P84444

SS
Gene name
Ccl21a (Scya21, Scya21a)
Protein name
C-C motif chemokine 21a
Names
6Ckine , Beta-chemokine exodus-2 , Small-inducible cytokine A21a , Thymus-derived chemotactic agent 4 , TCA4
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:18829
EC number
Protein Class

Descriptions

C-C motif chemokine 21 (CCL21) is chemokine that inhibits hemopoiesis and stimulates chemotaxis, and may play a role in mediating homing of lymphocytes to secondary lymphoid organ. CCL21 has an unstructured C-terminus that does not adopt a stable fold. This C-terminal tail of CCL21 makes autoinhibitory contacts with and modulates the structure and function of the CCL21 chemokine domain. CCL21's C-terminus transiently interacts with the chemokine domain of CCL21, thereby providing a putative structural correlate of functional autoinhibition.

Autoinhibitory domains (AIDs)

80-133 (C-terminal tail) SS

Target domain

1-79 (Chemokine domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P84444

Entry ID Method Resolution Chain Position Source
AF-P84444-F1 Predicted AlphaFoldDB

No variants for P84444

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P84444

No associated diseases with P84444

3 regional properties for P84444

Type Name Position InterPro Accession
domain Protein kinase domain 64 - 325 IPR000719
active_site Serine/threonine-protein kinase, active site 186 - 198 IPR008271
binding_site Protein kinase, ATP binding site 70 - 93 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

3 GO annotations of molecular function

Name Definition
CCR chemokine receptor binding Binding to a CCR chemokine receptor.
CCR7 chemokine receptor binding Binding to a CCR7 chemokine receptor.
chemokine activity The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.

44 GO annotations of biological process

Name Definition
cell maturation The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state.
cellular response to chemokine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.
cellular response to interleukin-1 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
cellular response to tumor necrosis factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
cellular response to type II interferon Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
chemokine (C-C motif) ligand 21 signaling pathway The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
chemokine-mediated signaling pathway The series of molecular signals initiated by a chemokine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
dendritic cell chemotaxis The movement of a dendritic cell in response to an external stimulus.
dendritic cell dendrite assembly Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells.
establishment of T cell polarity The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
immunological synapse formation The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
induction of positive chemotaxis Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
lymph node development The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes.
lymphocyte chemotaxis The directed movement of a lymphocyte in response to an external stimulus.
mesangial cell-matrix adhesion The binding of a mesangial cell to the extracellular matrix via adhesion molecules. A mesangial cell is a cell that encapsulates the capillaries and venules in the kidney.
monocyte chemotaxis The movement of a monocyte in response to an external stimulus.
negative regulation of dendritic cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process.
negative regulation of dendritic cell dendrite assembly Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly.
neutrophil chemotaxis The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
positive regulation of actin filament polymerization Any process that activates or increases the frequency, rate or extent of actin polymerization.
positive regulation of canonical NF-kappaB signal transduction Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
positive regulation of cell adhesion mediated by integrin Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.
positive regulation of cell motility Any process that activates or increases the frequency, rate or extent of cell motility.
positive regulation of cell-matrix adhesion Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
positive regulation of chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
positive regulation of dendritic cell antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation.
positive regulation of ERK1 and ERK2 cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of filopodium assembly Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
positive regulation of glycoprotein biosynthetic process Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
positive regulation of JNK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
positive regulation of macrophage chemotaxis Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.
positive regulation of myeloid dendritic cell chemotaxis Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis.
positive regulation of neutrophil chemotaxis Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
positive regulation of pseudopodium assembly Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia.
positive regulation of receptor-mediated endocytosis Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
positive regulation of T cell chemotaxis Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.
positive regulation of T cell migration Any process that activates or increases the frequency, rate or extent of T cell migration.
release of sequestered calcium ion into cytosol The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
response to prostaglandin E Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
ruffle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.
T cell costimulation The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O00585 CCL21 C-C motif chemokine 21 Homo sapiens (human) EV
P84444 Ccl21a C-C motif chemokine 21a Mus musculus (Mouse) SS
P86792 Ccl21b C-C motif chemokine 21b Mus musculus (Mouse) SS
P86793 Ccl21c C-C motif chemokine 21c Mus musculus (Mouse) SS
Q8HYP5 CCL21 C-C motif chemokine 21 Macaca mulatta (Rhesus macaque) SS
10 20 30 40 50 60
MAQMMTLSLL SLVLALCIPW TQGSDGGGQD CCLKYSQKKI PYSIVRGYRK QEPSLGCPIP
70 80 90 100 110 120
AILFSPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS PGCRKNRGTS KSGKKGKGSK
130
GCKRTEQTQP SRG