P70434

SS
Gene name
Irf7
Protein name
Interferon regulatory factor 7
Names
IRF-7
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:54123
EC number
Protein Class

Descriptions

IRF7 is the master regulator of type I interferon-dependent immune responses controlling both innate and adaptive immunity. In human IRF7 (Q92985), deletion of the autoinhibitory region makes IRF7 constutively super-active. Structural analysis revealed that the α-helices H3 and H4 in the autoinhibitory region mediate intramolecular interactions that keep the protein in an inactive form. Thus, the corresponding region in mouse Irf7 may be also involved in autoinhibition.

Autoinhibitory domains (AIDs)

237-420 (C-terminal autoinhibitory region) SS

Target domain

1-146 (N-terminal DNA-binding domain); 468-503 (Signal response domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P70434

Entry ID Method Resolution Chain Position Source
3QU3 X-ray 130 A A/B/C 1-134 PDB
AF-P70434-F1 Predicted AlphaFoldDB

16 variants for P70434

Variant ID(s) Position Change Description Diseaes Association Provenance
rs232821153 53 E>A No Ensembl
rs264525177 123 E>A No Ensembl
rs249676166 126 R>P No Ensembl
rs234530479 135 A>G No Ensembl
rs222916805 137 E>G No Ensembl
rs251278696 143 S>T No Ensembl
rs233664403 146 N>S No Ensembl
rs244197735 199 P>S No Ensembl
rs262079661 239 S>N No Ensembl
rs241107012 258 V>M No Ensembl
rs212256864 342 G>D No Ensembl
rs250283778 345 T>N No Ensembl
rs235447420 354 R>C No Ensembl
rs217166688 354 R>H No Ensembl
rs36290645 401 T>S No Ensembl
rs36944424 446 I>L No Ensembl

No associated diseases with P70434

2 regional properties for P70434

Type Name Position InterPro Accession
domain Ubiquitin-like domain 26 - 103 IPR000626
domain Rad60/SUMO-like domain 29 - 96 IPR022617

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • The phosphorylated and active form accumulates selectively in the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

16 GO annotations of biological process

Name Definition
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
immune system process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
immunoglobulin mediated immune response An immune response mediated by immunoglobulins, whether cell-bound or in solution.
positive regulation of interferon-alpha production Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
positive regulation of interferon-beta production Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of transcription, DNA-templated Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of type I interferon production Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
positive regulation of type I interferon-mediated signaling pathway Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway.
regulation of adaptive immune response Any process that modulates the frequency, rate, or extent of an adaptive immune response.
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of innate immune response Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
regulation of MyD88-dependent toll-like receptor signaling pathway Any process that modulates the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway.
regulation of MyD88-independent toll-like receptor signaling pathway Any process that modulates the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
type I interferon signaling pathway The series of molecular signals initiated by type I interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q90643 IRF3 Interferon regulatory factor 3 Gallus gallus (Chicken) SS
Q92985 IRF7 Interferon regulatory factor 7 Homo sapiens (Human) EV
Q61179 Irf9 Interferon regulatory factor 9 Mus musculus (Mouse) PR
P56477 Irf5 Interferon regulatory factor 5 Mus musculus (Mouse) SS
Q64287 Irf4 Interferon regulatory factor 4 Mus musculus (Mouse) EV
P70671 Irf3 Interferon regulatory factor 3 Mus musculus (Mouse) SS
P23611 Irf8 Interferon regulatory factor 8 Mus musculus (Mouse) PR
10 20 30 40 50 60
MAEVRGVQRV LFGDWLLGEV SSGQYEGLQW LNEARTVFRV PWKHFGRRDL DEEDAQIFKA
70 80 90 100 110 120
WAVARGRWPP SGVNLPPPEA EAAERRERRG WKTNFRCALH STGRFILRQD NSGDPVDPHK
130 140 150 160 170 180
VYELSRELGS TVGPATENRE EVSLSNALPT QGVSPGSFLA RENAGLQTPS PLLSSDAGDL
190 200 210 220 230 240
LLQVLQYSHI LESESGADPV PPQAPGQEQD RVYEEPYAAW QVEAVPSPRP QQPALTERSL
250 260 270 280 290 300
GFLDVTIMYK GRTVLQAVVG HPRCVFLYSP MAPAVRTSEP QPVIFPSPAE LPDQKQLHYT
310 320 330 340 350 360
ETLLQHVSPG LQLELRGPSL WALRMGKCKV YWEVGSPMGT TGPSTPPQLL ERNRHTPIFD
370 380 390 400 410 420
FSTFFRELEE FRARRRQGSP HYTIYLGFGQ DLSAGRPKEK TLILVKLEPW VCKAYLEGVQ
430 440 450
REGVSSLDSS SLGLCLSSTN SLYEDIEHFL MDLGQWP