AiPD: Autoinhibited Protein Database

P80192

Gene name	MAP3K9 (MLK1, PRKE1)
Protein name	Mitogen-activated protein kinase kinase kinase 9
Names	EC 2.7.11.25 , Mixed lineage kinase 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:4293
EC number	2.7.11.-: Protein-serine/threonine kinases
Protein Class

Descriptions

Mixed lineage kinase 3 (MLK3) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates the c-Jun N-terminal kinase (JNK) pathway through the dual phosphorylation of mitogen-activated protein kinase kinases 4/7 (MKK4/7). The catalytic domain of MLK3 is flanked by an N-terminal SH3 domain and a centrally located zipper and Cdc42/Rac-interactive binding (CRIB) motif. Zipper-mediated homo-oligomerization is required for full activity of MLK3, proper substrate phosphorylation, and activation of the JNK pathway. MLK3 is autoinhibited through an interaction between its SH3 domain and a proline-containing sequence between the zipper and the CRIB motif. Activated forms of the small GTPases Cdc42 and Rac interact with MLK3 in a CRIB motif-dependent manner to increase the autophosphorylation of MLK3 and substrate phosphorylation activity and to potentiate MLK3-induced activation of JNK. Activated Cdc42 translocates MLK3 to membranes and induces activation loop phosphorylation of MLK3.

Autoinhibitory domains (AIDs)

41-117 (SH3 domain) SS

Target domain	490-512 (Proline-rich region)
Relief mechanism	Partner binding
Assay

AID

41-117 (SH3 domain)

Target domain

490-512 (Proline-rich region)

Relief mechanism

Partner binding (Cdc42 binding)

Assay

Accessory elements

293-314 (Activation loop from InterPro)

Target domain	144-412 (Protein kinase domain)
Relief mechanism
Assay

References

Zhang H et al. (2001) "Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain", The Journal of biological chemistry, 276, 45598-603

Du Y et al. (2005) "Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3", The Journal of biological chemistry, 280, 42984-93

Handley ME et al. (2007) "Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity", International journal of experimental pathology, 88, 111-26

Kokoszka ME et al. (2018) "Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3", The Journal of biological chemistry, 293, 13553-13565

Autoinhibited structure

Activated structure

3 structures for P80192

Entry ID	Method	Resolution	Chain	Position	Source
3DTC	X-ray	260 A	A	136-406	PDB
4UY9	X-ray	281 A	A/B	135-456	PDB
AF-P80192-F1	Predicted				AlphaFoldDB

1188 variants for P80192

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs2055037752	3	P>L		No	gnomAD
rs2055037648	5	R>G		No	gnomAD
rs1272403745	6	A>T		No	TOPMed
rs2139878402	9	G>S		No	Ensembl
rs2055037348	10	C>F		No	TOPMed
rs2055037207	14	A>T		No	Ensembl
rs2055037152	14	A>V		No	Ensembl
rs1282524072	16	A>T		No	gnomAD
rs1014554355	18	A>V		No	TOPMed gnomAD
rs1005081428	19	P>L		No	TOPMed
rs887529850	20	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs753691995	21	G>W		No	ExAC TOPMed gnomAD
rs960014464	22	E>K		No	TOPMed
rs2055036474	23	D>N		No	TOPMed
rs1479118819	24	G>A		No	TOPMed gnomAD
rs1173430231	25	A>E		No	gnomAD
rs1034427131	26	G>R		No	TOPMed gnomAD
rs1034427131	26	G>W		No	TOPMed gnomAD
rs36280	27	A>S		No	TOPMed gnomAD
rs36280	27	A>T		No	TOPMed gnomAD
rs1427244393	27	A>V		No	gnomAD
rs1473170311	28	G>E		No	gnomAD
rs766214214	28	G>R		No	ExAC TOPMed gnomAD
rs2055035982	29	A>V		No	TOPMed
TCGA novel	30	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1294715594	31	E>G		No	Ensembl
rs1437672891	32	E>K		No	gnomAD
rs1201861960	33	E>G		No	TOPMed gnomAD
rs1256394999	33	E>K		No	gnomAD
rs1201861960	33	E>V		No	TOPMed gnomAD
rs1001587212	36	E>A		No	TOPMed gnomAD
rs1198593145	36	E>K		No	gnomAD
rs1459725624	37	E>A		No	gnomAD
rs2055035345	37	E>K		No	gnomAD
rs201322413 COSM1214457	38	E>A	large_intestine [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs201322413	38	E>G		No	ExAC TOPMed gnomAD
rs1228479489	38	E>K		No	gnomAD
COSM1214458 rs200801204	39	A>E	large_intestine [Cosmic]	No	cosmic curated TOPMed gnomAD
rs1277763391	39	A>T		No	gnomAD
rs200801204	39	A>V		No	TOPMed gnomAD
rs1431812059	40	A>E		No	TOPMed
rs1431812059	40	A>V		No	TOPMed
rs946151572	41	A>V		No	gnomAD
rs199678931	42	A>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1454740532	42	A>T		No	gnomAD
rs199678931	42	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1387274267	43	V>L		No	TOPMed
rs1365322420	44	G>D		No	TOPMed
rs1313052429	45	P>L		No	TOPMed gnomAD
rs2055033760	45	P>S		No	gnomAD
rs1469918803	46	G>E		No	TOPMed gnomAD
rs2055033491	47	E>A		No	TOPMed
rs1464487148	47	E>D		No	TOPMed gnomAD
rs770364615	49	G>A		No	ExAC TOPMed gnomAD
rs1487768265	49	G>R		No	TOPMed
rs1487768265	49	G>S		No	TOPMed
rs746310894	50	C>W		No	ExAC gnomAD
rs1442325529	52	A>V		No	TOPMed gnomAD
rs372951506	53	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs372951506	53	P>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1566774546	55	P>L		No	Ensembl
rs758078648	56	Y>C		No	TOPMed gnomAD
rs758078648	56	Y>F		No	TOPMed gnomAD
rs1435649576	57	W>*		No	TOPMed
rs1356997860	57	W>R		No	gnomAD
rs1293938741	58	T>A		No	TOPMed
rs778196126	58	T>M		No	ExAC TOPMed gnomAD
rs758632490	60	V>M		No	ExAC gnomAD
rs778812776	61	F>L		No	ExAC gnomAD
rs2055031985	62	E>G		No	gnomAD
rs755066097	62	E>K		No	ExAC gnomAD
rs755066097	62	E>Q		No	ExAC gnomAD
rs1165857994	64	E>*		No	gnomAD
rs933666193	64	E>G		No	Ensembl
rs1165857994	64	E>Q		No	gnomAD
rs1423200437	65	A>S		No	TOPMed gnomAD
rs1423200437	65	A>T		No	TOPMed gnomAD
rs1224436134	66	A>P		No	TOPMed gnomAD
rs2139877130	66	A>V		No	Ensembl
rs1384198599	67	G>S		No	gnomAD
rs766300372	69	D>H		No	ExAC gnomAD
rs766300372	69	D>N		No	ExAC gnomAD
rs1239816073	70	E>G		No	gnomAD
rs1450980919	70	E>K		No	TOPMed gnomAD
rs867624749	72	T>N		No	Ensembl
rs1340832360	72	T>P		No	gnomAD
TCGA novel	73	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs750161590	73	L>P		No	ExAC gnomAD
rs750161590	73	L>Q		No	ExAC gnomAD
rs2055030937	74	R>L		No	TOPMed
rs1039356391	76	G>D		No	Ensembl
rs2055030657	77	D>N		No	gnomAD
rs2055030099	79	V>M		No	Ensembl
COSM1370861 rs2055029934	83	S>F	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated gnomAD
rs2055029934	83	S>Y		No	gnomAD
rs1178484450	84	K>E		No	TOPMed
rs1178484450	84	K>Q		No	TOPMed
rs763560050	84	K>R		No	ExAC gnomAD
rs377295870	85	D>G		No	ESP ExAC TOPMed gnomAD
rs777340994	86	S>L		No	ExAC gnomAD
rs1365301547	87	Q>*		No	gnomAD
rs984396831	87	Q>H		No	Ensembl
rs374040206	89	S>A		No	ESP TOPMed
rs771546928	90	G>D		No	ExAC gnomAD
rs929825886	91	D>N		No	Ensembl
rs1416948546	93	G>A		No	gnomAD
rs2055029180	95	W>C		No	TOPMed gnomAD
rs747386773	96	T>I		No	ExAC TOPMed gnomAD
rs2055029099	96	T>P		No	Ensembl
rs747386773	96	T>S		No	ExAC TOPMed gnomAD
rs1594820493	97	G>A		No	Ensembl
rs1270928131	97	G>R		No	TOPMed gnomAD
rs2055028671	101	Q>R		No	Ensembl
rs1207052488	102	R>P		No	gnomAD
rs1443174732	102	R>W		No	TOPMed
rs779167690	103	V>L		No	ExAC gnomAD
rs779167690	103	V>M		No	ExAC gnomAD
rs867165007	104	G>D		No	gnomAD
rs534274868	104	G>S		No	1000Genomes ExAC TOPMed gnomAD
rs867165007	104	G>V		No	gnomAD
rs1293145353	106	F>L		No	TOPMed gnomAD
rs1662122148	107	P>S		No	TOPMed
rs1423311491	110	Y>C		No	gnomAD
rs567260112	110	Y>H		No	1000Genomes ExAC gnomAD
rs2055027804	112	T>I		No	TOPMed
rs896773882	112	T>P		No	Ensembl
rs1352384791	113	P>L		No	gnomAD
rs1414509681	114	R>H		No	gnomAD
rs1414509681	114	R>L		No	gnomAD
rs549400463	115	S>I		No	1000Genomes ExAC TOPMed gnomAD
rs549400463	115	S>N		No	1000Genomes ExAC TOPMed gnomAD
rs531286700	115	S>R		No	1000Genomes ExAC TOPMed gnomAD
rs549400463	115	S>T		No	1000Genomes ExAC TOPMed gnomAD
rs763794847	116	A>G		No	ExAC TOPMed gnomAD
rs751209048	116	A>P		No	ExAC gnomAD
rs1594820381	117	F>V		No	Ensembl
rs775078243	118	S>F		No	ExAC TOPMed gnomAD
rs1479564522	118	S>P		No	gnomAD
rs1204047440	119	S>G		No	gnomAD
rs1594820347	119	S>T		No	gnomAD
rs1443240521	120	R>H		No	gnomAD
rs2055026817	122	Q>E		No	TOPMed
rs1265024823	122	Q>H		No	gnomAD
rs766994142	123	P>A		No	ExAC TOPMed gnomAD
rs1323442210	123	P>L		No	gnomAD
rs766994142	123	P>S		No	ExAC TOPMed gnomAD
rs932015451	124	G>S		No	TOPMed gnomAD
rs2055026498	125	G>S		No	Ensembl
rs1297994886	126	E>G		No	gnomAD
rs1371678929	126	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1410806280	128	P>S		No	TOPMed gnomAD
rs1410806280	128	P>T		No	TOPMed gnomAD
rs773837469	130	C>F		No	ExAC TOPMed gnomAD
rs2055026195	130	C>W		No	TOPMed
rs772365254	132	P>Q		No	ExAC gnomAD
rs1334040534	132	P>S		No	gnomAD
rs1334040534	132	P>T		No	gnomAD
rs2055025903	134	I>T		No	TOPMed gnomAD
rs748544153	134	I>V		No	ExAC gnomAD
rs1161255136	135	Q>R		No	gnomAD
rs201937853	137	L>S		No	1000Genomes ExAC TOPMed gnomAD
rs961518449	142	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
COSM1658963 rs775097885	142	A>V	salivary_gland [Cosmic]	No	cosmic curated TOPMed gnomAD
rs2054924771	143	E>A		No	TOPMed gnomAD
rs774711179	143	E>Q		No	ExAC TOPMed gnomAD
rs2054924638	145	T>I		No	TOPMed gnomAD
rs2054924471	149	I>V		No	Ensembl
rs2054924371	150	I>V		No	Ensembl
rs2139861144	151	G>D		No	Ensembl
rs1162717009	153	G>A		No	gnomAD
rs2139861117	154	G>S		No	Ensembl
rs2054924171	155	F>Y		No	TOPMed
rs1362461090	156	G>E		No	TOPMed gnomAD
COSM3690174	157	K>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1566769765	158	V>F		No	Ensembl
TCGA novel	158	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs781046152	159	Y>C		No	ExAC TOPMed gnomAD
COSM3497602 rs770841109	160	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs142171628 COSM240595	160	R>H	prostate [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs1198599847	162	F>L		No	TOPMed
rs758110290	164	I>M		No	ExAC TOPMed gnomAD
rs777581351	164	I>T		No	ExAC TOPMed gnomAD
rs752441948	165	G>R		No	ExAC TOPMed gnomAD
rs1184494856 COSM433317	166	D>N	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs753342747	168	V>F		No	ExAC gnomAD
rs753342747	168	V>I		No	ExAC gnomAD
rs762342117	173	A>S		No	ExAC gnomAD
rs2054923471	174	R>C		No	TOPMed gnomAD
rs764569241	174	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs764569241	174	R>L		No	ExAC TOPMed gnomAD
rs200295742	175	H>Q		No	1000Genomes ExAC TOPMed gnomAD
rs763271384	175	H>R		No	ExAC TOPMed gnomAD
rs1343579550	175	H>Y		No	TOPMed gnomAD
rs934732804	176	D>H		No	TOPMed gnomAD
rs934732804	176	D>N		No	TOPMed gnomAD
rs1460687517	178	D>V		No	gnomAD
rs1457913712	179	E>K		No	gnomAD
rs1171296299	180	D>A		No	TOPMed gnomAD
rs776702942	180	D>E		No	ExAC gnomAD
rs374413255	180	D>N		No	ESP ExAC gnomAD
rs374413255	180	D>Y		No	ESP ExAC gnomAD
rs183066238	181	I>M		No	1000Genomes ExAC TOPMed gnomAD
rs868151792	181	I>V		No	TOPMed gnomAD
rs1433809496	185	I>M		No	Ensembl
rs2054922225	185	I>T		No	TOPMed gnomAD
rs1199135635	185	I>V		No	TOPMed gnomAD
rs1438809940	186	E>G		No	gnomAD
rs1252185407	187	N>S		No	gnomAD
rs923437687	188	V>I		No	TOPMed gnomAD
rs747019799	189	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs777544362	189	R>H		No	ExAC TOPMed gnomAD
rs2054921995	190	Q>R		No	Ensembl
rs376594979	196	A>S		No	ESP ExAC TOPMed gnomAD
rs376594979	196	A>T		No	ESP ExAC TOPMed gnomAD
rs1377097688	197	M>T		No	gnomAD
rs1239475856	199	K>N		No	gnomAD
rs2054921684	199	K>R		No	Ensembl
rs1337269416	200	H>D		No	gnomAD
rs1337269416	200	H>Y		No	gnomAD
rs754612694	201	P>A		No	ExAC TOPMed gnomAD
rs1817600785	201	P>L		No	gnomAD
rs1817600785	201	P>R		No	gnomAD
rs1389834144	202	N>S		No	gnomAD
rs748780174	203	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs2054921353	204	I>T		No	Ensembl
rs2054921386	204	I>V		No	TOPMed gnomAD
rs1471031732	205	A>T		No	gnomAD
rs1481945375	206	L>V		No	Ensembl
rs755556091	209	V>I		No	ExAC TOPMed gnomAD
rs755556091	209	V>L		No	ExAC TOPMed gnomAD
rs752148458	210	C>R		No	ExAC TOPMed gnomAD
rs2054921073	211	L>M		No	TOPMed gnomAD
rs774200566	211	L>P		No	Ensembl
rs2054920977	212	K>T		No	gnomAD
rs1447846323	213	E>D		No	gnomAD
rs937786253	214	P>A		No	gnomAD
rs764502562	215	N>S		No	ExAC
rs1365856572	216	L>F		No	gnomAD
rs2139860601	218	L>M		No	Ensembl
rs2054920637	219	V>G		No	TOPMed
rs1180122484	219	V>I		No	gnomAD
rs376560990	220	M>I		No	Ensembl
rs1418078621	220	M>L		No	gnomAD
rs1418078621	220	M>V		No	gnomAD
rs2054920478	221	E>*		No	TOPMed
rs2054920429	222	F>S		No	Ensembl
rs199845016	223	A>G		No	1000Genomes ExAC TOPMed gnomAD
COSM1323406	223	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs148675299	224	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA gnomAD
rs373287003	224	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs373287003	224	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs373287003	224	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs776593654	225	G>*		No	ExAC gnomAD
rs766524571	226	G>E		No	ExAC gnomAD
rs1402721137	228	L>W		No	TOPMed gnomAD
rs2054920048	229	N>H		No	TOPMed
rs2054920013	229	N>S		No	TOPMed
rs1352768289	231	V>M		No	gnomAD
rs144036386	233	S>P		No	ESP ExAC gnomAD
rs1316058516	234	G>R		No	gnomAD
rs747590864	235	K>Q		No	ExAC gnomAD
rs774250345	236	R>S		No	ExAC gnomAD
rs768445956	237	I>V		No	ExAC gnomAD
rs961113927	238	P>H		No	Ensembl
COSM1678109 rs373007964	238	P>T	haematopoietic_and_lymphoid_tissue [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
COSM3497599	239	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs139396475	240	D>H		No	ESP ExAC gnomAD
rs2054919263	241	I>V		No	Ensembl
rs1442420564	242	L>V		No	gnomAD
rs1241922530	244	N>H		No	gnomAD
rs2139860361	244	N>K		No	Ensembl
rs2054919110	245	W>G		No	Ensembl
rs1331616996	245	W>L		No	TOPMed
COSM1370860 rs202244940	246	A>T	large_intestine [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
VAR_040698	246	A>V	a metastatic melanoma sample; somatic mutation [UniProt]	No	UniProt
rs2054919008	247	V>M		No	TOPMed
rs778262427	249	I>F		No	ExAC gnomAD
rs1259641477	249	I>T		No	TOPMed gnomAD
TCGA novel	250	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2054918855	253	M>I		No	Ensembl
rs989501118	255	Y>*		No	TOPMed
rs753087369	256	L>F		No	ExAC gnomAD
rs2054918691	257	H>N		No	Ensembl
rs758741981	258	D>G		No	ExAC TOPMed gnomAD
rs1261510841	258	D>H		No	TOPMed gnomAD
rs758741981	258	D>V		No	ExAC TOPMed gnomAD
rs1261510841	258	D>Y		No	TOPMed gnomAD
rs1266675185 COSM459120	259	E>K	cervix Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs1248391787	260	A>S		No	gnomAD
rs1283608694	261	I>T		No	gnomAD
rs753129930	261	I>V		No	ExAC TOPMed gnomAD
rs766499534	263	P>A		No	ExAC gnomAD
rs868010261	263	P>H		No	TOPMed
rs868010261	263	P>L		No	TOPMed
rs200277034	265	I>V		No	1000Genomes ESP TOPMed gnomAD
rs760824974	267	R>C		No	ExAC gnomAD
rs773099721	267	R>H		No	ExAC TOPMed gnomAD
rs773099721	267	R>L		No	ExAC TOPMed gnomAD
rs2054917957	268	D>N		No	TOPMed
rs1167974510	272	S>N		No	TOPMed gnomAD
rs2054369636	274	I>M		No	gnomAD
rs770498608	277	L>F		No	ExAC TOPMed gnomAD
rs1384314056	281	E>V		No	gnomAD
rs2054369331	282	N>H		No	Ensembl
rs557062833	285	L>M		No	1000Genomes ExAC TOPMed gnomAD
rs2054369061	287	N>S		No	TOPMed
rs2054369013	288	K>R		No	gnomAD
rs2054368917	289	I>F		No	Ensembl
rs2054368857	292	I>V		No	Ensembl
rs2054368810	294	D>V		No	TOPMed
rs1378663115	295	F>C		No	TOPMed gnomAD
rs1378663115	295	F>S		No	TOPMed gnomAD
rs551815229	298	A>D		No	1000Genomes ExAC gnomAD
rs551815229	298	A>V		No	1000Genomes ExAC gnomAD
rs947471527	299	R>Q		No	TOPMed gnomAD
COSM3497598 rs757467747	299	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs1490598202	301	W>*		No	TOPMed gnomAD
rs2054368309	302	H>Q		No	gnomAD
COSM195176 rs2054368374	302	H>Y	large_intestine [Cosmic]	No	cosmic curated Ensembl
rs914738850	303	R>*		No	gnomAD
rs988982557	303	R>Q		No	TOPMed gnomAD
rs2054368140	304	T>I		No	TOPMed
rs764096308	306	K>T		No	ExAC gnomAD
rs1249020055	307	M>I		No	TOPMed
rs762755525	308	S>G		No	ExAC gnomAD
rs2054367932	308	S>T		No	Ensembl
rs752555260	309	A>S		No	ExAC TOPMed gnomAD
rs752555260	309	A>T		No	ExAC TOPMed gnomAD
rs370660341	309	A>V		No	1000Genomes ExAC gnomAD
TCGA novel	311	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs776326945	311	G>R		No	ExAC gnomAD
rs1163109119 COSM2136315	312	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed
rs1594785849	313	Y>D		No	Ensembl
COSM698798 rs200962207	317	A>T	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated Ensembl NCI-TCGA
COSM1707529 rs866106057	319	E>K	Variant assessed as Somatic; MODERATE impact. skin [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs770124979 COSM1370859	322	R>Q	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs776036323 COSM3497597	322	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs781577340	323	A>D		No	ExAC gnomAD
rs781577340	323	A>V		No	ExAC gnomAD
rs757487803	324	S>F		No	ExAC gnomAD
COSM6076161	325	M>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs777660953	325	M>T		No	ExAC TOPMed gnomAD
rs747112872	325	M>V		No	ExAC TOPMed gnomAD
rs2054366788	326	F>S		No	gnomAD
rs758479516	329	G>S		No	ExAC TOPMed gnomAD
rs1054281922	330	S>N		No	TOPMed
rs752614049	331	D>N		No	ExAC gnomAD
rs1391933994	332	V>M		No	TOPMed gnomAD
rs1566740567	335	Y>C		No	Ensembl
rs754875078	337	V>L		No	ExAC TOPMed gnomAD
rs2054203715	338	L>P		No	Ensembl
rs1300358993	342	L>V		No	gnomAD
rs766212301	343	L>V		No	ExAC gnomAD
rs755873556	347	V>M		No	ExAC gnomAD
COSM172300 rs1299953155	350	R>*	Variant assessed as Somatic; HIGH impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA gnomAD
rs1464177559	350	R>Q		No	gnomAD
rs1177731102	352	I>T		No	gnomAD
rs1376222649	353	D>G		No	gnomAD
COSM3497596 rs2054203012	354	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
rs1419294627	356	A>P		No	gnomAD
rs751015012	358	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1263257672	359	Y>S		No	gnomAD
rs1255130138	363	M>K		No	TOPMed gnomAD
rs1255130138	363	M>R		No	TOPMed gnomAD
TCGA novel	363	M>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1255130138	363	M>T		No	TOPMed gnomAD
rs141503439	363	M>V		No	ESP ExAC TOPMed gnomAD
rs760067989	364	N>K		No	ExAC TOPMed gnomAD
rs2054202465	366	L>F		No	Ensembl
rs879195926 COSM4757188	367	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl NCI-TCGA
COSM1678107 rs879195926	367	A>T	Variant assessed as Somatic; MODERATE impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl NCI-TCGA
rs2054202227	369	P>S		No	TOPMed
rs2054202113	370	I>T		No	TOPMed
rs771460603	370	I>V		No	ExAC gnomAD
COSM4901519	371	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs983821213	372	S>C		No	TOPMed
rs761093575	373	T>A		No	ExAC TOPMed gnomAD
rs1017260225	373	T>M		No	TOPMed gnomAD
rs1022747447	375	P>S		No	TOPMed gnomAD
rs748211903	377	P>R		No	ExAC
rs2054201696	378	F>C		No	Ensembl
rs779005476	378	F>L		No	ExAC gnomAD
rs1455164008	378	F>L		No	TOPMed gnomAD
rs768701260	379	A>T		No	ExAC TOPMed gnomAD
rs749264998	379	A>V		No	ExAC TOPMed gnomAD
rs1454053508	380	K>R		No	TOPMed gnomAD
rs779963503	382	M>V		No	ExAC gnomAD
rs755963592	383	E>Q		No	ExAC TOPMed gnomAD
rs1387661138	384	D>N		No	TOPMed
rs1230073684	385	C>Y		No	gnomAD
rs372283795	389	D>N		No	gnomAD
rs745679893	390	P>L		No	ExAC gnomAD
TCGA novel	390	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs756976430	392	S>*		No	ExAC gnomAD
rs756976430	392	S>L		No	ExAC gnomAD
rs780991502	392	S>P		No	ExAC gnomAD
rs2054188620	393	R>*		No	TOPMed
rs2054188575	393	R>Q		No	TOPMed
rs1399847365	397	T>A		No	TOPMed gnomAD
rs776638628	397	T>M		No	ExAC gnomAD
TCGA novel	399	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs758038259	400	L>V		No	ExAC gnomAD
rs1445416439	403	L>V		No	TOPMed
rs1389314441	406	I>R		No	TOPMed gnomAD
rs1389314441 COSM4927513	406	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1355173741	409	S>A		No	TOPMed gnomAD
rs202234944	410	G>D		No	ESP ExAC TOPMed gnomAD
rs756598509	410	G>S		No	ExAC gnomAD
rs1594776742	411	F>L		No	TOPMed
rs1295582220	412	F>Y		No	TOPMed
COSM3497595	413	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4851482	413	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1480665308	414	M>I		No	TOPMed gnomAD
rs1223995350	417	D>A		No	TOPMed gnomAD
rs1223995350	417	D>G		No	TOPMed gnomAD
rs2054187492	420	H>Y		No	TOPMed
rs764245442	423	Q>P		No	ExAC TOPMed gnomAD
rs764245442	423	Q>R		No	ExAC TOPMed gnomAD
rs2054187206	424	D>N		No	Ensembl
rs2054187150	425	N>D		No	Ensembl
rs1566739645	425	N>S		No	TOPMed gnomAD
rs1485836848	426	W>G		No	TOPMed gnomAD
rs865839912	426	W>L		No	Ensembl
rs1204907636	427	K>Q		No	Ensembl
rs201699297	428	H>Q		No	1000Genomes ExAC TOPMed gnomAD
rs763022930	428	H>Y		No	ExAC gnomAD
TCGA novel	429	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs868595607	429	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1218597263	431	Q>R		No	gnomAD
rs1240268098	432	E>K		No	Ensembl
rs1475079727	433	M>I		No	TOPMed gnomAD
COSM698799	435	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs551542312	436	Q>E		No	1000Genomes ExAC gnomAD
rs2054186502	437	L>R		No	Ensembl
rs745866425	438	R>G		No	ExAC gnomAD
rs1167954560	439	A>V		No	TOPMed gnomAD
rs1483855404	444	L>F		No	gnomAD
rs1483855404	444	L>I		No	gnomAD
rs201808611	445	R>C		No	ExAC TOPMed gnomAD
COSM957428 rs150546098	445	R>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs150546098	445	R>P		No	ESP ExAC TOPMed gnomAD
TCGA novel	446	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs754574540	446	T>I		No	ExAC TOPMed gnomAD
COSM3497594	447	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2054088049	447	W>C		No	Ensembl
rs748690112	447	W>S		No	ExAC gnomAD
rs781725690	448	E>K		No	ExAC gnomAD
rs1351065757	449	E>K		No	gnomAD
rs1301058346	452	T>M		No	TOPMed gnomAD
rs148357774	453	R>Q		No	ESP ExAC TOPMed gnomAD
rs752979159 COSM3497593	453	R>W	Variant assessed as Somatic; MODERATE impact. pancreas [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs376843564	455	A>P		No	ESP
rs2054087257	455	A>V		No	TOPMed gnomAD
rs1594771709	456	L>P		No	Ensembl
COSM1707528 rs549151946	456	L>V	skin [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs983867368	458	Q>R		No	TOPMed gnomAD
COSM4052111	459	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1273922532	460	N>K		No	TOPMed
rs931040989	461	Q>E		No	TOPMed
rs1416087523	463	E>K		No	gnomAD
rs569837216	464	L>R		No	1000Genomes ExAC gnomAD
rs1483217886	466	R>G		No	TOPMed gnomAD
rs1220234795	466	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1483217886	466	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
VAR_040699 COSM20543 rs773256562	467	R>C	large_intestine stomach a gastric adenocarcinoma sample; somatic mutation [Cosmic, UniProt]	No	cosmic curated UniProt ExAC dbSNP gnomAD
rs373021591	467	R>H		No	ESP ExAC TOPMed gnomAD
rs774068235	468	R>Q		No	1000Genomes ExAC TOPMed gnomAD
rs761687543	468	R>W		No	ExAC TOPMed gnomAD
rs768128204	469	E>G		No	ExAC gnomAD
rs1227606511	470	Q>R		No	gnomAD
rs143332721	471	E>D		No	ESP ExAC TOPMed gnomAD
rs779381219	471	E>K		No	ExAC gnomAD
rs145226088	474	E>K		No	1000Genomes ExAC TOPMed gnomAD
rs752943272	475	R>L		No	ExAC gnomAD
rs752943272	475	R>Q		No	ExAC gnomAD
rs1297774580	475	R>W		No	TOPMed gnomAD
rs1351635124	476	E>Q		No	gnomAD
COSM6076162	477	I>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1423743195	477	I>T		No	gnomAD
rs779198242	477	I>V		No	ExAC gnomAD
rs755109645	479	I>V		No	ExAC gnomAD
rs1477069784	481	E>G		No	gnomAD
rs959910708	481	E>K		No	TOPMed gnomAD
rs754071935	482	R>L		No	ExAC TOPMed gnomAD
rs754071935	482	R>Q		No	ExAC TOPMed gnomAD
rs1262960434 COSM1370857	482	R>W	Variant assessed as Somatic; MODERATE impact. large_intestine central_nervous_system [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs766411031	485	N>S		No	ExAC TOPMed gnomAD
rs375161594	486	I>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs767507468	487	I>F		No	ExAC TOPMed gnomAD
rs767507468	487	I>V		No	ExAC TOPMed gnomAD
rs1318479351	488	I>V		No	TOPMed gnomAD
rs1035216817	489	H>Q		No	Ensembl
rs761708031	489	H>Y		No	ExAC gnomAD
rs2054084481	490	Q>E		No	Ensembl
rs1216752547	492	C>S		No	gnomAD
TCGA novel	494	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs370542202	494	E>K		No	ESP ExAC gnomAD
rs1283704730	495	K>N		No	gnomAD
rs1387502876	496	P>A		No	TOPMed gnomAD
rs2054084063	496	P>L		No	gnomAD
rs1387502876	496	P>S		No	TOPMed gnomAD
rs1387502876	496	P>T		No	TOPMed gnomAD
VAR_040700 rs56196343	497	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	UniProt ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs1291849494	497	R>W		No	gnomAD
rs2054083783	500	K>T		No	Ensembl
COSM4643859 rs547034010	501	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs769357313	501	R>H		No	ExAC TOPMed gnomAD
rs769357313	501	R>L		No	ExAC TOPMed gnomAD
TCGA novel	502	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs111385383	503	G>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1423274051	504	K>N		No	gnomAD
rs1226734356	504	K>R		No	Ensembl
rs772500475	505	F>Y		No	ExAC gnomAD
rs2139732815	507	K>N		No	Ensembl
rs2054083024	509	R>Q		No	TOPMed
rs779197132	509	R>W		No	ExAC TOPMed gnomAD
COSM3497590	511	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2054082978	512	L>P		No	TOPMed
rs1566735468	513	K>M		No	TOPMed
rs373570314	513	K>N		No	ESP ExAC gnomAD
rs1566735468	513	K>R		No	TOPMed
rs1340570500	515	G>C		No	TOPMed gnomAD
rs1340570500	515	G>S		No	TOPMed gnomAD
rs1452334418	516	N>I		No	gnomAD
rs1452334418	516	N>S		No	gnomAD
rs147037059	517	R>C		No	ESP ExAC TOPMed gnomAD
rs200816838	517	R>H		No	1000Genomes ExAC TOPMed gnomAD
COSM4052110	519	S>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2054082411	520	L>P		No	gnomAD
rs2139732651 COSM698800	521	P>S	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs780432308	523	D>E		No	ExAC gnomAD
COSM6076163	523	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1238120254	529	T>M		No	TOPMed gnomAD
TCGA novel	530	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2054050071	532	A>G		No	Ensembl
TCGA novel	533	S>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2054049961 COSM3497589	533	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
rs141502233	534	P>L		No	ESP ExAC TOPMed gnomAD
rs141502233	534	P>R		No	ESP ExAC TOPMed gnomAD
rs147874450	536	M>T		No	ESP ExAC TOPMed gnomAD
rs745969786	536	M>V		No	ExAC TOPMed gnomAD
rs1223743642	537	D>E		No	TOPMed
rs2054049593	537	D>G		No	Ensembl
rs1038858386	537	D>H		No	TOPMed gnomAD
rs2054049263	540	K>N		No	TOPMed gnomAD
rs1312655852	540	K>Q		No	gnomAD
rs751515326	542	L>R		No	ExAC gnomAD
rs1230648389	543	I>T		No	TOPMed
rs2054048997	544	N>H		No	TOPMed
rs140979438	544	N>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs74907260	544	N>T		No	ExAC gnomAD
COSM4920552	545	S>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs758192028	546	R>C		No	TOPMed gnomAD
rs564950962	546	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs564950962	546	R>L		No	1000Genomes ExAC TOPMed gnomAD
COSM957426	549	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs776237182	550	P>L		No	ExAC TOPMed gnomAD
rs759137263	550	P>S		No	ExAC TOPMed gnomAD
rs759137263	550	P>T		No	ExAC TOPMed gnomAD
rs545676302	551	A>G		No	1000Genomes ExAC gnomAD
rs369129444	552	S>I		No	ESP ExAC gnomAD
rs1359037479	553	P>A		No	TOPMed gnomAD
rs1349978604	554	T>A		No	gnomAD
rs2054048052	554	T>N		No	TOPMed
rs1293393097	555	I>V		No	gnomAD
rs769145256	556	I>F		No	ExAC TOPMed gnomAD
COSM3497588 rs2054047843	557	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic gnomAD
rs749649763	558	R>C		No	ExAC gnomAD
rs775951489	558	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1594769632	560	R>*		No	TOPMed
rs770263201	561	A>T		No	ExAC gnomAD
rs746130985	561	A>V		No	ExAC TOPMed gnomAD
rs781556899	562	I>V		No	ExAC gnomAD
rs1241745614	565	T>R		No	gnomAD
rs1278842635	566	P>R		No	gnomAD
rs2054016087	566	P>S		No	Ensembl
rs2054015988	569	S>T		No	gnomAD
rs1465795351	570	S>G		No	Ensembl
rs779950314	572	T>I		No	ExAC gnomAD
rs2054015773	573	W>R		No	Ensembl
rs755837546	574	G>S		No	ExAC gnomAD
rs745598440	576	S>R		No	ExAC gnomAD
rs756837051	577	S>L		No	ExAC TOPMed gnomAD
rs1566732539	577	S>P		No	Ensembl
rs372484455	579	V>F		No	1000Genomes ESP ExAC TOPMed gnomAD
rs372484455	579	V>I		No	1000Genomes ESP ExAC TOPMed gnomAD
rs150993424	580	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs150993424	580	P>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2054015171	580	P>S		No	TOPMed gnomAD
rs2139720789	582	E>D		No	Ensembl
rs1278796124	582	E>K		No	gnomAD
rs1209249796	584	G>E		No	TOPMed gnomAD
rs1436945562	584	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1463462503	585	E>A		No	TOPMed
rs1463462503	585	E>G		No	TOPMed
rs1485126606	585	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1463462503	585	E>V		No	TOPMed
rs2139720707	586	E>K		No	Ensembl
COSM6140978	588	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs924647813	588	E>Q		No	TOPMed gnomAD
rs1350802161	588	E>V		No	gnomAD
COSM3497586	591	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs760936170	592	P>S		No	ExAC TOPMed gnomAD
rs760936170	592	P>T		No	ExAC TOPMed gnomAD
rs372081680	593	K>E		No	ESP TOPMed gnomAD
rs1423978157	594	K>Q		No	TOPMed gnomAD
rs2054014194	595	K>E		No	gnomAD
rs199721479	595	K>R		No	1000Genomes
rs142599599	597	R>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs139436577	597	R>Q		No	ESP TOPMed
rs142599599	597	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs572761925 COSM1678105	598	T>M	Variant assessed as Somatic; MODERATE impact. central_nervous_system haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs865971816	600	G>R		No	Ensembl
rs1160498676	601	P>L		No	TOPMed gnomAD
rs745589833	603	T>M		No	ExAC gnomAD
rs780897561	604	L>F		No	ExAC TOPMed gnomAD
rs756926877	605	G>S		No	ExAC TOPMed gnomAD
rs374508438	606	Q>E		No	ESP gnomAD
rs746538544	608	E>G		No	ExAC TOPMed gnomAD
TCGA novel	608	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs777473872	609	L>F		No	ExAC TOPMed gnomAD
rs2054013208	609	L>P		No	TOPMed
rs2054013208	609	L>R		No	TOPMed
rs754433823	611	S>L		No	ExAC TOPMed gnomAD
rs2054012869	613	D>G		No	TOPMed gnomAD
rs2054012869	613	D>V		No	TOPMed gnomAD
rs1479227792 COSM48535	615	G>A	lung [Cosmic]	No	cosmic curated gnomAD
rs370186142	615	G>R		No	ESP ExAC TOPMed gnomAD
rs1484678828	616	S>C		No	TOPMed
COSM3497585	616	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1305952794	617	P>S		No	gnomAD
TCGA novel	618	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2053981746	618	Q>R		No	Ensembl
TCGA novel	618	Q>S	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs750923784	619	R>K		No	ExAC gnomAD
rs781580404	620	R>C		No	ExAC TOPMed gnomAD
rs757616738	620	R>H		No	ExAC TOPMed gnomAD
rs757616738	620	R>P		No	ExAC TOPMed gnomAD
rs1196340028	621	E>G		No	Ensembl
TCGA novel	622	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2053981425	623	A>T		No	Ensembl
rs1323979524	623	A>V		No	gnomAD
rs1427780034	624	N>D		No	TOPMed gnomAD
rs2053981188	624	N>I		No	TOPMed
rs1427780034	624	N>Y		No	TOPMed gnomAD
rs1401740868	629	P>A		No	gnomAD
rs764239615	629	P>L		No	ExAC TOPMed gnomAD
TCGA novel	629	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1460828187	630	S>L		No	gnomAD
rs943230880	634	H>R		No	TOPMed
rs1176258852	635	F>L		No	TOPMed gnomAD
rs752675446	636	H>Y		No	ExAC gnomAD
rs765238955	638	G>D		No	ExAC gnomAD
rs1392714580	638	G>S		No	gnomAD
rs765238955	638	G>V		No	ExAC gnomAD
rs143859920	639	L>F		No	ESP ExAC TOPMed gnomAD
rs1260848025	639	L>P		No	TOPMed
rs2053957418	640	K>R		No	TOPMed
rs752941521	641	S>C		No	ExAC TOPMed gnomAD
rs752941521	641	S>Y		No	ExAC TOPMed gnomAD
rs759655188	643	V>A		No	ExAC gnomAD
rs759655188	643	V>E		No	ExAC gnomAD
rs1426424963	644	D>N		No	TOPMed gnomAD
VAR_040701 rs34322726	646	Y>C		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs760579283	647	K>E		No	ExAC gnomAD
TCGA novel	647	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1313854302	649	W>R		No	gnomAD
rs758241616	650	S>L		No	ExAC TOPMed gnomAD
rs2053956552	651	S>Y		No	TOPMed
rs774052286	654	P>S		No	ExAC TOPMed gnomAD
rs188387961	655	N>I		No	1000Genomes ExAC TOPMed gnomAD
rs188387961	655	N>S		No	1000Genomes ExAC TOPMed gnomAD
rs1452952140	657	V>G		No	gnomAD
rs370461429	657	V>M		No	ESP ExAC TOPMed gnomAD
rs1299305917	658	K>R		No	TOPMed
rs1369039993	659	G>C		No	gnomAD
TCGA novel	660	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs143943391	661	R>K		No	ESP ExAC TOPMed gnomAD
TCGA novel	662	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2053955915	662	S>N		No	Ensembl
rs758757927	662	S>R		No	ExAC
rs116289537	664	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs116289537	664	P>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1221091703	666	L>V		No	TOPMed gnomAD
rs2053955539	667	P>L		No	Ensembl
rs575813257	668	G>A		No	1000Genomes ExAC TOPMed gnomAD
rs575813257	668	G>E		No	1000Genomes ExAC TOPMed gnomAD
rs1263923343	668	G>R		No	gnomAD
rs575813257	668	G>V		No	1000Genomes ExAC TOPMed gnomAD
rs1263923343	668	G>W		No	gnomAD
rs1202780176	671	S>G		No	gnomAD
rs200983878	671	S>N		No	gnomAD
rs200983878	671	S>T		No	gnomAD
rs1265207599	672	L>P		No	TOPMed gnomAD
rs767285366	673	M>V		No	ExAC gnomAD
rs2053954988	675	M>T		No	gnomAD
rs2053955030	675	M>V		No	Ensembl
rs2053940309	676	E>G		No	Ensembl
rs764793311	677	D>H		No	ExAC TOPMed gnomAD
rs764793311	677	D>N		No	ExAC TOPMed gnomAD
rs1281968777	678	E>*		No	TOPMed gnomAD
rs1281968777	678	E>K		No	TOPMed gnomAD
rs1208307352	681	E>K		No	gnomAD
rs2139706452	682	G>R		No	Ensembl
rs759030999	683	P>Q		No	ExAC
rs1594763628	683	P>S		No	gnomAD
rs772563409	684	G>R		No	ExAC gnomAD
rs745505569	687	E>Q		No	ExAC TOPMed gnomAD
rs185207367	689	R>C		No	1000Genomes ExAC TOPMed gnomAD
COSM957424 rs147124893	689	R>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1594763581	692	H>L		No	Ensembl
rs1016751326 COSM3886305	693	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1433111208	693	S>P		No	gnomAD
rs1236615958	694	P>H		No	TOPMed gnomAD
rs1159993774	694	P>S		No	TOPMed gnomAD
rs2053938894	695	S>I		No	Ensembl
rs2053938838	696	Q>H		No	gnomAD
rs1475710727	702	P>R		No	gnomAD
rs757166012	702	P>S		No	ExAC TOPMed gnomAD
rs757166012	702	P>T		No	ExAC TOPMed gnomAD
rs751427569	704	P>A		No	ExAC TOPMed gnomAD
rs374128261	704	P>L		No	1000Genomes ExAC TOPMed gnomAD
rs931525178	705	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs146243565	705	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs146243565	705	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2139706103	706	G>E		No	Ensembl
rs2139706115 COSM3497583	706	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs1037286156	709	G>D		No	TOPMed gnomAD
rs1037286156	709	G>V		No	TOPMed gnomAD
rs764811729	710	D>E		No	ExAC TOPMed gnomAD
rs752402687 COSM1300792	710	D>N	urinary_tract [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs765783857	713	S>F		No	ExAC TOPMed gnomAD
rs2053937808	713	S>P		No	TOPMed
rs1355113648	717	I>N		No	TOPMed gnomAD
rs1248282828	718	H>R		No	gnomAD
rs2053937514	719	E>A		No	Ensembl
rs2139705968	719	E>D		No	Ensembl
rs762423971	719	E>Q		No	ExAC TOPMed gnomAD
rs1339144516	720	E>G		No	TOPMed gnomAD
TCGA novel	720	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2053937286	721	P>H		No	gnomAD
rs1594763435	721	P>S		No	TOPMed gnomAD
rs373164855	722	T>I		No	ESP ExAC gnomAD
rs373164855	722	T>N		No	ESP ExAC gnomAD
rs1318180197	723	P>A		No	gnomAD
rs566965450	724	V>G		No	1000Genomes ExAC TOPMed gnomAD
rs770105473	725	N>H		No	ExAC gnomAD
rs745952959	726	S>L		No	ExAC gnomAD
rs143232244	728	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs911342222	729	S>I		No	TOPMed gnomAD
rs911342222	729	S>N		No	TOPMed gnomAD
rs1469824084	730	T>N		No	gnomAD
rs1594763354	730	T>P		No	Ensembl
rs1283773667	731	P>A		No	TOPMed
rs2053936286	731	P>L		No	gnomAD
rs2053936286	731	P>R		No	gnomAD
rs747871429	734	T>M		No	ExAC TOPMed gnomAD
rs754709328	738	S>I		No	ExAC TOPMed gnomAD
rs754709328	738	S>N		No	ExAC TOPMed gnomAD
rs1288432646	739	L>F		No	TOPMed gnomAD
TCGA novel	740	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs990507598	741	R>Q		No	TOPMed gnomAD
rs145221753	741	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs958153782	742	G>S		No	TOPMed gnomAD
rs1461215725	742	G>V		No	gnomAD
rs1172015239	743	G>S		No	TOPMed gnomAD
rs1359181904	744	A>G		No	TOPMed gnomAD
rs200664597	745	H>P		No	ExAC gnomAD
rs755568141	746	H>P		No	ExAC gnomAD
rs1193788238	747	R>C		No	TOPMed gnomAD
COSM99078 rs372217059	747	R>H	stomach [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs149935990	748	R>C		No	ESP ExAC TOPMed gnomAD
rs375119611	748	R>H		No	ESP ExAC TOPMed gnomAD
rs375119611	748	R>L		No	ESP ExAC TOPMed gnomAD
rs375119611	748	R>P		No	ESP ExAC TOPMed gnomAD
rs759840472	750	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1236208108	751	V>M		No	TOPMed
COSM957423	753	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs999475384	755	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1594763182	756	C>W		No	Ensembl
rs776710305	757	G>R		No	ExAC TOPMed gnomAD
rs2053934474	757	G>V		No	TOPMed
rs773137594	758	A>T		No	ExAC gnomAD
rs3814874	759	V>F		No	1000Genomes ExAC TOPMed gnomAD
rs3814874	759	V>I		No	1000Genomes ExAC TOPMed gnomAD
rs2053934199	760	L>V		No	TOPMed
rs1253213832	761	A>P		No	TOPMed
rs1253213832	761	A>T		No	TOPMed
rs748056144	763	T>I		No	ExAC gnomAD
rs1176403355	768	D>G		No	TOPMed
rs749917098	771	E>*		No	ExAC gnomAD
rs764724247	771	E>D		No	ExAC gnomAD
rs753220614	774	K>R		No	ExAC TOPMed gnomAD
rs1014191193	775	C>Y		No	TOPMed gnomAD
rs778571437	777	L>P		No	ExAC TOPMed gnomAD
rs778571437	777	L>Q		No	ExAC TOPMed gnomAD
rs776922633	779	P>R		No	ExAC TOPMed gnomAD
COSM3886304	779	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2053932761	781	E>K		No	Ensembl
rs766443716	782	E>K		No	ExAC gnomAD
rs201326431	783	P>A		No	ESP ExAC TOPMed gnomAD
rs201326431	783	P>S		No	ESP ExAC TOPMed gnomAD
rs772109137	786	P>A		No	ExAC TOPMed gnomAD
rs772109137	786	P>S		No	ExAC TOPMed gnomAD
rs748151841	787	A>P		No	ExAC gnomAD
rs748151841	787	A>S		No	ExAC gnomAD
rs367998651	787	A>V		No	ESP ExAC TOPMed gnomAD
rs768511767	788	R>G		No	ExAC TOPMed gnomAD
rs368928316	788	R>Q		No	ESP ExAC TOPMed gnomAD
rs768511767	788	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs779790828	789	E>K		No	ExAC TOPMed gnomAD
TCGA novel	792	K>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs769286914	794	R>G		No	ExAC TOPMed gnomAD
COSM195156 rs745488869	794	R>Q	large_intestine [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
COSM1196072 rs769286914	794	R>W	lung [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs1156877131	795	E>G		No	gnomAD
rs1418240559	796	G>V		No	gnomAD
rs940301306	797	L>P		No	TOPMed gnomAD
rs1188842421	801	S>F		No	gnomAD
rs527720055	803	R>C		No	ExAC TOPMed gnomAD
rs756820633	803	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs753312100	804	P>L		No	ExAC
rs949120910	805	R>C		No	TOPMed gnomAD
rs755374301	805	R>H		No	ExAC TOPMed gnomAD
rs755374301	805	R>L		No	ExAC TOPMed gnomAD
rs1237537995 COSM1158234	806	R>Q	pancreas [Cosmic]	No	cosmic curated TOPMed gnomAD
rs754111307 COSM1239399	806	R>W	Variant assessed as Somatic; MODERATE impact. oesophagus [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1437582514	807	S>R		No	TOPMed
rs766645408	808	T>I		No	ExAC TOPMed gnomAD
rs2053930729	810	P>A		No	TOPMed gnomAD
rs1366047715	810	P>L		No	TOPMed
rs2053930617	811	P>A		No	TOPMed gnomAD
rs376367504	811	P>Q		No	ExAC TOPMed gnomAD
rs376367504	811	P>R		No	ExAC TOPMed gnomAD
rs2053930617	811	P>S		No	TOPMed gnomAD
rs2053930438	812	S>T		No	TOPMed gnomAD
TCGA novel	813	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs761825090	813	R>G		No	ExAC gnomAD
rs375769231	813	R>Q		No	ESP ExAC TOPMed gnomAD
rs991014475	815	L>P		No	gnomAD
rs762832980	816	F>L		No	ExAC gnomAD
rs1363212918	816	F>S		No	TOPMed gnomAD
rs775202278	817	K>E		No	ExAC gnomAD
rs769676505	817	K>R		No	ExAC gnomAD
rs1463097239	818	K>E		No	TOPMed gnomAD
rs1168740105	818	K>T		No	TOPMed gnomAD
rs1301985510	819	E>D		No	TOPMed gnomAD
rs2053929752	819	E>G		No	Ensembl
rs2053929808	819	E>K		No	Ensembl
rs2053929631	820	E>D		No	gnomAD
rs2139704550	821	P>T		No	Ensembl
COSM1579842 rs1454048742	822	M>I	central_nervous_system [Cosmic]	No	cosmic curated TOPMed gnomAD
rs2053929518	822	M>V		No	Ensembl
rs780975980	823	L>P		No	ExAC gnomAD
rs936340633	824	L>S		No	TOPMed gnomAD
rs770575759	825	L>R		No	ExAC gnomAD
rs2053929181	825	L>V		No	gnomAD
rs1263948044	826	G>E		No	gnomAD
rs1293853910	827	D>Y		No	TOPMed
rs746450605	828	P>S		No	ExAC TOPMed gnomAD
rs779504029	830	A>S		No	ExAC TOPMed gnomAD
rs1333176009	832	L>P		No	gnomAD
rs755389971	833	T>M		No	ExAC TOPMed gnomAD
rs1327616313	834	L>P		No	gnomAD
TCGA novel	835	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1292893278	836	S>F		No	gnomAD
rs2053928132	837	L>F		No	TOPMed gnomAD
rs541892601	840	I>M		No	1000Genomes ExAC gnomAD
rs767662014	840	I>T		No	ExAC gnomAD
rs369776021	840	I>V		No	ESP ExAC TOPMed
COSM4819111	841	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs764215927	842	E>*		No	ExAC gnomAD
rs764215927	842	E>K		No	ExAC gnomAD
rs2053927414	844	N>H		No	gnomAD
COSM3497580	845	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs140360648 COSM175520	847	R>C	large_intestine [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs140360648	847	R>G		No	ESP ExAC TOPMed gnomAD
rs775490417	847	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs775490417	847	R>L		No	ExAC gnomAD
rs1449370458	848	S>C		No	gnomAD
rs769767191	851	R>C		No	ExAC TOPMed gnomAD
rs200359887	851	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs909851769	852	S>F		No	TOPMed gnomAD
rs1289631586	852	S>T		No	gnomAD
rs909851769	852	S>Y		No	TOPMed gnomAD
rs2053926764	853	D>G		No	Ensembl
rs986655970	853	D>N		No	TOPMed gnomAD
rs199653677	854	S>N		No	ESP ExAC TOPMed gnomAD
rs200036746	854	S>R		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM3497578 rs1433904314	855	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed
rs771607431 COSM3497579	855	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
COSM3497577	856	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs749818618	858	V>L		No	ExAC gnomAD
rs780482958	859	V>M		No	ExAC TOPMed gnomAD
rs2053926177	860	Y>H		No	TOPMed
rs756476859	862	M>I		No	ExAC gnomAD
rs146720121	862	M>R		No	ESP TOPMed gnomAD
rs146720121	862	M>T		No	ESP TOPMed gnomAD
rs2053926064	862	M>V		No	gnomAD
rs542006154	863	P>A		No	ExAC TOPMed gnomAD
rs2053925687	864	V>I		No	Ensembl
rs1429141899	865	S>G		No	gnomAD
rs1028400714	865	S>N		No	Ensembl
rs1395770933	865	S>R		No	TOPMed gnomAD
rs1195984670	866	P>L		No	gnomAD
rs2053925346	867	V>G		No	Ensembl
rs1477358816	867	V>L		No	gnomAD
rs537793324	868	E>*		No	1000Genomes ExAC TOPMed gnomAD
rs537793324	868	E>K		No	1000Genomes ExAC TOPMed gnomAD
rs148644552	869	A>T		No	1000Genomes ExAC TOPMed gnomAD
rs1247916454	870	P>R		No	TOPMed gnomAD
rs898483258	870	P>T		No	Ensembl
rs1281639165	871	P>L		No	TOPMed
rs955976237	871	P>S		No	TOPMed gnomAD
rs2139703685	873	S>G		No	Ensembl
rs1184851386	874	P>L		No	TOPMed
rs200462474	875	C>R		No	1000Genomes ExAC TOPMed gnomAD
rs61746639	877	H>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs61746639	877	H>Y		No	1000Genomes ESP ExAC TOPMed gnomAD
rs3829955	878	N>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs765196740	881	V>F		No	ExAC gnomAD
rs1377194661	882	N>D		No	TOPMed
rs1409456795	882	N>S		No	TOPMed gnomAD
rs563264687	884	R>*		No	gnomAD
rs563264687	884	R>G		No	gnomAD
rs201816172	884	R>L		No	1000Genomes ExAC gnomAD
rs201816172	884	R>P		No	1000Genomes ExAC gnomAD
rs201816172	884	R>Q		No	1000Genomes ExAC gnomAD
rs776517219	885	V>I		No	ExAC TOPMed gnomAD
rs760285196	887	R>C		No	ExAC TOPMed gnomAD
rs772906765 COSM3690173	887	R>H	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs772906765	887	R>L		No	ExAC TOPMed gnomAD
rs760285196	887	R>S		No	ExAC TOPMed gnomAD
rs375220969	889	K>I		No	ESP ExAC TOPMed gnomAD
rs375220969	889	K>R		No	ESP ExAC TOPMed gnomAD
rs1202188625	890	R>*		No	gnomAD
rs148435060	890	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM3497575	892	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	894	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2053923005	894	Q>P		No	TOPMed
rs1820763742	895	S>Y		No	TOPMed gnomAD
rs746355381	896	L>M		No	ExAC gnomAD
rs866235964	898	P>A		No	gnomAD
TCGA novel	898	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs866235964	898	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1441358110	902	T>I		No	gnomAD
rs1284819361	903	L>F		No	TOPMed gnomAD
rs2139703358	905	T>A		No	Ensembl
rs779763210	905	T>I		No	gnomAD
rs757632696	906	P>A		No	ExAC gnomAD
rs757632696	906	P>S		No	ExAC gnomAD
rs200777804	907	S>L		No	1000Genomes ExAC gnomAD
rs934157684	907	S>P		No	TOPMed
rs774413853	907	S>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1158230879	908	Q>R		No	Ensembl
rs2053922021	909	P>L		No	TOPMed
rs1364350366	909	P>T		No	TOPMed gnomAD
rs200964112	910	S>G		No	ESP ExAC TOPMed gnomAD
rs2053921902	910	S>I		No	TOPMed
rs765286426	911	S>N		No	ExAC gnomAD
TCGA novel	911	S>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs370094241	913	R>Q		No	ESP ExAC TOPMed gnomAD
rs200148074	913	R>W		No	ExAC TOPMed gnomAD
rs371754296	914	R>Q		No	ESP ExAC TOPMed gnomAD
rs376380612	914	R>W		No	ESP ExAC TOPMed gnomAD
COSM3497573 rs1419510662	917	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs142743756	918	D>V		No	ESP ExAC TOPMed gnomAD
rs767160217	919	G>A		No	ExAC TOPMed gnomAD
rs761253772	920	A>G		No	ExAC TOPMed gnomAD
rs2053921172	921	L>P		No	Ensembl
rs2139703061	921	L>V		No	Ensembl
rs1463538851	923	P>R		No	gnomAD
rs777104984	924	E>G		No	ExAC gnomAD
rs760106094	924	E>Q		No	ExAC TOPMed gnomAD
rs1594762235	925	T>P		No	Ensembl
rs747328500	925	T>S		No	ExAC
rs1226822540	926	L>F		No	gnomAD
rs1270918759	927	L>R		No	gnomAD
rs2053920658	927	L>V		No	gnomAD
rs2139702918	928	A>G		No	Ensembl
rs777890302	929	S>C		No	ExAC TOPMed gnomAD
rs777890302	929	S>G		No	ExAC TOPMed gnomAD
rs1044774428	929	S>I		No	TOPMed
rs772290301	930	R>G		No	ExAC TOPMed gnomAD
rs1462257851	932	P>S		No	gnomAD
rs2053920230	933	S>F		No	TOPMed
rs1594762181	934	S>G		No	Ensembl
rs2053920081	935	N>D		No	gnomAD
rs1162192722	935	N>S		No	gnomAD
rs1468105779	936	G>E		No	TOPMed gnomAD
COSM1477737	937	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1422938149	937	L>S		No	gnomAD
rs779175250	938	S>G		No	ExAC gnomAD
rs1187802997	939	P>L		No	gnomAD
rs948860949	940	S>G		No	TOPMed
TCGA novel	940	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2053919588	941	P>R		No	Ensembl
rs755104317	941	P>S		No	ExAC TOPMed gnomAD
rs755104317	941	P>T		No	ExAC TOPMed gnomAD
rs1247283614	943	A>V		No	TOPMed gnomAD
rs188647861	944	G>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs188647861	944	G>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1173767110	947	K>E		No	gnomAD
rs1436484925	947	K>T		No	gnomAD
rs147509181	948	T>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs147509181	948	T>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1482976231	948	T>S		No	TOPMed
rs763672830	949	P>A		No	ExAC gnomAD
TCGA novel	949	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs762483751	949	P>R		No	ExAC TOPMed gnomAD
rs1184598561	951	P>L		No	TOPMed gnomAD
rs752205589	951	P>T		No	ExAC gnomAD
rs267604044	952	S>R		No	ExAC TOPMed gnomAD
rs761285831	953	R>*		No	ExAC TOPMed gnomAD
rs761285831	953	R>G		No	ExAC TOPMed gnomAD
rs773588650	953	R>Q		No	ExAC TOPMed gnomAD
rs2053890979	954	D>N		No	TOPMed gnomAD
rs1484289390	956	G>A		No	gnomAD
rs2053890878 COSM553596 COSM6076165	956	G>C	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic gnomAD
rs1254727141	957	E>K		No	TOPMed gnomAD
COSM433316	959	P>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2053890641	959	P>L		No	TOPMed gnomAD
rs767982685	960	R>C		No	ExAC gnomAD
rs1290657401	960	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs2053890398	964	P>S		No	TOPMed
rs138444992	965	N>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1399442138	966	V>M		No	gnomAD
rs2139698317	967	V>G		No	Ensembl
rs1346743038	969	P>S		No	gnomAD
rs775676672	970	P>A		No	ExAC TOPMed gnomAD
rs745872449	970	P>L		No	ExAC TOPMed gnomAD
rs745872449	970	P>Q		No	ExAC TOPMed gnomAD
TCGA novel	970	P>Q	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs775676672	970	P>S		No	ExAC TOPMed gnomAD
rs775676672	970	P>T		No	ExAC TOPMed gnomAD
rs913263535	971	T>I		No	gnomAD
rs913263535	971	T>N		No	gnomAD
rs780929648	974	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs373523963	974	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs373523963	974	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1200369157	975	W>*		No	gnomAD
rs374751641	978	Q>H		No	ESP ExAC TOPMed gnomAD
rs752262464	979	Q>R		No	ExAC TOPMed gnomAD
rs2053889084	980	D>Y		No	gnomAD
rs1029519642	981	S>P		No	TOPMed gnomAD
rs1328946617	982	T>I		No	gnomAD
rs1229737528	985	R>I		No	TOPMed
rs1594760391	985	R>S		No	Ensembl
rs966033544 COSM6076166 COSM553597	990	E>D	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs202240308	990	E>K		No	1000Genomes ExAC TOPMed gnomAD
rs750944190	991	F>L		No	ExAC gnomAD
TCGA novel	992	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs768096501	993	P>A		No	ExAC gnomAD
COSM5456457 rs774902596	994	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs762288591 COSM3356709	994	R>W	Variant assessed as Somatic; MODERATE impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1394945189	995	P>L		No	TOPMed gnomAD
COSM252596 rs1459689257	996	R>C	ovary [Cosmic]	No	cosmic curated TOPMed gnomAD
rs1167191415	996	R>H		No	TOPMed gnomAD
rs1594760323	997	P>A		No	Ensembl
rs763330038	998	S>F		No	ExAC gnomAD
rs769927112	999	A>S		No	ExAC TOPMed gnomAD
rs769927112	999	A>T		No	ExAC TOPMed gnomAD
rs2053887656	1000	N>H		No	Ensembl
rs776665738	1000	N>S		No	ExAC TOPMed gnomAD
rs776665738	1000	N>T		No	ExAC TOPMed gnomAD
COSM3497572	1000	N>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs746929733	1001	R>Q		No	ExAC TOPMed gnomAD
rs371313853	1001	R>W		No	ESP ExAC TOPMed gnomAD
rs747893572	1003	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs758186971 COSM3690172	1003	R>W	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1594760273	1005	D>A		No	Ensembl
rs778373003 COSM5534253	1006	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs2053886697	1008	W>*		No	Ensembl
rs1227456049	1008	W>R		No	gnomAD
rs138921681	1010	V>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs757877089	1011	S>F		No	ExAC gnomAD
rs1594760253	1011	S>P		No	Ensembl
rs757877089	1011	S>Y		No	ExAC gnomAD
rs1325355223	1012	P>S		No	gnomAD
rs1388788317	1013	S>R		No	gnomAD
rs555763754	1014	H>D		No	1000Genomes ExAC gnomAD
rs753034187	1014	H>R		No	TOPMed gnomAD
rs766056350	1015	A>P		No	ExAC TOPMed gnomAD
rs766056350	1015	A>S		No	ExAC TOPMed gnomAD
rs201827381 COSM1370854	1016	R>C	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1025327866	1016	R>H		No	TOPMed gnomAD
rs1253987862	1017	S>C		No	gnomAD
rs1253987862	1017	S>G		No	gnomAD
rs1201529344	1017	S>N		No	gnomAD
rs1594760182	1018	T>P		No	Ensembl
TCGA novel	1019	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1450260196	1020	P>A		No	gnomAD
rs759687858	1020	P>L		No	ExAC TOPMed gnomAD
COSM3420001	1020	P>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	1021	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs374489590	1024	S>C		No	ESP ExAC TOPMed gnomAD
rs959992514	1026	T>A		No	Ensembl
rs2053885056	1027	E>Q		No	gnomAD
rs148083571	1028	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs148083571	1028	T>R		No	ESP ExAC TOPMed gnomAD
rs771868006	1036	F>L		No	ExAC gnomAD
rs180995878	1037	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2053884447	1038	S>G		No	TOPMed
rs778649452	1039	S>G		No	ExAC TOPMed gnomAD
rs771498795	1040	S>N		No	ExAC gnomAD
rs145723754	1040	S>R		No	ESP ExAC TOPMed gnomAD
rs1243404785	1041	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
COSM1195797 rs371408609	1042	T>I	lung [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs933532598	1043	V>A		No	TOPMed gnomAD
rs933532598	1043	V>G		No	TOPMed gnomAD
rs2053883865	1044	E>A		No	TOPMed
rs2053883810	1045	E>*		No	Ensembl
rs2053883810	1045	E>K		No	Ensembl
rs758833277	1046	R>Q		No	ExAC TOPMed gnomAD
rs778353767	1046	R>W		No	ExAC TOPMed gnomAD
rs752959427 COSM553599	1047	P>R	lung [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs1333730804	1048	G>E		No	TOPMed gnomAD
rs1332877920	1048	G>R		No	TOPMed gnomAD
rs1483868100	1049	L>F		No	gnomAD
rs1287957693	1050	P>L		No	TOPMed
rs965981059	1051	A>P		No	TOPMed gnomAD
rs965981059	1051	A>S		No	TOPMed gnomAD
rs1263404910	1052	L>P		No	TOPMed
rs759720980	1052	L>V		No	ExAC TOPMed gnomAD
rs201818307	1053	L>F		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2053882942	1053	L>P		No	Ensembl
rs527635627	1054	P>L		No	ExAC TOPMed gnomAD
rs867399337	1054	P>S		No	TOPMed
rs1344022002	1055	F>L		No	gnomAD
rs1217423969	1055	F>L		No	TOPMed gnomAD
rs1301363942	1056	Q>E		No	gnomAD
rs983813911	1056	Q>R		No	TOPMed
rs773139386	1058	G>E		No	ExAC gnomAD
rs1279992477	1058	G>R		No	TOPMed gnomAD
rs146739032	1059	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs768491592	1060	L>V		No	ExAC TOPMed gnomAD
rs2053882095	1061	P>L		No	TOPMed gnomAD
rs749003418	1062	P>L		No	ExAC TOPMed gnomAD
COSM3497571	1062	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs560713687	1063	T>A		No	1000Genomes ExAC gnomAD
rs1294610686	1063	T>N		No	Ensembl
rs560713687	1063	T>P		No	1000Genomes ExAC gnomAD
rs560713687	1063	T>S		No	1000Genomes ExAC gnomAD
rs778449870	1064	E>A		No	ExAC gnomAD
rs745327663	1064	E>K		No	ExAC TOPMed gnomAD
rs745327663	1064	E>Q		No	ExAC TOPMed gnomAD
rs778449870	1064	E>V		No	ExAC gnomAD
rs374670001	1065	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs190369113	1065	R>W		No	1000Genomes ExAC TOPMed gnomAD
rs779213783	1066	T>M		No	ExAC TOPMed gnomAD
rs2053881387	1067	L>P		No	TOPMed
rs968520584	1069	D>E		No	TOPMed
rs1310892350	1069	D>Y		No	TOPMed gnomAD
rs1594759855	1072	A>V		No	Ensembl
rs750551594	1074	G>A		No	ExAC TOPMed gnomAD
rs1219637132	1075	Q>*		No	gnomAD
rs761721768	1079	S>N		No	ExAC TOPMed gnomAD
rs201830876	1081	V>L		No	1000Genomes ExAC TOPMed gnomAD
rs201830876	1081	V>M		No	1000Genomes ExAC TOPMed gnomAD
rs775309790 COSM957418	1082	P>L	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs1286093311	1082	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs769526586	1083	L>Q		No	ExAC gnomAD
rs769526586	1083	L>R		No	ExAC gnomAD
TCGA novel	1084	C>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs776047235	1086	A>G		No	ExAC TOPMed gnomAD
rs1386927844	1086	A>S		No	TOPMed gnomAD
COSM4700412 rs776047235	1086	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs748663344	1087	E>G		No	ExAC gnomAD
rs1307993783	1088	L>P		No	TOPMed gnomAD
rs755302161	1088	L>V		No	ExAC TOPMed gnomAD
rs1411795797	1090	T>K		No	TOPMed gnomAD
rs1248528644	1091	H>Q		No	TOPMed gnomAD
rs1190436703	1092	R>K		No	gnomAD
rs749614315	1093	P>A		No	ExAC TOPMed gnomAD
rs780374496	1093	P>H		No	ExAC TOPMed gnomAD
rs780374496 COSM2136247	1093	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs749614315	1093	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs756368396	1095	P>A		No	ExAC gnomAD
rs1322590535	1095	P>L		No	gnomAD
rs887919504	1096	Y>*		No	TOPMed gnomAD
rs1396834166	1096	Y>C		No	TOPMed
rs1396834166	1096	Y>F		No	TOPMed
rs1355739175	1097	E>G		No	gnomAD
rs750637587	1098	I>S		No	ExAC gnomAD
rs750637587	1098	I>T		No	ExAC gnomAD
rs1047892994	1102	F>C		No	Ensembl
rs757301027	1104	S>P		No	ExAC TOPMed gnomAD
rs1566725269	1105	S>W		No	Ensembl

1 associated diseases with P80192

Without disease ID

10 regional properties for P80192

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	144 - 412	IPR000719
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	220 - 233	IPR001245-1
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	258 - 276	IPR001245-2
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	311 - 321	IPR001245-3
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	330 - 352	IPR001245-4
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	374 - 396	IPR001245-5
domain	SH3 domain	52 - 116	IPR001452
active_site	Serine/threonine-protein kinase, active site	264 - 276	IPR008271
binding_site	Protein kinase, ATP binding site	150 - 171	IPR017441
domain	MLK1-3, SH3 domain	56 - 113	IPR035779

Functions

		Description
EC Number	2.7.11.-	Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

7 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
JUN kinase kinase kinase activity	Catalysis of the reaction
MAP kinase kinase activity	Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
molecular function activator activity	A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
protein serine kinase activity	Catalysis of the reactions
protein serine/threonine kinase activity	Catalysis of the reactions

4 GO annotations of biological process

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.

41 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A2VDU3	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	Bos taurus (Bovine)	SS
Q4TVR5	DSTYK	Dual serine/threonine and tyrosine protein kinase	Bos taurus (Bovine)	PR
Q3SZJ2	RIPK2	Receptor-interacting serine/threonine-protein kinase 2	Bos taurus (Bovine)	PR
Q6XUX0	DSTYK	Dual serine/threonine and tyrosine protein kinase	Gallus gallus (Chicken)	PR
P83104	Takl1	Putative mitogen-activated protein kinase kinase kinase 7-like	Drosophila melanogaster (Fruit fly)	PR
Q95UN8	slpr	Mitogen-activated protein kinase kinase kinase	Drosophila melanogaster (Fruit fly)	EV
P00540	MOS	Proto-oncogene serine/threonine-protein kinase mos	Homo sapiens (Human)	PR
Q5TCX8	MAP3K21	Mitogen-activated protein kinase kinase kinase 21	Homo sapiens (Human)	PR
Q6XUX3	DSTYK	Dual serine/threonine and tyrosine protein kinase	Homo sapiens (Human)	PR
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	Homo sapiens (Human)	SS
Q9NYL2	MAP3K20	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (Human)	PR
Q38SD2	LRRK1	Leucine-rich repeat serine/threonine-protein kinase 1	Homo sapiens (Human)	EV
O43353	RIPK2	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (Human)	PR
Q02779	MAP3K10	Mitogen-activated protein kinase kinase kinase 10	Homo sapiens (Human)	SS
Q16584	MAP3K11	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (Human)	EV
Q13418	ILK	Integrin-linked protein kinase	Homo sapiens (Human)	PR
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (Human)	EV
P10398	ARAF	Serine/threonine-protein kinase A-Raf	Homo sapiens (Human)	PR
P15056	BRAF	Serine/threonine-protein kinase B-raf	Homo sapiens (Human)	EV
Q8NB16	MLKL	Mixed lineage kinase domain-like protein	Homo sapiens (Human)	EV
P58801	Ripk2	Receptor-interacting serine/threonine-protein kinase 2	Mus musculus (Mouse)	PR
Q62073	Map3k7	Mitogen-activated protein kinase kinase kinase 7	Mus musculus (Mouse)	EV
Q9D2Y4	Mlkl	Mixed lineage kinase domain-like protein	Mus musculus (Mouse)	SS
Q9ESL4	Map3k20	Mitogen-activated protein kinase kinase kinase 20	Mus musculus (Mouse)	PR
P00536	Mos	Proto-oncogene serine/threonine-protein kinase mos	Mus musculus (Mouse)	PR
Q66L42	Map3k10	Mitogen-activated protein kinase kinase kinase 10	Mus musculus (Mouse)	SS
Q80XI6	Map3k11	Mitogen-activated protein kinase kinase kinase 11	Mus musculus (Mouse)	PR
Q8VDG6	Map3k21	Mitogen-activated protein kinase kinase kinase 21	Mus musculus (Mouse)	PR
Q3U1V8	Map3k9	Mitogen-activated protein kinase kinase kinase 9	Mus musculus (Mouse)	SS
P0C8E4	Map3k7	Mitogen-activated protein kinase kinase kinase 7	Rattus norvegicus (Rat)	SS
D3ZG83	Map3k10	Mitogen-activated protein kinase kinase kinase 10	Rattus norvegicus (Rat)	SS
P00539	Mos	Proto-oncogene serine/threonine-protein kinase mos	Rattus norvegicus (Rat)	PR
Q66HA1	Map3k11	Mitogen-activated protein kinase kinase kinase 11	Rattus norvegicus (Rat)	PR
Q9TZM3	lrk-1	Leucine-rich repeat serine/threonine-protein kinase 1	Caenorhabditis elegans	SS
Q9FPR3	EDR1	Serine/threonine-protein kinase EDR1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q2MHE4	HT1	Serine/threonine/tyrosine-protein kinase HT1	Arabidopsis thaliana (Mouse-ear cress)	PR
O22558	STY8	Serine/threonine-protein kinase STY8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8RWL6	STY17	Serine/threonine-protein kinase STY17	Arabidopsis thaliana (Mouse-ear cress)	PR
F4JTP5	STY46	Serine/threonine-protein kinase STY46	Arabidopsis thaliana (Mouse-ear cress)	PR
Q05609	CTR1	Serine/threonine-protein kinase CTR1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q67E00	dstyk	Dual serine/threonine and tyrosine protein kinase	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MEPSRALLGC	LASAAAAAPP	GEDGAGAGAE	EEEEEEEEAA	AAVGPGELGC	DAPLPYWTAV
70	80	90	100	110	120
FEYEAAGEDE	LTLRLGDVVE	VLSKDSQVSG	DEGWWTGQLN	QRVGIFPSNY	VTPRSAFSSR
130	140	150	160	170	180
CQPGGEDPSC	YPPIQLLEID	FAELTLEEII	GIGGFGKVYR	AFWIGDEVAV	KAARHDPDED
190	200	210	220	230	240
ISQTIENVRQ	EAKLFAMLKH	PNIIALRGVC	LKEPNLCLVM	EFARGGPLNR	VLSGKRIPPD
250	260	270	280	290	300
ILVNWAVQIA	RGMNYLHDEA	IVPIIHRDLK	SSNILILQKV	ENGDLSNKIL	KITDFGLARE
310	320	330	340	350	360
WHRTTKMSAA	GTYAWMAPEV	IRASMFSKGS	DVWSYGVLLW	ELLTGEVPFR	GIDGLAVAYG
370	380	390	400	410	420
VAMNKLALPI	PSTCPEPFAK	LMEDCWNPDP	HSRPSFTNIL	DQLTTIEESG	FFEMPKDSFH
430	440	450	460	470	480
CLQDNWKHEI	QEMFDQLRAK	EKELRTWEEE	LTRAALQQKN	QEELLRRREQ	ELAEREIDIL
490	500	510	520	530	540
ERELNIIIHQ	LCQEKPRVKK	RKGKFRKSRL	KLKDGNRISL	PSDFQHKFTV	QASPTMDKRK
550	560	570	580	590	600
SLINSRSSPP	ASPTIIPRLR	AIQLTPGESS	KTWGRSSVVP	KEEGEEEEKR	APKKKGRTWG
610	620	630	640	650	660
PGTLGQKELA	SGDEGSPQRR	EKANGLSTPS	ESPHFHLGLK	SLVDGYKQWS	SSAPNLVKGP
670	680	690	700	710	720
RSSPALPGFT	SLMEMEDEDS	EGPGSGESRL	QHSPSQSYLC	IPFPRGEDGD	GPSSDGIHEE
730	740	750	760	770	780
PTPVNSATST	PQLTPTNSLK	RGGAHHRRCE	VALLGCGAVL	AATGLGFDLL	EAGKCQLLPL
790	800	810	820	830	840
EEPEPPAREE	KKRREGLFQR	SSRPRRSTSP	PSRKLFKKEE	PMLLLGDPSA	SLTLLSLSSI
850	860	870	880	890	900
SECNSTRSLL	RSDSDEIVVY	EMPVSPVEAP	PLSPCTHNPL	VNVRVERFKR	DPNQSLTPTH
910	920	930	940	950	960
VTLTTPSQPS	SHRRTPSDGA	LKPETLLASR	SPSSNGLSPS	PGAGMLKTPS	PSRDPGEFPR
970	980	990	1000	1010	1020
LPDPNVVFPP	TPRRWNTQQD	STLERPKTLE	FLPRPRPSAN	RQRLDPWWFV	SPSHARSTSP
1030	1040	1050	1060	1070	1080
ANSSSTETPS	NLDSCFASSS	STVEERPGLP	ALLPFQAGPL	PPTERTLLDL	DAEGQSQDST
1090	1100
VPLCRAELNT	HRPAPYEIQQ	EFWS