P79996
Gene name |
MAPK9 (JNK2) |
Protein name |
Mitogen-activated protein kinase 9 |
Names |
MAP kinase 9, MAPK 9, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:395983 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
168-190 (Activation loop from InterPro)
Target domain |
26-321 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for P79996
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P79996-F1 | Predicted | AlphaFoldDB |
2 variants for P79996
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs732970738 | 179 | N>I | No | Ensembl | |
| rs735799011 | 292 | S>R | No | Ensembl |
No associated diseases with P79996
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| JUN kinase activity | Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors. |
| MAP kinase activity | Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| embryo development ending in birth or egg hatching | The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| JNK cascade | An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| rhythmic process | Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. |
21 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32485 | HOG1 | Mitogen-activated protein kinase HOG1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q5F3W3 | MAPK6 | Mitogen-activated protein kinase 6 | Gallus gallus (Chicken) | SS |
| P53779 | MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens (Human) | EV |
| P45983 | MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens (Human) | EV |
| P45984 | MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens (Human) | SS |
| Q91Y86 | Mapk8 | Mitogen-activated protein kinase 8 | Mus musculus (Mouse) | PR |
| Q9WTU6 | Mapk9 | Mitogen-activated protein kinase 9 | Mus musculus (Mouse) | PR |
| P49186 | Mapk9 | Mitogen-activated protein kinase 9 | Rattus norvegicus (Rat) | PR |
| Q336X9 | MPK6 | Mitogen-activated protein kinase 6 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5J4W4 | MPK2 | Mitogen-activated protein kinase 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q84UI5 | MPK1 | Mitogen-activated protein kinase 1 | Oryza sativa subsp. japonica (Rice) | SS |
| Q10N20 | MPK5 | Mitogen-activated protein kinase 5 | Oryza sativa subsp. japonica (Rice) | SS |
| O44408 | kgb-1 | GLH-binding kinase 1 | Caenorhabditis elegans | PR |
| Q39023 | MPK3 | Mitogen-activated protein kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39026 | MPK6 | Mitogen-activated protein kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39025 | MPK5 | Mitogen-activated protein kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39024 | MPK4 | Mitogen-activated protein kinase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M1Z5 | MPK10 | Mitogen-activated protein kinase 10 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GYQ5 | MPK12 | Mitogen-activated protein kinase 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LMM5 | MPK11 | Mitogen-activated protein kinase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LQQ9 | MPK13 | Mitogen-activated protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDSKCDSQF | YSVQVADSTF | TVLKRYQQLK | PIGSGAQGIV | CAAFDTVLGI | NVAVKKLSRP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FQNQTHAKRA | YRELVLLKCV | NHKNIISLLN | VFTPQKSLEE | FQDVYLVMEL | MDANLCQVIH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MELDHERMSY | LLYQMLCGIK | HLHSAGIIHR | DLKPSNIVVK | SDCTLKILDF | GLARTACTNF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MMTPYVVTRY | YRAPEVILGM | GYKENVDIWS | VGCIMGELVK | GCVIFQGTDH | IDQWNKVIEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LGTPSAEFMK | KLQPTVRNYV | ENRPKYPGIK | FEELFPDWIF | PSESDRDKLK | TSQARDLLSK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MLVVDPDKRI | SVDEALRHPY | ITVWYDPAEA | EAPPPQIYDA | QLEEREHAIE | EWKELIYKEV |
| 370 | 380 | ||||
| MDWEERSKNG | VVKDQPSAQM |