P92960
PR
Gene name |
ATHB-4 (At2g44910, T13E15.8) |
Protein name |
Potassium channel KAT3 |
Names |
AKT4, AtKC1, Potassium channel TKC |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G32650 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P92960
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7WM1 | EM | 280 A | B/D | 1-662 | PDB |
| 7XUF | EM | 330 A | A/C | 1-662 | PDB |
| AF-P92960-F1 | Predicted | AlphaFoldDB |
26 variants for P92960
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_15754766_G_T | 11 | P>Q | No | 1000Genomes | |
| tmp_4_15754710_C_T | 30 | A>T | No | 1000Genomes | |
| tmp_4_15754701_T_C | 33 | R>G | No | 1000Genomes | |
| ENSVATH12354458 | 35 | P>L | No | 1000Genomes | |
| tmp_4_15754574_T_A | 75 | K>I | No | 1000Genomes | |
| tmp_4_15754560_G_C | 80 | L>V | No | 1000Genomes | |
| tmp_4_15754165_G_T | 136 | T>N | No | 1000Genomes | |
| tmp_4_15754115_G_A | 153 | H>Y | No | 1000Genomes | |
| ENSVATH00548800 | 277 | T>I | No | 1000Genomes | |
| tmp_4_15753287_C_T | 328 | V>I | No | 1000Genomes | |
| ENSVATH00548798 | 334 | R>G | No | 1000Genomes | |
| tmp_4_15753137_C_A | 347 | R>L | No | 1000Genomes | |
| tmp_4_15753048_G_C | 377 | Q>E | No | 1000Genomes | |
| ENSVATH14327878 | 398 | R>C | No | 1000Genomes | |
| ENSVATH06813512 | 402 | E>K | No | 1000Genomes | |
| tmp_4_15752943_C_T | 412 | E>K | No | 1000Genomes | |
| ENSVATH12354366 | 470 | G>R | No | 1000Genomes | |
| tmp_4_15752365_C_T | 496 | V>I | No | 1000Genomes | |
| ENSVATH06813496 | 512 | N>S | No | 1000Genomes | |
| tmp_4_15752290_C_A | 521 | A>S | No | 1000Genomes | |
| tmp_4_15752155_T_G | 536 | K>N | No | 1000Genomes | |
| tmp_4_15751968_T_A | 568 | E>D | No | 1000Genomes | |
| tmp_4_15751955_A_T | 573 | S>T | No | 1000Genomes | |
| ENSVATH06813491 | 580 | I>K | No | 1000Genomes | |
| tmp_4_15751832_T_G | 581 | E>D | No | 1000Genomes | |
| tmp_4_15751519_T_A | 651 | D>V | No | 1000Genomes |
No associated diseases with P92960
1 regional properties for P92960
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Chemokine interleukin-8-like domain | 28 - 90 | IPR001811 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| voltage-gated potassium channel activity | Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| potassium ion transmembrane transport | A process in which a potassium ion is transported from one side of a membrane to the other. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
| response to nematode | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode. |
18 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UL51 | HCN2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Homo sapiens (Human) | SS |
| Q9Y3Q4 | HCN4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Homo sapiens (Human) | EV |
| O60741 | HCN1 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Homo sapiens (Human) | SS |
| Q9P1Z3 | HCN3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Homo sapiens (Human) | SS |
| O88704 | Hcn1 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Mus musculus (Mouse) | SS |
| O88705 | Hcn3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Mus musculus (Mouse) | SS |
| O70507 | Hcn4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Mus musculus (Mouse) | SS |
| O88703 | Hcn2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Mus musculus (Mouse) | EV |
| Q9JKA9 | Hcn2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Rattus norvegicus (Rat) | SS |
| Q9JKA7 | Hcn4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Rattus norvegicus (Rat) | SS |
| Q9JKB0 | Hcn1 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Rattus norvegicus (Rat) | SS |
| Q9JKA8 | Hcn3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Rattus norvegicus (Rat) | SS |
| Q6K3T2 | Os02g0245800 | Potassium channel KAT1 | Oryza sativa subsp japonica (Rice) | PR |
| A2ZX97 | Os01g0718700 | Potassium channel KAT6 | Oryza sativa subsp japonica (Rice) | PR |
| Q9SKD7 | CNGC3 | Probable cyclic nucleotide-gated ion channel 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDR2 | CNGC19 | Putative cyclic nucleotide-gated ion channel 19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SU64 | CNGC16 | Probable cyclic nucleotide-gated ion channel 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39128 | KAT1 | Potassium channel KAT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTTTTEARS | PLPLLLRRGR | SSTALSASTA | EARSPLSILQ | FRRRSSKDVR | NITSVSSSLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PAFGTFIEDD | NPSSKPFIVL | HFDRRYRLWE | LFLVILVGYS | AWASLFELAF | EKAAEGALLT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IDLVVDFFFA | VDIILTFFVS | YLDNTTYLNV | TDHKLIAKRY | LKSVAFVMDV | ASTLPIQFIY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KTITGDVGRG | QAFGFLNLLR | LWRLRRVAEL | FKRLEKDAHF | NYFVIRVIKL | LCVTIFWIHL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AGCILYWIAY | HYPRPTDTWI | GSQVEDFKER | SVWLGYTYSM | YWSIVTLTTV | GYGDLHAVNS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| REKTFNMFYM | LFNIGLTSYI | IGIMTNLVVH | GALRTFAMRS | AINDILRYTS | KNRLPDTMRE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QMLAHMQLKF | KTAELRQEEV | LQDLPKAIRS | SINQHLFRSI | IEEAYLFKGF | PEGLLVQLVS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QIQAEYFPPK | MEIILQNEIP | TDFYVIVSGG | VDIIASKGVS | EQVLAKLGPG | SMAGEIGVVF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NIPQPFTVRT | RRLSQVIRIG | HHKFKEMVQS | DNDVDAKMII | ANFMTYLKGL | NDELKKEIPF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LRDLLDDADA | QVQETVQSEE | TPQSNDEEIV | TVSRHENGQI | EERRREGVPK | RVIIHGQAPP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NQDNKNNGDS | NGRLIILPDS | IQLLFDLAEK | KLGKRGSTIA | MADGAHVEQI | DALRENDHLY |
| IF |