P93050
Gene name |
BSH (At3g17590, MKP6.15) |
Protein name |
Probable LRR receptor-like serine/threonine-protein kinase RKF3 |
Names |
Receptor-like kinase in flowers 3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G48010 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
429-435 (Activation loop from InterPro)
Target domain |
283-563 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
446-453 (Activation loop from InterPro)
Target domain |
283-563 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for P93050
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P93050-F1 | Predicted | AlphaFoldDB |
25 variants for P93050
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH13672548 | 5 | R>C | No | 1000Genomes | |
| tmp_2_19641484_T_C | 7 | I>T | No | 1000Genomes | |
| tmp_2_19641495_T_A | 11 | F>I | No | 1000Genomes | |
| ENSVATH02000454 | 13 | V>L | No | 1000Genomes | |
| ENSVATH02000455 | 16 | S>T | No | 1000Genomes | |
| ENSVATH02000456 | 17 | F>L | No | 1000Genomes | |
| ENSVATH13672551 | 69 | P>L | No | 1000Genomes | |
| ENSVATH14625955 | 92 | F>S | No | 1000Genomes | |
| tmp_2_19641834_A_G | 124 | N>D | No | 1000Genomes | |
| ENSVATH02000460 | 156 | P>S | No | 1000Genomes | |
| tmp_2_19641966_G_A | 168 | D>N | No | 1000Genomes | |
| tmp_2_19642028_C_A | 188 | D>E | No | 1000Genomes | |
| ENSVATH14625956 | 201 | A>V | No | 1000Genomes | |
| ENSVATH13672552 | 202 | S>C | No | 1000Genomes | |
| ENSVATH13672553 | 217 | S>Y | No | 1000Genomes | |
| tmp_2_19642182_A_G | 240 | K>E | No | 1000Genomes | |
| tmp_2_19642219_A_T | 252 | E>V | No | 1000Genomes | |
| tmp_2_19642473_G_A | 337 | V>I | No | 1000Genomes | |
| ENSVATH05737434 | 365 | S>I | No | 1000Genomes | |
| tmp_2_19642578_C_T | 372 | H>Y | No | 1000Genomes | |
| tmp_2_19643001_T_G | 513 | L>V | No | 1000Genomes | |
| tmp_2_19643110_C_A | 549 | T>K | No | 1000Genomes | |
| tmp_2_19643115_G_A | 551 | D>N | No | 1000Genomes | |
| tmp_2_19643157_A_T | 565 | I>L | No | 1000Genomes | |
| tmp_2_19643290_G_T | 609 | G>V | No | 1000Genomes |
No associated diseases with P93050
5 regional properties for P93050
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 283 - 563 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 286 - 557 | IPR001245 |
| active_site | Serine/threonine-protein kinase, active site | 408 - 420 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 289 - 311 | IPR017441 |
| domain | SPARK domain | 20 - 166 | IPR043891 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
50 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P46197 | NPR2 | Atrial natriuretic peptide receptor 2 | Bos taurus (Bovine) | PR |
| O97799 | KIT | Mast/stem cell growth factor receptor Kit | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q6QNF3 | PDGFRB | Platelet-derived growth factor receptor beta | Canis lupus familiaris (Dog) (Canis familiaris) | SS |
| Q24488 | Ror | Tyrosine-protein kinase transmembrane receptor Ror | Drosophila melanogaster (Fruit fly) | SS |
| Q9V6K3 | Nrk | Tyrosine-protein kinase transmembrane receptor Ror2 | Drosophila melanogaster (Fruit fly) | SS |
| Q9Y616 | IRAK3 | Interleukin-1 receptor-associated kinase 3 | Homo sapiens (Human) | PR |
| P53667 | LIMK1 | LIM domain kinase 1 | Homo sapiens (Human) | PR |
| P53671 | LIMK2 | LIM domain kinase 2 | Homo sapiens (Human) | PR |
| Q96S53 | TESK2 | Dual specificity testis-specific protein kinase 2 | Homo sapiens (Human) | PR |
| Q8K4B2 | Irak3 | Interleukin-1 receptor-associated kinase 3 | Mus musculus (Mouse) | PR |
| Q8CFA1 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Mus musculus (Mouse) | PR |
| O54785 | Limk2 | LIM domain kinase 2 | Mus musculus (Mouse) | PR |
| Q8VCT9 | Tesk2 | Dual specificity testis-specific protein kinase 2 | Mus musculus (Mouse) | PR |
| Q4QQS0 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Rattus norvegicus (Rat) | PR |
| Q9ASQ5 | CRCK3 | Calmodulin-binding receptor-like cytoplasmic kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STF0 | LECRKS3 | Receptor like protein kinase S.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCZ4 | FER | Receptor-like protein kinase FERONIA | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LYN6 | At3g56050 | Probable inactive receptor-like protein kinase At3g56050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94C25 | At5g20050 | Probable receptor-like protein kinase At5g20050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLW0 | At5g24010 | Probable receptor-like protein kinase At5g24010 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTC0 | PBL19 | Probable serine/threonine-protein kinase PBL19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FIL7 | CRCK1 | Calmodulin-binding receptor-like cytoplasmic kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43293 | PBL11 | Probable serine/threonine-protein kinase PBL11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN94 | At5g59670 | Receptor-like protein kinase At5g59670 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| C0LGG3 | At1g51820 | Probable LRR receptor-like serine/threonine-protein kinase At1g51820 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43298 | TMK1 | Receptor protein kinase TMK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGI2 | At1g67720 | Probable LRR receptor-like serine/threonine-protein kinase At1g67720 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQR3 | At2g14510 | Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LIG2 | At3g21340 | Receptor-like protein kinase At3g21340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SNA3 | At3g46340 | Putative receptor-like protein kinase At3g46340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2S4 | LECRKS4 | L-type lectin-domain containing receptor kinase S.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWZ5 | SD25 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGW2 | PAM74 | Probable LRR receptor-like serine/threonine-protein kinase PAM74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN93 | At5g59680 | Probable LRR receptor-like serine/threonine-protein kinase At5g59680 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84JQ4 | PRK2 | Pollen receptor-like kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZS4 | NIK3 | Protein NSP-INTERACTING KINASE 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AG2 | SERK1 | Somatic embryogenesis receptor kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64477 | At2g19130 | G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9XIC7 | SERK2 | Somatic embryogenesis receptor kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| E7F3X9 | ddr1 | receptor protein-tyrosine kinase | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLFLRRIAVV | FFVFTSFSAA | QNSTCPLDFS | VLEPFRRPKP | DGATTCQYLL | QGLRLLYSHH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LRQTGSFLPP | PESAASCWAA | LQSSVAGFLP | RFDVRSTCGF | QTPWISQGCM | DITTRSQFES |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LIPNSSLATT | AMRCNTSLES | NTPCASCTQS | LSAFQPYLSG | PSLGNVSDCA | SFPSIYAAAF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ANSLGPTDKG | TAKCLFQLDL | ASPTSSGANK | VKVLVSSFSV | LLVASVLVIT | AWFWYCRRKK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SKLLKPRDTS | LEAGTQSRLD | SMSESTTLVK | FSFDEIKKAT | NNFSRHNIIG | RGGYGNVFKG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ALPDGTQVAF | KRFKNCSAGG | DANFAHEVEV | IASIRHVNLL | ALRGYCTATT | PYEGHQRIIV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| CDLVSNGSLH | DHLFGDLEAQ | LAWPLRQRIA | LGMARGLAYL | HYGAQPSIIH | RDIKASNILL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DERFEAKVAD | FGLAKFNPEG | MTHMSTRVAG | TMGYVAPEYA | LYGQLTEKSD | VYSFGVVLLE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LLSRRKAIVT | DEEGQPVSVA | DWAWSLVREG | QTLDVVEDGM | PEKGPPEVLE | KYVLIAVLCS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HPQLHARPTM | DQVVKMLESN | EFTVIAIPQR | PIPLVACREE | IDRSVSSSSG | SGKLTSPTGY |
| 610 | |||||
| QAFSFGGDGP | SGNTNTT |