P97310
PR
Gene name |
Mcm2 (Bm28, Cdcl1, Kiaa0030, Mcmd2) |
Protein name |
DNA replication licensing factor MCM2 |
Names |
Minichromosome maintenance protein 2 homolog, Nuclear protein BM28 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:17216 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P97310
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P97310-F1 | Predicted | AlphaFoldDB |
32 variants for P97310
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388837603 | 4 | S>Y | No | EVA | |
| rs3388809250 | 128 | L>P | No | EVA | |
| rs3388830030 | 152 | R>H | No | EVA | |
| rs3388851027 | 159 | E>D | No | EVA | |
| rs3412877962 | 190 | G>W | No | EVA | |
| rs3388822505 | 196 | H>Y | No | EVA | |
| rs3388845639 | 202 | F>V | No | EVA | |
| rs3388851021 | 208 | D>N | No | EVA | |
| rs36257874 | 242 | H>Q | No | EVA | |
| rs3413134289 | 249 | P>Q | No | EVA | |
| rs3388837552 | 255 | L>M | No | EVA | |
| rs3388847080 | 280 | H>Y | No | EVA | |
| rs3410427082 | 309 | S>R | No | EVA | |
| rs234042252 | 450 | K>E | No | EVA | |
| rs3388842197 | 452 | A>S | No | EVA | |
| rs3388842198 | 453 | V>L | No | EVA | |
| rs3388842920 | 455 | E>K | No | EVA | |
| rs3388832896 | 469 | K>T | No | EVA | |
| rs3388809205 | 502 | G>R | No | EVA | |
| rs3388825564 | 521 | L>M | No | EVA | |
| rs3388832858 | 542 | R>H | No | EVA | |
| rs3388839561 | 616 | I>T | No | EVA | |
| rs3388851046 | 631 | N>K | No | EVA | |
| rs3388842251 | 651 | E>* | No | EVA | |
| rs3397193814 | 662 | V>E | No | EVA | |
| rs3388847098 | 716 | P>H | No | EVA | |
| rs243857368 | 732 | R>H | No | EVA | |
| rs3388840979 | 750 | L>V | No | EVA | |
| rs3388837612 | 762 | I>F | No | EVA | |
| rs3388845629 | 765 | R>H | No | EVA | |
| rs3388851052 | 841 | A>V | No | EVA | |
| rs3388838567 | 899 | L>M | No | EVA |
No associated diseases with P97310
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| CMG complex | A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| MCM complex | A hexameric protein complex required for the initiation and regulation of DNA replication. |
| nuclear origin of replication recognition complex | A multisubunit complex that is located at the replication origins of a chromosome in the nucleus. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
| DNA replication origin binding | Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. |
| metal ion binding | Binding to a metal ion. |
| single-stranded DNA binding | Binding to single-stranded DNA. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| cellular response to interleukin-4 | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. |
| cochlea development | The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound. |
| DNA replication initiation | The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. |
| DNA unwinding involved in DNA replication | The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. |
| double-strand break repair via break-induced replication | The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome. |
| mitotic DNA replication initiation | Any DNA replication initiation involved in mitotic cell cycle DNA replication. |
| negative regulation of DNA helicase activity | Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent DNA helicase activity. |
| nucleosome assembly | The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
| regulation of DNA-templated DNA replication initiation | Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P49736 | MCM2 | DNA replication licensing factor MCM2 | Homo sapiens (Human) | PR |
| Q61881 | Mcm7 | DNA replication licensing factor MCM7 | Mus musculus (Mouse) | PR |
| P97311 | Mcm6 | DNA replication licensing factor MCM6 | Mus musculus (Mouse) | PR |
| Q69QA6 | MCM9 | Probable DNA helicase MCM9 | Oryza sativa subsp japonica (Rice) | PR |
| F4IFF3 | MCM9 | Probable DNA helicase MCM9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAESSESLSA | SSPARQRRRI | SDPLTSSPGR | SSRRADALTS | SPGRDLPPFE | DESEGLLGTE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GPMEEEEDGE | ELIGDGMERD | YRPIPELDVY | EAEGLALDDE | DVEELTASQR | EAAERTMRQR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DREAGRGLGR | MRRGLLYDSS | EEDEERPARK | RRHVERATED | GEEDEEMIES | IENLEDLKGH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SVREWVSMAG | PRLEIHHRFK | NFLRTHVDSH | GHNVFKERIS | DMCKENRESL | VVNYEDLAAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EHVLAYFLPE | APAELLQIFD | EAALEVVLAM | YPKYDRITNH | IHVRISHLPL | VEELRSLRQL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HLNQLIRTSG | VVTSCTGVLP | QLSMVKYNCS | KCNFVLGPFC | QSQNQEVKPG | SCPECQSAGP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FEINMEETIY | QNYQRIRIQE | SPGKVAAGRL | PRSKDAILLA | DLVDSCKPGD | EIELTGIYHN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NYDGSLNTAN | GFPVFATIIL | ANHVAKKDNK | VAVGELTDED | VKMITGLSKD | QQIGEKIFAS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IAPSIYGHED | IKRGLALALF | GGEPKNPGGK | HKVRGDINVL | LCGDPGTAKS | QFLKYIEKVS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SRAIFTTGQG | ASAVGLTAYV | QRHPVSREWT | LEAGALVLAD | RGVCLIDEFD | KMNDQDRTSI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HEAMEQQSIS | ISKAGIVTSL | QARCTVIAAA | NPIGGRYDPS | LTFSENVDLT | EPIISRFDVL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| CVVRDTVDPV | QDEMLARFVV | GSHVRHHPSN | KKDEGLTNGG | TLEPAMPNTY | GVEPLPQEVL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KKYIIYAKER | VRPKLNQMDQ | DKVARMYSDL | RKESMATGSI | PITVRHIESM | IRMAEAHARM |
| 790 | 800 | 810 | 820 | 830 | 840 |
| HLRDYVMEDD | VNMAIRVMME | SFIDTQKFSV | MRSMRKTFAR | YLSFRRDNND | LLLFILKQLV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| AEQVTYQRNR | FGAQQDTIEI | PEKDLMDKAR | QINIHNLSAF | YDSDLFKFNK | FSRDLKRKLI |
| LQQF |