P63166
SS
Gene name |
Sumo1 (Smt3c, Smt3h3, Ubl1) |
Protein name |
Small ubiquitin-related modifier 1 |
Names |
SUMO-1 , SMT3 homolog 3 , Ubiquitin-homology domain protein PIC1 , Ubiquitin-like protein SMT3C , Smt3C |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:22218 |
EC number |
|
Protein Class |
|
Descriptions
The N-terminal region of SUMO1 functions as an autoinhibition domain by blocking its binding to the phosphorylated SIMs of PML and Daxx. This autoinhibition is relieved by zinc, which stabilizes the complex between SUMO1 and a phospho-mimetic form of the SIM of PML, suggesting a paralog specific function of SUMO1 in regulating SUMO1-SIM interactions required for PML-NB formation and function.
Autoinhibitory domains (AIDs)
Target domain |
20-97 (Ubiquitin-like domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for P63166
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P63166-F1 | Predicted | AlphaFoldDB |
4 variants for P63166
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388472769 | 7 | K>N | No | EVA | |
| rs3388474204 | 24 | L>F | No | EVA | |
| rs3539229073 | 79 | E>G | No | EVA | |
| rs584699717 | 99 | S>L | No | EVA |
No associated diseases with P63166
6 regional properties for P63166
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Coagulation factor 5/8 C-terminal domain | 30 - 185 | IPR000421 |
| domain | Protein kinase domain | 610 - 905 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 610 - 905 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class II, conserved site | 790 - 798 | IPR002011 |
| active_site | Tyrosine-protein kinase, active site | 762 - 774 | IPR008266 |
| domain | Tyrosine-protein kinase, catalytic domain | 610 - 905 | IPR020635 |
Functions
14 GO annotations of cellular component
| Name | Definition |
|---|---|
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| heterochromatin | A compact and highly condensed form of chromatin that is refractory to transcription. |
| nuclear body | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nuclear stress granule | A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| PML body | A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. |
| septin ring | A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form. |
| voltage-gated potassium channel complex | A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. |
| XY body | A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| potassium channel regulator activity | Binds to and modulates the activity of a potassium channel. |
| protein tag activity | A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation. |
| small protein activating enzyme binding | Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme. |
| transcription factor binding | Binding to a transcription factor, a protein required to initiate or regulate transcription. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
| ubiquitin-like protein ligase binding | Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase. |
| ubiquitin-specific protease binding | Binding to a ubiquitin-specific protease. |
18 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to cadmium ion | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. |
| cellular response to heat | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
| negative regulation of action potential | Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. |
| negative regulation of delayed rectifier potassium channel activity | Any process that stops, prevents or reduces the frequency, rate or extent of delayed rectifier potassium channel activity. |
| negative regulation of protein import into nucleus | Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus. |
| negative regulation of transcription by transcription factor localization | Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor. |
| PML body organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia). |
| positive regulation of ATPase-coupled calcium transmembrane transporter activity | Any process that activates or increases the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity. |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| positive regulation of protein-containing complex assembly | Any process that activates or increases the frequency, rate or extent of protein complex assembly. |
| protein localization to nuclear pore | A process in which a protein is transported to, or maintained in, a nuclear pore. |
| protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
| protein sumoylation | The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. |
| regulation of calcium ion transmembrane transport | Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport. |
| regulation of cardiac muscle cell contraction | Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of protein stability | Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. |
| roof of mouth development | The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. |
34 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12306 | SMT3 | Ubiquitin-like protein SMT3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| Q17QV3 | SUMO3 | Small ubiquitin-related modifier 3 | Bos taurus (Bovine) | SS |
| Q5E9D1 | SUMO1 | Small ubiquitin-related modifier 1 | Bos taurus (Bovine) | SS |
| Q5ZHQ1 | SUMO3 | Small ubiquitin-related modifier 3 | Gallus gallus (Chicken) | SS |
| Q5ZJM9 | SUMO2 | Small ubiquitin-related modifier 2 | Gallus gallus (Chicken) | SS |
| Q8QGH2 | SUMO1 | Small ubiquitin-related modifier 1 | Gallus gallus (Chicken) | SS |
| Q9VCP1 | CG4449 | Uncharacterized protein CG4449 | Drosophila melanogaster (Fruit fly) | PR |
| P61956 | SUMO2 | Small ubiquitin-related modifier 2 | Homo sapiens (Human) | SS |
| Q6EEV6 | SUMO4 | Small ubiquitin-related modifier 4 | Homo sapiens (Human) | SS |
| P63165 | SUMO1 | Small ubiquitin-related modifier 1 | Homo sapiens (Human) | EV |
| P55854 | SUMO3 | Small ubiquitin-related modifier 3 | Homo sapiens (Human) | SS |
| G2XKQ0 | SUMO1P1 | Small ubiquitin-related modifier 5 | Homo sapiens (Human) | SS |
| P61957 | Sumo2 | Small ubiquitin-related modifier 2 | Mus musculus (Mouse) | SS |
| Q9Z172 | Sumo3 | Small ubiquitin-related modifier 3 | Mus musculus (Mouse) | SS |
| P61958 | SUMO2 | Small ubiquitin-related modifier 2 | Sus scrofa (Pig) | SS |
| A7WLH8 | SUMO1 | Small ubiquitin-related modifier 1 | Sus scrofa (Pig) | SS |
| P61959 | Sumo2 | Small ubiquitin-related modifier 2 | Rattus norvegicus (Rat) | SS |
| Q5I0H3 | Sumo1 | Small ubiquitin-related modifier 1 | Rattus norvegicus (Rat) | SS |
| Q5XIF4 | Sumo3 | Small ubiquitin-related modifier 3 | Rattus norvegicus (Rat) | SS |
| P55857 | SUMO1 | Small ubiquitin-related modifier 1 | Oryza sativa subsp. japonica (Rice) | SS |
| P55853 | smo-1 | Small ubiquitin-related modifier | Caenorhabditis elegans | SS |
| B3H5R8 | SUMO8 | Putative small ubiquitin-related modifier 8 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P55852 | SUMO1 | Small ubiquitin-related modifier 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8VZI7 | SUMO5 | Small ubiquitin-related modifier 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FKC5 | SUMO4 | Putative small ubiquitin-related modifier 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FLP5 | SUMO3 | Small ubiquitin-related modifier 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8A8 | SUMO7 | Putative small ubiquitin-related modifier 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FLP6 | SUMO2 | Small ubiquitin-related modifier 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q28H04 | sumo2 | Small ubiquitin-related modifier 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q6DEP7 | sumo1 | Small ubiquitin-related modifier 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q6DI05 | sumo3 | Small ubiquitin-related modifier 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6DHL4 | sumo2 | Small ubiquitin-related modifier 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6NV25 | sumo3l | Small ubiquitin-related modifier 3-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7SZR5 | sumo1 | Small ubiquitin-related modifier 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDQEAKPST | EDLGDKKEGE | YIKLKVIGQD | SSEIHFKVKM | TTHLKKLKES | YCQRQGVPMN |
| 70 | 80 | 90 | 100 | ||
| SLRFLFEGQR | IADNHTPKEL | GMEEEDVIEV | YQEQTGGHST | V |