P87378

SS
Gene name
crk
Protein name
Adapter molecule crk
Names
CRK2, SH2/SH3 adaptor crk
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:398951
EC number
Protein Class

Descriptions

CRK regulates transcription and cytoskeletal reorganization for cell growth and motility by linking tyrosine kinases to small G proteins. The SH2 and nSH3 domains are used to recruit their target proteins. The interaction between SH2 and inter-domain linker between nSH3 and cSH3 detaches the SH2-targeting proteins. In mouse CRK, mutant experiments, it was discovered that cSH3 negatively regulates the function of nSH3.

Autoinhibitory domains (AIDs)

217-289 (C-terminal SH3 domain) SS

Target domain

125-185 (N-terminal SH3 domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P87378

Entry ID Method Resolution Chain Position Source
AF-P87378-F1 Predicted AlphaFoldDB

No variants for P87378

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P87378

No associated diseases with P87378

5 regional properties for P87378

Type Name Position InterPro Accession
domain SH2 domain 11 - 112 IPR000980
domain SH3 domain 125 - 185 IPR001452-1
domain SH3 domain 228 - 289 IPR001452-2
domain CRK, N-terminal SH3 domain 128 - 182 IPR035457
domain CRK, C-terminal SH3 domain 230 - 286 IPR035458

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell membrane
  • Translocated to the plasma membrane upon cell adhesion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
ephrin receptor signaling pathway The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGNFDSEDR ASWYWGKQNR QEAVNLLQGQ RHGVFLVRDS TTIPGDYVLS VSENSKVSHY
70 80 90 100 110 120
IINSVTNNRQ SSTAGMVQSR FRIGDQEFDS LPTLLEFYKI HYLDTTTLIE PVSKSKQSGV
130 140 150 160 170 180
IQRQEEVEYL RALFDFIGND DEDLPFKKGD ILRIREKPEE QWWNAEDSDG RRGMIPVPYV
190 200 210 220 230 240
EKYRPPSSPG SALIGGNQEN SHPQPLGGPE PGPYAQPSVN TPLPNLQNGP IFARVIQKRV
250 260 270 280 290
PNAYDKTALA LEVGDLVKVT KINVSGQWEG ECNGKYGHFP FTHVRLLEQN PEEDFS