P97793
SS
Gene name |
Alk |
Protein name |
ALK tyrosine kinase receptor |
Names |
EC 2.7.10.1 , Anaplastic lymphoma kinase , CD antigen CD246 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:11682 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
ALK is a receptor tyrosine kinase involved in the development of several human cancers. Its autoinhibition is mediated by an intramolecular interaction between β-sheet (β1' and β2') and DFG helix in an activation loop, which occludes the substrate binding site. The activation loop contains phosphorylation sites, which need to be phosphorylated for ALK activation.
Autoinhibitory domains (AIDs)
Target domain |
1120-1396 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
1273-1298 (Activation loop from InterPro)
Target domain |
1120-1396 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Bossi RT et al. (2010) "Crystal structures of anaplastic lymphoma kinase in complex with ATP competitive inhibitors", Biochemistry, 49, 6813-25
- Donella-Deana A et al. (2005) "Unique substrate specificity of anaplastic lymphoma kinase (ALK): development of phosphoacceptor peptides for the assay of ALK activity", Biochemistry, 44, 8533-42
- Craddock BP et al. (2007) "Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region", FEBS letters, 581, 3235-40
- Tu CH et al. (2016) "Pyrazolylamine Derivatives Reveal the Conformational Switching between Type I and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK)", Journal of medicinal chemistry, 59, 3906-19
- Uchikawa E et al. (2019) "Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex", eLife, 8,
- Nielsen J et al. (2022) "Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling", Journal of molecular biology, 434, 167458
- Chen YS et al. (2021) "Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone-receptor activation", Proceedings of the National Academy of Sciences of the United States of America, 118,
- Huang X et al. (2009) "Structural insights into the inhibited states of the Mer receptor tyrosine kinase", Journal of structural biology, 165, 88-96
Autoinhibited structure
Activated structure
1 structures for P97793
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P97793-F1 | Predicted | AlphaFoldDB |
91 variants for P97793
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs107714419 | 4 | A>V | No | EVA | |
| rs3407940073 | 8 | W>R | No | EVA | |
| rs1132838364 | 13 | L>V | No | EVA | |
| rs108923499 | 22 | G>E | No | EVA | |
| rs3389457363 | 77 | R>Q | No | EVA | |
| rs219545409 | 82 | P>S | No | EVA | |
| rs3389472887 | 104 | L>M | No | EVA | |
| rs33365774 | 114 | D>E | No | EVA | |
| rs3389482734 | 134 | G>D | No | EVA | |
| rs3389437541 | 140 | R>M | No | EVA | |
| rs3389390253 | 144 | Q>* | No | EVA | |
| rs108274460 | 153 | T>R | No | EVA | |
| rs3389491739 | 159 | I>N | No | EVA | |
| rs33592590 | 165 | V>A | No | EVA | |
| rs3408003064 | 185 | H>L | No | EVA | |
| rs3389474027 | 228 | G>E | No | EVA | |
| rs51467189 | 232 | M>L | No | EVA | |
| rs230684894 | 288 | G>R | No | EVA | |
| rs3389446799 | 297 | V>M | No | EVA | |
| rs3389486557 | 312 | E>K | No | EVA | |
| rs33524345 | 314 | E>D | No | EVA | |
| rs3389482740 | 315 | H>L | No | EVA | |
| rs3389491727 | 316 | S>F | No | EVA | |
| rs3389494236 | 350 | T>I | No | EVA | |
| rs3389471233 | 365 | Y>* | No | EVA | |
| rs3389486566 | 367 | A>T | No | EVA | |
| rs3389479407 | 369 | L>I | No | EVA | |
| rs3389486506 | 401 | A>V | No | EVA | |
| rs3406109664 | 467 | Q>R | No | EVA | |
| rs3389437562 | 500 | P>S | No | EVA | |
| rs3389479990 | 504 | R>G | No | EVA | |
| rs3389482751 | 535 | G>S | No | EVA | |
| rs3389494287 | 536 | A>T | No | EVA | |
| rs3508137923 | 539 | T>I | No | EVA | |
| rs257503556 | 568 | V>I | No | EVA | |
| rs45823252 | 583 | R>Q | No | EVA | |
| rs3508155854 | 585 | V>I | No | EVA | |
| rs256007941 | 591 | D>N | No | EVA | |
| rs3389491788 | 594 | L>S | No | EVA | |
| rs3389472821 | 601 | V>L | No | EVA | |
| rs3389478862 | 643 | S>I | No | EVA | |
| rs46035867 | 668 | S>T | No | EVA | |
| rs3508139523 | 682 | D>N | No | EVA | |
| rs3389478876 | 697 | P>H | No | EVA | |
| rs3412564331 | 715 | S>C | No | EVA | |
| rs3389457343 | 715 | S>R | No | EVA | |
| rs3389471217 | 717 | V>M | No | EVA | |
| rs3389437581 | 720 | S>G | No | EVA | |
| rs3389491722 | 776 | Y>N | No | EVA | |
| rs3389473994 | 782 | Q>H | No | EVA | |
| rs3389486504 | 853 | Y>H | No | EVA | |
| rs3389472843 | 867 | S>R | No | EVA | |
| rs3389446885 | 875 | N>K | No | EVA | |
| rs3389427990 | 882 | G>S | No | EVA | |
| rs3389486554 | 901 | L>M | No | EVA | |
| rs3389390285 | 905 | A>G | No | EVA | |
| rs3389481448 | 905 | A>T | No | EVA | |
| rs3389473915 | 916 | K>* | No | EVA | |
| rs3389481433 | 925 | F>C | No | EVA | |
| rs3389472846 | 925 | F>I | No | EVA | |
| rs3389494282 | 925 | F>L | No | EVA | |
| rs3389427976 | 928 | G>S | No | EVA | |
| rs3389427932 | 963 | I>F | No | EVA | |
| rs3389471234 | 982 | E>K | No | EVA | |
| rs236379187 | 1020 | D>A | No | EVA | |
| rs3553399116 | 1030 | T>P | No | EVA | |
| rs3389491781 | 1038 | S>* | No | EVA | |
| rs3389494222 | 1066 | K>R | No | EVA | |
| rs3389474054 | 1073 | M>I | No | EVA | |
| rs3389491757 | 1077 | L>V | No | EVA | |
| rs3389471249 | 1086 | K>R | No | EVA | |
| rs3389481477 | 1112 | L>V | No | EVA | |
| rs3389472897 | 1155 | T>M | No | EVA | |
| rs3389479466 | 1159 | V>M | No | EVA | |
| rs3389491718 | 1237 | I>N | No | EVA | |
| rs3389472878 | 1253 | D>E | No | EVA | |
| rs3389479460 | 1267 | G>E | No | EVA | |
| rs3389479401 | 1269 | I>T | No | EVA | |
| rs3389474038 | 1271 | K>R | No | EVA | |
| rs3389478807 | 1272 | I>M | No | EVA | |
| rs3389479413 | 1278 | A>V | No | EVA | |
| rs46043448 | 1284 | A>V | No | EVA | |
| rs3389486494 | 1333 | P>L | No | EVA | |
| rs3389437598 | 1372 | H>Q | No | EVA | |
| rs581657112 | 1464 | A>V | No | EVA | |
| rs3407888423 | 1526 | K>N | No | EVA | |
| rs3553540075 | 1528 | T>P | No | EVA | |
| rs3407858776 | 1529 | H>Q | No | EVA | |
| rs3407932805 | 1535 | E>G | No | EVA | |
| rs3553249947 | 1546 | G>S | No | EVA | |
| rs3407996109 | 1622 | P>W | No | EVA |
No associated diseases with P97793
1 regional properties for P97793
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Calcineurin-like phosphoesterase domain, ApaH type | 1 - 106 | IPR004843 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| cell body | The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| heparin binding | Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. |
| identical protein binding | Binding to an identical protein or proteins. |
| protein tyrosine kinase activity | Catalysis of the reaction |
| receptor signaling protein tyrosine kinase activator activity | Binds to and increases the activity of a receptor signaling protein tyrosine kinase. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| adult behavior | Behavior in a fully developed and mature organism. |
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| energy homeostasis | Any process involved in the balance between food intake (energy input) and energy expenditure. |
| hippocampus development | The progression of the hippocampus over time from its initial formation until its mature state. |
| negative regulation of lipid catabolic process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| peptidyl-tyrosine autophosphorylation | The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein. |
| positive regulation of dendrite development | Any process that activates or increases the frequency, rate or extent of dendrite development. |
| regulation of cell population proliferation | Any process that modulates the frequency, rate or extent of cell proliferation. |
| regulation of dopamine receptor signaling pathway | Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. |
| regulation of neuron differentiation | Any process that modulates the frequency, rate or extent of neuron differentiation. |
| response to environmental enrichment | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the provision of a combination of complex inanimate and social stimulations in the organism's housing environment. |
| swimming behavior | The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
55 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q769I5 | MET | Hepatocyte growth factor receptor | Bos taurus (Bovine) | PR |
| A0M8S8 | MET | Hepatocyte growth factor receptor | Felis catus (Cat) (Felis silvestris catus) | PR |
| P29376 | LTK | Leukocyte tyrosine kinase receptor | Homo sapiens (Human) | SS |
| Q04912 | MST1R | Macrophage-stimulating protein receptor | Homo sapiens (Human) | EV |
| P08581 | MET | Hepatocyte growth factor receptor | Homo sapiens (Human) | EV |
| P14616 | INSRR | Insulin receptor-related protein | Homo sapiens (Human) | SS |
| P08922 | ROS1 | Proto-oncogene tyrosine-protein kinase ROS | Homo sapiens (Human) | SS |
| Q9UM73 | ALK | ALK tyrosine kinase receptor | Homo sapiens (Human) | EV |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q62371 | Ddr2 | Discoidin domain-containing receptor 2 | Mus musculus (Mouse) | SS |
| Q03146 | Ddr1 | Epithelial discoidin domain-containing receptor 1 | Mus musculus (Mouse) | SS |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| P70424 | Erbb2 | Receptor tyrosine-protein kinase erbB-2 | Mus musculus (Mouse) | SS |
| Q61527 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Mus musculus (Mouse) | SS |
| Q61526 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Mus musculus (Mouse) | SS |
| Q01279 | Egfr | Epidermal growth factor receptor | Mus musculus (Mouse) | SS |
| Q01887 | Ryk | Tyrosine-protein kinase RYK | Mus musculus (Mouse) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| P97523 | Met | Hepatocyte growth factor receptor | Rattus norvegicus (Rat) | PR |
| Q64716 | Insrr | Insulin receptor-related protein | Rattus norvegicus (Rat) | SS |
| Q8I7I5 | rol-3 | Protein roller-3 | Caenorhabditis elegans | PR |
| Q19238 | F09A5.2 | Putative tyrosine-protein kinase F09A5.2 | Caenorhabditis elegans | SS |
| H2KZU7 | svh-2 | Tyrosine-protein kinase receptor svh-2 | Caenorhabditis elegans | SS |
| F8W3R9 | alk | ALK tyrosine kinase receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| F1QVU0 | ltk | Tyrosine-protein kinase receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGAAGFLWLL | PPLLLAAASY | SGAATDQRAG | SPASGPPLQP | REPLSYSRLQ | RKSLAVDFVV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PSLFRVYARD | LLLPQPRSPS | EPEAGGLEAR | GSLALDCEPL | LRLLGPLPGI | SWADGASSPS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PEAGPTLSRV | LKGGSVRKLR | RAKQLVLELG | EETILEGCIG | PPEEVAAVGI | LQFNLSELFS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WWILHGEGRL | RIRLMPEKKA | SEVGREGRLS | SAIRASQPRL | LFQIFGTGHS | SMESPSETPS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PPGTFMWNLT | WTMKDSFPFL | SHRSRYGLEC | SFDFPCELEY | SPPLHNHGNQ | SWSWRHVPSE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EASRMNLLDG | PEAEHSQEMP | RGSFLLLNTS | ADSKHTILSP | WMRSSSDHCT | LAVSVHRHLQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PSGRYVAQLL | PHNEAGREIL | LVPTPGKHGW | TVLQGRVGRP | ANPFRVALEY | ISSGNRSLSA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VDFFALKNCS | EGTSPGSKMA | LQSSFTCWNG | TVLQLGQACD | FHQDCAQGED | EGQLCSKLPA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GFYCNFENGF | CGWTQSPLSP | HMPRWQVRTL | RDAHSQGHQG | RALLLSTTDI | LASEGATVTS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ATFPAPMKNS | PCELRMSWLI | RGVLRGNVSL | VLVENKTGKE | QSRTVWHVAT | DEGLSLWQHT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VLSLLDVTDR | FWLQIVTWWG | PGSRATVGFD | NISISLDCYL | TISGEEKMSL | NSVPKSRNLF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EKNPNKESKS | WANISGPTPI | FDPTVHWLFT | TCGASGPHGP | TQAQCNNAYQ | NSNLSVVVGS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EGPLKGVQIW | KVPATDTYSI | SGYGAAGGKG | GKNTMMRSHG | VSVLGIFNLE | KGDTLYILVG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| QQGEDACPRA | NQLIQKVCVG | ENNVIEEEIR | VNRSVHEWAG | GGGGGGGATY | VFKMKDGVPV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PLIIAAGGGG | RAYGAKTETF | HPERLESNSS | VLGLNGNSGA | AGGGGGWNDN | TSLLWAGKSL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LEGAAGGHSC | PQAMKKWGWE | TRGGFGGGGG | GCSSGGGGGG | YIGGNAASNN | DPEMDGEDGV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SFISPLGILY | TPALKVMEGH | GEVNIKHYLN | CSHCEVDECH | MDPESHKVIC | FCDHGTVLAD |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| DGVSCIVSPT | PEPHLPLSLI | LSVVTSALVA | ALVLAFSGIM | IVYRRKHQEL | QAMQMELQSP |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| EYKLSKLRTS | TIMTDYNPNY | CFAGKTSSIS | DLKEVPRKNI | TLIRGLGHGA | FGEVYEGQVS |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| GMPNDPSPLQ | VAVKTLPEVC | SEQDELDFLM | EALIISKFNH | QNIVRCIGVS | LQALPRFILL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| ELMAGGDLKS | FLRETRPRPN | QPTSLAMLDL | LHVARDIACG | CQYLEENHFI | HRDIAARNCL |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| LTCPGAGRIA | KIGDFGMARD | IYRASYYRKG | GCAMLPVKWM | PPEAFMEGIF | TSKTDTWSFG |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| VLLWEIFSLG | YMPYPSKSNQ | EVLEFVTSGG | RMDPPKNCPG | PVYRIMTQCW | QHQPEDRPNF |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| AIILERIEYC | TQDPDVINTA | LPIEYGPVVE | EEEKVPMRPK | DPEGMPPLLV | SPQPAKHEEA |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| SAAPQPAALT | APGPSVKKPP | GAGAGAGAGA | GAGPVPRGAA | DRGHVNMAFS | QPNPPPELHK |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| GPGSRNKPTS | LWNPTYGSWF | TEKPAKKTHP | PPGAEPQARA | GAAEGGWTGP | GAGPRRAEAA |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| LLLEPSALSA | TMKEVPLFRL | RHFPCGNVNY | GYQQQGLPLE | ATAAPGDTML | KSKNKVTQPG |
| P |