P97369
Gene name |
Ncf4 |
Protein name |
Neutrophil cytosol factor 4 |
Names |
NCF-4, Neutrophil NADPH oxidase factor 4, p40-phox, p40phox |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:17972 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P97369
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P97369-F1 | Predicted | AlphaFoldDB |
18 variants for P97369
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389364536 | 5 | Q>H | No | EVA | |
| rs3389370802 | 7 | L>M | No | EVA | |
| rs212081003 | 22 | V>I | No | EVA | |
| rs31704358 | 85 | S>N | No | EVA | |
| rs3389380485 | 176 | E>* | No | EVA | |
| rs3413039316 | 222 | S>F | No | EVA | |
| rs3389380439 | 248 | T>I | No | EVA | |
| rs584605011 | 272 | A>V | No | EVA | |
| rs3389374227 | 277 | E>D | No | EVA | |
| rs222642271 | 286 | S>N | No | EVA | |
| rs3389365712 | 291 | E>K | No | EVA | |
| rs3389380465 | 302 | D>N | No | EVA | |
| rs3389380464 | 302 | D>V | No | EVA | |
| rs3389334858 | 316 | Q>E | No | EVA | |
| rs3389365750 | 320 | F>L | No | EVA | |
| rs3389380486 | 329 | K>N | No | EVA | |
| rs3389361833 | 331 | N>I | No | EVA | |
| rs3405431124 | 340 | P>C | No | EVA |
No associated diseases with P97369
6 regional properties for P97369
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PB1 domain | 237 - 329 | IPR000270 |
| domain | SH3 domain | 170 - 229 | IPR001452 |
| domain | Phox homology | 18 - 140 | IPR001683 |
| domain | Neutrophil cytosol factor P40, PB1 domain | 238 - 329 | IPR034853 |
| domain | Neutrophil cytosol factor 4, PX domain | 19 - 141 | IPR034912 |
| domain | Neutrophil cytosol factor P40, SH3 domain | 174 - 227 | IPR035541 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| NADPH oxidase complex | A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatidylinositol-3-phosphate binding | Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. |
| superoxide-generating NADPH oxidase activator activity | Increases the activity of the enzyme superoxide-generating NADPH oxidase. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| phagocytosis | A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. |
| respiratory burst | A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. |
| superoxide anion generation | The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O77774 | NCF1 | Neutrophil cytosol factor 1 | Bos taurus (Bovine) | SS |
| P14598 | NCF1 | Neutrophil cytosol factor 1 | Homo sapiens (Human) | EV |
| Q5HYK7 | SH3D19 | SH3 domain-containing protein 19 | Homo sapiens (Human) | PR |
| Q09014 | Ncf1 | Neutrophil cytosol factor 1 | Mus musculus (Mouse) | SS |
| A2AAY5 | Sh3pxd2b | SH3 and PX domain-containing protein 2B | Mus musculus (Mouse) | SS |
| O89032 | Sh3pxd2a | SH3 and PX domain-containing protein 2A | Mus musculus (Mouse) | SS |
| F1M707 | Ncf1 | Neutrophil cytosolic factor 1 | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALAQQLRSE | SDFEQLPDDV | AVSANIADIE | EKRGFTSHFV | FVIEVKTKGG | SKYLIYRRYR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QFYALQSKLE | ERFGPESKNS | PFTCSLPTLP | AKVYMGAKQE | IAETRIPALN | AYMKNLLSLP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VCVLMDPDVR | IFFYQSAYDA | EQVPQALRRL | RPRTRKIKGV | SPQGAIMDRM | EAPRAEALFD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FTGNSKLELS | FKAGDVIFLL | SKINKDWLEG | TSQGATGIFP | GSFVKILKDF | PEDEDTTNWL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RCYFYEDTGK | TIKDIAVEED | LSSTPLFKDL | LALMRREFQR | EDIALSYQDA | EGDLVRLLSD |
| 310 | 320 | 330 | |||
| EDVGLMVKQA | RGLPSQKRLF | PWKLHVTQKD | NYSVYNTVP |