P94414

PR
Gene name
yclJ (BSU03750)
Protein name
Sensor histidine kinase YclK
Names
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU03760
EC number
2.7.13.3: Protein-histidine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-152 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P94414

Entry ID Method Resolution Chain Position Source
AF-P94414-F1 Predicted AlphaFoldDB

No variants for P94414

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P94414

No associated diseases with P94414

8 regional properties for P94414

Type Name Position InterPro Accession
domain Histidine kinase/HSP90-like ATPase 358 - 470 IPR003594
domain HAMP domain 185 - 239 IPR003660
domain Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 245 - 313 IPR003661
domain Signal transduction histidine kinase-related protein, C-terminal 394 - 408 IPR004358-1
domain Signal transduction histidine kinase-related protein, C-terminal 412 - 422 IPR004358-2
domain Signal transduction histidine kinase-related protein, C-terminal 430 - 448 IPR004358-3
domain Signal transduction histidine kinase-related protein, C-terminal 454 - 467 IPR004358-4
domain Histidine kinase domain 254 - 470 IPR005467

Functions

Description
EC Number 2.7.13.3 Protein-histidine kinases
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphorelay response regulator activity Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
protein kinase activator activity Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.

1 GO annotations of biological process

Name Definition
osmosensory signaling via phosphorelay pathway The series of molecular signals generated in response to osmotic change, as mediated through a phosphorelay system.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMKIKYLYQL LLSHISILIL AFVIIISLFS HFVKEFAYQN KVEELTSYAV QIANEFQSGQ
70 80 90 100 110 120
VDMRRLYPYQ DILSTRKTQF IIFNEEQQPY FLPEGFHHPP REQLKKSEWN KLKKGQTVTI
130 140 150 160 170 180
RADGRFDDEV SLVAQPIFVQ NEFKGAVLLI SPISGVEQMV NQVNLYMFYA VISTLVITIL
190 200 210 220 230 240
VSWLLSKFHV KRIQKLREAT DKVASGDYDI HLENSYGDEI GVLASDFNIM AKKLKQSRDE
250 260 270 280 290 300
IERLEKRRRQ FIADVSHELK TPLTTINGLV EGLNSHTIPE DKKDKCFSLI SEETKRMLRL
310 320 330 340 350 360
VKENLDYEKI RSQQITLNKL DVPLIEVFEI VKEHLQQQAE EKQNKLMIQV EDHVIVHADY
370 380 390 400 410 420
DRFIQILVNI TKNSIQFTQN GDIWLRGMEG YKETIIEIED TGIGIPKEDI EHIWERFYKA
430 440 450 460 470
DISRTNTAYG EYGLGLSIVR QLVEMHQGTV EIKSEEGKGT KFIIRLPLTA KQQ