P70175

SS
Gene name
Dlg3 (Dlgh3)
Protein name
Disks large homolog 3
Names
Synapse-associated protein 102 , SAP-102 , SAP102
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:53310
EC number
Protein Class

Descriptions

Dlg1 is a member of the membrane-associated guanylate kinase (MAGUK) family of PDZ domain-containing proteins and regulates surface expression of NMDA receptors. PDZ domain adjacent to SH3 and SH3 domain interacts with GK domain for autoinhibition.

Autoinhibitory domains (AIDs)

382-469 (PDZ 3 domain) SS

Target domain

639-827 (GK domain)

Relief mechanism

Ligand binding

Assay

479-580 (SH3 domain) SS

Target domain

639-827 (GK domain)

Relief mechanism

Partner binding, Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P70175

Entry ID Method Resolution Chain Position Source
AF-P70175-F1 Predicted AlphaFoldDB

32 variants for P70175

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3409874361 4 H>Y No EVA
rs3554917850 35 V>G No EVA
rs3411288307 58 T>P No EVA
rs3411174749 61 S>* No EVA
rs3411500868 115 D>G No EVA
rs3389567918 160 G>D No EVA
rs3389579198 210 S>P No EVA
rs3389583821 231 V>A No EVA
rs3389570873 274 Y>* No EVA
rs3389549320 306 D>V No EVA
rs3389581959 342 P>L No EVA
rs3389581954 455 G>R No EVA
rs3411288297 483 Y>H No EVA
rs3389536034 495 I>F No EVA
rs3389570207 508 S>T No EVA
rs3389581977 518 E>* No EVA
rs3389573832 555 N>S No EVA
rs3408801138 559 D>E No EVA
rs3389579216 568 T>N No EVA
rs3389537362 591 A>P No EVA
rs3389564813 621 A>G No EVA
rs3389526851 670 D>V No EVA
rs3389570144 672 V>F No EVA
rs3389526823 700 V>I No EVA
rs3389526811 733 L>I No EVA
rs3409876074 778 K>N* No EVA
rs3389581944 790 Q>E No EVA
rs3389582003 799 F>L No EVA
rs3389537338 813 F>Y No EVA
rs3389549344 817 V>I No EVA
rs3389562464 830 K>I No EVA
rs3389562414 846 P>T No EVA

No associated diseases with P70175

10 regional properties for P70175

Type Name Position InterPro Accession
domain SH3 domain 519 - 589 IPR001452
domain PDZ domain 149 - 236 IPR001478-1
domain PDZ domain 242 - 331 IPR001478-2
domain PDZ domain 402 - 485 IPR001478-3
domain Guanylate kinase-like domain 659 - 834 IPR008144
domain Guanylate kinase/L-type calcium channel beta subunit 658 - 837 IPR008145
domain Disks large homolog 1-4, PDZ-associated domain 329 - 403 IPR019583
domain Disks large homologue 1, N-terminal PEST domain 49 - 148 IPR019590
conserved_site Guanylate kinase, conserved site 691 - 708 IPR020590
domain Disks Large homologue 3, SH3 domain 520 - 586 IPR035763

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

16 GO annotations of cellular component

Name Definition
AMPA glutamate receptor complex An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
bicellular tight junction An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
cell-cell junction A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendritic shaft Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
neuromuscular junction The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
postsynaptic density membrane The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
postsynaptic density, intracellular component A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

8 GO annotations of molecular function

Name Definition
ionotropic glutamate receptor binding Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
kinase binding Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
PDZ domain binding Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.
phosphatase binding Binding to a phosphatase.
protein domain specific binding Binding to a specific domain of a protein.
protein phosphatase binding Binding to a protein phosphatase.
structural constituent of postsynaptic density The action of a molecule that contributes to the structural integrity of a postsynaptic density.
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

8 GO annotations of biological process

Name Definition
cell-cell adhesion The attachment of one cell to another cell via adhesion molecules.
chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
embryo development The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
establishment of planar polarity Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.
establishment or maintenance of epithelial cell apical/basal polarity Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
receptor clustering The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
receptor localization to synapse Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
regulation of postsynaptic membrane neurotransmitter receptor levels Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane.

21 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P31007 dlg1 Disks large 1 tumor suppressor protein Drosophila melanogaster (Fruit fly) EV
Q9BXL7 CARD11 Caspase recruitment domain-containing protein 11 Homo sapiens (Human) EV
P78352 DLG4 Disks large homolog 4 Homo sapiens (Human) SS
Q12959 DLG1 Disks large homolog 1 Homo sapiens (Human) SS
Q15700 DLG2 Disks large homolog 2 Homo sapiens (Human) SS
Q92796 DLG3 Disks large homolog 3 Homo sapiens (Human) SS
Q8CIS0 Card11 Caspase recruitment domain-containing protein 11 Mus musculus (Mouse) SS
Q99KF0 Card14 Caspase recruitment domain-containing protein 14 Mus musculus (Mouse) PR
Q80TE7 Lrrc7 Leucine-rich repeat-containing protein 7 Mus musculus (Mouse) PR
Q811D0 Dlg1 Disks large homolog 1 Mus musculus (Mouse) SS
Q62108 Dlg4 Disks large homolog 4 Mus musculus (Mouse) SS
Q91XM9 Dlg2 Disks large homolog 2 Mus musculus (Mouse) SS
Q63622 Dlg2 Disks large homolog 2 Rattus norvegicus (Rat) EV
Q62696 Dlg1 Disks large homolog 1 Rattus norvegicus (Rat) SS
P31016 Dlg4 Disks large homolog 4 Rattus norvegicus (Rat) SS
Q62936 Dlg3 Disks large homolog 3 Rattus norvegicus (Rat) SS
G5ECY0 dlg-1 Disks large homolog 1 Caenorhabditis elegans SS
Q28C55 dlg1 Disks large homolog 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q6R005 dlg4 Disks large homolog 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5PYH5 dlg1l Discs large homolog 1-like protein Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5PYH7 dlg2 Disks large homolog 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MHKHQHCCKC PECYEVTRLA ALRRLEPPGY GDWQVPDPYG PSGGNGASSG YGGYSSQTLP
70 80 90 100 110 120
SQAGATPTPR TKAKLIPTGR DVGPVPPKPV PGKSTPKLNG SGPGWWPECT CTNRDWYEQA
130 140 150 160 170 180
SPAPLLVNPE ALEPSLSVNG SDGMFKYEEI VLERGNSGLG FSIAGGIDNP HVPDDPGIFI
190 200 210 220 230 240
TKIIPGGAAA MDGRLGVNDC VLRVNEVDVS EVVHSRAVEA LKEAGPVVRL VVRRRQPPPE
250 260 270 280 290 300
TIMEVNLLKG PKGLGFSIAG GIGNQHIPGD NSIYITKIIE GGAAQKDGRL QIGDRLLAVN
310 320 330 340 350 360
NTNLQDVRHE EAVASLKNTS DMVYLKVAKP GSIHLNDMYA PPDYASTFTA LADNHISHNS
370 380 390 400 410 420
SLGYLGAVES KVTYPAPPQV PPTRYSPIPR HMLAEEDFTR EPRKIILHKG STGLGFNIVG
430 440 450 460 470 480
GEDGEGIFVS FILAGGPADL SGELRRGDRI LSVNGVNLRN ATHEQAAAAL KRAGQSVTIV
490 500 510 520 530 540
AQYRPEEYSR FESKIHDLRE QMMNSSMSSG SGSLRTSEKR SLYVRALFDY DRTRDSCLPS
550 560 570 580 590 600
QGLSFSYGDI LHVINASDDE WWQARLVTPH GESEQIGVIP SKKRVEKKER ARLKTVKFHA
610 620 630 640 650 660
RTGMIESNRD FPGLSDDYYG AKNLKGVTSN TSDSESSSKG QEDAILSYEP VTRQEIHYAR
670 680 690 700 710 720
PVIILGPMKD RVNDDLISEF PHKFGSCVPH TTRPRRDNEV DGQDYHFVVS REQMEKDIQD
730 740 750 760 770 780
NKFIEAGQFN DNLYGTSIQS VRAVAERGKH CILDVSGNAI KRLQQAQLYP IAIFIKPKSI
790 800 810 820 830 840
EALMEMNRRQ TYEQANKIFD KAMKLEQEFG EYFTAIVQGD SLEEIYNKIK QIIEDQSGHY
IWVPSPEKL