P83099
Gene name |
Pkcdelta |
Protein name |
Putative protein kinase C delta type homolog |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG42349 |
EC number |
2.7.11.13: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
484-507 (Activation loop from InterPro)
Target domain |
343-601 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for P83099
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P83099-F1 | Predicted | AlphaFoldDB |
No variants for P83099
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P83099 | |||||
No associated diseases with P83099
11 regional properties for P83099
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 343 - 601 | IPR000719 |
| domain | AGC-kinase, C-terminal | 602 - 671 | IPR000961 |
| domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | 144 - 195 | IPR002219-1 |
| domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | 216 - 268 | IPR002219-2 |
| active_site | Serine/threonine-protein kinase, active site | 463 - 475 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 349 - 372 | IPR017441 |
| domain | Protein kinase, C-terminal | 622 - 663 | IPR017892 |
| domain | Diacylglycerol/phorbol-ester binding | 142 - 156 | IPR020454-1 |
| domain | Diacylglycerol/phorbol-ester binding | 158 - 167 | IPR020454-2 |
| domain | Diacylglycerol/phorbol-ester binding | 171 - 182 | IPR020454-3 |
| domain | Diacylglycerol/phorbol-ester binding | 255 - 267 | IPR020454-4 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.13 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calcium-dependent protein kinase C activity | Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. |
| metal ion binding | Binding to a metal ion. |
| myosin light chain kinase activity | Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| flight | Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
34 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P24583 | PKC1 | Protein kinase C-like 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| A1A4I4 | PKN1 | Serine/threonine-protein kinase N1 | Bos taurus (Bovine) | SS |
| Q9W0V1 | Pdk1 | 3-phosphoinositide-dependent protein kinase 1 | Drosophila melanogaster (Fruit fly) | SS |
| A1Z9X0 | aPKC | Atypical protein kinase C | Drosophila melanogaster (Fruit fly) | SS |
| P13677 | inaC | Protein kinase C, eye isozyme | Drosophila melanogaster (Fruit fly) | SS |
| P05130 | Pkc53E | Protein kinase C, brain isozyme | Drosophila melanogaster (Fruit fly) | SS |
| Q8INB9 | Akt | RAC serine/threonine-protein kinase | Drosophila melanogaster (Fruit fly) | SS |
| Q9NBK5 | trc | Serine/threonine-protein kinase tricornered | Drosophila melanogaster (Fruit fly) | SS |
| A1Z7T0 | Pkn | Serine/threonine-protein kinase N | Drosophila melanogaster (Fruit fly) | SS |
| Q6P5Z2 | PKN3 | Serine/threonine-protein kinase N3 | Homo sapiens (Human) | SS |
| Q96LW2 | RSKR | Ribosomal protein S6 kinase-related protein | Homo sapiens (Human) | PR |
| Q02156 | PRKCE | Protein kinase C epsilon type | Homo sapiens (Human) | SS |
| P24723 | PRKCH | Protein kinase C eta type | Homo sapiens (Human) | SS |
| Q16512 | PKN1 | Serine/threonine-protein kinase N1 | Homo sapiens (Human) | EV |
| Q16513 | PKN2 | Serine/threonine-protein kinase N2 | Homo sapiens (Human) | EV |
| Q04759 | PRKCQ | Protein kinase C theta type | Homo sapiens (Human) | PR |
| Q05655 | PRKCD | Protein kinase C delta type | Homo sapiens (Human) | SS |
| P70268 | Pkn1 | Serine/threonine-protein kinase N1 | Mus musculus (Mouse) | SS |
| P23298 | Prkch | Protein kinase C eta type | Mus musculus (Mouse) | PR |
| Q8BWW9 | Pkn2 | Serine/threonine-protein kinase N2 | Mus musculus (Mouse) | SS |
| Q8K045 | Pkn3 | Serine/threonine-protein kinase N3 | Mus musculus (Mouse) | SS |
| P16054 | Prkce | Protein kinase C epsilon type | Mus musculus (Mouse) | PR |
| Q02111 | Prkcq | Protein kinase C theta type | Mus musculus (Mouse) | PR |
| P28867 | Prkcd | Protein kinase C delta type | Mus musculus (Mouse) | PR |
| Q63433 | Pkn1 | Serine/threonine-protein kinase N1 | Rattus norvegicus (Rat) | SS |
| Q64617 | Prkch | Protein kinase C eta type | Rattus norvegicus (Rat) | PR |
| P09216 | Prkce | Protein kinase C epsilon type | Rattus norvegicus (Rat) | PR |
| O08874 | Pkn2 | Serine/threonine-protein kinase N2 | Rattus norvegicus (Rat) | SS |
| P09215 | Prkcd | Protein kinase C delta type | Rattus norvegicus (Rat) | PR |
| P34722 | tpa-1 | Protein kinase C-like 1 | Caenorhabditis elegans | PR |
| Q9SUA3 | D6PKL1 | Serine/threonine-protein kinase D6PKL1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64682 | PID | Protein kinase PINOID | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUL2 | WAG2 | Serine/threonine-protein kinase WAG2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A7MBL8 | pkn2 | Serine/threonine-protein kinase N2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMFTRAQVRK | QKTSNSSSQR | PRSSGGSTRH | ETRYKQSSTS | SSGAGSGLSG | ASGASGARRD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QYRDRDHYGK | HSFELPRQHS | KEEAYHRDRE | SSAGGVDRGE | RSGIGGNGGG | VTGGGVYVDR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RTRPRSITNR | RGAIKHQKTH | DINGHRFVAK | FFRQPTFCAF | CNLFLWGFGK | QGYQCIICQT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VVHKKCHDKL | LGKCSGSVFT | SASTILLRER | FKIDMPHRFK | PHTFMSPTFC | DHCGSLMGGF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FIQGLKCEEC | DVNCHKKCER | LTANLCGVNQ | KLIVEALNHV | KRGAREARDS | PSTPPSLNPA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YKIEASEEHD | ETSYTYSQFQ | KSGRFTAPAT | VIPRFKNYSV | DDFHFLAVLG | KGSFGKVLLA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ELRDTTYYYA | IKCLKKDVVL | EDDDVDSTLI | ERKVLALGTK | HPYLCHLFCT | FQTESHLFFV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MEYLNGGDLM | FHIQESGRFS | EERARFYGAE | IISGLKFLHK | KGIIYRDLKL | DNVLLDYEGH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VRIADFGMCK | LQIYLDKTAD | SFCGTPDYMA | PEIIKGEKYN | QNVDWWSFGV | LLYEMLIGQS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PFSGCDEDEL | FWSICNEIPW | FPVYISAEAT | GILKGLLEKD | YTKRIGSQYS | PAGDIADHIF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FRPIDWGLLE | KRQIEPPFKP | QVKHPLDTQY | FDRVFTRERV | RLTPIDKEIL | ASMDQKQFHG |
| 670 | |||||
| FTYTNPHITL | D |