P70424
SS
Gene name |
Erbb2 (Kiaa3023, Neu) |
Protein name |
Receptor tyrosine-protein kinase erbB-2 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13866 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Erbb2 is a receptor tyrosine protein kinase playing critical roles in regulating cell proliferation, differentiation, and migration. The potential autoinhibitory regions were predicted by sequence similarity with human EGFR (P00533).
Autoinhibitory domains (AIDs)
Target domain |
172-314 (Domain II) |
Relief mechanism |
Partner binding, PTM |
Assay |
|
Accessory elements
863-888 (Activation loop from InterPro)
Target domain |
721-988 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Zhang X et al. (2006) "An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor", Cell, 125, 1137-49
- Ferguson KM et al. (2003) "EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization", Molecular cell, 11, 507-17
- Whitson KB et al. (2005) "Functional effects of glycosylation at Asn-579 of the epidermal growth factor receptor", Biochemistry, 44, 14920-31
- Contessa JN et al. (2008) "Inhibition of N-linked glycosylation disrupts receptor tyrosine kinase signaling in tumor cells", Cancer research, 68, 3803-9
Autoinhibited structure
Activated structure
1 structures for P70424
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P70424-F1 | Predicted | AlphaFoldDB |
14 variants for P70424
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs254290595 | 14 | A>V | No | Ensembl | |
| rs27070987 | 122 | P>S | No | Ensembl | |
| rs235966616 | 127 | T>S | No | Ensembl | |
| rs29390172 | 130 | A>T | No | Ensembl | |
| rs240020901 | 131 | P>Q | No | Ensembl | |
| rs250938967 | 132 | G>S | No | Ensembl | |
| rs221386931 | 134 | T>I | No | Ensembl | |
| rs246162825 | 511 | V>I | No | Ensembl | |
| rs260711884 | 557 | R>S | No | Ensembl | |
| rs229529273 | 578 | Y>F | No | Ensembl | |
| rs258056445 | 662 | V>I | No | Ensembl | |
| rs212617650 | 839 | E>D | No | Ensembl | |
| rs215383025 | 1139 | E>D | No | Ensembl | |
| rs250361886 | 1161 | I>V | No | Ensembl |
No associated diseases with P70424
11 regional properties for P70424
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 1038 - 1169 | IPR000008 |
| domain | Phosphatidylinositol-specific phospholipase C, X domain | 312 - 457 | IPR000909 |
| domain | SH2 domain | 530 - 635 | IPR000980-1 |
| domain | SH2 domain | 644 - 735 | IPR000980-2 |
| domain | SH3 domain | 769 - 829 | IPR001452 |
| domain | Phospholipase C, phosphatidylinositol-specific, Y domain | 930 - 1044 | IPR001711 |
| domain | Pleckstrin homology domain | 1 - 133 | IPR001849-1 |
| domain | Pleckstrin homology domain | 789 - 910 | IPR001849-2 |
| domain | PLC-gamma, C-terminal SH2 domain | 641 - 744 | IPR035023 |
| domain | PLC-gamma, N-terminal SH2 domain | 527 - 627 | IPR035024 |
| domain | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain | 773 - 827 | IPR035723 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
20 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basal plasma membrane | The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| ERBB3:ERBB2 complex | A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lateral loop | Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode. |
| membrane raft | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
| microvillus | Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. |
| myelin sheath | An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
15 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ErbB-3 class receptor binding | Binding to the protein-tyrosine kinase receptor ErbB-3/HER3. |
| growth factor binding | Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. |
| Hsp90 protein binding | Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. |
| identical protein binding | Binding to an identical protein or proteins. |
| protein C-terminus binding | Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| protein phosphatase binding | Binding to a protein phosphatase. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| protein-containing complex binding | Binding to a macromolecular complex. |
| RNA polymerase I core binding | Binding to a RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
| transmembrane signaling receptor activity | Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
41 GO annotations of biological process
| Name | Definition |
|---|---|
| cell surface receptor signaling pathway | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| cellular response to epidermal growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. |
| cellular response to growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. |
| estrous cycle | A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. |
| glial cell differentiation | The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. |
| heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| motor neuron axon guidance | The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. |
| myelination | The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| negative regulation of immature T cell proliferation in thymus | Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| neuromuscular junction development | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. |
| neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neuron. |
| oligodendrocyte differentiation | The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. |
| peptidyl-tyrosine phosphorylation | The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. |
| peripheral nervous system development | The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. |
| phosphatidylinositol 3-kinase signaling | A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions. |
| positive regulation of cell adhesion | Any process that activates or increases the frequency, rate or extent of cell adhesion. |
| positive regulation of cell growth | Any process that activates or increases the frequency, rate, extent or direction of cell growth. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of epithelial cell proliferation | Any process that activates or increases the rate or extent of epithelial cell proliferation. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| positive regulation of kinase activity | Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| positive regulation of MAP kinase activity | Any process that activates or increases the frequency, rate or extent of MAP kinase activity. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| positive regulation of phosphatidylinositol 3-kinase signaling | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| positive regulation of protein targeting to membrane | Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. |
| positive regulation of Ras protein signal transduction | Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction. |
| positive regulation of transcription by RNA polymerase I | Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I. |
| positive regulation of translation | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| regulation of ERK1 and ERK2 cascade | Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| regulation of microtubule-based process | Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. |
| response to axon injury | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| sympathetic nervous system development | The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| wound healing | The series of events that restore integrity to a damaged tissue, following an injury. |
50 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P13387 | EGFR | Epidermal growth factor receptor | Gallus gallus (Chicken) | SS |
| P00533 | EGFR | Epidermal growth factor receptor | Homo sapiens (Human) | EV |
| P21860 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | Homo sapiens (Human) | SS |
| Q15303 | ERBB4 | Receptor tyrosine-protein kinase erbB-4 | Homo sapiens (Human) | SS |
| P04626 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (Human) | SS |
| Q01279 | Egfr | Epidermal growth factor receptor | Mus musculus (Mouse) | SS |
| Q61526 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Mus musculus (Mouse) | SS |
| Q01887 | Ryk | Tyrosine-protein kinase RYK | Mus musculus (Mouse) | PR |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| Q62371 | Ddr2 | Discoidin domain-containing receptor 2 | Mus musculus (Mouse) | SS |
| Q03146 | Ddr1 | Epithelial discoidin domain-containing receptor 1 | Mus musculus (Mouse) | SS |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| P97793 | Alk | ALK tyrosine kinase receptor | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| Q61527 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Mus musculus (Mouse) | SS |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| Q62799 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Rattus norvegicus (Rat) | SS |
| Q62956 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Rattus norvegicus (Rat) | SS |
| P06494 | Erbb2 | Receptor tyrosine-protein kinase erbB-2 | Rattus norvegicus (Rat) | SS |
| P55245 | EGFR | Epidermal growth factor receptor | Macaca mulatta (Rhesus macaque) | SS |
| O16262 | nipi-4 | Protein nipi-4 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELAAWCRWG | FLLALLSPGA | AGTQVCTGTD | MKLRLPASPE | THLDMLRHLY | QGCQVVQGNL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ELTYLPANAS | LSFLQDIQEV | QGYMLIAHNR | VKHVPLQRLR | IVRGTQLFED | KYALAVLDNR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DPLDNVTTAA | PGRTPEGLRE | LQLRSLTEIL | KGGVLIRGNP | QLCYQDMVLW | KDVLRKNNQL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| APVDMDTNRS | RACPPCAPTC | KDNHCWGESP | EDCQILTGTI | CTSGCARCKG | RLPTDCCHEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CAAGCTGPKH | SDCLACLHFN | HSGICELHCP | ALITYNTDTF | ESMLNPEGRY | TFGASCVTTC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PYNYLSTEVG | SCTLVCPPNN | QEVTAEDGTQ | RCEKCSKPCA | GVCYGLGMEH | LRGARAITSD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NIQEFAGCKK | IFGSLAFLPE | SFDGNPSSGV | APLKPEHLQV | FETLEEITGY | LYISAWPESF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QDLSVFQNLR | VIRGRILHDG | AYSLTLQGLG | IHSLGLRSLR | ELGSGLALIH | RNTHLCFVNT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VPWDQLFRNP | HQALLHSGNR | PEEACGLEGL | VCNSLCARGH | CWGPGPTQCV | NCSQFLRGQE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| CVEECRVWKG | LPREYVRGKH | CLPCHPECQP | QNSSETCYGS | EADQCEACAH | YKDSSSCVAR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| CPSGVKPDLS | YMPIWKYPDE | EGICQPCPIN | CTHSCVDLDE | RGCPAEQRAS | PVTFIIATVV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GVLLFLIIVV | VIGILIKRRR | QKIRKYTMRR | LLQETELVEP | LTPSGAVPNQ | AQMRILKETE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LRKLKVLGSG | AFGTVYKGIW | IPDGENVKIP | VAIKVLRENT | SPKANKEILD | EAYVMAGVGS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PYVSRLLGIC | LTSTVQLVTQ | LMPYGCLLDH | VREHRGRLGS | QDLLNWCVQI | AKGMSYLEEV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RLVHRDLAAR | NVLVKSPNHV | KITDFGLARL | LDIDETEYHA | DGGKVPIKWM | ALESILRRRF |
| 910 | 920 | 930 | 940 | 950 | 960 |
| THQSDVWSYG | VTVWELMTFG | AKPYDGIPAR | EIPDLLEKGE | RLPQPPICTI | DVYMIMVKCW |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| MIDSECRPRF | RELVSEFSRM | ARDPQRFVVI | QNEDLGPSSP | MDSTFYRSLL | EDDDMGELVD |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| AEEYLVPQQG | FFSPDPALGT | GSTAHRRHRS | SSARSGGGEL | TLGLEPSEEE | PPRSPLAPSE |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| GAGSDVFDGD | LAVGVTKGLQ | SLSPHDLSPL | QRYSEDPTLP | LPPETDGYVA | PLACSPQPEY |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| VNQPEVRPQS | PLTPEGPPPP | IRPAGATLER | PKTLSPGKNG | VVKDVFAFGG | AVENPEYLAP |
| 1210 | 1220 | 1230 | 1240 | 1250 | |
| RAGTASQPHP | SPAFSPAFDN | LYYWDQNSSE | QGPPPSTFEG | TPTAENPEYL | GLDVPV |