P70207

SS
Gene name
Plxna2 (Kiaa0463)
Protein name
Plexin-A2
Names
Plex 2, Plexin-2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:18845
EC number
Protein Class

Descriptions

Plexin cell surface receptors bind to semaphorin ligands and transduce signals for regulating neuronal axon guidance. In mouse Plexin-A3 (P70208), the autoinhibitory regions including an Rho GTPase-binding domain (RBD) and a segment preceding C1 domain make extensive interactions with the GAP domain (C1 and C2 domains), which may enable it to regulate the GAP conformation in response to semaphorin binding. According to human Plexin-A1 (Q9UIW2) study, the Sema domain may be also involved in autoinhibition.

Autoinhibitory domains (AIDs)

52-489 (Sema domain) SS

Target domain

1311-1863 (Plexin, RasGAP domain)

Relief mechanism

Partner binding

Assay

1261-1341 (Segment preceding C1 domain) SS

Target domain

1311-1863 (Plexin, RasGAP domain)

Relief mechanism

Assay

1471-1672 (RBD domain) SS

Target domain

1311-1863 (Plexin, RasGAP domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for P70207

Entry ID Method Resolution Chain Position Source
3AL8 X-ray 360 A B 31-561 PDB
3AL9 X-ray 210 A A/B 31-561 PDB
3OKT X-ray 230 A A 35-703 PDB
3OKY X-ray 220 A A 35-703 PDB
4GZA X-ray 700 A A/B/C/D/E/F 33-703 PDB
5L5G X-ray 1000 A A/B/C/D 33-1231 PDB
5L74 X-ray 136 A A 655-803 PDB
AF-P70207-F1 Predicted AlphaFoldDB

9 variants for P70207

Variant ID(s) Position Change Description Diseaes Association Provenance
rs46926340 266 M>I No Ensembl
rs242405851 970 T>I No Ensembl
rs232487728 971 M>K No Ensembl
rs252042269 995 E>K No Ensembl
rs216866271 997 Y>D No Ensembl
rs229626889 998 G>R No Ensembl
rs249444515 1007 V>I No Ensembl
rs246420248 1073 R>K No Ensembl
rs266049805 1098 L>M No Ensembl

No associated diseases with P70207

No regional properties for P70207

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P70207

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
collagen-containing extracellular matrix An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
semaphorin receptor complex A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

2 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

14 GO annotations of biological process

Name Definition
cell surface receptor signaling pathway The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
centrosome localization Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.
cerebellar granule cell precursor tangential migration The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium.
limb bud formation The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable.
negative regulation of cell adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
neural tube development The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
pharyngeal system development The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.
positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.
regulation of cell shape Any process that modulates the surface configuration of a cell.
regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase.
semaphorin-plexin signaling pathway The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
semaphorin-plexin signaling pathway involved in axon guidance Any semaphorin-plexin signaling pathway that is involved in axon guidance.
somitogenesis The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q769I5 MET Hepatocyte growth factor receptor Bos taurus (Bovine) PR
A0M8S8 MET Hepatocyte growth factor receptor Felis catus (Cat) (Felis silvestris catus) PR
Q04912 MST1R Macrophage-stimulating protein receptor Homo sapiens (Human) EV
P08581 MET Hepatocyte growth factor receptor Homo sapiens (Human) EV
O43157 PLXNB1 Plexin-B1 Homo sapiens (Human) EV SS
Q9HCM2 PLXNA4 Plexin-A4 Homo sapiens (Human) SS
P51805 PLXNA3 Plexin-A3 Homo sapiens (Human) SS
Q9UIW2 PLXNA1 Plexin-A1 Homo sapiens (Human) EV SS
O15031 PLXNB2 Plexin-B2 Homo sapiens (Human) SS
Q9ULL4 PLXNB3 Plexin-B3 Homo sapiens (Human) SS
O75051 PLXNA2 Plexin-A2 Homo sapiens (Human) SS
Q62190 Mst1r Macrophage-stimulating protein receptor Mus musculus (Mouse) SS
P16056 Met Hepatocyte growth factor receptor Mus musculus (Mouse) PR
B2RXS4 Plxnb2 Plexin-B2 Mus musculus (Mouse) SS
P70206 Plxna1 Plexin-A1 Mus musculus (Mouse) EV SS
Q3UH93 Plxnd1 Plexin-D1 Mus musculus (Mouse) SS
Q80UG2 Plxna4 Plexin-A4 Mus musculus (Mouse) SS
Q8CJH3 Plxnb1 Plexin-B1 Mus musculus (Mouse) SS
Q9QY40 Plxnb3 Plexin-B3 Mus musculus (Mouse) SS
Q9QZC2 Plxnc1 Plexin-C1 Mus musculus (Mouse) SS
P70208 Plxna3 Plexin-A3 Mus musculus (Mouse) EV SS
Q2QLE0 MET Hepatocyte growth factor receptor Sus scrofa (Pig) PR
P97523 Met Hepatocyte growth factor receptor Rattus norvegicus (Rat) PR
D3ZPX4 Plxna3 Plexin-A3 Rattus norvegicus (Rat) SS
D3ZLH5 Plxnb3 Plexin-B3 Rattus norvegicus (Rat) SS
Q6BEA0 plxna4 Plexin-A4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
B0S5N4 plxna3 Plexin A3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MEQRRFYLRA MQADNLSVVL LSVAWLLLAR GTTGMPQYST FHSENRDWTF NHLTVHRRTG
70 80 90 100 110 120
AVYVGAINRV YKLTGNLTIQ VAHKTGPEED NKACYPPLIV QPCSEVLTLT NNVNKLLIID
130 140 150 160 170 180
YSENRLLACG SLYQGVCKLL RLDDLFILVE PSHKKEHYLS SVNKTGTMYG VIVRSEGEDG
190 200 210 220 230 240
KLFIGTAVDG KQDYFPTLSS RKLPRDPESS AMLDYELHSD FVSSLIKIPS DTLALVSHFD
250 260 270 280 290 300
IFYIYGFASG GFVYFLTVQP ETPDGMAINS AGDLFYTSRI VRLCKDDPKF HSYVSLPFGC
310 320 330 340 350 360
TRAGVEYRLL QAAYLAKPGE ALAQAFNISS DEDVLFAIFS KGQKQYHHPP DDSALCAFPI
370 380 390 400 410 420
RAINLQIKER LQSCYHGEGN LELNWLLGKD VQCTKAPVPI DDNFCGLDIN QPLGGSTPVE
430 440 450 460 470 480
GLTLYTTSRD RLTSVASYVY NGYSVVFVGT KSGKLKKIRA DGPPHGGVQY EMVSVFKDGS
490 500 510 520 530 540
PILRDMAFSI NQLYLYVMSE RQVTRVPVES CEQYTTCGEC LSSGDPHCGW CALHNMCSRR
550 560 570 580 590 600
DKCQRAWEAN RFAASISQCM SLEVHPNSIS VSDHSRLLSL VVNDAPNLSE GIACAFGNLT
610 620 630 640 650 660
EVEGQVSGSQ VICISPGPKD VPVIPLDQDW FGLELQLRSK ETGKIFVSTE FKFYNCSAHQ
670 680 690 700 710 720
LCLSCVNSAF RCHWCKYRNL CTHDPTTCSF QEGRINVSED CPQLVPTEEI LIPVGEVKPI
730 740 750 760 770 780
TLKARNLPQP QSGQRGYECV LSIQGAVHRV PALRFNSSSV QCQNSSYQYD GMDISNLAVD
790 800 810 820 830 840
FAVVWNGNFI IDNPQDLKVH LYKCAAQRES CGLCLKADHK FECGWCSGER RCTLHQHCPS
850 860 870 880 890 900
TSSPWLDWSS HNVKCSNPQI TEILTVSGPP EGGTRVTIHG VNLGLDFSEI AHHVQVAGVP
910 920 930 940 950 960
CTPIPGEYII AEQIVCEMGH AVIGTTSGPV RLCIGECKPE FMTKSHQQYT FVNPSVLSLS
970 980 990 1000 1010 1020
PIRGPESGGT MVTITGHYLG AGSSVAVYLG NQTCEFYGRS MNEIVCVSPP SSNGLGPVPV
1030 1040 1050 1060 1070 1080
SVSVDRARVD SSLQFEYIDD PRVQRIEPEW SITSGHTPLT ITGFNLDVIQ EPRVRVKFNG
1090 1100 1110 1120 1130 1140
KESVNVCTVV NTTTLTCLAP SLTSDYRPGL DTVERPDEFG FLFNNVQSLL IYNDTKFIYY
1150 1160 1170 1180 1190 1200
PNPTFELLSP TGILDQKPGS PIILKGKNLC PPASGGAKLN YTVMIGETPC TVTVSETQLL
1210 1220 1230 1240 1250 1260
CEPPNLTGQH KVMVHVGGMV FSPGSVSVIS DSLLTLPAII SIAAGGSLLL IIVIIVLIAY
1270 1280 1290 1300 1310 1320
KRKSRENDLT LKRLQMQMDN LESRVALECK EAFAELQTDI NELTSDLDRS GIPYLDYRTY
1330 1340 1350 1360 1370 1380
AMRVLFPGIE DHPVLRELEV QGNGQQHVEK ALKLFAQLIN NKVFLLTFIR TLELQRSFSM
1390 1400 1410 1420 1430 1440
RDRGNVASLI MTGLQGRLEY ATDVLKQLLS DLIDKNLENK NHPKLLLRRT ESVAEKMLTN
1450 1460 1470 1480 1490 1500
WFAFLLHKFL KECAGEPLFM LYCAIKQQME KGPIDAITGE ARYSLSEDKL IRQQIEYKTL
1510 1520 1530 1540 1550 1560
ILNCVNPDNE NSPEIPVKVL NCDTITQVKE KILDAVYKNV PYSQRPRAVD MDLEWRQGRI
1570 1580 1590 1600 1610 1620
ARVVLQDEDI TTKIEGDWKR LNTLMHYQVS DRSVVALVPK QTSSYNIPAS ASISRTSISR
1630 1640 1650 1660 1670 1680
YDSSFRYTGS PDSLRSRVPM ITPDLESGVK VWHLVKNHDH GDQKEGDRGS KMVSEIYLTR
1690 1700 1710 1720 1730 1740
LLATKGTLQK FVDDLFETLF STVHRGSALP LAIKYMFDFL DEQADRHSIH DTDVRHTWKS
1750 1760 1770 1780 1790 1800
NCLPLRFWVN VIKNPQFVFD IHKGSITDAC LSVVAQTFMD SCSTSEHRLG KDSPSNKLLY
1810 1820 1830 1840 1850 1860
AKDIPSYKNW VERYYADIAK LPAISDQDMN AYLAEQSRLH ATEFNMLSAL NEIYSYVSKY
1870 1880 1890
SEELIGALEQ DEQARRQRLA YKVEHLINAM SIES