P97822
Gene name |
Anp32e (Cpd1) |
Protein name |
Acidic leucine-rich nuclear phosphoprotein 32 family member E |
Names |
Cerebellar postnatal development protein 1 , LANP-like protein , LANP-L |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:66471 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
1-163 (Leucine-rich region) |
Relief mechanism |
PTM, Others |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P97822
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P97822-F1 | Predicted | AlphaFoldDB |
13 variants for P97822
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388652554 | 60 | L>P | No | EVA | |
| rs3388646456 | 76 | I>F | No | EVA | |
| rs3388652591 | 86 | K>R | No | EVA | |
| rs3388651830 | 95 | L>P | No | EVA | |
| rs3388650732 | 146 | D>N | No | EVA | |
| rs3393363273 | 146 | D>V | No | EVA | |
| rs3393416768 | 147 | G>E | No | EVA | |
| rs3393416657 | 148 | F>S | No | EVA | |
| rs3393337250 | 149 | D>V | No | EVA | |
| rs259392663 | 162 | D>E | No | EVA | |
| rs221968187 | 164 | D>E | No | EVA | |
| rs238933994 | 192 | D>E | No | EVA | |
| rs3388651731 | 246 | K>Q | No | EVA |
No associated diseases with P97822
2 regional properties for P97822
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Leucine-rich repeat | 89 - 110 | IPR001611-1 |
| repeat | Leucine-rich repeat | 114 - 135 | IPR001611-2 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Swr1 complex | A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| histone chaperone activity | Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone). |
| phosphatase inhibitor activity | Binds to and stops, prevents or reduces the activity of a phosphatase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| regulation of apoptotic process | Any process that modulates the occurrence or rate of cell death by apoptotic process. |
18 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SZC6 | ANP32B | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Bos taurus (Bovine) | SS |
| P51122 | ANP32A | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Bos taurus (Bovine) | SS |
| Q5ZMN0 | ANP32B | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Gallus gallus (Chicken) | SS |
| Q5F4A3 | ANP32E | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Gallus gallus (Chicken) | SS |
| Q9V895 | Anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Drosophila melanogaster (Fruit fly) | SS |
| P39687 | ANP32A | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Homo sapiens (Human) | EV |
| Q92688 | ANP32B | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Homo sapiens (Human) | SS |
| Q9BTT0 | ANP32E | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Homo sapiens (Human) | SS |
| Q9EST5 | Anp32b | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Mus musculus (Mouse) | SS |
| O35381 | Anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Mus musculus (Mouse) | SS |
| Q9EST6 | Anp32b | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Rattus norvegicus (Rat) | SS |
| P49911 | Anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Rattus norvegicus (Rat) | SS |
| Q5XIE0 | Anp32e | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Rattus norvegicus (Rat) | SS |
| Q7Y180 | Os03g0668900 | Acidic leucine-rich nuclear phosphoprotein 32-related protein 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q9SCQ7 | At3g50690 | Acidic leucine-rich nuclear phosphoprotein 32-related protein | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q6P1U7 | anp32b | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q7ZUP0 | anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6NUW5 | anp32e | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEMKKKINME | LKNRAPEEVT | ELVLDNCLCV | NGEIEGLNDT | FKELEFLSMA | NVELSSLARL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PSLNKLRKLE | LSDNIISGGL | EVLAEKCPNL | TYLNLSGNKI | KDLSTVEALQ | NLKNLKSLDL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FNCEITNLED | YRESIFELLQ | QITYLDGFDQ | EDNEAPDSEE | EDDDDEDGDE | DEEDEDEDEA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GPPEGYEEEE | DDDEDEAGSE | VGEGEEEVGL | SYLMKDEIQD | EEDDDDYVDE | GEEEEEEEEE |
| 250 | |||||
| GLRGEKRKRD | AEDDGEEDDD |