P97523

PR
Gene name
Met
Protein name
Hepatocyte growth factor receptor
Names
HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:24553
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

936-1097 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

1222-1249 (Activation loop from InterPro)

Target domain

1079-1346 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P97523

Entry ID Method Resolution Chain Position Source
AF-P97523-F1 Predicted AlphaFoldDB

No variants for P97523

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P97523

No associated diseases with P97523

11 regional properties for P97523

Type Name Position InterPro Accession
domain Protein kinase domain 1079 - 1346 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 1079 - 1337 IPR001245
domain Sema domain 27 - 516 IPR001627
domain IPT domain 563 - 656 IPR002909-1
domain IPT domain 657 - 740 IPR002909-2
domain IPT domain 742 - 837 IPR002909-3
domain IPT domain 839 - 936 IPR002909-4
active_site Tyrosine-protein kinase, active site 1201 - 1213 IPR008266
domain PSI domain 520 - 563 IPR016201
binding_site Protein kinase, ATP binding site 1085 - 1111 IPR017441
domain Tyrosine-protein kinase, catalytic domain 1079 - 1338 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Membrane; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

14 GO annotations of cellular component

Name Definition
basal plasma membrane The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
excitatory synapse A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
postsynaptic density An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
sperm flagellum A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.

12 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
beta-catenin binding Binding to a catenin beta subunit.
hepatocyte growth factor receptor activity Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
identical protein binding Binding to an identical protein or proteins.
phosphatidylinositol 3-kinase binding Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
phospholipase binding Binding to a phospholipase.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein phosphatase binding Binding to a protein phosphatase.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein-containing complex binding Binding to a macromolecular complex.
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

75 GO annotations of biological process

Name Definition
adult behavior Behavior in a fully developed and mature organism.
brain development The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
branching morphogenesis of an epithelial tube The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.
cardiac muscle cell development The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.
cardiac muscle contraction Muscle contraction of cardiac muscle tissue.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cellular response to arsenic-containing substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
cellular response to glucose stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
cellular response to growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
cellular response to inorganic substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
cellular response to interleukin-6 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
cellular response to peptide hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
central nervous system neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.
chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
endothelial cell morphogenesis The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.
establishment of localization in cell Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
establishment of skin barrier Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability.
excitatory postsynaptic potential A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
flagellated sperm motility The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.
glucose homeostasis Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
glucose transmembrane transport The process in which glucose is transported across a membrane.
hepatocyte growth factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to a hepatocyte growth factor receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
lactation The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
liver development The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
male gonad development The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
modulation of chemical synaptic transmission Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
muscle cell migration The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism.
muscle organ development The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
myoblast proliferation The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
myotube differentiation The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of guanyl-nucleotide exchange factor activity Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity.
negative regulation of hydrogen peroxide-mediated programmed cell death Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death.
negative regulation of peptidyl-threonine phosphorylation Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
negative regulation of Rho protein signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
negative regulation of stress fiber assembly Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
negative regulation of thrombin-activated receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of transforming growth factor beta production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron.
neuron migration The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
oligodendrocyte development The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
pancreas development The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.
phagocytosis A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
placenta development The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
positive chemotaxis The directed movement of a motile cell or organism towards a higher concentration of a chemical.
positive regulation of dendrite morphogenesis Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
positive regulation of DNA replication Any process that activates or increases the frequency, rate or extent of DNA replication.
positive regulation of endothelial cell chemotaxis Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of glucose transmembrane transport Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of kinase activity Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
positive regulation of microtubule polymerization Any process that activates or increases the frequency, rate or extent of microtubule polymerization.
positive regulation of mitotic nuclear division Any process that activates or increases the frequency, rate or extent of mitosis.
positive regulation of neuron projection development Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
positive regulation of p38MAPK cascade Any process that activates or increases the frequency, rate or extent of p38MAPK cascade.
positive regulation of peptidyl-serine phosphorylation Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
positive regulation of peptidyl-threonine phosphorylation Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of protein kinase B signaling Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
reactive oxygen species metabolic process The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Any process that modulates the rate, frequency, or extent of branching involved in salivary gland morphogenesis as a result of signals being generated by the mesenchyme and received and interpreted by the salivary gland epithelium.
regulation of cellular response to oxidative stress Any process that modulates the frequency, rate or extent of cellular response to oxidative stress.
regulation of interleukin-6 production Any process that modulates the frequency, rate, or extent of interleukin-6 production.
response to acidic pH Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
response to organic cyclic compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
response to peptide hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
semaphorin-plexin signaling pathway The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
skeletal muscle tissue development The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

60 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q769I5 MET Hepatocyte growth factor receptor Bos taurus (Bovine) PR
A0M8S8 MET Hepatocyte growth factor receptor Felis catus (Cat) (Felis silvestris catus) PR
Q75ZY9 MET Hepatocyte growth factor receptor Canis lupus familiaris (Dog) (Canis familiaris) PR
Q2QLA9 MET Hepatocyte growth factor receptor Equus caballus (Horse) PR
P29376 LTK Leukocyte tyrosine kinase receptor Homo sapiens (Human) SS
Q04912 MST1R Macrophage-stimulating protein receptor Homo sapiens (Human) EV
P14616 INSRR Insulin receptor-related protein Homo sapiens (Human) SS
P08922 ROS1 Proto-oncogene tyrosine-protein kinase ROS Homo sapiens (Human) SS
Q9UM73 ALK ALK tyrosine kinase receptor Homo sapiens (Human) EV
O43157 PLXNB1 Plexin-B1 Homo sapiens (Human) EV SS
Q9HCM2 PLXNA4 Plexin-A4 Homo sapiens (Human) SS
O75051 PLXNA2 Plexin-A2 Homo sapiens (Human) SS
P51805 PLXNA3 Plexin-A3 Homo sapiens (Human) SS
Q9UIW2 PLXNA1 Plexin-A1 Homo sapiens (Human) EV SS
O15031 PLXNB2 Plexin-B2 Homo sapiens (Human) SS
Q9ULL4 PLXNB3 Plexin-B3 Homo sapiens (Human) SS
P08581 MET Hepatocyte growth factor receptor Homo sapiens (Human) EV
Q9WTL4 Insrr Insulin receptor-related protein Mus musculus (Mouse) SS
Q62190 Mst1r Macrophage-stimulating protein receptor Mus musculus (Mouse) SS
P97793 Alk ALK tyrosine kinase receptor Mus musculus (Mouse) SS
Q9QY40 Plxnb3 Plexin-B3 Mus musculus (Mouse) SS
P70208 Plxna3 Plexin-A3 Mus musculus (Mouse) EV SS
Q3UH93 Plxnd1 Plexin-D1 Mus musculus (Mouse) SS
P70207 Plxna2 Plexin-A2 Mus musculus (Mouse) SS
B2RXS4 Plxnb2 Plexin-B2 Mus musculus (Mouse) SS
Q8CJH3 Plxnb1 Plexin-B1 Mus musculus (Mouse) SS
Q9QZC2 Plxnc1 Plexin-C1 Mus musculus (Mouse) SS
Q80UG2 Plxna4 Plexin-A4 Mus musculus (Mouse) SS
P70206 Plxna1 Plexin-A1 Mus musculus (Mouse) EV SS
P16056 Met Hepatocyte growth factor receptor Mus musculus (Mouse) PR
Q2QLE0 MET Hepatocyte growth factor receptor Sus scrofa (Pig) PR
D3ZPX4 Plxna3 Plexin-A3 Rattus norvegicus (Rat) SS
D3ZLH5 Plxnb3 Plexin-B3 Rattus norvegicus (Rat) SS
G3V9H8 Ret Proto-oncogene tyrosine-protein kinase receptor Ret Rattus norvegicus (Rat) SS
Q62838 Musk Muscle, skeletal receptor tyrosine protein kinase Rattus norvegicus (Rat) SS
Q63604 Ntrk2 BDNF/NT-3 growth factors receptor Rattus norvegicus (Rat) SS
P35739 Ntrk1 High affinity nerve growth factor receptor Rattus norvegicus (Rat) SS
Q03351 Ntrk3 NT-3 growth factor receptor Rattus norvegicus (Rat) SS
Q91ZT1 Flt4 Vascular endothelial growth factor receptor 3 Rattus norvegicus (Rat) SS
O08775 Kdr Vascular endothelial growth factor receptor 2 Rattus norvegicus (Rat) SS
Q64716 Insrr Insulin receptor-related protein Rattus norvegicus (Rat) SS
P24062 Igf1r Insulin-like growth factor 1 receptor Rattus norvegicus (Rat) SS
Q498D6 Fgfr4 Fibroblast growth factor receptor 4 Rattus norvegicus (Rat) PR
P57097 Mertk Tyrosine-protein kinase Mer Rattus norvegicus (Rat) SS
Q62956 Erbb4 Receptor tyrosine-protein kinase erbB-4 Rattus norvegicus (Rat) SS
Q62799 Erbb3 Receptor tyrosine-protein kinase erbB-3 Rattus norvegicus (Rat) SS
Q05030 Pdgfrb Platelet-derived growth factor receptor beta Rattus norvegicus (Rat) SS
P20786 Pdgfra Platelet-derived growth factor receptor alpha Rattus norvegicus (Rat) SS
P15127 Insr Insulin receptor Rattus norvegicus (Rat) SS
Q63474 Ddr1 Epithelial discoidin domain-containing receptor 1 Rattus norvegicus (Rat) SS
P53767 Flt1 Vascular endothelial growth factor receptor 1 Rattus norvegicus (Rat) PR
Q04589 Fgfr1 Fibroblast growth factor receptor 1 Rattus norvegicus (Rat) SS
P06494 Erbb2 Receptor tyrosine-protein kinase erbB-2 Rattus norvegicus (Rat) SS
Q00495 Csf1r Macrophage colony-stimulating factor 1 receptor Rattus norvegicus (Rat) PR
Q8I7I5 rol-3 Protein roller-3 Caenorhabditis elegans PR
H2KZU7 svh-2 Tyrosine-protein kinase receptor svh-2 Caenorhabditis elegans SS
F1QVU0 ltk Tyrosine-protein kinase receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
F8W3R9 alk ALK tyrosine kinase receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q6BEA0 plxna4 Plexin-A4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
B0S5N4 plxna3 Plexin A3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MKAPTALAPG ILLLLLTLAQ RSHGECKEAL VKSEMNVNMK YQLPNFTAET PIHNVVLPGH
70 80 90 100 110 120
HIYLGATNYI YVLNDKDLQK VSEFKTGPVV EHPDCFPCQD CSSKANVSGG VWKDNVNMAL
130 140 150 160 170 180
LVDTYYDDQL ISCGSVNRGT CQRHVLPPDN AADIQSEVHC MFSPLAEEES GQCPDCVVSA
190 200 210 220 230 240
LGAKVLLSEK DRFINFFVGN TINSSYPPDY SLHSISVRRL KETQDGFKFL TDQSYIDVLP
250 260 270 280 290 300
EFRDSYPIKY IHAFESNHFI YFLTVQKETL DAQTFHTRII RFCSVDSGLH SYMEMPLECI
310 320 330 340 350 360
LTEKRRKRST REEVFNILQA AYVSKPGANL AKQIGASPYD DILYGVFAQS KPDSAEPMNR
370 380 390 400 410 420
SAVCAFPIKY VNDFFNKIVN KNNVRCLQHF YGPNHEHCFN RTLLRNSSGC EVRSDEYRTE
430 440 450 460 470 480
FTTALQRVDL FMGRLNHVLL TSISTFIKGD LTIANLGTSE GRFMQVVLSR TAHFTPHVNF
490 500 510 520 530 540
LLDSYPVSPE VIVEHPSNQN GYTLVVTGKK ITKIPLNGLG CGHFQSCSQC LSPPYFIQCG
550 560 570 580 590 600
WCHNRCVHSN ECPSGTWTQE ICLPAVYKVF PTSAPLEGGT MLTICGWDFG FKKNNKFDLR
610 620 630 640 650 660
KTKVLLGNES CTLTLSESTT NTLKCTVGPA MSEHFNVSVI VSNSRETTQY SAFSYVDPVI
670 680 690 700 710 720
TSISPRYGPH AGGTLLTLTG KYLNSGNSRH ISIGGKTCTL KSVSDSILEC YTPGHTVSAE
730 740 750 760 770 780
FPVKLKIDLA DRVTSSFSYR EDPVVSEIHP TKSFISGGST ITGIGKNLNS VSTPKLVIEV
790 800 810 820 830 840
HDVGVNYTVA CQHRSSSEII CCTTPSLRQL DLQLPLKTKA FFLLDGILSK HFDLTYVHDP
850 860 870 880 890 900
MFKPFEKPVM ISMGNENVVE IKGDDIDPEA VKGEVLKVGN KSCENLHWHS EALLCTVPSD
910 920 930 940 950 960
LLKLNGGELN IEWKQAVSST VLGKVIVQPD QNFAGLIIGA VSISVVVLLV SGLFLWLRKR
970 980 990 1000 1010 1020
KHKDLGSELV RYDARVHTPH LDRLVSARSV SPTTEMVSNE SVDYRATFPE DQFPNSSQNG
1030 1040 1050 1060 1070 1080
ACRQVQYLLT DLSPILTSGD SDISSPLLQN TVHIDLSALN PELVQAVPHV VIGPSSLIVH
1090 1100 1110 1120 1130 1140
FNEVIGRGHF GCVYHGTLLD SDGKKIHCAV KSLNRITDIE EVSQFLTEGI IMKDFSHPNV
1150 1160 1170 1180 1190 1200
LSLLGICLRS EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLVSKK
1210 1220 1230 1240 1250 1260
FVHRDLAARN CMLDEKFTVK VADFGLARDM YDKEYYSVHN KTGAKLPVKW MALESLQTQK
1270 1280 1290 1300 1310 1320
FTTKSDVWSF GVLLWELMTR GAPPYPDVNT FDITIYLLQG RRLLQPEYCP DALYEVMLKC
1330 1340 1350 1360 1370 1380
WHPKAEMRPS VSELVSRISS IFSTFIGEHY VHVNATYVNV KCVAPYPSLL PSQDNIDGEA
NT