P84244
PR
Gene name |
H3-3b |
Protein name |
Histone H3.3 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:15081 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P84244
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2RVN | NMR | - | B | 2-18 | PDB |
| 5XM0 | X-ray | 287 A | A/E | 1-136 | PDB |
| 5XM1 | X-ray | 345 A | A/E | 1-136 | PDB |
| AF-P84244-F1 | Predicted | AlphaFoldDB |
4 variants for P84244
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389218175 | 29 | S>G | No | EVA | |
| rs3388516143 | 69 | Q>K | No | EVA | |
| rs3388521980 | 131 | I>M | No | EVA | |
| rs3388524343 | 135 | R>H | No | EVA |
No associated diseases with P84244
1 regional properties for P84244
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Histone H2A/H2B/H3 | 1 - 132 | IPR007125 |
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| Barr body | A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. |
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. |
| chromosome, centromeric region | The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. |
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| inner kinetochore | The region of a kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome. |
| nuclear chromosome | A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleosome | A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| nucleosomal DNA binding | Binding to the DNA portion of a nucleosome. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| RNA polymerase II core promoter sequence-specific DNA binding | Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene. |
| structural constituent of chromatin | The action of a molecule that contributes to the structural integrity of chromatin. |
18 GO annotations of biological process
| Name | Definition |
|---|---|
| cell population proliferation | The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
| embryo implantation | Attachment of the blastocyst to the uterine lining. |
| male gonad development | The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. |
| multicellular organism growth | The increase in size or mass of an entire multicellular organism, as opposed to cell growth. |
| muscle cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. |
| negative regulation of chromosome condensation | Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation. |
| nucleosome assembly | The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
| nucleus organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. |
| oocyte maturation | A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. |
| oogenesis | The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. |
| osteoblast differentiation | The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. |
| pericentric heterochromatin assembly | The compaction of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by methylation of histone H3K9, into heterochromatin, resulting in the repression of transcription at pericentric DNA. |
| positive regulation of cell growth | Any process that activates or increases the frequency, rate, extent or direction of cell growth. |
| regulation of centromere complex assembly | Any process that modulates the rate, frequency, or extent of centromere complex assembly, the aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. |
| single fertilization | The union of male and female gametes to form a zygote. |
| spermatid development | The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
| subtelomeric heterochromatin assembly | The compaction of chromatin into heterochromatin at the subtelomeric region. |
39 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P68428 | Histone H3.2 | Triticum aestivum (Wheat) | PR | |
| P68432 | Histone H3.1 | Bos taurus (Bovine) | PR | |
| P84227 | Histone H3.2 | Bos taurus (Bovine) | PR | |
| Q5E9F8 | H3-3B | Histone H3.3 | Bos taurus (Bovine) | PR |
| P84229 | H3-VIII | Histone H3.2 | Gallus gallus (Chicken) | PR |
| P84247 | H3-X | Histone H3.3 | Gallus gallus (Chicken) | PR |
| Q71V89 | HIS3 | Histone H3.3 | Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) | PR |
| P02299 | His3 | Histone H3 | Drosophila melanogaster (Fruit fly) | PR |
| Q71H73 | Histone H3.3 | Vitis vinifera (Grape) | PR | |
| Q71DI3 | H3C13 | Histone H3.2 | Homo sapiens (Human) | PR |
| P68431 | H3C12 | Histone H3.1 | Homo sapiens (Human) | PR |
| Q16695 | H3-4 | Histone H3.1t | Homo sapiens (Human) | PR |
| P84243 | H3-3B | Histone H3.3 | Homo sapiens (Human) | PR |
| P69246 | H3C4 | Histone H3.2 | Zea mays (Maize) | PR |
| P84244 | H3-3b | Histone H3.3 | Mus musculus (Mouse) | PR |
| P68433 | H3c11 | Histone H3.1 | Mus musculus (Mouse) | PR |
| P84228 | H3c15 | Histone H3.2 | Mus musculus (Mouse) | PR |
| P02301 | H3-5 | Histone H3.3C | Mus musculus (Mouse) | PR |
| Q71LE2 | H3-3A | Histone H3.3 | Sus scrofa (Pig) | PR |
| O35799 | Hfe | Hereditary hemochromatosis protein homolog | Rattus norvegicus (Rat) | PR |
| Q6LED0 | Histone H3.1 | Rattus norvegicus (Rat) | PR | |
| P84245 | H3-3b | Histone H3.3 | Rattus norvegicus (Rat) | PR |
| Q0JCT1 | H3 | Histone H3.3 | Oryza sativa subsp japonica (Rice) | PR |
| Q2RAD9 | H3R-21 | Histone H3.2 | Oryza sativa subsp japonica (Rice) | PR |
| P08898 | his-2 | Histone H3 | Caenorhabditis elegans | PR |
| Q10453 | his-71 | Histone H3.3 type 1 | Caenorhabditis elegans | PR |
| Q27490 | his-70 | Histone H3.3-like type 1 | Caenorhabditis elegans | PR |
| Q27532 | his-74 | Histone H3.3-like type 2 | Caenorhabditis elegans | PR |
| Q9U281 | his-72 | Histone H3.3 type 2 | Caenorhabditis elegans | PR |
| Q9FKQ3 | At5g65350 | Histone H3-like 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P59226 | HTR2 | Histone H3.1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FX60 | At1g13370 | Histone H3-like 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FXI7 | MGH3 | Histone H3-like 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LR02 | At1g75600 | Histone H3-like 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P59169 | HTR4 | Histone H3.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q28D37 | TGas081o10.1 | Histone H3.2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6P823 | TGas113e22.1 | Histone H3.3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q4QRF4 | zgc:113984; | Histone H3.2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q6PI20 | h3f3a | Histone H3.3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARTKQTARK | STGGKAPRKQ | LATKAARKSA | PSTGGVKKPH | RYRPGTVALR | EIRRYQKSTE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLIRKLPFQR | LVREIAQDFK | TDLRFQSAAI | GALQEASEAY | LVGLFEDTNL | CAIHAKRVTI |
| 130 | |||||
| MPKDIQLARR | IRGERA |