P84228
PR
Gene name |
H3c15 |
Protein name |
Histone H3.2 |
Names |
H3-clustered histone 13, H3-clustered histone 14, H3-clustered histone 15, H3-clustered histone 2, H3-clustered histone 3, H3-clustered histone 4, H3-clustered histone 6, H3-clustered histone 7 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:97114 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
10 structures for P84228
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2V86 | X-ray | 205 A | D/E | 2-9 | PDB |
| 2V87 | X-ray | 180 A | D/E | 2-14 | PDB |
| 2V88 | X-ray | 200 A | D/F | 2-8 | PDB |
| 4QWN | X-ray | 210 A | E/F | 30-44 | PDB |
| 4QX7 | X-ray | 234 A | E/F | 30-44 | PDB |
| 4QX8 | X-ray | 165 A | E/F | 30-44 | PDB |
| 4QXB | X-ray | 160 A | E/F | 30-44 | PDB |
| 4QXC | X-ray | 175 A | E/F | 30-44 | PDB |
| 4QXH | X-ray | 220 A | E/F | 30-44 | PDB |
| AF-P84228-F1 | Predicted | AlphaFoldDB |
10 variants for P84228
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389285036 | 19 | K>* | No | EVA | |
| rs3389204735 | 20 | Q>E | No | EVA | |
| rs3413126593 | 41 | R>H | No | EVA | |
| rs3389247672 | 68 | F>Y | No | EVA | |
| rs3393418980 | 75 | I>L | No | EVA | |
| rs3389269806 | 103 | G>V | No | EVA | |
| rs864279939 | 113 | I>V | No | EVA | |
| rs3389266894 | 114 | H>Q | No | EVA | |
| rs3389290222 | 119 | T>A | No | EVA | |
| rs3389266885 | 132 | R>H | No | EVA |
No associated diseases with P84228
1 regional properties for P84228
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Histone H2A/H2B/H3 | 1 - 132 | IPR007125 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| nuclear chromosome | A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleosome | A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| structural constituent of chromatin | The action of a molecule that contributes to the structural integrity of chromatin. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| gene expression | The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| nucleosome assembly | The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
| regulation of gene expression, epigenetic | A process that modulates the frequency, rate or extent of gene expression through chromatin remodelling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal. |
| stem cell population maintenance | The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types. |
37 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P68428 | Histone H3.2 | Triticum aestivum (Wheat) | PR | |
| Q5E9F8 | H3-3B | Histone H3.3 | Bos taurus (Bovine) | PR |
| P68432 | Histone H3.1 | Bos taurus (Bovine) | PR | |
| P84227 | Histone H3.2 | Bos taurus (Bovine) | PR | |
| P84247 | H3-X | Histone H3.3 | Gallus gallus (Chicken) | PR |
| P84229 | H3-VIII | Histone H3.2 | Gallus gallus (Chicken) | PR |
| P02299 | His3 | Histone H3 | Drosophila melanogaster (Fruit fly) | PR |
| Q71H73 | Histone H3.3 | Vitis vinifera (Grape) | PR | |
| P84243 | H3-3B | Histone H3.3 | Homo sapiens (Human) | PR |
| P68431 | H3C12 | Histone H3.1 | Homo sapiens (Human) | PR |
| Q16695 | H3-4 | Histone H3.1t | Homo sapiens (Human) | PR |
| Q71DI3 | H3C13 | Histone H3.2 | Homo sapiens (Human) | PR |
| P69246 | H3C4 | Histone H3.2 | Zea mays (Maize) | PR |
| P84228 | H3c15 | Histone H3.2 | Mus musculus (Mouse) | PR |
| P68433 | H3c11 | Histone H3.1 | Mus musculus (Mouse) | PR |
| P84244 | H3-3b | Histone H3.3 | Mus musculus (Mouse) | PR |
| P02301 | H3-5 | Histone H3.3C | Mus musculus (Mouse) | PR |
| Q71LE2 | H3-3A | Histone H3.3 | Sus scrofa (Pig) | PR |
| P84245 | H3-3b | Histone H3.3 | Rattus norvegicus (Rat) | PR |
| O35799 | Hfe | Hereditary hemochromatosis protein homolog | Rattus norvegicus (Rat) | PR |
| Q6LED0 | Histone H3.1 | Rattus norvegicus (Rat) | PR | |
| Q0JCT1 | H3 | Histone H3.3 | Oryza sativa subsp japonica (Rice) | PR |
| Q2RAD9 | H3R-21 | Histone H3.2 | Oryza sativa subsp japonica (Rice) | PR |
| Q27490 | his-70 | Histone H3.3-like type 1 | Caenorhabditis elegans | PR |
| Q10453 | his-71 | Histone H3.3 type 1 | Caenorhabditis elegans | PR |
| Q27532 | his-74 | Histone H3.3-like type 2 | Caenorhabditis elegans | PR |
| P08898 | his-2 | Histone H3 | Caenorhabditis elegans | PR |
| Q9FX60 | At1g13370 | Histone H3-like 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FXI7 | MGH3 | Histone H3-like 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FKQ3 | At5g65350 | Histone H3-like 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P59226 | HTR2 | Histone H3.1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LR02 | At1g75600 | Histone H3-like 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P59169 | HTR4 | Histone H3.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6P823 | TGas113e22.1 | Histone H3.3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q28D37 | TGas081o10.1 | Histone H3.2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6PI20 | h3f3a | Histone H3.3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q4QRF4 | zgc:113984; | Histone H3.2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARTKQTARK | STGGKAPRKQ | LATKAARKSA | PATGGVKKPH | RYRPGTVALR | EIRRYQKSTE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLIRKLPFQR | LVREIAQDFK | TDLRFQSSAV | MALQEASEAY | LVGLFEDTNL | CAIHAKRVTI |
| 130 | |||||
| MPKDIQLARR | IRGERA |