P97820

PR
Gene name
Map4k4 (Nik)
Protein name
Mitogen-activated protein kinase kinase kinase kinase 4
Names
HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, Nck-interacting kinase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:26921
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

510-741 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P97820

Entry ID Method Resolution Chain Position Source
AF-P97820-F1 Predicted AlphaFoldDB

No variants for P97820

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P97820

No associated diseases with P97820

4 regional properties for P97820

Type Name Position InterPro Accession
domain Protein kinase domain 25 - 288 IPR000719
domain Citron homology (CNH) domain 915 - 1213 IPR001180
active_site Serine/threonine-protein kinase, active site 148 - 160 IPR008271
binding_site Protein kinase, ATP binding site 31 - 53 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
creatine kinase activity Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+).
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

17 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of insulin secretion involved in cellular response to glucose stimulus Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
negative regulation of neuron projection development Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
negative regulation of neuron projection regeneration Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage.
neuron projection morphogenesis The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
positive regulation of ARF protein signal transduction Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction.
positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of focal adhesion assembly Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
positive regulation of focal adhesion disassembly Any process that activates or increases the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components.
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
positive regulation of JNK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
positive regulation of keratinocyte migration Any process that activates or increases the frequency, rate or extent of keratinocyte migration.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of JNK cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.
regulation of MAPK cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7Z2Y5 NRK Nik-related protein kinase Homo sapiens (Human) PR
O95819 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens (Human) PR
Q9R0G8 Nrk Nik-related protein kinase Mus musculus (Mouse) PR
Q9JI11 Stk4 Serine/threonine-protein kinase 4 Mus musculus (Mouse) PR
Q9JI10 Stk3 Serine/threonine-protein kinase 3 Mus musculus (Mouse) SS
Q3ULB5 Pak6 Serine/threonine-protein kinase PAK 6 Mus musculus (Mouse) PR
Q8C015 Pak5 Serine/threonine-protein kinase PAK 5 Mus musculus (Mouse) SS
Q8BTW9 Pak4 Serine/threonine-protein kinase PAK 4 Mus musculus (Mouse) PR
Q8CIN4 Pak2 Serine/threonine-protein kinase PAK 2 Mus musculus (Mouse) SS
Q61036 Pak3 Serine/threonine-protein kinase PAK 3 Mus musculus (Mouse) SS
Q9JM52 Mink1 Misshapen-like kinase 1 Mus musculus (Mouse) PR
P83510 Tnik Traf2 and NCK-interacting protein kinase Mus musculus (Mouse) PR
O88643 Pak1 Serine/threonine-protein kinase PAK 1 Mus musculus (Mouse) SS
O23304 BLUS1 Serine/threonine-protein kinase BLUS1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTVTA AIKVMDVTED
70 80 90 100 110 120
EEEEITLEIN MLKKYSHHRN IATYYGAFIK KSPPGHDDQL WLVMEFCGAG SITDLVKNTK
130 140 150 160 170 180
GNTLKEDWIA YISREILRGL AHLHIHHVIH RDIKGQNVLL TENAEVKLVD FGVSAQLDRT
190 200 210 220 230 240
VGRRNTFIGT PYWMAPEVIA CDENPDATYD YRSDLWSCGI TAIEMAEGGP PLCDMHPMRA
250 260 270 280 290 300
LFLIPRNPPP RLKSKKWSKK FFSFIEGCLV KNYMQRPSTE QLLKHPFIRD QPNERQVRIQ
310 320 330 340 350 360
LKDHIDRTRK KRGEKDETEY EYSGSEEEEE EVPEQEGEPS SIVNVPGEST LRRDFLRLQQ
370 380 390 400 410 420
ENKERSEALR RQQLLQEQQL REQEEYKRQL LAERQKRIEQ QKEQRRRLEE QQRREREARR
430 440 450 460 470 480
QQEREQRRRE QEEKRRLEEL ERRRKEEEER RRAEEEKRRV EREQEYIRRQ LEEEQRHLEI
490 500 510 520 530 540
LQQQLLQEQA MLLHDHRRPH AQQQPPPPQQ QDRSKPSFHA PEPKPHYDPA DRAREVQWSH
550 560 570 580 590 600
LASLKNNVSP VSRSHSFSDP SPKFAHHHLR SQDPCPPSRS EGLSQSSDSK SEVPEPTQKA
610 620 630 640 650 660
WSRSDSDEVP PRVPVRTTSR SPVLSRRDSP LQGGGQQNSQ AGQRNSTSSI EPRLLWERVE
670 680 690 700 710 720
KLVPRPGSGS SSGSSNSGSQ PGSHPGSQSG SGERFRVRSS SKSEGSPSPR QESAAKKPDD
730 740 750 760 770 780
KKEVFRSLKP AGEVDLTALA KELRAVEDVR PPHKVTDYSS SSEESGTTDE EEEDVEQEGA
790 800 810 820 830 840
DDSTSGPEDT RAASSPNLSN GETESVKTMI VHDDVESEPA MTPSKEGTLI VRQTQSASST
850 860 870 880 890 900
LQKHKSSSSF TPFIDPRLLQ ISPSSGTTVT SVVGFSCDGL RPEAIRQDPT RKGSVVNVNP
910 920 930 940 950 960
TNTRPQSDTP EIRKYKKRFN SEILCAALWG VNLLVGTESG LMLLDRSGQG KVYPLISRRR
970 980 990 1000 1010 1020
FQQMDVLEGL NVLVTISGKK DKLRVYYLSW LRNKILHNDP EVEKKQGWTT VGDLEGCVHY
1030 1040 1050 1060 1070 1080
KVVKYERIKF LVIALKSSVE VYAWAPKPYH KFMAFKSFGE LLHKPLLVDL TVEEGQRLKV
1090 1100 1110 1120 1130 1140
IYGSCAGFHA VDVDSGSVYD IYLPTHIQCS IKPHAIIILP NTDGMELLVC YEDEGVYVNT
1150 1160 1170 1180 1190 1200
YGRITKDVVL QWGEMPTSVA YIRSNQTMGW GEKAIEIRSV ETGHLDGVFM HKRAQRLKFL
1210 1220 1230
CGRNDKVFFS SVRSGGSSQV YFMTLGRTSL LSW