P68433

PR
Gene name
H3c11
Protein name
Histone H3.1
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:97908
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

16 structures for P68433

Entry ID Method Resolution Chain Position Source
1GUW NMR - B 2-17 PDB
1U35 X-ray 300 A A/E 1-136 PDB
2V83 X-ray 240 A D/E 2-10 PDB
2W5Z X-ray 220 A C 2-9 PDB
2WP1 X-ray 210 A P/Q 15-24 PDB
2XL3 X-ray 270 A D/F 2-9 PDB
4EZH X-ray 252 A C/D 25-35 PDB
5B1L X-ray 235 A A/E 1-136 PDB
5B1M X-ray 234 A A/E 1-136 PDB
5IX1 X-ray 260 A P/Q 2-16 PDB
5IX2 X-ray 290 A P/Q 2-33 PDB
7OS4 X-ray 254 A E/F/G/H 14-32 PDB
7QPH X-ray 190 A E/F/G/H 23-32 PDB
7QRD X-ray 200 A L/M 11-26 PDB
7VFI EM 398 A C 53-61 PDB
AF-P68433-F1 Predicted AlphaFoldDB

10 variants for P68433

Variant ID(s) Position Change Description Diseaes Association Provenance
rs579441064 6 Q>H No EVA
rs3389266909 11 S>F No EVA
rs3389271672 23 T>S No EVA
rs3389271402 47 V>M No EVA
rs3389202186 74 E>G No EVA
rs3403871608 75 I>V No EVA
rs3389202173 104 L>M No EVA
rs3389246123 116 K>* No EVA
rs3389290174 129 R>H No EVA
rs3389273044 129 R>H No EVA

No associated diseases with P68433

1 regional properties for P68433

Type Name Position InterPro Accession
domain Histone H2A/H2B/H3 1 - 132 IPR007125

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
nuclear chromosome A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
structural constituent of chromatin The action of a molecule that contributes to the structural integrity of chromatin.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

37 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P68428 Histone H3.2 Triticum aestivum (Wheat) PR
Q5E9F8 H3-3B Histone H3.3 Bos taurus (Bovine) PR
P84227 Histone H3.2 Bos taurus (Bovine) PR
P68432 Histone H3.1 Bos taurus (Bovine) PR
P84247 H3-X Histone H3.3 Gallus gallus (Chicken) PR
P84229 H3-VIII Histone H3.2 Gallus gallus (Chicken) PR
P02299 His3 Histone H3 Drosophila melanogaster (Fruit fly) PR
Q71H73 Histone H3.3 Vitis vinifera (Grape) PR
P84243 H3-3B Histone H3.3 Homo sapiens (Human) PR
Q71DI3 H3C13 Histone H3.2 Homo sapiens (Human) PR
Q16695 H3-4 Histone H3.1t Homo sapiens (Human) PR
P68431 H3C12 Histone H3.1 Homo sapiens (Human) PR
P69246 H3C4 Histone H3.2 Zea mays (Maize) PR
P68433 H3c11 Histone H3.1 Mus musculus (Mouse) PR
P84228 H3c15 Histone H3.2 Mus musculus (Mouse) PR
P84244 H3-3b Histone H3.3 Mus musculus (Mouse) PR
P02301 H3-5 Histone H3.3C Mus musculus (Mouse) PR
Q71LE2 H3-3A Histone H3.3 Sus scrofa (Pig) PR
P84245 H3-3b Histone H3.3 Rattus norvegicus (Rat) PR
O35799 Hfe Hereditary hemochromatosis protein homolog Rattus norvegicus (Rat) PR
Q6LED0 Histone H3.1 Rattus norvegicus (Rat) PR
Q0JCT1 H3 Histone H3.3 Oryza sativa subsp japonica (Rice) PR
Q2RAD9 H3R-21 Histone H3.2 Oryza sativa subsp japonica (Rice) PR
Q27490 his-70 Histone H3.3-like type 1 Caenorhabditis elegans PR
Q10453 his-71 Histone H3.3 type 1 Caenorhabditis elegans PR
Q27532 his-74 Histone H3.3-like type 2 Caenorhabditis elegans PR
P08898 his-2 Histone H3 Caenorhabditis elegans PR
Q9FX60 At1g13370 Histone H3-like 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FXI7 MGH3 Histone H3-like 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FKQ3 At5g65350 Histone H3-like 5 Arabidopsis thaliana (Mouse-ear cress) PR
P59226 HTR2 Histone H3.1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LR02 At1g75600 Histone H3-like 3 Arabidopsis thaliana (Mouse-ear cress) PR
P59169 HTR4 Histone H3.3 Arabidopsis thaliana (Mouse-ear cress) PR
Q6P823 TGas113e22.1 Histone H3.3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q28D37 TGas081o10.1 Histone H3.2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6PI20 h3f3a Histone H3.3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q4QRF4 zgc:113984; Histone H3.2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR EIRRYQKSTE
70 80 90 100 110 120
LLIRKLPFQR LVREIAQDFK TDLRFQSSAV MALQEACEAY LVGLFEDTNL CAIHAKRVTI
130
MPKDIQLARR IRGERA