P97367

SS
Gene name
Meis2 (Mrg1, Stra10)
Protein name
Homeobox protein Meis2
Names
Meis1-related protein 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:17536
EC number
Protein Class

Descriptions

Meis2 is a homeodomain protein containing a conserved homothorax (Hth) domain that is present in all Meis and Prep family proteins and in the Drosophila Hth protein. According to a study with human MEIS2, The region (150?193 residues) of MEIS2 is an autoinhibitory region which encompasses homology region 2 (hr2) of the Hth domain. The Hth domain interacts with Pbx proteins, thereby promoting cooperative binding of Meis?Pbx dimers to a composite DNA element, and this interaction facilitates binding of the Pbx partner to DNA.

Autoinhibitory domains (AIDs)

150-193 (hr2 region) SS

Target domain

340-470 (C-terminal transcriptional activation domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P97367

Entry ID Method Resolution Chain Position Source
AF-P97367-F1 Predicted AlphaFoldDB

No variants for P97367

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P97367

No associated diseases with P97367

3 regional properties for P97367

Type Name Position InterPro Accession
domain Homeobox domain 274 - 341 IPR001356
domain Homeobox KN domain 294 - 333 IPR008422
domain Homeobox protein PKNOX/Meis, N-terminal 110 - 193 IPR032453

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm, perinuclear region
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

7 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
transcription factor binding Binding to a transcription factor, a protein required to initiate or regulate transcription.

14 GO annotations of biological process

Name Definition
animal organ morphogenesis Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
brain development The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
embryonic pattern specification The process that results in the patterns of cell differentiation that will arise in an embryo.
eye development The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
negative regulation of myeloid cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.
pancreas development The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.
positive regulation of cardiac muscle myoblast proliferation Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of mitotic cell cycle Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to growth factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
response to mechanical stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
visual learning Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8MIB7 TGIF2LX Homeobox protein TGIF2LX Pan troglodytes (Chimpanzee) PR
O00470 MEIS1 Homeobox protein Meis1 Homo sapiens (Human) SS
Q8IUE1 TGIF2LX Homeobox protein TGIF2LX Homo sapiens (Human) PR
O14770 MEIS2 Homeobox protein Meis2 Homo sapiens (Human) EV
O35984 Pbx2 Pre-B-cell leukemia transcription factor 2 Mus musculus (Mouse) PR
P97368 Meis3 Homeobox protein Meis3 Mus musculus (Mouse) PR
Q75LX9 Os03g0673500 Putative homeobox protein knotted-1-like 5 Oryza sativa subsp japonica (Rice) PR
Q75LX7 OSH10 Homeobox protein knotted-1-like 4 Oryza sativa subsp japonica (Rice) PR
Q1PFD1 BLH11 BEL1-like homeodomain protein 11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SIW1 BLH7 BEL1-like homeodomain protein 7 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV
70 80 90 100 110 120
MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN
130 140 150 160 170 180
EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK
190 200 210 220 230 240
GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH
250 260 270 280 290 300
ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT
310 320 330 340 350 360
HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAGFLLD PSVSQGAAYS
370 380 390 400 410 420
PEGQPMGSFV LDGQQHMGIR PAGLQSMPGD YVSQGGPMGM GMAQPSYTPP QMTPHPTQLR
430 440 450 460 470
HGPPMHSYLP SHPHHPAMVM HGGPPTHPGM TMSAQSPTML NSVDPNVGGQ VMDIHAQ