P81270

SS
Gene name
Erg (Erg-3)
Protein name
Transcriptional regulator ERG
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:13876
EC number
Protein Class

Descriptions

The Ets-Related Gene (ERG) belongs to the Ets family of transcription factors and is critically important for maintenance of the hematopoietic stem cell population. In the presence of the NID(N-terminal inhibitory domain) and CID (C-terminal inhibitory domain), the conformational exchangeprocesses vanish, indicating that in the autoinhibited state.

Autoinhibitory domains (AIDs)

279-296 (NID) SS

Target domain

317-402 (Ets domain)

Relief mechanism

Ligand binding, Others

Assay

385-395 (CID) SS

Target domain

317-402 (Ets domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P81270

Entry ID Method Resolution Chain Position Source
AF-P81270-F1 Predicted AlphaFoldDB

1 variants for P81270

Variant ID(s) Position Change Description Diseaes Association Provenance
rs229741061 67 A>T No Ensembl

No associated diseases with P81270

16 regional properties for P81270

Type Name Position InterPro Accession
domain C2 domain 1528 - 1648 IPR000008
domain Dbl homology (DH) domain 1205 - 1391 IPR000219
domain EH domain 1 - 89 IPR000261-1
domain EH domain 193 - 289 IPR000261-2
conserved_site Guanine-nucleotide dissociation stimulator, CDC24, conserved site 1339 - 1364 IPR001331
domain SH3 domain 717 - 778 IPR001452-1
domain SH3 domain 883 - 941 IPR001452-2
domain SH3 domain 972 - 1030 IPR001452-3
domain SH3 domain 1044 - 1106 IPR001452-4
domain SH3 domain 1123 - 1182 IPR001452-5
domain Pleckstrin homology domain 1408 - 1528 IPR001849
domain EF-hand domain 33 - 68 IPR002048-1
domain EF-hand domain 233 - 268 IPR002048-2
binding_site EF-Hand 1, calcium-binding site 46 - 58 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 246 - 258 IPR018247-2
domain Intersectin-1, AP2 binding region 775 - 887 IPR032140

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Localized in cytoplasmic mRNP granules containing untranslated mRNAs
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

5 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

3 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

39 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A1A4L6 ETS2 Protein C-ets-2 Bos taurus (Bovine) SS
Q2KIC2 ETV1 ETS translocation variant 1 Bos taurus (Bovine) SS
P15062 ETS1 Transforming protein p68/c-ets-1 Gallus gallus (Chicken) SS
P10157 ETS2 Protein C-ets-2 Gallus gallus (Chicken) SS
Q90837 ERG Transcriptional regulator Erg Gallus gallus (Chicken) SS
A2T762 ETV3 ETS translocation variant 3 Pan troglodytes (Chimpanzee) PR
Q04688 Ets97D DNA-binding protein Ets97D Drosophila melanogaster (Fruit fly) PR
P50548 ERF ETS domain-containing transcription factor ERF Homo sapiens (Human) PR
P41970 ELK3 ETS domain-containing protein Elk-3 Homo sapiens (Human) SS
P41161 ETV5 ETS translocation variant 5 Homo sapiens (Human) SS
P43268 ETV4 ETS translocation variant 4 Homo sapiens (Human) EV
P28324 ELK4 ETS domain-containing protein Elk-4 Homo sapiens (Human) EV
P15036 ETS2 Protein C-ets-2 Homo sapiens (Human) EV
P41162 ETV3 ETS translocation variant 3 Homo sapiens (Human) PR
P14921 ETS1 Protein C-ets-1 Homo sapiens (Human) EV
P50549 ETV1 ETS translocation variant 1 Homo sapiens (Human) EV
P19419 ELK1 ETS domain-containing protein Elk-1 Homo sapiens (Human) EV
Q06546 GABPA GA-binding protein alpha chain Homo sapiens (Human) SS
P11308 ERG Transcriptional regulator ERG Homo sapiens (Human) EV
P97360 Etv6 Transcription factor ETV6 Mus musculus (Mouse) EV
Q8VDK3 Elf5 ETS-related transcription factor Elf-5 Mus musculus (Mouse) SS
Q60775 Elf1 ETS-related transcription factor Elf-1 Mus musculus (Mouse) PR
Q9Z2U4 Elf4 ETS-related transcription factor Elf-4 Mus musculus (Mouse) PR
Q9JHC9 Elf2 ETS-related transcription factor Elf-2 Mus musculus (Mouse) PR
Q00422 Gabpa GA-binding protein alpha chain Mus musculus (Mouse) EV
Q9WTP3 Spdef SAM pointed domain-containing Ets transcription factor Mus musculus (Mouse) PR
P70459 Erf ETS domain-containing transcription factor ERF Mus musculus (Mouse) PR
P28322 Etv4 ETS translocation variant 4 Mus musculus (Mouse) SS
Q9CXC9 Etv5 ETS translocation variant 5 Mus musculus (Mouse) SS
P41164 Etv1 ETS translocation variant 1 Mus musculus (Mouse) SS
P41971 Elk3 ETS domain-containing protein Elk-3 Mus musculus (Mouse) EV
P41158 Elk4 ETS domain-containing protein Elk-4 Mus musculus (Mouse) PR
P41969 Elk1 ETS domain-containing protein Elk-1 Mus musculus (Mouse) PR
P15037 Ets2 Protein C-ets-2 Mus musculus (Mouse) SS
P27577 Ets1 Protein C-ets-1 Mus musculus (Mouse) EV
P41156 Ets1 Protein C-ets-1 Rattus norvegicus (Rat) SS
A4GTP4 Elk1 ETS domain-containing protein Elk-1 Rattus norvegicus (Rat) PR
Q9PUQ1 etv4 ETS translocation variant 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
A3FEM2 fev Protein FEV Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ TSKMSPRVPQ
70 80 90 100 110 120
QDWLSQAPAR VTIKMECNPS QVNGSRNSPD ECSVNKGGKM VGSPDTVGMS YGSYMEEKHV
130 140 150 160 170 180
PPPNMTTNER RVIVPADPTL WSTDHVRQWL EWAVKEYGLL DVDVLLFQNI DGKELCKMTK
190 200 210 220 230 240
DDFQRLTPSY NADILLSHLH YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN
250 260 270 280 290 300
TSVYPEATQR ITTRPDLPYE PPRRSAWTGH SHLTPQSKAA QPSPSAVPKT EDQRPQLDPY
310 320 330 340 350 360
QILGPTSSRL ANPGSGQIQL WQFLLELLSD SSNSNCITWE GTNGEFKMTD PDEVARRWGE
370 380 390 400 410 420
RKSKPNMNYD KLSRALRYYY DKNIMTKVHG KRYAYKFDFH GIAQALQPHP PESSLYKYPS
430 440 450 460 470 480
DLPYMGSYHA HPQKMNFVSP HPPALPVTSS SFFASPNPYW NSPTGGIYPN TRLPASHMPS
HLGTYY