P92949
PR
Gene name |
CDC5 (MAC1, MYBCD5, At1g09770, F21M12.15) |
Protein name |
Ferric reduction oxidase 2 |
Names |
AtFRO2, Ferric-chelate reductase 2, Protein FERRIC CHELATE REDUCTASE DEFECTIVE 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G01580 |
EC number |
1.16.1.7: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P92949
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P92949-F1 | Predicted | AlphaFoldDB |
43 variants for P92949
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH13848366 | 10 | G>D | No | 1000Genomes | |
| tmp_1_209430_C_G | 12 | N>K | No | 1000Genomes | |
| tmp_1_209450_T_C | 19 | F>S | No | 1000Genomes | |
| ENSVATH01002137 | 40 | M>I | No | 1000Genomes | |
| ENSVATH00000971 | 95 | F>I | No | 1000Genomes | |
| ENSVATH00000972 | 97 | N>K | No | 1000Genomes | |
| ENSVATH10443403 | 104 | I>L | No | 1000Genomes | |
| ENSVATH10443404 | 125 | P>A | No | 1000Genomes | |
| tmp_1_210120_C_T | 163 | S>L | No | 1000Genomes | |
| ENSVATH00000976 | 189 | I>T | No | 1000Genomes | |
| ENSVATH04503191 | 242 | A>S | No | 1000Genomes | |
| ENSVATH01002143 | 242 | A>V | No | 1000Genomes | |
| tmp_1_210599_T_G | 243 | S>A | No | 1000Genomes | |
| tmp_1_210609_A_G | 246 | E>G | No | 1000Genomes | |
| tmp_1_211056_T_C | 251 | I>T | No | 1000Genomes | |
| tmp_1_211071_A_G | 256 | K>R | No | 1000Genomes | |
| tmp_1_211088_G_T | 262 | A>S | No | 1000Genomes | |
| tmp_1_211179_C_G | 292 | T>S | No | 1000Genomes | |
| ENSVATH01002151 | 298 | V>A | No | 1000Genomes | |
| ENSVATH10443478 | 315 | A>T | No | 1000Genomes | |
| ENSVATH04503205 | 330 | F>L | No | 1000Genomes | |
| tmp_1_211313_G_A | 337 | V>I | No | 1000Genomes | |
| tmp_1_211335_T_C | 344 | I>T | No | 1000Genomes | |
| tmp_1_211348_C_A | 348 | D>E | No | 1000Genomes | |
| tmp_1_211509_A_T | 371 | N>Y | No | 1000Genomes | |
| tmp_1_211659_G_A | 421 | D>N | No | 1000Genomes | |
| ENSVATH04503209 | 423 | L>H | No | 1000Genomes | |
| ENSVATH00000984 | 442 | E>D | No | 1000Genomes | |
| ENSVATH04503216 | 445 | V>L | No | 1000Genomes | |
| tmp_1_211932_C_G | 466 | T>R | No | 1000Genomes | |
| tmp_1_211938_A_T | 468 | Q>L | No | 1000Genomes | |
| tmp_1_211968_C_T | 478 | T>I | No | 1000Genomes | |
| tmp_1_211991_T_C | 486 | S>P | No | 1000Genomes | |
| tmp_1_211995_C_T | 487 | S>L | No | 1000Genomes | |
| ENSVATH13848373 | 511 | I>F | No | 1000Genomes | |
| ENSVATH13848373 | 511 | I>V | No | 1000Genomes | |
| tmp_1_212258_A_T | 575 | I>F | No | 1000Genomes | |
| ENSVATH01002157 | 603 | L>V | No | 1000Genomes | |
| tmp_1_212406_A_T | 624 | Y>F | No | 1000Genomes | |
| tmp_1_212408_G_C | 625 | G>R | No | 1000Genomes | |
| ENSVATH04503223 | 651 | N>S | No | 1000Genomes | |
| tmp_1_212503_C_G | 656 | I>M | No | 1000Genomes | |
| ENSVATH10443525 | 710 | S>F | No | 1000Genomes |
No associated diseases with P92949
4 regional properties for P92949
Functions
| Description | ||
|---|---|---|
| EC Number | 1.16.1.7 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ferric-chelate reductase (NADH) activity | Catalysis of the reaction: 2 Fe3+-siderophore + NAD(+) + H(+) -> 2 Fe2+-siderophore + NADH. |
| ferric-chelate reductase activity | Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor. |
| metal ion binding | Binding to a metal ion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| iron ion homeostasis | Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. |
| response to bacterium | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. |
| siderophore-dependent iron import into cell | A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96PH1 | NOX5 | NADPH oxidase 5 | Homo sapiens (Human) | EV |
| Q948U0 | RBOHA | Respiratory burst oxidase homolog protein A | Solanum tuberosum (Potato) | PR |
| Q948T9 | RBOHB | Respiratory burst oxidase homolog protein B | Solanum tuberosum (Potato) | PR |
| Q5ZAJ0 | RBOHB | Respiratory burst oxidase homolog protein B | Oryza sativa subsp japonica (Rice) | PR |
| O48538 | RBOHF | Respiratory burst oxidase homolog protein F | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W110 | FRO4 | Ferric reduction oxidase 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FIJ0 | RBOHD | Respiratory burst oxidase homolog protein D | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FJD6 | RBOHH | Putative respiratory burst oxidase homolog protein H | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SUT8 | RBOHI | Probable respiratory burst oxidase homolog protein I | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4I4K7 | FRO3 | Ferric reduction oxidase 3, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81211 | RBOHE | Respiratory burst oxidase homolog protein E | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEIEKSNNGG | SNPSAGEEFK | DMIKGVTKFL | MMVIFLGTIM | LWIMMPTLTY | RTKWLPHLRI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KFGTSTYFGA | TGTTLFMYMF | PMMVVACLGC | VYLHFKNRKS | PHHIDRETKG | GVWSKLRKPM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVKGPLGIVS | VTEITFLAMF | VALLLWCFIT | YLRNSFATIT | PKSAAAHDES | LWQAKLESAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LRLGLIGNIC | LAFLFLPVAR | GSSLLPAMGL | TSESSIKYHI | WLGHMVMALF | TVHGLCYIIY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WASMHEISQM | IMWDTKGVSN | LAGEIALAAG | LVMWATTYPK | IRRRFFEVFF | YTHYLYIVFM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LFFVLHVGIS | FSFIALPGFY | IFLVDRFLRF | LQSRENVRLL | AARILPSDTM | ELTFSKNSKL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VYSPTSIMFV | NIPSISKLQW | HPFTITSSSK | LEPEKLSIVI | KKEGKWSTKL | HQRLSSSDQI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DRLAVSVEGP | YGPASADFLR | HEALVMVCGG | SGITPFISVI | RDLIATSQKE | TCKIPKITLI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CAFKKSSEIS | MLDLVLPLSG | LETELSSDIN | IKIEAFITRD | NDAGDEAKAG | KIKTLWFKPS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LSDQSISSIL | GPNSWLWLGA | ILASSFLIFM | IIIGIITRYY | IYPIDHNTNK | IYSLTSKTII |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YILVISVSIM | ATCSAAMLWN | KKKYGKVESK | QVQNVDRPSP | TSSPTSSWGY | NSLREIESTP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QESLVQRTNL | HFGERPNLKK | LLLDVEGSSV | GVLVCGPKKM | RQKVAEICSS | GLAENLHFES |
| ISFSW |