | S>R | No | EVA | |
rs3389262980 | 163 | W>C | No | EVA | |
rs3389348332 | 163 | W>R | No | EVA | |
rs3389343616 | 180 | Y>* | No | EVA | |
rs3389331555 | 187 | P>S | No | EVA | |
rs3389295105 | 192 | S>F | No | EVA | |
rs3389338230 | 194 | V>M | No | EVA | |
rs3389262990 | 221 | G>S | No | EVA | |
rs3389331605 | 222 | H>R | No | EVA | |
rs3389344772 | 228 | H>Y | No | EVA | |
rs3389338216 | 234 | D>G | No | EVA | |
rs3389348387 | 247 | Q>* | No | EVA | |
rs3405014711 | 251 | E>D | No | EVA | |
rs3405014694 | 256 | K>N | No | EVA | |
rs3405337295 | 256 | K>N | No | EVA | |
rs3389323707 | 315 | I>N | No | EVA | |
rs3389357426 | 332 | Q>H | No | EVA | |
rs3389339738 | 334 | S>I | No | EVA | |
rs3389312771 | 343 | Y>* | No | EVA | |
rs3389323649 | 345 | N>K | No | EVA | |
rs3389337117 | 377 | S>G | No | EVA | |
rs3389340847 | 397 | L>F | No | EVA | |
rs3404547497 | 414 | D>E | No | EVA | |
rs3405420932 | 414 | D>H | No | EVA | |
rs3389295085 | 415 | S>R | No | EVA | |
rs3389357474 | 440 | C>Y | No | EVA | |
rs13463176 | 500 | V>A | No | EVA | |
rs3389343590 | 533 | K>N | No | EVA | |
rs3389586095 | 568 | C>G | No | EVA | |
rs3389344846 | 595 | A>T | No | EVA | |
rs3389303649 | 602 | K>M | No | EVA | |
rs3389303650 | 632 | Y>H | No | EVA | |
rs3389338281 | 673 | S>A | No | EVA | |
rs3389312846 | 696 | V>M | No | EVA | |
rs3405307093 | 753 | E>* | No | EVA | |
rs3389303672 | 769 | P>T | No | EVA | |
rs3389340819 | 773 | P>S | No | EVA | |
rs3389262966 | 804 | E>* | No | EVA | |
rs3389303621 | 807 | Y>F | No | EVA | |
rs3389344838 | 849 | D>N | No | EVA | |
rs3389343607 | 865 | C>Y | No | EVA | |
rs243182314 | 900 | V>M | No | EVA | |
rs3389295078 | 906 | G>V | No | EVA | |
rs3389323653 | 911 | F>L | No | EVA | |
rs3389262967 | 924 | Y>* | No | EVA | |
rs3389262941 | 937 | A>S | No | EVA | |
rs3389312836 | 985 | D>E | No | EVA |
No associated diseases with P98063
15 regional properties for P98063
Type | Name | Position | InterPro Accession |
---|---|---|---|
ptm | EGF-type aspartate/asparagine hydroxylation site | 568 - 579 | IPR000152 |
domain | EGF-like domain | 552 - 593 | IPR000742-1 |
domain | EGF-like domain | 711 - 748 | IPR000742-2 |
domain | CUB domain | 327 - 439 | IPR000859-1 |
domain | CUB domain | 440 - 552 | IPR000859-2 |
domain | CUB domain | 596 - 708 | IPR000859-3 |
domain | CUB domain | 752 - 864 | IPR000859-4 |
domain | CUB domain | 865 - 981 | IPR000859-5 |
domain | Peptidase M12A | 126 - 325 | IPR001506 |
domain | EGF-like calcium-binding domain | 552 - 593 | IPR001881-1 |
domain | EGF-like calcium-binding domain | 708 - 748 | IPR001881-2 |
domain | Peptidase, metallopeptidase | 131 - 273 | IPR006026 |
conserved_site | EGF-like calcium-binding, conserved site | 552 - 577 | IPR018097-1 |
conserved_site | EGF-like calcium-binding, conserved site | 708 - 732 | IPR018097-2 |
domain | Tolloid/BMP1 peptidase domain | 126 - 325 | IPR034036 |
Functions
Description | ||
---|---|---|
EC Number | 3.4.24.19 | Metalloendopeptidases |
Subcellular Localization |
|
|
PANTHER Family | ||
PANTHER Subfamily | ||
PANTHER Protein Class | ||
PANTHER Pathway Category | No pathway information available |
4 GO annotations of cellular component
Name | Definition |
---|---|
collagen-containing extracellular matrix | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. |
extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
vesicle | Any small, fluid-filled, spherical organelle enclosed by membrane. |
7 GO annotations of molecular function
Name | Definition |
---|---|
calcium ion binding | Binding to a calcium ion (Ca2+). |
cytokine activity | The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. |
growth factor activity | The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. |
identical protein binding | Binding to an identical protein or proteins. |
metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
peptidase activity | Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. |
zinc ion binding | Binding to a zinc ion (Zn). |
7 GO annotations of biological process
Name | Definition |
---|---|
cartilage development | The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. |
cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
dorsal/ventral pattern formation | The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. |
ossification | The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. |
positive regulation of cartilage development | Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. |
protein processing | Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. |
proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
19 homologous proteins in AiPD
UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
---|---|---|---|---|
Q9DER7 | TLL1 | Tolloid-like protein 1 | Gallus gallus (Chicken) | PR |
P25723 | tld | Dorsal-ventral patterning protein tolloid | Drosophila melanogaster (Fruit fly) | PR |
P98066 | TNFAIP6 | Tumor necrosis factor-inducible gene 6 protein | Homo sapiens (Human) | PR |
O43897 | TLL1 | Tolloid-like protein 1 | Homo sapiens (Human) | PR |
Q9Y6L7 | TLL2 | Tolloid-like protein 2 | Homo sapiens (Human) | PR |
P13497 | BMP1 | Bone morphogenetic protein 1 | Homo sapiens (Human) | PR |
O08859 | Tnfaip6 | Tumor necrosis factor-inducible gene 6 protein | Mus musculus (Mouse) | PR |
Q9WVM6 | Tll2 | Tolloid-like protein 2 | Mus musculus (Mouse) | PR |
Q6HA09 | Astl | Astacin-like metalloendopeptidase | Mus musculus (Mouse) | PR |
Q62381 | Tll1 | Tolloid-like protein 1 | Mus musculus (Mouse) | PR |
Q9U3S9 | nas-6 | Zinc metalloproteinase nas-6 | Caenorhabditis elegans | PR |
P55112 | nas-4 | Zinc metalloproteinase nas-4 | Caenorhabditis elegans | PR |
P55113 | nas-7 | Zinc metalloproteinase nas-7 | Caenorhabditis elegans | PR |
Q18439 | nas-8 | Zinc metalloproteinase nas-8 | Caenorhabditis elegans | PR |
Q20942 | nas-38 | Zinc metalloproteinase nas-38 | Caenorhabditis elegans | PR |
Q21252 | nas-3 | Zinc metalloproteinase nas-3 | Caenorhabditis elegans | PR |
P55115 | nas-15 | Zinc metalloproteinase nas-15 | Caenorhabditis elegans | PR |
Q20176 | nas-39 | Zinc metalloproteinase nas-39 | Caenorhabditis elegans | PR |
O57460 | tll1 | Dorsal-ventral patterning tolloid-like protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
10 | 20 | 30 | 40 | 50 | 60 |
MPGVARPPLP | LLSLPLLLLL | LLLPRAGRPL | DLADYTYDLG | EEDAPELLNY | KDPCKAAAFL |
70 | 80 | 90 | 100 | 110 | 120 |
GDIALDEEDL | RAFQVQQAAV | LRQQTARRPS | IKAAGNSSAL | GGQGTSGQPQ | RESRGRWRGR |
130 | 140 | 150 | 160 | 170 | 180 |
PRSRRAATSR | PERVWPDGVI | PFVIGGNFTG | SQRAVFRQAM | RHWEKHTCVT | FLERTDEDSY |
190 | 200 | 210 | 220 | 230 | 240 |
IVFTYRPCGC | CSYVGRRGGG | PQAISIGKNC | DKFGIVVHEL | GHVIGFWHEH | TRPDRDRHVS |
250 | 260 | 270 | 280 | 290 | 300 |
IVRENIQPGQ | EYNFLKMEVQ | EVESLGETYD | FDSIMHYARN | TFSRGIFLDT | IVPKYEVNGV |
310 | 320 | 330 | 340 | 350 | 360 |
KPSIGQRTRL | SKGDIAQARK | LYKCPACGET | LQDSTGNFSS | PEYPNGYSAH | MHCVWRISVT |
370 | 380 | 390 | 400 | 410 | 420 |
PGEKIILNFT | SMDLYRSRLC | WYDYVEVRDG | FWRKAPLRGR | FCGGKLPEPI | VSTDSRLWVE |
430 | 440 | 450 | 460 | 470 | 480 |
FRSSSNWVGK | GFFAVYEAIC | GGDVKKDNGH | IQSPNYPDDY | RPSKVCIWRI | QVSEGFHVGL |
490 | 500 | 510 | 520 | 530 | 540 |
TFQSFEIERH | DSCAYDYLEV | RDGHSESSNL | IGRYCGYEKP | DDIKSTSSRL | WLKFVSDGSI |
550 | 560 | 570 | 580 | 590 | 600 |
NKAGFAVNFF | KEVDECSRPN | RGGCEQRCLN | TLGSYKCSCD | PGYELAPDKR | RCEAACGGFL |
610 | 620 | 630 | 640 | 650 | 660 |
TKLNGSITSP | GWPKEYPPNK | NCIWQLVAPT | QYRISLQFDF | FETEGNDVCK | YDFVEVRSGL |
670 | 680 | 690 | 700 | 710 | 720 |
TADSKLHGKF | CGSEKPEVIT | SQYNNMRVEF | KSDNTVSKKG | FKAHFFSDKD | ECSKDNGGCQ |
730 | 740 | 750 | 760 | 770 | 780 |
QDCVNTFGSY | ECQCRSGFVL | HDNKHDCKEA | GCEHKVTSTS | GTITSPNWPD | KYPSKKECTW |
790 | 800 | 810 | 820 | 830 | 840 |
AISSTPGHRV | KLTFVEMDIE | SQPECAYDHL | EVFDGRDAKA | PVLGRFCGSK | KPEPVLATGN |
850 | 860 | 870 | 880 | 890 | 900 |
RMFLRFYSDN | SVQRKGFQAS | HSTECGGQVR | ADVKTKDLYS | HAQFGDNNYP | GGVDCEWVIV |
910 | 920 | 930 | 940 | 950 | 960 |
AEEGYGVELV | FQTFEVEEET | DCGYDYIELF | DGYDSTAPRL | GRYCGSGPPE | EVYSAGDSVL |
970 | 980 | 990 | |||
VKFHSDDTIS | KKGFHLRYTS | TKFQDTLHSR | K |