Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

2 structures for P94421

Entry ID Method Resolution Chain Position Source
3GFV X-ray 175 A A/B 21-317 PDB
AF-P94421-F1 Predicted AlphaFoldDB

No variants for P94421

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P94421

No associated diseases with P94421

2 regional properties for P94421

Type Name Position InterPro Accession
domain ABC transporter periplasmic binding domain 56 - 317 IPR002491
domain FatB domain 44 - 313 IPR033870

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor
  • Membrane raft ; Lipid-anchor
  • Also found in the extracellular protein fraction (PubMed:10658653)
  • May exist in both membrane-tethered and soluble form (Probable)
  • Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion (PubMed:23651456)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
iron ion transport The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKFALLFIA LVTAVVISAC GNQSTSSKGS DTKKEQITVK HQLDKNGTKV PKNPKKVVVF
70 80 90 100 110 120
DFGSLDTLDK LGLDDIVAGL PKQVLPKYLS KFKDDKYADV GSLKEPDFDK VAELDPDLII
130 140 150 160 170 180
ISARQSESYK EFSKIAPTIY LGVDTAKYME SFKSDAETIG KIFDKEDKVK DELANIDHSI
190 200 210 220 230 240
ADVKKTAEKL NKNGLVIMAN DGKISAFGPK SRYGLIHDVF GVAPADQNIK ASTHGQSVSY
250 260 270 280 290 300
EYISKTNPDY LFVIDRGTAI GETSSTKQVV ENDYVKNVNA VKNGHVIYLD SATWYLSGGG
310
LESMTQMIKE VKDGLEK