AiPD: Autoinhibited Protein Database

Gene name	Mcm6 (Mcmd6, Mis5)
Protein name	DNA replication licensing factor MCM6
Names	Mis5 homolog
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:17219
EC number	3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-50 (Predicted disordered autoinhibitory region) PR

1-50 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P97311-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs13474747	52	E>K	No	EVA
rs1132649173	63	V>L	No	EVA
rs3388496024	76	S>A	No	EVA
rs3388494532	94	L>M	No	EVA
rs3388495612	95	K>E	No	EVA
rs3388498264	272	G>DG*	No	EVA
rs3388496074	273	A>G	No	EVA
rs3388494525	290	R>*	No	EVA
rs3388495572	290	R>K	No	EVA
rs3388496260	330	T>K	No	EVA
rs3388495949	332	K>S	No	EVA
rs3388496349	357	T>A	No	EVA
rs3388495527	476	A>V	No	EVA
rs3388495513	489	V>M	No	EVA
rs3388496867	490	K>R	No	EVA
rs3390626417	561	E>C	No	EVA
rs3388493382	578	F>I	No	EVA
rs3388493414	629	E>D	No	EVA
rs3388496295	646	K>SDG*	No	EVA
rs3388493923	647	E>K	No	EVA
rs3388495163	648	A>V	No	EVA
rs3388494556	655	S>L	No	EVA
rs3388495080	674	M>V	No	EVA
rs254082028	682	G>S	No	EVA
rs3388496011	688	D>V	No	EVA
rs3388496830	704	S>G	No	EVA
rs248087811	713	L>M	No	EVA
rs3388496687	746	S>N	No	EVA
rs3388495130	769	K>E	No	EVA
rs3388495965	773	I>F	No	EVA
rs3390643910	795	L>*	No	EVA
rs244469577	806	E>G	No	EVA
rs3388495998	808	D>E	No	EVA

Type	Name	Position	InterPro Accession
domain	B-box-type zinc finger	94 - 135	IPR000315
domain	Zinc finger, RING-type	16 - 66	IPR001841
domain	B30.2/SPRY domain	275 - 473	IPR001870
domain	SPRY domain	346 - 470	IPR003877
domain	Butyrophylin-like, SPRY domain	292 - 309	IPR003879-1
domain	Butyrophylin-like, SPRY domain	331 - 355	IPR003879-2
domain	Butyrophylin-like, SPRY domain	363 - 376	IPR003879-3
domain	Butyrophylin-like, SPRY domain	407 - 431	IPR003879-4
domain	Butyrophylin-like, SPRY domain	438 - 456	IPR003879-5
domain	SPRY-associated	293 - 345	IPR006574
conserved_site	Zinc finger, RING-type, conserved site	31 - 40	IPR017907
domain	Zinc finger, B-box, chordata	107 - 124	IPR020457-1
domain	Zinc finger, B-box, chordata	126 - 140	IPR020457-2
domain	Zinc finger, RING-type, eukaryotic	16 - 63	IPR027370
domain	TRIM17, PRY/SPRY domain	295 - 470	IPR035687

		Description
EC Number	3.6.4.12	Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization	Nucleus Chromosome	Binds to chromatin during G1 and detaches from it during S phase
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
CMG complex	A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication.
MCM complex	A hexameric protein complex required for the initiation and regulation of DNA replication.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA helicase activity	Unwinding of a DNA helix, driven by ATP hydrolysis.
identical protein binding	Binding to an identical protein or proteins.
single-stranded DNA binding	Binding to single-stranded DNA.

Name	Definition
DNA replication initiation	The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
DNA unwinding involved in DNA replication	The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
double-strand break repair via break-induced replication	The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.
mitotic DNA replication	Any nuclear DNA replication that is involved in a mitotic cell cycle.
regulation of DNA-templated DNA replication initiation	Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2KIZ8	MCM6	DNA replication licensing factor MCM6	Bos taurus (Bovine)	PR
Q9V461	Mcm6	DNA replication licensing factor Mcm6	Drosophila melanogaster (Fruit fly)	PR
Q14566	MCM6	DNA replication licensing factor MCM6	Homo sapiens (Human)	PR
Q61881	Mcm7	DNA replication licensing factor MCM7	Mus musculus (Mouse)	PR
P97310	Mcm2	DNA replication licensing factor MCM2	Mus musculus (Mouse)	PR
Q62724	Mcm6	DNA replication licensing factor MCM6	Rattus norvegicus (Rat)	PR
Q6F353	Os05g0235800	DNA replication licensing factor MCM6	Oryza sativa subsp japonica (Rice)	PR
P34647	mcm-6	DNA replication licensing factor mcm-6	Caenorhabditis elegans	PR
Q9SF37	MCM8	Probable DNA helicase MCM8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q28CM3	mmcm6	Maternal DNA replication licensing factor mcm6	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6P1V8	zmcm6	Zygotic DNA replication licensing factor mcm6	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR