P83510
PR
Gene name |
Tnik (Kiaa0551) |
Protein name |
Traf2 and NCK-interacting protein kinase |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:665113 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
170-193 (Activation loop from InterPro)
Target domain |
25-289 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for P83510
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P83510-F1 | Predicted | AlphaFoldDB |
78 variants for P83510
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388625558 | 18 | L>Q | No | EVA | |
| rs3412829850 | 25 | F>I | No | EVA | |
| rs3388627385 | 83 | A>V | No | EVA | |
| rs3388626610 | 89 | F>Y | No | EVA | |
| rs3392836025 | 120 | T>A | No | EVA | |
| rs3388622051 | 170 | V>L | No | EVA | |
| rs3392650221 | 393 | K>R | No | EVA | |
| rs3388622097 | 434 | E>K | No | EVA | |
| rs3388618023 | 441 | E>* | No | EVA | |
| rs3388627392 | 443 | E>A | No | EVA | |
| rs3388621527 | 467 | E>K | No | EVA | |
| rs3388618007 | 502 | P>A | No | EVA | |
| rs3388626607 | 517 | Q>R | No | EVA | |
| rs3388627378 | 542 | F>L | No | EVA | |
| rs1133883488 | 550 | A>T | No | EVA | |
| rs3388628037 | 565 | Q>* | No | EVA | |
| rs3388627380 | 568 | A>V | No | EVA | |
| rs3388627336 | 588 | K>* | No | EVA | |
| rs3388618047 | 594 | Q>H | No | EVA | |
| rs3388615975 | 595 | E>D | No | EVA | |
| rs3388621077 | 597 | L>M | No | EVA | |
| rs3388621123 | 605 | E>V | No | EVA | |
| rs3388620505 | 606 | M>V | No | EVA | |
| rs3388622474 | 626 | K>R | No | EVA | |
| rs3388627964 | 628 | D>E | No | EVA | |
| rs3388626529 | 629 | R>K | No | EVA | |
| rs3388625886 | 641 | P>Q | No | EVA | |
| rs3388621115 | 691 | S>G | No | EVA | |
| rs3388616023 | 719 | P>H | No | EVA | |
| rs3388625499 | 773 | E>* | No | EVA | |
| rs254308630 | 804 | E>G | No | EVA | |
| rs3388607834 | 809 | G>R | No | EVA | |
| rs254478804 | 814 | H>Q | No | EVA | |
| rs3388625298 | 818 | V>M | No | EVA | |
| rs3388622013 | 852 | H>Y | No | EVA | |
| rs3388622444 | 856 | F>L | No | EVA | |
| rs3388622484 | 879 | G>A | No | EVA | |
| rs3412781014 | 881 | S>N | No | EVA | |
| rs3388607841 | 895 | L>F | No | EVA | |
| rs3388622050 | 905 | T>I | No | EVA | |
| rs3388625509 | 937 | T>I | No | EVA | |
| rs3411548101 | 977 | L>F | No | EVA | |
| rs3388622068 | 983 | I>M | No | EVA | |
| rs3388613923 | 988 | V>M | No | EVA | |
| rs3388622028 | 989 | N>Y | No | EVA | |
| rs3388607915 | 997 | S>N | No | EVA | |
| rs3388621078 | 998 | D>H | No | EVA | |
| rs3388622393 | 999 | T>S | No | EVA | |
| rs3388621575 | 1008 | R>P | No | EVA | |
| rs3388607860 | 1023 | L>F | No | EVA | |
| rs3388621114 | 1036 | R>I | No | EVA | |
| rs3388622432 | 1037 | S>N | No | EVA | |
| rs3388625895 | 1038 | G>S | No | EVA | |
| rs3388613998 | 1056 | V>M | No | EVA | |
| rs3392639933 | 1069 | K>N | No | EVA | |
| rs3392729569 | 1070 | K>R | No | EVA | |
| rs3388615948 | 1072 | K>R | No | EVA | |
| rs3388626553 | 1100 | T>S | No | EVA | |
| rs3388620494 | 1123 | I>F | No | EVA | |
| rs3388625297 | 1132 | Y>C | No | EVA | |
| rs3388625894 | 1139 | Y>H | No | EVA | |
| rs3413086466 | 1173 | G>D | No | EVA | |
| rs3388626554 | 1183 | V>D | No | EVA | |
| rs3388618041 | 1187 | N>Y | No | EVA | |
| rs3388627370 | 1194 | P>L | No | EVA | |
| rs3388627325 | 1197 | I>T | No | EVA | |
| rs3388625914 | 1205 | A>V | No | EVA | |
| rs3388622059 | 1215 | M>K | No | EVA | |
| rs3388625360 | 1222 | E>G | No | EVA | |
| rs3392859520 | 1248 | S>A | No | EVA | |
| rs3392836953 | 1248 | S>Y | No | EVA | |
| rs3388621131 | 1275 | L>W | No | EVA | |
| rs3388620543 | 1277 | G>V | No | EVA | |
| rs3388621057 | 1286 | R>S | No | EVA | |
| rs3388628025 | 1289 | F>Y | No | EVA | |
| rs3388627306 | 1296 | K>M | No | EVA | |
| rs3388626618 | 1302 | V>M | No | EVA | |
| rs3388621112 | 1310 | V>E | No | EVA |
No associated diseases with P83510
4 regional properties for P83510
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| postsynaptic density, intracellular component | A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
| presynapse | The part of a synapse that is part of the presynaptic cell. |
| recycling endosome | An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
16 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton reorganization | A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. |
| cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| microvillus assembly | Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. |
| neuron projection morphogenesis | The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. |
| positive regulation of dendrite morphogenesis | Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis. |
| positive regulation of JNK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of dendrite morphogenesis | Any process that modulates the frequency, rate or extent of dendrite morphogenesis. |
| regulation of MAPK cascade | Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. |
| regulation of neurotransmitter receptor localization to postsynaptic specialization membrane | Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O95819 | MAP4K4 | Mitogen-activated protein kinase kinase kinase kinase 4 | Homo sapiens (Human) | PR |
| Q7Z2Y5 | NRK | Nik-related protein kinase | Homo sapiens (Human) | PR |
| Q9R0G8 | Nrk | Nik-related protein kinase | Mus musculus (Mouse) | PR |
| Q9JI11 | Stk4 | Serine/threonine-protein kinase 4 | Mus musculus (Mouse) | PR |
| Q9JI10 | Stk3 | Serine/threonine-protein kinase 3 | Mus musculus (Mouse) | SS |
| Q3ULB5 | Pak6 | Serine/threonine-protein kinase PAK 6 | Mus musculus (Mouse) | PR |
| Q8C015 | Pak5 | Serine/threonine-protein kinase PAK 5 | Mus musculus (Mouse) | SS |
| Q8BTW9 | Pak4 | Serine/threonine-protein kinase PAK 4 | Mus musculus (Mouse) | PR |
| Q8CIN4 | Pak2 | Serine/threonine-protein kinase PAK 2 | Mus musculus (Mouse) | SS |
| Q61036 | Pak3 | Serine/threonine-protein kinase PAK 3 | Mus musculus (Mouse) | SS |
| Q9JM52 | Mink1 | Misshapen-like kinase 1 | Mus musculus (Mouse) | PR |
| P97820 | Map4k4 | Mitogen-activated protein kinase kinase kinase kinase 4 | Mus musculus (Mouse) | PR |
| O88643 | Pak1 | Serine/threonine-protein kinase PAK 1 | Mus musculus (Mouse) | SS |
| O23304 | BLUS1 | Serine/threonine-protein kinase BLUS1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASDSPARSL | DEIDLSALRD | PAGIFELVEL | VGNGTYGQVY | KGRHVKTGQL | AAIKVMDVTG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DEEEEIKQEI | NMLKKYSHHR | NIATYYGAFI | KKNPPGMDDQ | LWLVMEFCGA | GSVTDLIKNT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KGNTLKEEWI | AYICREILRG | LSHLHQHKVI | HRDIKGQNVL | LTENAEVKLV | DFGVSAQLDR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TVGRRNTFIG | TPYWMAPEVI | ACDENPDATY | DFKSDLWSLG | ITAIEMAEGA | PPLCDMHPMR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ALFLIPRNPA | PRLKSKKWSK | KFQSFIESCL | VKNHSQRPAT | EQLMKHPFIR | DQPNERQVRI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QLKDHIDRTK | KKRGEKDETE | YEYSGSEEEE | EENDSGEPSS | ILNLPGESTL | RRDFLRLQLA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NKERSEALRR | QQLEQQQREN | EEHKRQLLAE | RQKRIEEQKE | QRRRLEEQQR | REKELRKQQE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| REQRRHYEEQ | MRREEERRRA | EHEQEYKRKQ | LEEQRQAERL | QRQLKQERDY | LVSLQHQRQE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QRPLEKKPLY | HYKEGMSPSE | KPAWAKEVEE | RSRLNRQSSP | AMPHKVANRI | SDPNLPPRSE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SFSISGVQPA | RTPPMLRPVD | PQIPQLVAVK | SQGPALTASQ | SVHEQPTKGL | SGFQEALNVT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SHRVEMPRQN | SDPTSENPPL | PTRIEKFDRS | SWLRQEEDIP | PKVPQRTTSI | SPALARKNSP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GNGSALGPRL | GSQPIRASNP | DLRRTEPVLE | SSLQRTSSGS | SSSSSTPSSQ | PSSQGGSQPG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SQAGSSERSR | VRANSKSEGS | PVLPHEPSKV | KPEESRDITR | PSRPADLTAL | AKELRELRIE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ETNRPLKKVT | DYSSSSEESE | SSEEEEEDGE | SETHDGTVAV | SDIPRLIPTG | APGNNEQYNM |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GMVGTHGLET | SHADTFGGSI | SREGTLMIRE | TAEEKKRSGH | SDSNGFAGHI | NLPDLVQQSH |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SPAGTPTEGL | GRVSTHSQEM | DSGAEYGIGS | STKASFTPFV | DPRVYQTSPT | DEDEEDDESS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| AAALFTSELL | RQEQAKLNEA | RKISVVNVNP | TNIRPHSDTP | EIRKYKKRFN | SEILCAALWG |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| VNLLVGTENG | LMLLDRSGQG | KVYNLINRRR | FQQMDVLEGL | NVLVTISGKK | NKLRVYYLSW |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LRNRILHNDP | EVEKKQGWIT | VGDLEGCIHY | KVVKYERIKF | LVIALKNAVE | IYAWAPKPYH |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| KFMAFKSFAD | LQHKPLLVDL | TVEEGQRLKV | IFGSHTGFHV | IDVDSGNSYD | IYIPSHIQGN |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| ITPHAIVILP | KTDGMEMLVC | YEDEGVYVNT | YGRITKDVVL | QWGEMPTSVA | YIHSNQIMGW |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| GEKAIEIRSV | ETGHLDGVFM | HKRAQRLKFL | CERNDKVFFA | SVRSGGSSQV | FFMTLNRNSM |
| MNW |