P97368
PR
Gene name |
Meis3 (Mrg2) |
Protein name |
Homeobox protein Meis3 |
Names |
Meis1-related protein 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:17537 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P97368
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P97368-F1 | Predicted | AlphaFoldDB |
18 variants for P97368
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs39449386 | 18 | T>M | No | EVA | |
| rs3388883354 | 52 | D>G | No | EVA | |
| rs3388881199 | 54 | D>N | No | EVA | |
| rs3388881246 | 73 | A>V | No | EVA | |
| rs3388881170 | 113 | A>T | No | EVA | |
| rs3388870261 | 138 | Q>L | No | EVA | |
| rs3388855918 | 207 | I>F | No | EVA | |
| rs3388883352 | 220 | T>I | No | EVA | |
| rs3397478153 | 228 | L>Q | No | EVA | |
| rs3388843239 | 254 | G>R | No | EVA | |
| rs3388883768 | 278 | N>D | No | EVA | |
| rs3388883767 | 279 | I>T | No | EVA | |
| rs3388882360 | 289 | S>* | No | EVA | |
| rs3388864803 | 338 | A>S | No | EVA | |
| rs3388872592 | 352 | E>* | No | EVA | |
| rs36254234 | 353 | T>I | No | EVA | |
| rs3388855828 | 360 | R>K | No | EVA | |
| rs3388879385 | 379 | L>L | No | EVA |
No associated diseases with P97368
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| sequence-specific double-stranded DNA binding | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| animal organ morphogenesis | Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. |
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| embryonic pattern specification | The process that results in the patterns of cell differentiation that will arise in an embryo. |
| eye development | The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. |
| negative regulation of apoptotic signaling pathway | Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of protein kinase B signaling | Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8MIB7 | TGIF2LX | Homeobox protein TGIF2LX | Pan troglodytes (Chimpanzee) | PR |
| O00470 | MEIS1 | Homeobox protein Meis1 | Homo sapiens (Human) | SS |
| Q8IUE1 | TGIF2LX | Homeobox protein TGIF2LX | Homo sapiens (Human) | PR |
| O14770 | MEIS2 | Homeobox protein Meis2 | Homo sapiens (Human) | EV |
| Q99687 | MEIS3 | Homeobox protein Meis3 | Homo sapiens (Human) | SS |
| A8K0S8 | MEIS3P2 | Putative homeobox protein Meis3-like 2 | Homo sapiens (Human) | PR |
| A6NDR6 | MEIS3P1 | Putative homeobox protein Meis3-like 1 | Homo sapiens (Human) | PR |
| O35984 | Pbx2 | Pre-B-cell leukemia transcription factor 2 | Mus musculus (Mouse) | PR |
| P97367 | Meis2 | Homeobox protein Meis2 | Mus musculus (Mouse) | SS |
| Q75LX9 | Os03g0673500 | Putative homeobox protein knotted-1-like 5 | Oryza sativa subsp japonica (Rice) | PR |
| Q75LX7 | OSH10 | Homeobox protein knotted-1-like 4 | Oryza sativa subsp japonica (Rice) | PR |
| Q1PFD1 | BLH11 | BEL1-like homeodomain protein 11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIW1 | BLH7 | BEL1-like homeodomain protein 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARRYDELRH | YPGITEHTTA | LASFSEAAPS | VPRAPGPYTP | HRPPQLQAPG | LDSDSLKREK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DDIYGHPLFP | LLALVFEKCE | LATCSPRDGA | SAGLGSPPGG | DVCSSDSFNE | DIAAFAKQIR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SERPLFSSNP | ELDNLMVQAI | QVLRFHLLEL | EKVHDLCDNF | CHRYITCLKG | KMPIDLVIED |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RDGSCREDLE | DYAASCPSLP | DQNTTWIRDH | EDSGSVHLGT | PGPSSGGLAS | QSGDNSSDQG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DGLDTSVASP | SSAGEDEDLD | LERRRNKKRG | IFPKVATNIM | RAWLFQHLSH | PYPSEEQKKQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LAQDTGLTIL | QVNNWFINAR | RRIVQPMIDQ | SNRTGQGASF | NPEGQPMAGF | TETQPQVTVR |
| 370 | |||||
| TPGSMGMNLN | LEGEWHYL |