P83917
PR
Gene name |
Cbx1 (Cbx) |
Protein name |
Chromobox protein homolog 1 |
Names |
Heterochromatin protein 1 homolog beta, HP1 beta, Heterochromatin protein p25, M31, Modifier 1 protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12412 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for P83917
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1AP0 | NMR | - | A | 10-80 | PDB |
| 1DZ1 | NMR | - | A/B | 104-171 | PDB |
| 1GUW | NMR | - | A | 10-80 | PDB |
| 1S4Z | NMR | - | A/B | 104-176 | PDB |
| AF-P83917-F1 | Predicted | AlphaFoldDB |
2 variants for P83917
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389199655 | 139 | K>I | No | EVA | |
| rs3389159822 | 146 | L>P | No | EVA |
No associated diseases with P83917
8 regional properties for P83917
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Chromo/chromo shadow domain | 20 - 79 | IPR000953-1 |
| domain | Chromo/chromo shadow domain | 116 - 175 | IPR000953-2 |
| domain | Chromo shadow domain | 111 - 173 | IPR008251 |
| domain | Chromo domain subgroup | 18 - 26 | IPR017984-1 |
| domain | Chromo domain subgroup | 31 - 45 | IPR017984-2 |
| domain | Chromo domain subgroup | 46 - 58 | IPR017984-3 |
| conserved_site | Chromo domain, conserved site | 38 - 58 | IPR023779 |
| domain | Chromo domain | 21 - 69 | IPR023780 |
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| chromocenter | A region in which centric, heterochromatic portions from more than one chromosomes form a compact structure. |
| chromosome, centromeric region | The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. |
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| female pronucleus | The pronucleus originating from the ovum that is being fertilized. |
| male pronucleus | The pronucleus originating from the spermatozoa that was involved in fertilization. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| pericentric heterochromatin | Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3). |
| site of DNA damage | A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| histone methyltransferase binding | Binding to a histone methyltransferase enzyme. |
| identical protein binding | Binding to an identical protein or proteins. |
| methylated histone binding | Binding to a histone in which a residue has been modified by methylation. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q99549 | MPHOSPH8 | M-phase phosphoprotein 8 | Homo sapiens (Human) | PR |
| Q9Y232 | CDYL | Chromodomain Y-like protein | Homo sapiens (Human) | PR |
| Q8N8U2 | CDYL2 | Chromodomain Y-like protein 2 | Homo sapiens (Human) | PR |
| P83916 | CBX1 | Chromobox protein homolog 1 | Homo sapiens (Human) | PR |
| Q9WTK2 | Cdyl | Chromodomain Y-like protein | Mus musculus (Mouse) | PR |
| Q9D5D8 | Cdyl2 | Chromodomain Y-like protein 2 | Mus musculus (Mouse) | PR |
| Q6AYK9 | Cdyl | Chromodomain Y-like protein | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGKKQNKKKV | EEVLEEEEEE | YVVEKVLDRR | VVKGKVEYLL | KWKGFSDEDN | TWEPEENLDC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PDLIAEFLQS | QKTAHETDKS | EGGKRKADSD | SEDKGEESKP | KKKKEESEKP | RGFARGLEPE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RIIGATDSSG | ELMFLMKWKN | SDEADLVPAK | EANVKCPQVV | ISFYEERLTW | HSYPSEDDDK |
| KDDKN |