P86793

SS
Gene name
Ccl21c (Scya21c)
Protein name
C-C motif chemokine 21c
Names
6Ckine , Beta-chemokine exodus-2 , Small-inducible cytokine A21c , Thymus-derived chemotactic agent 4 , TCA4
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:100042493, mmu:100504239, mmu:100504346, mmu:100862177,
EC number
Protein Class

Descriptions

C-C motif chemokine 21 (CCL21) is chemokine that inhibits hemopoiesis and stimulates chemotaxis, and may play a role in mediating homing of lymphocytes to secondary lymphoid organ. CCL21 has an unstructured C-terminus that does not adopt a stable fold. This C-terminal tail of CCL21 makes autoinhibitory contacts with and modulates the structure and function of the CCL21 chemokine domain. CCL21's C-terminus transiently interacts with the chemokine domain of CCL21, thereby providing a putative structural correlate of functional autoinhibition.

Autoinhibitory domains (AIDs)

80-133 (C-terminal tail) SS

Target domain

1-79 (Chemokine domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P86793

Entry ID Method Resolution Chain Position Source
AF-P86793-F1 Predicted AlphaFoldDB

No variants for P86793

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P86793

No associated diseases with P86793

1 regional properties for P86793

Type Name Position InterPro Accession
domain Chemokine interleukin-8-like domain 28 - 90 IPR001811

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

2 GO annotations of molecular function

Name Definition
CCR chemokine receptor binding Binding to a CCR chemokine receptor.
chemokine activity The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.

10 GO annotations of biological process

Name Definition
cellular response to interleukin-1 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
cellular response to tumor necrosis factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
cellular response to type II interferon Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
chemokine-mediated signaling pathway The series of molecular signals initiated by a chemokine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
lymphocyte chemotaxis The directed movement of a lymphocyte in response to an external stimulus.
monocyte chemotaxis The movement of a monocyte in response to an external stimulus.
neutrophil chemotaxis The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
positive regulation of ERK1 and ERK2 cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O00585 CCL21 C-C motif chemokine 21 Homo sapiens (human) EV
P84444 Ccl21a C-C motif chemokine 21a Mus musculus (Mouse) SS
P86792 Ccl21b C-C motif chemokine 21b Mus musculus (Mouse) SS
P86793 Ccl21c C-C motif chemokine 21c Mus musculus (Mouse) SS
Q8HYP5 CCL21 C-C motif chemokine 21 Macaca mulatta (Rhesus macaque) SS
10 20 30 40 50 60
MAQMMTLSLL SLVLALCIPW TQGSDGGGQD CCLKYSQKKI PYSIVRGYRK QEPSLGCPIP
70 80 90 100 110 120
AILFLPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS PGCRKNRGTS KSGKKGKGSK
130
GCKRTEQTQP SRG