P97360
Gene name |
Etv6 (Tel, Tel1) |
Protein name |
Transcription factor ETV6 |
Names |
ETS translocation variant 6, ETS-related protein Tel1, Tel |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14011 |
EC number |
|
Protein Class |
ETS (PTHR11849) |
Descriptions
Etv6 is a transcriptional repressor containing a PNT domain and plays roles in normal cellular processes as well as a variety of human malignancies. The C-terminal inhibitory domain (CID) attenuates the binding of Etv6 by 10-fold, which is achieved by an α-helix H5 in the CID that blocks the DNA binding surface of Etv6. Interestingly, the LID (linker inhibitory damper) of Etv6 interferes with the autoinhibition by CID.
Autoinhibitory domains (AIDs)
Target domain |
336-416 (ETS domain) |
Relief mechanism |
Partner binding, Others |
Assay |
Deletion assay, Mutagenesis experiment, Structural analysis |
Accessory elements
No accessory elements
References
- Green SM et al. (2010) "DNA binding by the ETS protein TEL (ETV6) is regulated by autoinhibition and self-association", The Journal of biological chemistry, 285, 18496-504
- Coyne HJ 3rd et al. (2012) "Autoinhibition of ETV6 (TEL) DNA binding: appended helices sterically block the ETS domain", Journal of molecular biology, 421, 67-84
Autoinhibited structure
Activated structure
5 structures for P97360
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2LF7 | NMR | - | A | 335-436 | PDB |
| 2LF8 | NMR | - | A | 335-458 | PDB |
| 2MD5 | NMR | - | A | 329-426 | PDB |
| 4MHG | X-ray | 220 A | A | 329-426 | PDB |
| AF-P97360-F1 | Predicted | AlphaFoldDB |
1 variants for P97360
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs31921736 | 220 | A>S | No | Ensembl |
No associated diseases with P97360
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR11849 | ETS |
| PANTHER Subfamily | PTHR11849:SF19 | TRANSCRIPTION FACTOR ETV6 |
| PANTHER Protein Class |
DNA-binding transcription factor
helix-turn-helix transcription factor winged helix/forkhead transcription factor |
|
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription repressor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| hematopoietic stem cell proliferation | The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. |
| mesenchymal cell apoptotic process | Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| neurogenesis | Generation of cells within the nervous system. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| vitellogenesis | The production of yolk. Yolk is a mixture of materials used for embryonic nutrition. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q58DT0 | ELF5 | ETS-related transcription factor Elf-5 | Bos taurus (Bovine) | SS |
| Q0VC65 | ETV6 | Transcription factor ETV6 | Bos taurus (Bovine) | SS |
| P32519 | ELF1 | ETS-related transcription factor Elf-1 | Homo sapiens (Human) | PR |
| Q9UKW6 | ELF5 | ETS-related transcription factor Elf-5 | Homo sapiens (Human) | EV |
| Q99607 | ELF4 | ETS-related transcription factor Elf-4 | Homo sapiens (Human) | PR |
| Q9Y603 | ETV7 | Transcription factor ETV7 | Homo sapiens (Human) | SS |
| P78545 | ELF3 | ETS-related transcription factor Elf-3 | Homo sapiens (Human) | SS |
| P41212 | ETV6 | Transcription factor ETV6 | Homo sapiens (Human) | SS |
| Q60775 | Elf1 | ETS-related transcription factor Elf-1 | Mus musculus (Mouse) | PR |
| Q8VDK3 | Elf5 | ETS-related transcription factor Elf-5 | Mus musculus (Mouse) | SS |
| Q9Z2U4 | Elf4 | ETS-related transcription factor Elf-4 | Mus musculus (Mouse) | PR |
| Q9JHC9 | Elf2 | ETS-related transcription factor Elf-2 | Mus musculus (Mouse) | PR |
| Q00422 | Gabpa | GA-binding protein alpha chain | Mus musculus (Mouse) | EV |
| Q9WTP3 | Spdef | SAM pointed domain-containing Ets transcription factor | Mus musculus (Mouse) | PR |
| P70459 | Erf | ETS domain-containing transcription factor ERF | Mus musculus (Mouse) | PR |
| P81270 | Erg | Transcriptional regulator ERG | Mus musculus (Mouse) | SS |
| P28322 | Etv4 | ETS translocation variant 4 | Mus musculus (Mouse) | SS |
| Q9CXC9 | Etv5 | ETS translocation variant 5 | Mus musculus (Mouse) | SS |
| P41164 | Etv1 | ETS translocation variant 1 | Mus musculus (Mouse) | SS |
| P41971 | Elk3 | ETS domain-containing protein Elk-3 | Mus musculus (Mouse) | EV |
| P41158 | Elk4 | ETS domain-containing protein Elk-4 | Mus musculus (Mouse) | PR |
| P41969 | Elk1 | ETS domain-containing protein Elk-1 | Mus musculus (Mouse) | PR |
| P15037 | Ets2 | Protein C-ets-2 | Mus musculus (Mouse) | SS |
| P27577 | Ets1 | Protein C-ets-1 | Mus musculus (Mouse) | EV |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSETPAQSSI | KQERISYTPP | ESPVASHRSS | TPLHVHTVPR | ALRMEEDSIH | LPTHLRLQPI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YWSRDDVAQW | LKWAENEFSL | RPIESNKFEM | NGKALLLLTK | EDFRYRSPHS | GDVLYELLQH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ILKQRKSRML | FSPFFPPGDS | IHTKPEVLLH | QNHDEDNCVQ | RTPRTPAESV | HHNPPTIELL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HRPRSPITTN | HRPSPDPEQQ | RPQRSPLDNM | SRRLSPVEKA | QGPRLQQENN | HQETYPLSVS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PVENNHCLPS | SPWQESTRVI | QLMPSPIMHP | LILNPRHSHS | VDFKQSRHSE | DGMNREGKPI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NLSHREDLAY | LNHIMVSMSP | PEEHAMPIGR | IADCRLLWDY | VYQLLSDSRY | ENFIRWEDKE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SKIFRIVDPN | GLARLWGNHK | NRTNMTYEKM | SRALRHYYKL | NIIRKEPGQR | LLFRFMKTPD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EIMSGRTDRL | EHLESQVLDE | QTYQEDEPTI | ASPVGWPRGN | LPTGTAGGVM | EAGELGVAVK |
| EETRE |