P68510
PR
Gene name |
Ywhah |
Protein name |
14-3-3 protein eta |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:22629 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P68510
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5YQG | X-ray | 210 A | A/B/C/D | 1-246 | PDB |
| AF-P68510-F1 | Predicted | AlphaFoldDB |
14 variants for P68510
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388747399 | 30 | V>A | No | EVA | |
| rs3388752260 | 37 | L>V | No | EVA | |
| rs3388754958 | 51 | N>K | No | EVA | |
| rs3388757148 | 59 | S>Y | No | EVA | |
| rs3388754756 | 78 | K>N | No | EVA | |
| rs3388737998 | 79 | L>F | No | EVA | |
| rs3388752267 | 101 | L>S | No | EVA | |
| rs3412731901 | 106 | K>T | No | EVA | |
| rs3388761102 | 107 | F>I | No | EVA | |
| rs3388749803 | 115 | F>L | No | EVA | |
| rs3412998780 | 144 | N>H | No | EVA | |
| rs1133045456 | 219 | S>Y | No | EVA | |
| rs3388749705 | 225 | L>F | No | EVA | |
| rs3388738673 | 240 | E>D | No | EVA |
No associated diseases with P68510
3 regional properties for P68510
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | 14-3-3 protein, conserved site | 41 - 51 | IPR023409-1 |
| conserved_site | 14-3-3 protein, conserved site | 211 - 230 | IPR023409-2 |
| domain | 14-3-3 domain | 3 - 242 | IPR023410 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| intercalated disc | A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| identical protein binding | Binding to an identical protein or proteins. |
| nuclear glucocorticoid receptor binding | Binding to a nuclear glucocorticoid receptor. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| sodium channel regulator activity | Binds to and modulates the activity of a sodium channel. |
| transmembrane transporter binding | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| glucocorticoid catabolic process | The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. |
| glucocorticoid receptor signaling pathway | The series of molecular signals initiated by glucocorticoid binding to its receptor. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| membrane depolarization during action potential | The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| negative regulation of dendrite morphogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
| regulation of mitotic nuclear division | Any process that modulates the frequency, rate or extent of mitosis. |
| regulation of sodium ion transmembrane transporter activity | Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. |
| regulation of sodium ion transport | Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
37 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P61981 | YWHAG | 14-3-3 protein gamma | Homo sapiens (Human) | PR |
| P31946 | YWHAB | 14-3-3 protein beta/alpha | Homo sapiens (Human) | PR |
| P27348 | YWHAQ | 14-3-3 protein theta | Homo sapiens (Human) | PR |
| P63104 | YWHAZ | 14-3-3 protein zeta/delta | Homo sapiens (Human) | PR |
| Q04917 | YWHAH | 14-3-3 protein eta | Homo sapiens (Human) | PR |
| P49106 | GRF1 | 14-3-3-like protein GF14-6 | Zea mays (Maize) | PR |
| P63101 | Ywhaz | 14-3-3 protein zeta/delta | Mus musculus (Mouse) | PR |
| P93784 | HOX | 14-3-3-like protein 16R | Solanum tuberosum (Potato) | PR |
| Q41418 | 14-3-3-like protein | Solanum tuberosum (Potato) | PR | |
| P63102 | Ywhaz | 14-3-3 protein zeta/delta | Rattus norvegicus (Rat) | PR |
| Q6EUP4 | GF14E | 14-3-3-like protein GF14-E | Oryza sativa subsp japonica (Rice) | PR |
| Q06967 | GF14F | 14-3-3-like protein GF14-F | Oryza sativa subsp japonica (Rice) | PR |
| Q7XTE8 | GF14B | 14-3-3-like protein GF14-B | Oryza sativa subsp japonica (Rice) | PR |
| Q6ZKC0 | GF14C | 14-3-3-like protein GF14-C | Oryza sativa subsp japonica (Rice) | PR |
| Q84J55 | GF14A | 14-3-3-like protein GF14-A | Oryza sativa subsp japonica (Rice) | PR |
| Q2R2W2 | GF14D | 14-3-3-like protein GF14-D | Oryza sativa subsp japonica (Rice) | PR |
| Q2R1D5 | GF14H | Putative 14-3-3-like protein GF14-H | Oryza sativa subsp japonica (Rice) | PR |
| Q96450 | GF14A | 14-3-3-like protein A | Glycine max (Soybean) (Glycine hispida) | PR |
| Q96453 | GF14D | 14-3-3-like protein D | Glycine max (Soybean) (Glycine hispida) | PR |
| Q96452 | GF14C | 14-3-3-like protein C | Glycine max (Soybean) (Glycine hispida) | PR |
| Q9C5W6 | GRF12 | 14-3-3-like protein GF14 iota | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9S9Z8 | GRF11 | 14-3-3-like protein GF14 omicron | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P46077 | GRF4 | 14-3-3-like protein GF14 phi | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q01525 | GRF2 | 14-3-3-like protein GF14 omega | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96300 | GRF7 | 14-3-3-like protein GF14 nu | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P42645 | GRF5 | 14-3-3-like protein GF14 upsilon | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P42644 | GRF3 | 14-3-3-like protein GF14 psi | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96299 | GRF9 | 14-3-3-like protein GF14 mu | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P42652 | TFT4 | 14-3-3 protein 4 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P93212 | TFT7 | 14-3-3 protein 7 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P93209 | TFT3 | 14-3-3 protein 3 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P93207 | TFT10 | 14-3-3 protein 10 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P93211 | TFT6 | 14-3-3 protein 6 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P93206 | TFT1 | 14-3-3 protein 1 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P93208 | TFT2 | 14-3-3 protein 2 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P93213 | TFT8 | 14-3-3 protein 8 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P93214 | TFT9 | 14-3-3 protein 9 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGDREQLLQR | ARLAEQAERY | DDMASAMKAV | TELNEPLSNE | DRNLLSVAYK | NVVGARRSSW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RVISSIEQKT | MADGNEKKLE | KVKAYREKIE | KELETVCNDV | LALLDKFLIK | NCNDFQYESK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VFYLKMKGDY | YRYLAEVASG | EKKNSVVEAS | EAAYKEAFEI | SKEHMQPTHP | IRLGLALNFS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VFYYEIQNAP | EQACLLAKQA | FDDAIAELDT | LNEDSYKDST | LIMQLLRDNL | TLWTSDQQDE |
| EAGEGN |