P70206

EV SS
Gene name
Plxna1 (Kiaa4053)
Protein name
Plexin-A1
Names
Plex 1, Plexin-1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:18844
EC number
Protein Class
PLEXIN (PTHR22625)

Descriptions

Plexins are a large family of cell surface receptors for the axon guidance molecules semaphorins. Semaphorin-plexin signaling is essential for the regulation of neuronal development and other processes. Dysfunction in plexin pathways has been implicated in various diseases including neurological disorders and cancer.
Plexins are transmembrane proteins with a multidomain extracellular region that contains an N-terminal Sema domain. Before semaphorin binding, Plexin is an inactive monomer or dimer in which the RapGAP activity is autoinhibited. Binding of semaphorin to the Sema domain of plexin leads to activation of its cytoplasmic region, which relays the signal to downstream pathways. Mouse Plexin-A3 (P70208) possesses a segment preceding C1 domain and RDB domain as autoinhibitory elements.

Autoinhibitory domains (AIDs)

23-510 (Sema domain) EV

Target domain

1316-1864 (Plexin, cytoplasmic RasGAP domain)

Relief mechanism

Partner binding

Assay

Structural analysis, Mutagenesis experiment

1243-1315 (Segment preceding C1 domain) SS

Target domain

1316-1864 (Plexin, cytoplasmic RasGAP domain)

Relief mechanism

Assay

1486-1598 (RBD domain) SS

Target domain

1316-1864 (Plexin, cytoplasmic RasGAP domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P70206

Entry ID Method Resolution Chain Position Source
3RYT X-ray 358 A A/B 1269-1894 PDB
5L56 X-ray 400 A A 37-1236 PDB
5L59 X-ray 600 A A/B 37-1236 PDB
5L5C X-ray 600 A A 37-1236 PDB
5L7N X-ray 220 A A 861-1241 PDB
AF-P70206-F1 Predicted AlphaFoldDB

2 variants for P70206

Variant ID(s) Position Change Description Diseaes Association Provenance
rs29880105 32 G>V No Ensembl
rs258594658 38 A>S No Ensembl

No associated diseases with P70206

15 regional properties for P70206

Type Name Position InterPro Accession
domain Sema domain 23 - 510 IPR001627
repeat Plexin repeat 512 - 557 IPR002165-1
repeat Plexin repeat 807 - 859 IPR002165-2
domain IPT domain 861 - 957 IPR002909-1
domain IPT domain 958 - 1043 IPR002909-2
domain IPT domain 1045 - 1145 IPR002909-3
domain IPT domain 1147 - 1242 IPR002909-4
domain Plexin, cytoplasmic RasGAP domain 1316 - 1864 IPR013548
domain PSI domain 512 - 562 IPR016201-1
domain PSI domain 658 - 705 IPR016201-2
domain PSI domain 806 - 860 IPR016201-3
domain Plexin, TIG domain 1 567 - 657 IPR041019
domain Plexin, TIG domain 2 712 - 805 IPR041362
domain Plexin-A1, Sema domain 36 - 511 IPR042744
domain Plexin, cytoplasmic RhoGTPase-binding domain 1486 - 1598 IPR046800

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane; Single-pass type I membrane protein
PANTHER Family PTHR22625 PLEXIN
PANTHER Subfamily PTHR22625:SF35 PLEXIN-A1
PANTHER Protein Class transmembrane signal receptor
PANTHER Pathway Category Axon guidance mediated by semaphorins
PlexinA1

6 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
semaphorin receptor complex A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

1 GO annotations of molecular function

Name Definition
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

10 GO annotations of biological process

Name Definition
dichotomous subdivision of terminal units involved in salivary gland branching The process in which a salivary epithelial cord bifurcates at its end.
negative regulation of cell adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
neuron projection extension Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuron projection guidance The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.
regulation of cell shape Any process that modulates the surface configuration of a cell.
regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase.
regulation of smooth muscle cell migration Any process that modulates the frequency, rate or extent of smooth muscle cell migration.
semaphorin-plexin signaling pathway involved in axon guidance Any semaphorin-plexin signaling pathway that is involved in axon guidance.

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q769I5 MET Hepatocyte growth factor receptor Bos taurus (Bovine) PR
A0M8S8 MET Hepatocyte growth factor receptor Felis catus (Cat) (Felis silvestris catus) PR
Q04912 MST1R Macrophage-stimulating protein receptor Homo sapiens (Human) EV
P08581 MET Hepatocyte growth factor receptor Homo sapiens (Human) EV
O43157 PLXNB1 Plexin-B1 Homo sapiens (Human) EV SS
Q9HCM2 PLXNA4 Plexin-A4 Homo sapiens (Human) SS
O75051 PLXNA2 Plexin-A2 Homo sapiens (Human) SS
P51805 PLXNA3 Plexin-A3 Homo sapiens (Human) SS
O15031 PLXNB2 Plexin-B2 Homo sapiens (Human) SS
Q9ULL4 PLXNB3 Plexin-B3 Homo sapiens (Human) SS
Q9UIW2 PLXNA1 Plexin-A1 Homo sapiens (Human) EV SS
Q62190 Mst1r Macrophage-stimulating protein receptor Mus musculus (Mouse) SS
P16056 Met Hepatocyte growth factor receptor Mus musculus (Mouse) PR
B2RXS4 Plxnb2 Plexin-B2 Mus musculus (Mouse) SS
P70207 Plxna2 Plexin-A2 Mus musculus (Mouse) SS
Q3UH93 Plxnd1 Plexin-D1 Mus musculus (Mouse) SS
Q80UG2 Plxna4 Plexin-A4 Mus musculus (Mouse) SS
Q8CJH3 Plxnb1 Plexin-B1 Mus musculus (Mouse) SS
Q9QY40 Plxnb3 Plexin-B3 Mus musculus (Mouse) SS
Q9QZC2 Plxnc1 Plexin-C1 Mus musculus (Mouse) SS
P70208 Plxna3 Plexin-A3 Mus musculus (Mouse) EV SS
Q2QLE0 MET Hepatocyte growth factor receptor Sus scrofa (Pig) PR
P97523 Met Hepatocyte growth factor receptor Rattus norvegicus (Rat) PR
D3ZPX4 Plxna3 Plexin-A3 Rattus norvegicus (Rat) SS
D3ZLH5 Plxnb3 Plexin-B3 Rattus norvegicus (Rat) SS
Q6BEA0 plxna4 Plexin-A4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
B0S5N4 plxna3 Plexin A3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MPLPPLSSRT LLLLLLLLLR GVWIAISSPP AGLGPQPAFR TFVASDWGLT HLVVHEQTGE
70 80 90 100 110 120
VYVGAVNRIY KLSGNLTLLR AHVTGPVEDN EKCYPPPSVQ SCPHGLGSTD NVNKLLLLDY
130 140 150 160 170 180
AANRLLACGS ASQGICQFLR LDDLFKLGEP HHRKEHYLSS VREAGSMAGV LIAGPPGQGQ
190 200 210 220 230 240
AKLFVGTPID GKSEYFPTLS SRRLMANEED ADMFGFVYQD EFVSSQLKIP SDTLSKFPAF
250 260 270 280 290 300
DIYYVYSFRS EQFVYYLTLQ LDTQLTSPDA AGEHFFTSKI VRLCVNDPKF YSYVEFPIGC
310 320 330 340 350 360
EQAGVEYRLV QDAYLSRPGQ ALAKQLGLAE DEEVLFTVFA QGQKNRVKPP KESALCLFTL
370 380 390 400 410 420
RAIKEKIKER IQSCYRGEGK LSLPWLLNKE LGCINSPLQI DDDFCGQDFN QPLGGTVTIE
430 440 450 460 470 480
GTPLFVDKED GLTAVAAYDY QGRTVVFAGT RSGRIRKILV DLANPSGRPA LAYESVVAQE
490 500 510 520 530 540
GNPILRDLVL SPNRQYLYAM TEKQVTQVPV ESCVQYTSCE LCLGSRDPHC GWCVLHSICS
550 560 570 580 590 600
RQDACERAEE PQRFASDLLQ CVQLTVQPRN VSVTMSQVPL VLQAWNVPDL SAGVNCSFED
610 620 630 640 650 660
FTETESILED GRIHCHSPSA REVAPITQGQ GDQRVVKLYL KSKETGKKFA SVDFVFYNCS
670 680 690 700 710 720
VHQSCLACVN GSFPCHWCKY RHVCTNNAAD CAFLEGRVNM SEDCPQILPS THIYVPVGVV
730 740 750 760 770 780
KPITLAARNL PQPQSGQRGY ECLFHIPGSP ARVTALRFNS SSLQCQNSSY SYEGNDVSDL
790 800 810 820 830 840
PVNLSVVWNG NFVIDNPQNI QAHLYKCPAL RQSCGLCLKA DPRFECGWCV AERRCSLRHH
850 860 870 880 890 900
CPADSPASWM HAHHGSSRCT DPKILKLSPE TGPRQGGTRL TITGENLGLR FEDVRLGVHV
910 920 930 940 950 960
GKVLCSPVES EYISAEQIVC EIGDASTLRA HDALVEVCVR DCSLHYRALS PKRFTFVTPT
970 980 990 1000 1010 1020
FYRVSPSRGP LSGGTWIGIE GSHLNAGSDV AVSIGGRPCS FSWRNSREIR CLTPPGHTPG
1030 1040 1050 1060 1070 1080
SAPIVININR AQLSNPEVKY NYTEDPTILR IDPEWSINSG GTLLTVTGTN LATVREPRIR
1090 1100 1110 1120 1130 1140
AKYGGIEREN SCMVYNDTTM VCRAPSIDNP KRSPPELGER PDEIGFIMDN VRTLLVLNSS
1150 1160 1170 1180 1190 1200
SFLYYPDPVL EPLSPTGLLE LKPSSPLILK GRNLLPPAPG NSRLNYTVLI GSTPCILTVS
1210 1220 1230 1240 1250 1260
ETQLLCEAPN LTGQHKVTVR AGGFEFSPGM LQVYSDSLLT LPAIVGIGGG GGLLLLVIVA
1270 1280 1290 1300 1310 1320
VLIAYKRKSR DADRTLKRLQ LQMDNLESRV ALECKEAFAE LQTDIHELTS DLDGAGIPFL
1330 1340 1350 1360 1370 1380
DYRTYAMRVL FPGIEDHPVL KEMEVQANVE KSLTLFGQLL TKKHFLLTFI RTLEAQRSFS
1390 1400 1410 1420 1430 1440
MRDRGNVASL IMTALQGEME YATGVLKQLL SDLIEKNLES KNHPKLLLRR TESVAEKMLT
1450 1460 1470 1480 1490 1500
NWFTFLLYKF LKECAGEPLF MLYCAIKQQM EKGPIDAITG EARYSLSEDK LIRQQIDYKT
1510 1520 1530 1540 1550 1560
LTLNCVNPEH ENAPEVPVKG LNCDTVTQVK EKLLDAVYKG VPYSQRPKAG DMDLEWRQGR
1570 1580 1590 1600 1610 1620
MARIILQDED VTTKIDNDWK RLNTLAHYQV TDGSSVALVP KQTSAYNISN SSTFTKSLSR
1630 1640 1650 1660 1670 1680
YESMLRTASS PDSLRSRTPM ITPDLESGTK LWHLVKNHDH LDQREGDRGS KMVSEIYLTR
1690 1700 1710 1720 1730 1740
LLATKGTLQK FVDDLFETIF STAHRGSALP LAIKYMFDFL DEQADKHQIH DSDVRHTWKS
1750 1760 1770 1780 1790 1800
NCLPLRFWVN VIKNPQFVFD IHKNSITDAC LSVVAQTFMD SCSTSEHKLG KDSPSNKLLY
1810 1820 1830 1840 1850 1860
AKDIPNYKSW VERYYADIAK MPAISDQDMS AYLAEQSRLH LSQFNSMSAL HEIYSYIAKY
1870 1880 1890
KDEILVALEK DEQARRQRLR SKLEQVVDTM ALSS