P69908

PR
Gene name
gadA (gadS, b3517, JW3485)
Protein name
Glutamate decarboxylase alpha
Names
GAD-alpha
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b3517
EC number
4.1.1.15: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P69908

Entry ID Method Resolution Chain Position Source
1XEY X-ray 205 A A/B 1-466 PDB
AF-P69908-F1 Predicted AlphaFoldDB

No variants for P69908

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P69908

No associated diseases with P69908

5 regional properties for P69908

Type Name Position InterPro Accession
domain PDZ domain 115 - 196 IPR001478-1
domain PDZ domain 223 - 301 IPR001478-2
domain PDZ domain 329 - 412 IPR001478-3
domain PDZ domain 467 - 548 IPR001478-4
domain PDZ domain 6 492 - 532 IPR041489

Functions

Description
EC Number 4.1.1.15 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
glutamate decarboxylase activity Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

2 GO annotations of biological process

Name Definition
glutamate catabolic process The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid.
intracellular pH elevation Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q04792 GAD1 Glutamate decarboxylase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P69910 gadB Glutamate decarboxylase beta Escherichia coli (strain K12) EV
Q9LSH2 GAD5 Glutamate decarboxylase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZPS3 GAD4 Glutamate decarboxylase 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q42521 GAD1 Glutamate decarboxylase 1 Arabidopsis thaliana (Mouse-ear cress) SS
P54767 Glutamate decarboxylase Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MDQKLLTDFR SELLDSRFGA KAISTIAESK RFPLHEMRDD VAFQIINDEL YLDGNARQNL
70 80 90 100 110 120
ATFCQTWDDE NVHKLMDLSI NKNWIDKEEY PQSAAIDLRC VNMVADLWHA PAPKNGQAVG
130 140 150 160 170 180
TNTIGSSEAC MLGGMAMKWR WRKRMEAAGK PTDKPNLVCG PVQICWHKFA RYWDVELREI
190 200 210 220 230 240
PMRPGQLFMD PKRMIEACDE NTIGVVPTFG VTYTGNYEFP QPLHDALDKF QADTGIDIDM
250 260 270 280 290 300
HIDAASGGFL APFVAPDIVW DFRLPRVKSI SASGHKFGLA PLGCGWVIWR DEEALPQELV
310 320 330 340 350 360
FNVDYLGGQI GTFAINFSRP AGQVIAQYYE FLRLGREGYT KVQNASYQVA AYLADEIAKL
370 380 390 400 410 420
GPYEFICTGR PDEGIPAVCF KLKDGEDPGY TLYDLSERLR LRGWQVPAFT LGGEATDIVV
430 440 450 460
MRIMCRRGFE MDFAELLLED YKASLKYLSD HPKLQGIAQQ NSFKHT