P70208

EV SS
Gene name
Plxna3
Protein name
Plexin-A3
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:18846
EC number
Protein Class
PLEXIN (PTHR22625)

Descriptions

Plexin cell surface receptors bind to semaphorin ligands and transduce signals for regulating neuronal axon guidance. The intracellular region of plexins is essential for signaling and contains a R-Ras/M-Ras GTPase activating protein (GAP) domain that is divided into two segments by a Rho GTPase-binding domain (RBD). The autoinhibitory regions including an Rho GTPase-binding domain (RBD) and a segment preceding C1 domain make extensive interactions with the GAP domain (C1 and C2 domains), which may enable it to regulate the GAP conformation in response to semaphorin binding. Activation of Plexin requires both binding of semaphorin to the extracellular region and a Rho-family GTPase (Rac1 or Rnd1) to the RBD. According to human Plexin-A1 (Q9UIW2) study, the Sema domain in Plexin-A3 may be also involved in autoinhibition.

Autoinhibitory domains (AIDs)

1244-1324 (Segment preceding C1 domain) EV

Target domain

1294-1842 (Plexin, RasGAP domain)

Relief mechanism

Assay

Structural analysis, Mutagenesis experiment

1450-1650 (RBD domain) EV

Target domain

1294-1842 (Plexin, RasGAP domain)

Relief mechanism

Partner binding

Assay

Structural analysis

36-470 (Sema domain) SS

Target domain

1294-1842 (Plexin, RasGAP domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P70208

Entry ID Method Resolution Chain Position Source
3IG3 X-ray 199 A A 1247-1872 PDB
AF-P70208-F1 Predicted AlphaFoldDB

4 variants for P70208

Variant ID(s) Position Change Description Diseaes Association Provenance
rs257709899 563 M>V No Ensembl
rs217140698 1004 L>V No Ensembl
rs241435728 1153 I>V No Ensembl
rs29036718 1171 Q>R No Ensembl

No associated diseases with P70208

5 regional properties for P70208

Type Name Position InterPro Accession
repeat Plexin repeat 491 - 531 IPR002165-1
repeat Plexin repeat 638 - 678 IPR002165-2
domain Plexin, cytoplasmic RasGAP domain 1294 - 1842 IPR013548
domain Plexin, TIG domain 1 547 - 637 IPR041019
domain Plexin, cytoplasmic RhoGTPase-binding domain 1464 - 1576 IPR046800

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane; Single-pass type I membrane protein
PANTHER Family PTHR22625 PLEXIN
PANTHER Subfamily PTHR22625:SF32 PLEXIN-A3
PANTHER Protein Class transmembrane signal receptor
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
semaphorin receptor complex A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

1 GO annotations of molecular function

Name Definition
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

17 GO annotations of biological process

Name Definition
axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
branchiomotor neuron axon guidance The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
facial nerve structural organization The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
hippocampus development The progression of the hippocampus over time from its initial formation until its mature state.
negative chemotaxis The directed movement of a motile cell or organism towards a lower concentration of a chemical.
negative regulation of axon extension involved in axon guidance Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance.
negative regulation of cell adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
neuron projection extension Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuron projection guidance The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis.
positive regulation of cytoskeleton organization Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
pyramidal neuron development The progression of a pyramidal neuron from its initial formation to its mature state.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.
regulation of cell shape Any process that modulates the surface configuration of a cell.
regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase.
semaphorin-plexin signaling pathway involved in axon guidance Any semaphorin-plexin signaling pathway that is involved in axon guidance.
trigeminal nerve structural organization The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q769I5 MET Hepatocyte growth factor receptor Bos taurus (Bovine) PR
A0M8S8 MET Hepatocyte growth factor receptor Felis catus (Cat) (Felis silvestris catus) PR
Q04912 MST1R Macrophage-stimulating protein receptor Homo sapiens (Human) EV
P08581 MET Hepatocyte growth factor receptor Homo sapiens (Human) EV
O43157 PLXNB1 Plexin-B1 Homo sapiens (Human) EV SS
Q9HCM2 PLXNA4 Plexin-A4 Homo sapiens (Human) SS
O75051 PLXNA2 Plexin-A2 Homo sapiens (Human) SS
Q9UIW2 PLXNA1 Plexin-A1 Homo sapiens (Human) EV SS
O15031 PLXNB2 Plexin-B2 Homo sapiens (Human) SS
Q9ULL4 PLXNB3 Plexin-B3 Homo sapiens (Human) SS
P51805 PLXNA3 Plexin-A3 Homo sapiens (Human) SS
Q62190 Mst1r Macrophage-stimulating protein receptor Mus musculus (Mouse) SS
P16056 Met Hepatocyte growth factor receptor Mus musculus (Mouse) PR
Q3UH93 Plxnd1 Plexin-D1 Mus musculus (Mouse) SS
Q9QZC2 Plxnc1 Plexin-C1 Mus musculus (Mouse) SS
Q9QY40 Plxnb3 Plexin-B3 Mus musculus (Mouse) SS
P70207 Plxna2 Plexin-A2 Mus musculus (Mouse) SS
P70206 Plxna1 Plexin-A1 Mus musculus (Mouse) EV SS
B2RXS4 Plxnb2 Plexin-B2 Mus musculus (Mouse) SS
Q8CJH3 Plxnb1 Plexin-B1 Mus musculus (Mouse) SS
Q80UG2 Plxna4 Plexin-A4 Mus musculus (Mouse) SS
Q2QLE0 MET Hepatocyte growth factor receptor Sus scrofa (Pig) PR
P97523 Met Hepatocyte growth factor receptor Rattus norvegicus (Rat) PR
D3ZLH5 Plxnb3 Plexin-B3 Rattus norvegicus (Rat) SS
D3ZPX4 Plxna3 Plexin-A3 Rattus norvegicus (Rat) SS
Q6BEA0 plxna4 Plexin-A4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
B0S5N4 plxna3 Plexin A3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MPTVCLLPLL FFTIGGCLGS SRPFRTFVVT DTTLTHLAVH RVTGEVFVGA VNRVFKLAPN
70 80 90 100 110 120
LTELRAHVTG PIEDNARCYP PPSMRVCSHR LVPVDNVNKL LLIDYAARRL VACGSIWQGI
130 140 150 160 170 180
CQFLRLDDLF KLGEPHHRKE HYLSGAQEPD SMAGVIVEQV QGPSKLFVGT AVDGKSEYFP
190 200 210 220 230 240
TLSSRKLIDD EDSGDMFSLV YQDEFVSSQI KIPSDTLSLY PAFDIYYIYG FVSASFVYFL
250 260 270 280 290 300
TLQLDTQQTL LDTAGEKFFT SKIVRMCAGD SEFYSYVEFP IGCSWRGVEY RLVQSAHLAK
310 320 330 340 350 360
PGLLLAQALG VPADEDVLFT IFSQGQKNRA NPPRQTILCL FTLSSINAHI RRRIQSCYRG
370 380 390 400 410 420
EGTLALPWLL NKELPCINTP LQINGNFCGL VLNQPLGGLH VIEGLPLLAD STDGMASVAA
430 440 450 460 470 480
YTYHQHSVVF IGTRSGNLKK VRVDGSQDAQ LYETVSVVQG SPILRDLLFS PDHRHIYLLS
490 500 510 520 530 540
EKQVSQLPVE TCEQYLSCAA CLGSGDPHCG WCVLQHRCCR EGACPGASAP HGFAEELSKC
550 560 570 580 590 600
IQVRVRPNNV SVTSSGVQLT VAMRNVPDLS VGVSCSFEEV TESEAILLPS GELRCPSPSL
610 620 630 640 650 660
QELQTLTRGH GATHTVRLQL LSMETGVRFA GVDFVFYNCS ALQSCMSCVG SPYPCHWCKY
670 680 690 700 710 720
RHVCTSHPHE CSFQEGRVHS PEGCPEILPQ GDLLIPVGVM QPLTLRAKNL PQPQSGQKNY
730 740 750 760 770 780
ECVVRVQGRQ HRVPAVRFNS SSVQCQNASY FYEGDEFGDT ELDFSVVWDG DFPIDKPPSF
790 800 810 820 830 840
RALLYKCWAQ RPSCGLCLKA DPRFNCGWCI SEHRCQLRAH CPAPKSNWMH PSQKGARCSH
850 860 870 880 890 900
PRITQIHPLT GPKEGGTRVT IVGENLGLTS REVGLRVAGV RCNSIPTEYV SAERIVCEME
910 920 930 940 950 960
ESLVPSPPPG PAELCVGDCS ADFRTQSQQL YSFVTPTFDR VSPSRGPASG GTRLTISGIS
970 980 990 1000 1010 1020
LDAGSRVTVI IRDGECQFVR RDAEAIVCIS PVSTLGPSQS PITLAIDHAN ISNTGVIYTY
1030 1040 1050 1060 1070 1080
TQDPTVTHLE PTWSIINGST SITVSGTHLL TVQEPRVRAK YRGIETTNTC QVINDTAMLC
1090 1100 1110 1120 1130 1140
KAPGIFLGHP QPRAQGEHPD EFGFLLDHVQ AARSLNRSSF TYYPDPSFEP LGPSGVLDVK
1150 1160 1170 1180 1190 1200
PGSHVVLKGK NLIPAAAGSS RLNYTVLIGG QPCALTVSDT QLLCDSPSQT GRQPVMVLVG
1210 1220 1230 1240 1250 1260
GLEFWLGTLH ITADRALTLP AMVGLAAGGG LLLLAITVVL VAYKRKTQDA DRTLKRLQLQ
1270 1280 1290 1300 1310 1320
MDNLESRVAL ECKEAFAELQ TDINELTNHM DGVQIPFLDY RTYAVRVLFP GIEAHPVLKE
1330 1340 1350 1360 1370 1380
LDTPPNVEKA LRLFGQLLHS RAFLLTFIHT LEAQSSFSMR DRGTVASLTM VALQSRLDYA
1390 1400 1410 1420 1430 1440
TGLLKQLLAD LIEKNLESKN HPKLLLRRTE SVAEKMLTNW FTFLLHKFLK ECAGEPLFLL
1450 1460 1470 1480 1490 1500
YCAIKQQMEK GPIDAITGEA RYSLSEDKLI RQQIDYKTLT LHCVCPESEG SAQVPVKVLN
1510 1520 1530 1540 1550 1560
CDSITQAKDK LLDTVYKGIP YSQRPKAEDM DLEWRQGRMA RIILQDEDIT TKIECDWKRV
1570 1580 1590 1600 1610 1620
NSLAHYQVTD GSLVALVPKQ VSAYNMANSF TFTRSLSRYE SLLRAASSPD SLRSRAPMLT
1630 1640 1650 1660 1670 1680
PDQEAGTKLW HLVRNHDHTD HREGDRGSKM VSEIYLTRLL ATKGTLQKFV DDLFETVFST
1690 1700 1710 1720 1730 1740
AHRGSALPLA IKYMFDFLDE QADQRQISDP DVRHTWKSNC LPLRFWVNVI KNPQFVFDIH
1750 1760 1770 1780 1790 1800
KNSITDACLS VVAQTFMDSC STSEHRLGKD SPSNKLLYAK DIPNYKSWVE RYYRDIAKMA
1810 1820 1830 1840 1850 1860
SISDQDMDAY LVEQSRLHAN DFNVLSALSE LYFYVTKYRQ EILTSLDRDA SCRKHKLRQK
1870
LEQIITLVSS SS