P70218
Gene name |
Map4k1 (Hpk1) |
Protein name |
Mitogen-activated protein kinase kinase kinase kinase 1 |
Names |
Hematopoietic progenitor kinase, HPK, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:26411 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
154-177 (Activation loop from InterPro)
Target domain |
17-274 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
2 structures for P70218
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1UTI | X-ray | 150 A | D | 465-480 | PDB |
| AF-P70218-F1 | Predicted | AlphaFoldDB |
44 variants for P70218
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3412824826 | 11 | K>* | No | EVA | |
| rs3388891688 | 14 | R>P | No | EVA | |
| rs3388892947 | 26 | G>E | No | EVA | |
| rs3388896750 | 41 | D>N | No | EVA | |
| rs3388896713 | 90 | C>Y | No | EVA | |
| rs3388882559 | 109 | L>V | No | EVA | |
| rs3388895669 | 124 | G>E | No | EVA | |
| rs3388854101 | 130 | S>T | No | EVA | |
| rs3388877303 | 141 | A>S | No | EVA | |
| rs3388882578 | 150 | E>K | No | EVA | |
| rs3388895160 | 177 | Y>* | No | EVA | |
| rs3388869800 | 190 | G>D | No | EVA | |
| rs3388895177 | 191 | G>R | No | EVA | |
| rs3388896795 | 193 | N>S | No | EVA | |
| rs3388869788 | 209 | A>T | No | EVA | |
| rs3388890508 | 212 | Q>H | No | EVA | |
| rs3388877324 | 236 | R>L | No | EVA | |
| rs3388877323 | 273 | L>M | No | EVA | |
| rs3388891752 | 330 | D>G | No | EVA | |
| rs3397307693 | 352 | A>D | No | EVA | |
| rs3388896721 | 359 | P>S | No | EVA | |
| rs243193247 | 364 | G>R | No | EVA | |
| rs3388875266 | 425 | R>Q | No | EVA | |
| rs3388885643 | 440 | P>S | No | EVA | |
| rs31155356 | 444 | C>R | No | EVA | |
| rs3388892989 | 468 | P>Q | No | EVA | |
| rs3388892980 | 480 | K>N | No | EVA | |
| rs3388877322 | 482 | E>Q | No | EVA | |
| rs3388885669 | 494 | V>L | No | EVA | |
| rs3388869793 | 504 | I>M | No | EVA | |
| rs3396933886 | 520 | L>M | No | EVA | |
| rs3388895735 | 528 | I>N | No | EVA | |
| rs264692411 | 566 | P>S | No | EVA | |
| rs3388887616 | 609 | D>E | No | EVA | |
| rs3388869776 | 663 | L>P | No | EVA | |
| rs259613735 | 687 | Q>H | No | EVA | |
| rs3388892931 | 690 | K>R | No | EVA | |
| rs3388885667 | 697 | V>E | No | EVA | |
| rs3388895209 | 705 | W>* | No | EVA | |
| rs3388875296 | 755 | M>L | No | EVA | |
| rs31836292 | 807 | V>I | No | EVA | |
| rs46422041 | 808 | V>E | No | EVA | |
| rs3388869799 | 813 | P>H | No | EVA | |
| rs3388898049 | 819 | A>P | No | EVA |
No associated diseases with P70218
5 regional properties for P70218
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 481 - 814 | IPR002073 |
| domain | GAF domain | 71 - 230 | IPR003018-1 |
| domain | GAF domain | 252 - 439 | IPR003018-2 |
| domain | HD/PDEase domain | 554 - 741 | IPR003607 |
| conserved_site | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | 597 - 608 | IPR023174 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| MAP kinase kinase kinase kinase activity | Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell population proliferation | The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
| cellular response to phorbol 13-acetate 12-myristate | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| JNK cascade | An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12851 | MAP4K2 | Mitogen-activated protein kinase kinase kinase kinase 2 | Homo sapiens (Human) | EV |
| Q8IVH8 | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Homo sapiens (Human) | SS |
| Q9Y4K4 | MAP4K5 | Mitogen-activated protein kinase kinase kinase kinase 5 | Homo sapiens (Human) | PR |
| Q92918 | MAP4K1 | Mitogen-activated protein kinase kinase kinase kinase 1 | Homo sapiens (Human) | EV |
| Q61161 | Map4k2 | Mitogen-activated protein kinase kinase kinase kinase 2 | Mus musculus (Mouse) | SS |
| Q99JP0 | Map4k3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Mus musculus (Mouse) | SS |
| O54988 | Slk | STE20-like serine/threonine-protein kinase | Mus musculus (Mouse) | PR |
| O55098 | Stk10 | Serine/threonine-protein kinase 10 | Mus musculus (Mouse) | PR |
| Q6P9R2 | Oxsr1 | Serine/threonine-protein kinase OSR1 | Mus musculus (Mouse) | PR |
| Q9Z1W9 | Stk39 | STE20/SPS1-related proline-alanine-rich protein kinase | Mus musculus (Mouse) | PR |
| Q99JT2 | Stk26 | Serine/threonine-protein kinase 26 | Mus musculus (Mouse) | PR |
| Q99KH8 | Stk24 | Serine/threonine-protein kinase 24 | Mus musculus (Mouse) | PR |
| Q9Z2W1 | Stk25 | Serine/threonine-protein kinase 25 | Mus musculus (Mouse) | PR |
| Q8BPM2 | Map4k5 | Mitogen-activated protein kinase kinase kinase kinase 5 | Mus musculus (Mouse) | PR |
| Q924I2 | Map4k3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALVDPDIFN | KDPREHYDLL | QRLGGGTYGE | VFKARDKVSK | DLVALKMVKM | EPDDDVATLQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KEILMLKTCR | HANIVAYHGS | YLWLQKLWIC | MEFCGAGSLQ | DIYQVTGSLS | ELQISYVCRE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VLQGLAYLHS | EKKIHRDIKG | ANILINDCGE | VKLADFGISA | QIGATLARRL | SFIGTPYWMA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PEVAAVALKG | GYNELCDIWS | LGITAIELAE | LQPPLFDVHP | LRVLFLMTKS | GYQPPRLKEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SRWSSSFHNF | VKVTLTKNSK | KRPSATKMLS | HQLVSQPGLN | RGLILDLLDK | MKNPGKGLPV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DIEDEEPEPP | PAIPRRIRST | YRASSLGIPD | ADCCRRQMEF | QRPRCVDCRP | QAETVRLYPP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AHFGSTSPRS | QLSDSDDDYD | DVDIPAPSEN | IPPPLPPKPK | FRSPSDDGSG | GIRDDGQLSP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GVLVRCASGP | PPRTPRPGPP | PATCSPHLTA | RSDPSLWNPA | APEPGQPPLV | PPRKEKMRGK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MENEKRREKY | PLLVKLFNGC | PLQIHSTAAW | THPSTKDQNL | LLGAEEGIFI | LNRNDQEATL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EMIFPGRTTW | LYCINNLLMS | LSGKTPYLYS | HSILGLLERK | DGRTGSPIAH | ISPHRLLARK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NMVSSKIQDT | KGCRACCVAE | SASSGGPFLC | GALETSVVLL | QWYQPMNKFL | LVRQVLFPLP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TPLPVFTLLT | TPGSELPAVC | IGVSPGQAAK | SVLFHTVRFG | ALSCWLDDSS | TEHKGPVQVI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QVKEDMVMVL | MDGSLKLVTP | EGAPAPGLRT | PEIPMTEAVE | AVAMVEDRLE | AFWKHGVQVW |
| 790 | 800 | 810 | 820 | ||
| APGLKQPLQE | LRDPTLTFRL | LCSPRPVVVE | TRPTDDPTAP | SNLYIQE |