P70451
PR
Gene name |
Fer (Fert2) |
Protein name |
Tyrosine-protein kinase Fer |
Names |
Proto-oncogene c-Fer, p94-Fer |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14158 |
EC number |
2.7.10.2: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P70451
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P70451-F1 | Predicted | AlphaFoldDB |
26 variants for P70451
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3407950502 | 60 | Q>H | No | EVA | |
| rs3389435044 | 142 | Q>* | No | EVA | |
| rs3389442992 | 171 | Y>F | No | EVA | |
| rs3389476912 | 176 | M>K | No | EVA | |
| rs3389469211 | 203 | T>P | No | EVA | |
| rs3389471494 | 221 | A>S | No | EVA | |
| rs3389435098 | 333 | L>I | No | EVA | |
| rs3389454668 | 346 | K>R | No | EVA | |
| rs243703346 | 445 | V>L | No | EVA | |
| rs3389478046 | 509 | Q>* | No | EVA | |
| rs3389482465 | 561 | H>R | No | EVA | |
| rs3389474988 | 564 | V>F | No | EVA | |
| rs3389482513 | 572 | K>E | No | EVA | |
| rs3389491176 | 581 | G>A | No | EVA | |
| rs3389487915 | 635 | Y>N | No | EVA | |
| rs237145094 | 664 | R>K | No | EVA | |
| rs3389386496 | 678 | S>I | No | EVA | |
| rs3389482493 | 680 | N>D | No | EVA | |
| rs3389478075 | 680 | N>S | No | EVA | |
| rs3407862635 | 685 | D>A | No | EVA | |
| rs3408209961 | 685 | D>Y | No | EVA | |
| rs3389476872 | 725 | I>T | No | EVA | |
| rs3407247161 | 729 | A>V | No | EVA | |
| rs3389467615 | 730 | P>R | No | EVA | |
| rs3406868275 | 738 | Y>* | No | EVA | |
| rs3389425108 | 785 | N>S | No | EVA |
No associated diseases with P70451
10 regional properties for P70451
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 564 - 815 | IPR000719 |
| domain | SH2 domain | 459 - 551 | IPR000980 |
| domain | FCH domain | 1 - 92 | IPR001060 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 565 - 815 | IPR001245 |
| active_site | Tyrosine-protein kinase, active site | 681 - 693 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 570 - 592 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 564 - 815 | IPR020635 |
| domain | F-BAR domain | 1 - 259 | IPR031160 |
| domain | Fes/Fps/Fer, SH2 domain | 454 - 539 | IPR035849 |
| domain | Tyrosine-protein kinase Fer, F-BAR domain | 5 - 238 | IPR037452 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.2 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
12 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cell junction | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. |
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extrinsic component of cytoplasmic side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. |
| lamellipodium | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. |
| microtubule cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| type III intermediate filament | A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments. |
16 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cadherin binding | Binding to cadherin, a type I membrane protein involved in cell adhesion. |
| cytoskeletal protein binding | Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). |
| delta-catenin binding | Binding to the delta subunit of the catenin complex. |
| epidermal growth factor receptor binding | Binding to an epidermal growth factor receptor. |
| gamma-catenin binding | Binding to catenin complex gamma subunit. |
| lipid binding | Binding to a lipid. |
| non-membrane spanning protein tyrosine kinase activity | Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein phosphatase 1 binding | Binding to a protein phosphatase 1. |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| protein tyrosine kinase binding | Binding to protein tyrosine kinase. |
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
| small GTPase binding | Binding to a small monomeric GTPase. |
42 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton reorganization | A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. |
| adherens junction assembly | The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. |
| adherens junction disassembly | The disaggregation of an adherens junction into its constituent components. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. |
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cell population proliferation | The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
| cell-cell adhesion mediated by cadherin | The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains. |
| cellular response to insulin stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. |
| cellular response to macrophage colony-stimulating factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus. |
| cellular response to reactive oxygen species | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. |
| chemotaxis | The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
| cytokine-mediated signaling pathway | The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| diapedesis | The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. |
| extracellular matrix-cell signaling | Any process that mediates the transfer of information between the extracellular matrix and a cell. |
| Fc-epsilon receptor signaling pathway | The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. |
| germ cell development | The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| insulin receptor signaling pathway via phosphatidylinositol 3-kinase | An insulin receptor signaling pathway in which the signal is transmitted via the phosphatidylinositol 3-kinase cascade. |
| interleukin-6-mediated signaling pathway | The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| Kit signaling pathway | The series of molecular signals initiated by the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell. |
| microtubule cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
| negative regulation of mast cell activation involved in immune response | Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response. |
| peptidyl-tyrosine phosphorylation | The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. |
| platelet-derived growth factor receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| positive regulation of actin filament polymerization | Any process that activates or increases the frequency, rate or extent of actin polymerization. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of NF-kappaB transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of epidermal growth factor receptor signaling pathway | Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. |
| regulation of fibroblast migration | Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. |
| regulation of lamellipodium assembly | Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. |
| regulation of mast cell degranulation | Any process that modulates the frequency, rate, or extent of mast cell degranulation. |
| regulation of protein phosphorylation | Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. |
| response to lipopolysaccharide | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
| response to platelet-derived growth factor | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. |
| Sertoli cell development | The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| substrate adhesion-dependent cell spreading | The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| tyrosine phosphorylation of STAT protein | The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. |
30 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9TTY2 | FER | Tyrosine-protein kinase Fer | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P16591 | FER | Tyrosine-protein kinase Fer | Homo sapiens (Human) | PR |
| P48025 | Syk | Tyrosine-protein kinase SYK | Mus musculus (Mouse) | SS |
| P43404 | Zap70 | Tyrosine-protein kinase ZAP-70 | Mus musculus (Mouse) | SS |
| Q64434 | Ptk6 | Protein-tyrosine kinase 6 | Mus musculus (Mouse) | SS |
| P14234 | Fgr | Tyrosine-protein kinase Fgr | Mus musculus (Mouse) | SS |
| P25911 | Lyn | Tyrosine-protein kinase Lyn | Mus musculus (Mouse) | EV |
| P39688 | Fyn | Tyrosine-protein kinase Fyn | Mus musculus (Mouse) | SS |
| P05480 | Src | Proto-oncogene tyrosine-protein kinase Src | Mus musculus (Mouse) | EV |
| P06240 | Lck | Proto-oncogene tyrosine-protein kinase LCK | Mus musculus (Mouse) | SS |
| P16277 | Blk | Tyrosine-protein kinase Blk | Mus musculus (Mouse) | SS |
| P08103 | Hck | Tyrosine-protein kinase HCK | Mus musculus (Mouse) | SS |
| Q04736 | Yes1 | Tyrosine-protein kinase Yes | Mus musculus (Mouse) | SS |
| Q922K9 | Frk | Tyrosine-protein kinase FRK | Mus musculus (Mouse) | SS |
| Q03526 | Itk | Tyrosine-protein kinase ITK/TSK | Mus musculus (Mouse) | SS |
| P35991 | Btk | Tyrosine-protein kinase BTK | Mus musculus (Mouse) | EV |
| P24604 | Tec | Tyrosine-protein kinase Tec | Mus musculus (Mouse) | SS |
| P41242 | Matk | Megakaryocyte-associated tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| P41241 | Csk | Tyrosine-protein kinase CSK | Mus musculus (Mouse) | EV |
| Q9QVP9 | Ptk2b | Protein-tyrosine kinase 2-beta | Mus musculus (Mouse) | PR |
| P34152 | Ptk2 | Focal adhesion kinase 1 | Mus musculus (Mouse) | SS |
| Q99ML2 | Tnk1 | Non-receptor tyrosine-protein kinase TNK1 | Mus musculus (Mouse) | PR |
| O54967 | Tnk2 | Activated CDC42 kinase 1 | Mus musculus (Mouse) | SS |
| Q6J9G1 | Styk1 | Tyrosine-protein kinase STYK1 | Mus musculus (Mouse) | PR |
| P00520 | Abl1 | Tyrosine-protein kinase ABL1 | Mus musculus (Mouse) | EV |
| Q62270 | Srms | Tyrosine-protein kinase Srms | Mus musculus (Mouse) | SS |
| Q4JIM5 | Abl2 | Tyrosine-protein kinase ABL2 | Mus musculus (Mouse) | SS |
| P09760 | Fer | Tyrosine-protein kinase Fer | Rattus norvegicus (Rat) | PR |
| O01798 | spe-8 | Spermatocyte protein spe-8 | Caenorhabditis elegans | PR |
| Q9SUA3 | D6PKL1 | Serine/threonine-protein kinase D6PKL1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGFGSDLKNS | QEAVLKLQDW | ELRLLETVKK | FMALRIKSDK | EYAYTLQNLC | NQVDKESTVQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VNYVSNVSKS | WLLMIQQTEQ | LSRIMKTHAE | DLNSGPLHRL | TMMIKDKQQV | KKSYVGIHQQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IEAEMIKVTK | TELEKLKSSY | RQLIKEMNSA | KEKYKEALAK | GKETEKAKER | YDKATMKLHM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LHNQYVLALK | GAQLHQSQYY | DTTLPLLLDS | VQKMQEEMIK | ALKGIFDDYS | QITSLVTEEI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VNVHKEIQMS | VEQIDPSTEY | NNFIDVHRTT | AAKEQEIEFD | TSLLEENENL | QANEIMWNNL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TADSLQVMLK | TLAEELTQTQ | QMLLHKEAAV | LELEKRIEES | FETCEKKSDI | VLLLGQKQAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EELKQSVQQL | RCTEAKCAAQ | KALLEQKVQE | NDGKEPPPVV | NYEEDARSVT | SMERKERLSK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FESIRHSIAG | IIKSPKSVLG | SSTQVCDVIS | VGERPLAEHD | WYHGAIPRIE | AQELLKQQGD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FLVRESHGKP | GEYVLSVYSD | GQRRHFIIQF | VDNLYRFEGT | GFSNIPQLID | HHFNTKQVIT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KKSGVVLLNP | IPKDKKWVLN | HEDVSLGELL | GKGNFGEVYK | GTLKDKTPVA | IKTCKEDLPQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ELKIKFLQEA | KILKQYDHPN | IVKLIGVCTQ | RQPVYIIMEL | VPGGDFLTFL | RKRKDELKLK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QLVRFSLDVA | AGMLYLESKN | CIHRDLAARN | CLVGENNTLK | ISDFGMSRQE | DGGVYSSSGL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KQIPIKWTAP | EALNYGRYSS | ESDVWSFGIL | LWETFSLGVC | PYPGMTNQQA | REQVERGYRM |
| 790 | 800 | 810 | 820 | ||
| SAPQNCPEEV | FTIMMKCWDY | KPENRPKFND | LHKELTVIKK | MIT |