P63096

EV
Gene name
GNAI1
Protein name
Guanine nucleotide-binding protein G
Names
i subunit alpha-1 , Adenylate cyclase-inhibiting G alpha protein
Species
Homo sapiens (Human)
KEGG Pathway
hsa:2770
EC number
Protein Class
GTP-BINDING PROTEIN ALPHA SUBUNIT (PTHR10218)

Descriptions

Gαi1 is a G-protein alpha subunit that plays a crucial role in signal transduction pathway initiated by G-protein-coupled receptor (GPCR) activation. G proteins function as transducers downstream of GPCRs in numerous signaling cascades. The alpha subunit contains the guanine nucleotide binding site and alternates between an active (GTP-bound state) and an inactive (GDP-bound state). Activated GPCR induces conformational change in Gαi1, which allows for GDP-to-GTP exchange by binding to the GPCR-binding site within a Ras-like domain, leading to dissociation of the Gαi1 subunit and initiation of downstream signaling.

Autoinhibitory domains (AIDs)

62-177 (α-H domain) EV

Target domain

184-348 (Ras-like domain)

Relief mechanism

Ligand binding, Partner binding

Assay

Structural analysis, Deletion assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

296 structures for P63096

Entry ID Method Resolution Chain Position Source
1KJY X-ray 270 A A/C 30-354 PDB
1Y3A X-ray 250 A A/B/C/D 26-354 PDB
2G83 X-ray 280 A A/B 33-345 PDB
2GTP X-ray 255 A A/B 32-354 PDB
2IK8 X-ray 271 A A/C 31-354 PDB
2OM2 X-ray 220 A A/C 31-354 PDB
2XNS X-ray 341 A A/B 30-354 PDB
3ONW X-ray 238 A A/B 31-354 PDB
3QE0 X-ray 300 A A/B/C 33-354 PDB
3QI2 X-ray 280 A A/B 31-354 PDB
3UMR X-ray 224 A A 1-354 PDB
3UMS X-ray 260 A A 1-354 PDB
4G5Q X-ray 290 A A/B/C/D 25-354 PDB
5JS7 NMR - A 30-354 PDB
5JS8 NMR - A 30-354 PDB
5TDH X-ray 300 A A/H 1-354 PDB
6CMO EM 450 A A 1-354 PDB
6CRK X-ray 200 A A 2-354 PDB
6DDE EM 350 A A 1-354 PDB
6DDF EM 350 A A 1-354 PDB
6KPF EM 290 A A 1-354 PDB
6KPG EM 300 A A 2-354 PDB
6LFM EM 350 A A 2-354 PDB
6LFO EM 340 A A 2-354 PDB
6LML EM 390 A A 1-354 PDB
6N4B EM 300 A A 1-354 PDB
6OMM EM 317 A A 2-354 PDB
6OS9 EM 300 A A 1-354 PDB
6OSA EM 300 A A 1-354 PDB
6OT0 EM 390 A A 1-354 PDB
6PB0 EM 300 A A 61-184 PDB
6PB1 EM 280 A A 61-184 PDB
6PT0 EM 320 A A 1-354 PDB
6QNO EM 438 A A 1-354 PDB
6VU8 EM 414 A B 2-354 PDB
6XBJ EM 388 A A 1-354 PDB
6XBK EM 324 A A 1-354 PDB
6XBL EM 390 A A 1-354 PDB
6XBM EM 315 A A 1-354 PDB
7CMU EM 300 A A 1-354 PDB
7CMV EM 270 A A 1-354 PDB
7DB6 EM 330 A A 1-354 PDB
7DW9 EM 260 A PDB
7E2X EM 300 A A 1-354 PDB
7E2Y EM 300 A A 1-354 PDB
7E2Z EM 310 A A 1-354 PDB
7E32 EM 290 A A 1-354 PDB
7E33 EM 290 A A 1-354 PDB
7E9G EM 350 A A 1-354 PDB
7EB2 EM 350 A A 1-354 PDB
7EJX EM 240 A A 1-354 PDB
7EO2 EM 289 A B 1-354 PDB
7EO4 EM 286 A B 1-354 PDB
7EUO EM 290 A A 1-354 PDB
7EVY EM 298 A A 1-354 PDB
7EVZ EM 307 A A 1-354 PDB
7EW0 EM 342 A A 1-354 PDB
7EW1 EM 340 A D 1-354 PDB
7EW2 EM 310 A A 1-354 PDB
7EW3 EM 310 A A 1-354 PDB
7EW4 EM 320 A A 1-354 PDB
7EW7 EM 327 A A 1-354 PDB
7EXD EM 340 A A 1-354 PDB
7EZH EM 320 A A 1-354 PDB
7EZK EM 310 A PDB
7EZM EM 290 A A 2-30 PDB
7F1Q EM 290 A A 1-354 PDB
7F1R EM 300 A A 1-354 PDB
7F1S EM 280 A A 1-354 PDB
7F4D EM 300 A PDB
7F4F EM 290 A PDB
7F4H EM 270 A PDB
7F4I EM 310 A PDB
7JHJ EM 320 A A 2-354 PDB
7JVR EM 280 A A 1-354 PDB
7L0P EM 410 A A 1-354 PDB
7L0Q EM 430 A A 1-354 PDB
7L0R EM 420 A A 1-354 PDB
7L0S EM 450 A A 1-354 PDB
7MTS EM 320 A C 1-354 PDB
7NA7 EM 270 A A 1-354 PDB
7NA8 EM 270 A A 1-354 PDB
7O7F EM 315 A A 1-354 PDB
7P02 EM 287 A A 229-242 PDB
7RKM EM 350 A A 2-354 PDB
7RKN EM 360 A A 2-354 PDB
7RKX EM 310 A A 2-354 PDB
7RKY EM 380 A A 2-354 PDB
7S8M EM 254 A B 1-354 PDB
7S8O EM 258 A B 1-354 PDB
7SBF EM 290 A A 1-354 PDB
7SCG EM 300 A A 1-354 PDB
7SQO EM 317 A A 1-354 PDB
7T2G EM 250 A A 1-354 PDB
7T2H EM 320 A A 1-354 PDB
7T6B EM 319 A A 1-32 PDB
7T6S EM 300 A A 2-354 PDB
7T6T EM 320 A A 2-354 PDB
7T6U EM 290 A A 2-354 PDB
7T6V EM 310 A A 2-354 PDB
7TRK EM 280 A A 1-354 PDB
7TRP EM 240 A A 1-354 PDB
7TRQ EM 250 A A 1-354 PDB
7TRS EM 280 A A 1-354 PDB
7TUZ EM 312 A A 1-354 PDB
7U2K EM 330 A A 1-354 PDB
7U2L EM 320 A A 1-354 PDB
7V68 EM 340 A A 1-354 PDB
7V69 EM 340 A A 1-354 PDB
7V6A EM 360 A A 1-354 PDB
7V9L EM 260 A PDB
7VAB EM 320 A PDB
7VDH EM 290 A A 1-354 PDB
7VDL EM 322 A A 1-354 PDB
7VDM EM 298 A A 1-354 PDB
7VFX EM 280 A A 1-354 PDB
7VGX EM 320 A A 2-354 PDB
7VGY EM 310 A B 2-354 PDB
7VGZ EM 330 A C 2-354 PDB
7VH0 EM 346 A B 2-354 PDB
7VIE EM 286 A D 1-354 PDB
7VIF EM 283 A D 1-354 PDB
7VIG EM 289 A D 1-354 PDB
7VIH EM 298 A D 1-354 PDB
7VKT EM 290 A B 1-354 PDB
7VL8 EM 290 A A 1-354 PDB
7VL9 EM 260 A A 1-354 PDB
7VLA EM 270 A A 1-354 PDB
7VUG EM 320 A A 2-354 PDB
7VUY EM 284 A A 1-354 PDB
7VUZ EM 289 A A 1-354 PDB
7VV3 EM 297 A A 1-354 PDB
7VV5 EM 276 A A 1-354 PDB
7W0L EM 357 A A 1-354 PDB
7W0M EM 371 A A 1-354 PDB
7W0N EM 421 A A 1-354 PDB
7W0O EM 378 A A 1-354 PDB
7W0P EM 316 A A 1-354 PDB
7WF7 EM 340 A B 1-354 PDB
7WIC EM 280 A A 1-354 PDB
7WIG EM 270 A A 1-354 PDB
7WJ5 EM 372 A A 1-354 PDB
7WQ3 EM 270 A A 1-354 PDB
7WU4 EM 340 A A 181-354 PDB
7WU5 EM 300 A PDB
7WU9 EM 338 A A 2-354 PDB
7WUI EM 310 A PDB
7WUJ EM 330 A PDB
7WVU EM 330 A A 1-354 PDB
7WYB EM 297 A B 1-354 PDB
7WZ4 EM 300 A A 1-354 PDB
7X2V EM 309 A B 1-354 PDB
7X5H EM 310 A A 1-354 PDB
7X9A EM 320 A A 1-354 PDB
7X9B EM 340 A A 1-354 PDB
7X9C EM 300 A A 1-354 PDB
7X9Y EM 310 A A 1-354 PDB
7XA3 EM 290 A A 1-354 PDB
7XAT EM 285 A B 1-354 PDB
7XAU EM 297 A B 1-354 PDB
7XAV EM 287 A B 1-354 PDB
7XBW EM 280 A C 1-354 PDB
7XBX EM 340 A C 1-354 PDB
7XK2 EM 310 A A 1-354 PDB
7XK8 EM 330 A A 1-354 PDB
7XMR EM 310 A A 1-354 PDB
7XMS EM 290 A A 1-354 PDB
7XMT EM 280 A A 1-354 PDB
7XTA EM 320 A A 1-354 PDB
7XXH EM 290 A A 2-24 PDB
7Y12 EM 310 A A 1-354 PDB
7Y15 EM 290 A A 1-354 PDB
7Y1F EM 330 A A 1-354 PDB
7Y64 EM 290 A A 1-354 PDB
7Y65 EM 320 A A 1-354 PDB
7Y66 EM 290 A A 1-354 PDB
7Y67 EM 280 A A 1-354 PDB
7Y89 EM 302 A C 4-354 PDB
7YAC EM 324 A A 1-354 PDB
7YAE EM 337 A A 1-354 PDB
7YDJ EM 303 A PDB
7YDP EM 310 A PDB
7YKD EM 281 A C 4-354 PDB
7YON EM 295 A A 1-354 PDB
7YOO EM 311 A A 1-354 PDB
7YU3 EM 340 A A 1-354 PDB
7YU5 EM 330 A A 1-354 PDB
7YU6 EM 350 A A 1-354 PDB
7YU7 EM 380 A A 1-354 PDB
7YU8 EM 450 A A 1-354 PDB
8DZP EM 271 A B 1-354 PDB
8EF5 EM 330 A A/F 1-354 PDB
8EF6 EM 320 A A/F 1-354 PDB
8EFB EM 320 A A 1-354 PDB
8EFL EM 320 A A/F 1-354 PDB
8EFO EM 280 A A/F 1-354 PDB
8EFQ EM 330 A A 1-354 PDB
8F7Q EM 322 A A/F 1-354 PDB
8F7R EM 328 A A/F 1-354 PDB
8F7S EM 300 A A/F 1-354 PDB
8F7W EM 319 A A 1-354 PDB
8F7X EM 328 A A 1-354 PDB
8FEG EM 254 A C 1-354 PDB
8G05 EM 300 A A 1-354 PDB
8G59 EM 264 A A 1-329 PDB
8G94 EM 315 A B 1-354 PDB
8GCM EM 350 A A 1-354 PDB
8GCP EM 310 A A 1-354 PDB
8GDC EM 350 A A 1-354 PDB
8GHV EM 280 A A 1-354 PDB
8GUQ EM 308 A A 1-354 PDB
8GUR EM 284 A A 1-354 PDB
8GUS EM 297 A A 1-354 PDB
8GUT EM 298 A A 1-354 PDB
8H2G EM 301 A B 1-354 PDB
8H4I EM 306 A PDB
8HBD EM 299 A A 1-354 PDB
8HK2 EM 290 A B 2-354 PDB
8HK3 EM 320 A A 2-354 PDB
8HK5 EM 300 A C 2-354 PDB
8HN8 EM 300 A A 1-354 PDB
8HNK EM 301 A A 1-354 PDB
8HNL EM 298 A A 1-354 PDB
8HNM EM 294 A A 1-354 PDB
8HOC EM 300 A A 1-354 PDB
8HQE EM 297 A A 1-354 PDB
8HQM EM 295 A A 1-354 PDB
8HQN EM 300 A A 1-354 PDB
8HS3 EM 314 A A 1-354 PDB
8HSC EM 322 A A 1-354 PDB
8HVI EM 304 A B 1-354 PDB
8I7V EM 277 A B 1-354 PDB
8I7W EM 339 A B 1-354 PDB
8IA8 EM 286 A C 4-354 PDB
8IC0 EM 341 A B 1-354 PDB
8ID3 EM 310 A A 1-354 PDB
8ID4 EM 310 A A 1-354 PDB
8ID6 EM 280 A A 1-354 PDB
8ID8 EM 300 A A 1-354 PDB
8ID9 EM 300 A A 1-354 PDB
8IHB EM 285 A A 1-354 PDB
8IHF EM 297 A A 1-354 PDB
8IHH EM 306 A A 1-354 PDB
8IHI EM 311 A A 1-354 PDB
8IHJ EM 307 A A 1-354 PDB
8IJ3 EM 328 A C 4-354 PDB
8IJA EM 269 A C 4-354 PDB
8IJB EM 323 A C 4-354 PDB
8IJD EM 325 A C 4-354 PDB
8INR EM 273 A PDB
8IOC EM 286 A PDB
8IOD EM 259 A PDB
8IRS EM 300 A A 1-354 PDB
8IRT EM 270 A A 1-354 PDB
8IRV EM 310 A PDB
8IW4 EM 349 A PDB
8IW7 EM 297 A PDB
8IW9 EM 308 A PDB
8IY5 EM 280 A A 1-354 PDB
8J18 EM 289 A A 1-354 PDB
8J19 EM 323 A A 1-354 PDB
8J1A EM 324 A A 1-354 PDB
8J20 EM 320 A C 1-354 PDB
8J21 EM 330 A C 1-354 PDB
8J22 EM 320 A B 1-354 PDB
8J24 EM 260 A C 1-354 PDB
8J6J EM 280 A A 1-354 PDB
8J6P EM 255 A A 3-354 PDB
8J6Q EM 260 A A 3-354 PDB
8J6R EM 276 A A 3-354 PDB
8JD3 EM 330 A A 1-354 PDB
8JD5 EM 360 A A 1-354 PDB
8JGB EM 284 A A 1-354 PDB
8JGG EM 300 A A 1-354 PDB
8JHY EM 287 A D 1-354 PDB
8JII EM 317 A D 1-354 PDB
8JIL EM 350 A D 1-354 PDB
8JIM EM 298 A D 1-354 PDB
8JIP EM 285 A PDB
8JIR EM 257 A PDB
8JR9 EM 257 A PDB
8JSP EM 365 A A 4-354 PDB
8JZ7 EM 260 A D 1-354 PDB
8K2X EM 320 A A 1-354 PDB
8K4N EM 283 A A 1-354 PDB
8KFX EM 296 A A 1-354 PDB
8KFY EM 306 A A 1-354 PDB
8KFZ EM 330 A A 1-354 PDB
8SAI EM 327 A D 1-354 PDB
8SG1 EM 294 A A 4-354 PDB
8U1U EM 310 A B 1-354 PDB
8W8B EM 300 A A 1-354 PDB
8W8R EM 330 A A 1-349 PDB
8WRB EM 291 A A 1-354 PDB
8XBH EM 283 A A 1-354 PDB
AF-P63096-F1 Predicted AlphaFoldDB

290 variants for P63096

Variant ID(s) Position Change Description Diseaes Association Provenance
RCV002249061
VAR_087204
rs2116052322
 40 G>C Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities NEDHISB [ClinVar, UniProt] Yes ClinVar
Ensembl
dbSNP
UniProt
VAR_087205 40 G>R NEDHISB [UniProt] Yes UniProt
VAR_087206 45 G>D NEDHISB [UniProt] Yes UniProt
rs2115631937
RCV001823048
 45 G>V GNAI1-related disorder [ClinVar] Yes ClinVar
Ensembl
dbSNP
VAR_087207 48 T>I NEDHISB [UniProt] Yes UniProt
RCV002249684
RCV001095673
VAR_087208
rs1788434338
 48 T>K Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities Neurodevelopmental disorder NEDHISB [ClinVar, UniProt] Yes ClinVar
Ensembl
dbSNP
UniProt
rs1788434582
RCV001268270
VAR_087209
 52 Q>P NEDHISB; loss of GTP binding [UniProt] Yes ClinVar
Ensembl
dbSNP
UniProt
VAR_087210 75 S>del NEDHISB; uncertain significance [UniProt] Yes UniProt
RCV001780011
rs2115632680
 80 S>A Neurodevelopmental disorder [ClinVar] Yes ClinVar
Ensembl
dbSNP
VAR_087211 172 Q>del NEDHISB [UniProt] Yes UniProt
rs2115683966
RCV001824503
VAR_087212
 173 D>V NEDHISB [UniProt] Yes ClinVar
Ensembl
dbSNP
UniProt
VAR_087213 186 E>del NEDHISB; uncertain significance [UniProt] Yes UniProt
rs1788864590
VAR_087214
RCV002246432
RCV001569146
 224 C>Y Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities NEDHISB [ClinVar, UniProt] Yes ClinVar
TOPMed
dbSNP
UniProt
RCV002276505
rs1277446306
 269 N>K GNAI1 associated Neurodevelopmental disorder [ClinVar] Yes ClinVar
dbSNP
gnomAD
VAR_087215 270 K>N NEDHISB [UniProt] Yes UniProt
VAR_087216
rs2115712676
RCV002248391
 270 K>R Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities NEDHISB [ClinVar, UniProt] Yes ClinVar
Ensembl
dbSNP
UniProt
RCV002248392
VAR_087217
rs2115712712
 272 D>G Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities NEDHISB [ClinVar, UniProt] Yes ClinVar
Ensembl
dbSNP
UniProt
rs2115713066
RCV002273305
 290 Y>F Neurodevelopmental disorder [ClinVar] Yes ClinVar
Ensembl
dbSNP
VAR_087218 326 A>P NEDHISB [UniProt] Yes UniProt
VAR_087219
RCV002248390
rs2115727431
 332 V>E Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities NEDHISB; uncertain significance [ClinVar, UniProt] Yes ClinVar
Ensembl
dbSNP
UniProt
rs1224009797
RCV001758457
 5 L>P No ClinVar
TOPMed
dbSNP
gnomAD
rs1162724911 6 S>R No TOPMed
gnomAD
rs773988706 7 A>T No ExAC
TOPMed
gnomAD
rs1293940480 8 E>A No TOPMed
gnomAD
rs1293940480 8 E>V No TOPMed
gnomAD
rs760895601 9 D>E No ExAC
TOPMed
gnomAD
rs1397814226 9 D>N No gnomAD
COSM485597 10 K>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1340678679 11 A>E No gnomAD
rs1340678679 11 A>V No gnomAD
rs1433259734 13 V>L No TOPMed
gnomAD
rs776765120 15 R>W No ExAC
TOPMed
gnomAD
rs1787387719 17 K>E No TOPMed
COSM3640797 17 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs554748156 17 K>R No 1000Genomes
ExAC
TOPMed
gnomAD
rs1787387941 21 R>H No TOPMed
RCV001264620
rs1787388036
 23 L>missing No ClinVar
dbSNP
rs1787388145 25 E>Q No TOPMed
rs886804159 26 D>A No TOPMed
gnomAD
rs1180244878 27 G>S No gnomAD
rs1417639782 33 E>D No gnomAD
rs1583996658 33 E>K No Ensembl
rs372783127 39 L>= Variant assessed as Somatic; LOW impact. [NCI-TCGA] No NCI-TCGA
rs769148846 43 E>K No ExAC
gnomAD
COSM453437 44 S>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1788434172 46 K>* No Ensembl
TCGA novel 46 K>M Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs770175485 46 K>R No ExAC
gnomAD
rs1788434297 48 T>A No gnomAD
rs1788434297
RCV001526691
 48 T>P No ClinVar
dbSNP
gnomAD
TCGA novel 49 I>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1336698236 49 I>V No TOPMed
rs2115632430 55 I>S No Ensembl
rs1788436246 56 I>M No Ensembl
rs1788436294 57 H>R No TOPMed
rs1353589309 60 G>A No TOPMed
gnomAD
rs1353589309 60 G>D No TOPMed
gnomAD
rs779641348 62 S>L No ExAC
gnomAD
rs1788436533 64 E>K No TOPMed
rs1340040890 65 E>* No gnomAD
rs751050803 65 E>D No ExAC
gnomAD
TCGA novel 67 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs550911078 67 K>T No 1000Genomes
TCGA novel 70 K>E Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs367776716 71 A>G No ESP
ExAC
TOPMed
gnomAD
rs367776716 71 A>V No ESP
ExAC
TOPMed
gnomAD
rs1319027288 74 Y>C No TOPMed
gnomAD
rs773307363 77 T>A No ExAC
TOPMed
gnomAD
rs771149857 77 T>I No ExAC
gnomAD
rs771149857 77 T>N No ExAC
gnomAD
COSM3929192 78 I>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1487731728 81 I>V No gnomAD
rs200973929 82 I>T No 1000Genomes
ExAC
TOPMed
gnomAD
rs1193344371 82 I>V No gnomAD
rs1472132546 84 I>V No TOPMed
gnomAD
rs182034954 87 A>V No 1000Genomes
rs1788437748 88 M>L No gnomAD
rs566542184 88 M>T No 1000Genomes
ExAC
gnomAD
rs1788437748
RCV002254045
 88 M>V No ClinVar
dbSNP
gnomAD
rs1788437829 89 G>R No gnomAD
rs761858891 90 R>K No ExAC
TOPMed
gnomAD
rs1400805039
COSM1673232
 93 I>T large_intestine [Cosmic] No cosmic curated
gnomAD
rs955811912 93 I>V No TOPMed
gnomAD
rs765148271 94 D>A No ExAC
TOPMed
gnomAD
rs765148271 94 D>G No ExAC
TOPMed
gnomAD
TCGA novel 94 D>Y Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1283536547 96 G>D No TOPMed
gnomAD
rs1283536547 96 G>V No TOPMed
gnomAD
rs367989878 97 D>A No ESP
ExAC
TOPMed
gnomAD
rs766033442 99 A>D No ExAC
gnomAD
rs535549285 99 A>T No 1000Genomes
ExAC
gnomAD
rs752261322 100 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs754417098 100 R>W No ExAC
TOPMed
gnomAD
rs548773475 101 A>E No 1000Genomes
ExAC
TOPMed
gnomAD
rs548773475
COSM145453
 101 A>V Variant assessed as Somatic; MODERATE impact. oesophagus haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
1000Genomes
ExAC
NCI-TCGA
TOPMed
gnomAD
rs1788636733 102 D>G No Ensembl
COSM6178773 102 D>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1258014515 103 D>G No gnomAD
rs1788636780 103 D>N No Ensembl
rs1258014515 103 D>V No gnomAD
rs1481220831 104 A>T No gnomAD
TCGA novel 104 A>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs142908338 105 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ESP
NCI-TCGA
TOPMed
gnomAD
rs758691743
COSM269251
 105 R>H Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
rs1788637124 106 Q>P No TOPMed
TCGA novel 109 V>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 111 A>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs774459209 116 E>D No Ensembl
rs569973389 117 G>A No 1000Genomes
rs1476883165 119 M>K No gnomAD
rs747063794 119 M>V No ExAC
gnomAD
rs986358825 120 T>I No TOPMed
rs1170003605 121 A>T No gnomAD
COSM6178772 122 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1788637809 123 L>F No Ensembl
rs1788637860 123 L>P No Ensembl
rs2115668506 124 A>P No Ensembl
rs773134896 124 A>V No ExAC
gnomAD
rs1584045095 125 G>R No TOPMed
rs1788638071 126 V>I No TOPMed
rs770957575 127 I>M No ExAC
gnomAD
rs35545354 127 I>T No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1335604046 127 I>V No gnomAD
rs1788638378 128 K>R No Ensembl
rs1174216714 130 L>S No TOPMed
rs1584045143 131 W>* No Ensembl
rs1584045141 131 W>G No Ensembl
rs1397620498 132 K>E No gnomAD
rs942163781 132 K>R No TOPMed
rs1722838527 133 D>G No TOPMed
rs759363974 133 D>N No ExAC
gnomAD
rs771688081 135 G>S No ExAC
gnomAD
rs775142147 136 V>I No ExAC
gnomAD
rs760188122 137 Q>K No ExAC
gnomAD
rs763521326 138 A>S No ExAC
gnomAD
rs763521326 138 A>T No ExAC
gnomAD
rs1271356769 139 C>S No gnomAD
rs191814694 140 F>L No 1000Genomes
TOPMed
gnomAD
rs145021139 141 N>I No ESP
ExAC
TOPMed
gnomAD
rs145021139 141 N>S No ESP
ExAC
TOPMed
gnomAD
rs1788639490 142 R>I No Ensembl
rs758884255 144 R>Q No ExAC
gnomAD
TCGA novel 145 E>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1584045219 147 Q>H No Ensembl
rs751761285 151 S>C No ExAC
gnomAD
rs368834370 152 A>S No ESP
ExAC
TOPMed
gnomAD
rs1314128142 153 A>V No Ensembl
rs756206752 158 D>E No ExAC
gnomAD
rs2115683838 160 D>A No Ensembl
rs778777547 160 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs1788727649 161 R>K No TOPMed
gnomAD
rs1407827636 162 I>V No TOPMed
rs745806214 165 P>A No ExAC
TOPMed
gnomAD
rs745806214 165 P>T No ExAC
TOPMed
gnomAD
rs897276806 166 N>D No Ensembl
rs1788727810 167 Y>D No TOPMed
rs1387120752 169 P>L No TOPMed
gnomAD
COSM3923998
rs1204209552
 169 P>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
NCI-TCGA
gnomAD
rs1420173226 171 Q>E No TOPMed
rs1180471133 174 V>I No TOPMed
rs1408290484 177 T>I No gnomAD
rs1788728185 178 R>T No Ensembl
rs1562842351 181 T>I No Ensembl
rs1788728360 182 T>I No Ensembl
rs2115684055
RCV001765393
 183 G>missing No ClinVar
dbSNP
COSM4911810 184 I>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1173391823 185 V>I No gnomAD
rs1584048872 188 H>R No Ensembl
TCGA novel 190 T>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 190 T>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1243909467 194 L>R No TOPMed
gnomAD
COSM4848672 201 V>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1337409948 204 Q>E No gnomAD
rs1788863320 204 Q>R No Ensembl
COSM3431776 205 R>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs910988907
COSM196932
 208 R>Q Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
Ensembl
NCI-TCGA
COSM1092027 213 H>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1562844525 216 E>K No Ensembl
rs17852392 219 T>A No Ensembl
rs772844909 219 T>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
gnomAD
TCGA novel 220 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM196933
rs1211791957
 220 A>V Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
TOPMed
gnomAD
rs549996015 223 F>I No 1000Genomes
ExAC
gnomAD
rs774942165 225 V>A No ExAC
rs1025287036 225 V>I No TOPMed
rs1187632806 228 S>G No TOPMed
gnomAD
COSM3394899
rs1403981151
 231 D>N pancreas [Cosmic] No cosmic curated
gnomAD
rs922293765 234 L>V No TOPMed
rs764370373 235 A>V No ExAC
TOPMed
gnomAD
rs2115707096 238 E>D No Ensembl
rs753886455 240 M>T No ExAC
gnomAD
rs1788866072 240 M>V No gnomAD
rs1788895532
COSM1092029
 242 R>* endometrium [Cosmic] No cosmic curated
gnomAD
rs1788895532 242 R>G No gnomAD
rs911562127 247 M>K No TOPMed
rs1788895878 251 D>E No TOPMed
gnomAD
rs1788895823 251 D>G No TOPMed
gnomAD
rs1331183452 253 I>M No TOPMed
rs1788895971 254 C>Y No TOPMed
rs1466308269 256 N>D No TOPMed
gnomAD
rs1163446805 256 N>S No gnomAD
TCGA novel 257 K>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM4420716 257 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1346935768 259 F>V No gnomAD
rs12721453 261 D>N No Ensembl
rs775831477 262 T>K No ExAC
gnomAD
COSM4876466 264 I>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
TCGA novel 265 I>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 266 L>R Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs761843186 271 K>N No ExAC
gnomAD
RCV001816465
rs2115712706
 272 D>N No ClinVar
Ensembl
dbSNP
rs975250753 273 L>V No TOPMed
gnomAD
rs535650213 274 F>I No 1000Genomes
ExAC
gnomAD
rs923267671 276 E>* No TOPMed
gnomAD
rs954904149 276 E>G No TOPMed
gnomAD
rs2115712787
RCV001774462
 276 E>L No ClinVar
Ensembl
dbSNP
rs954904149 276 E>V No TOPMed
gnomAD
rs1244226395
RCV000598656
CA575882515
 278 I>missing No ClinGen
ClinVar
dbSNP
rs1180055744 278 I>T No gnomAD
rs751395120 278 I>V No ExAC
gnomAD
rs1363490208 279 K>E No gnomAD
rs1470617220 279 K>R No TOPMed
gnomAD
rs1788897709 280 K>N No TOPMed
gnomAD
rs1788897660 280 K>R No Ensembl
TCGA novel 282 P>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs908500528 282 P>L No TOPMed
rs908500528 282 P>R No TOPMed
TCGA novel 283 L>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs755993821
COSM1092030
 284 T>I Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
gnomAD
rs1788898088 285 I>M No Ensembl
rs777524714 285 I>V No ExAC
gnomAD
rs1788898155 286 C>Y No gnomAD
rs367981356 287 Y>C No ExAC
gnomAD
rs1454400629 287 Y>H No gnomAD
rs772836802 288 P>A No TOPMed
gnomAD
rs17852394 288 P>Q No Ensembl
rs772836802 288 P>S No TOPMed
gnomAD
rs772836802 288 P>T No TOPMed
gnomAD
TCGA novel 289 E>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1334841117 291 A>T No gnomAD
rs767511386 292 G>A No ExAC
TOPMed
gnomAD
rs767511386 292 G>E No ExAC
TOPMed
gnomAD
TCGA novel 293 S>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1788990033 295 T>I No TOPMed
TCGA novel 295 T>I Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1227100605 296 Y>C No TOPMed
gnomAD
rs753742190 296 Y>H No ExAC
gnomAD
rs1434894043 297 E>D No TOPMed
gnomAD
rs764841177 299 A>T No ExAC
gnomAD
COSM748032
rs1788990508
 302 Y>C lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] No NCI-TCGA Cosmic
cosmic curated
TOPMed
gnomAD
TCGA novel 304 Q>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 309 D>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM748031 310 L>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs372256817 311 N>D No ESP
TOPMed
gnomAD
rs1584059315 311 N>S No Ensembl
rs1788990833 314 K>T No Ensembl
rs1788990885
COSM1313313
 315 D>N Variant assessed as Somatic; MODERATE impact. urinary_tract [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
TOPMed
rs1369121503 319 I>T No gnomAD
TCGA novel 320 Y>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1396776828 320 Y>H No TOPMed
rs1788991352 321 T>A No TOPMed
gnomAD
rs1384388891 321 T>I No TOPMed
gnomAD
rs1788991452 322 H>Y No TOPMed
rs755277179 325 C>R No ExAC
gnomAD
COSM1092031 326 A>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1390724642 327 T>A No TOPMed
gnomAD
COSM748030 331 N>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs781525050 332 V>M No ExAC
gnomAD
rs772886652 333 Q>H No ExAC
TOPMed
gnomAD
rs552102809 335 V>G No 1000Genomes
rs770033700 336 F>L No ExAC
gnomAD
COSM4687382 336 F>L Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1294148085 338 A>V No gnomAD
rs773328998 339 V>L No ExAC
gnomAD
rs771135868 343 I>V No ExAC
gnomAD
rs1383142864 344 I>V No gnomAD
rs1788993053 346 N>D No Ensembl
rs1788993100 346 N>K No Ensembl
TCGA novel 346 N>K Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1189213040 348 L>V No Ensembl
rs1788994023 350 D>Y No Ensembl
COSM3833293 351 C>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM339898 352 G>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
TCGA novel 352 G>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 354 F>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 354 F>L Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
COSM1092032 354 F>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1351222111 354 F>S No gnomAD
rs1451026867 355 F>Q No gnomAD
rs760674936 355 F>Y No ExAC
gnomAD

1 associated diseases with P63096

[MIM: 619854]: Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities (NEDHISB)

An autosomal dominant disorder characterized by global developmental delay, impaired intellectual development, delayed or absent speech, hypotonia, behavioral abnormalities, and epilepsy that ranges from self-limiting to intractable. More variable features include non-specific dysmorphic facial features, distal skeletal anomalies, and brain imaging abnormalities. . Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID
  • An autosomal dominant disorder characterized by global developmental delay, impaired intellectual development, delayed or absent speech, hypotonia, behavioral abnormalities, and epilepsy that ranges from self-limiting to intractable. More variable features include non-specific dysmorphic facial features, distal skeletal anomalies, and brain imaging abnormalities. . Note=The disease is caused by variants affecting the gene represented in this entry.

15 regional properties for P63096

Type Name Position InterPro Accession
domain PB1 domain 15 - 98 IPR000270
domain Protein kinase domain 252 - 518 IPR000719
domain AGC-kinase, C-terminal 519 - 590 IPR000961
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 130 - 182 IPR002219
active_site Serine/threonine-protein kinase, active site 372 - 384 IPR008271
binding_site Protein kinase, ATP binding site 258 - 285 IPR017441
domain Protein kinase, C-terminal 540 - 580 IPR017892
domain Diacylglycerol/phorbol-ester binding 128 - 142 IPR020454-1
domain Diacylglycerol/phorbol-ester binding 144 - 153 IPR020454-2
domain Diacylglycerol/phorbol-ester binding 157 - 168 IPR020454-3
domain Diacylglycerol/phorbol-ester binding 169 - 181 IPR020454-4
domain Atypical Protein Kinase C zeta, catalytic domain 236 - 592 IPR034662
domain Protein kinase C, PB1 domain 16 - 98 IPR034877
domain Protein kinase C zeta type, conserved region 1 129 - 183 IPR047314
domain PB1-like domain 15 - 98 IPR053793

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Cytoplasm, cell cortex
  • Membrane ; Lipid-anchor
  • Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis
  • Detected at the cleavage furrow or the midbody (PubMed:17635935)
  • Localized at the plasma membrane throughout mitosis
  • Colocalizes with RIC8A and RGS14 at the plasma membrane
PANTHER Family PTHR10218 GTP-BINDING PROTEIN ALPHA SUBUNIT
PANTHER Subfamily PTHR10218:SF359 GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1
PANTHER Protein Class heterotrimeric G-protein
G-protein
PANTHER Pathway Category Nicotine pharmacodynamics pathway
GNAI
5HT1 type receptor mediated signaling pathway
G-protein
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Gialpha
Inflammation mediated by chemokine and cytokine signaling pathway
Galphai
Endogenous cannabinoid signaling
Galpha
Gonadotropin-releasing hormone receptor pathway
gnai/o
Dopamine receptor mediated signaling pathway
Gialpha
Gonadotropin-releasing hormone receptor pathway
gnai
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
G-Protein
Metabotropic glutamate receptor group III pathway
G-Protein
Opioid prodynorphin pathway
G-protein
GABA-B receptor II signaling
Gi/oalpha
PI3 kinase pathway
Galpha
Metabotropic glutamate receptor group II pathway
G-protein
Enkephalin release
G-Protein (i)
Opioid proenkephalin pathway
G-protein
Opioid proopiomelanocortin pathway
G-protein
Inflammation mediated by chemokine and cytokine signaling pathway
Galphai/q

10 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular exosome A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
heterotrimeric G-protein complex Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
midbody A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

8 GO annotations of molecular function

Name Definition
D2 dopamine receptor binding Binding to a D2 dopamine receptor.
G protein-coupled receptor binding Binding to a G protein-coupled receptor.
G protein-coupled serotonin receptor binding Binding to a metabotropic serotonin receptor.
G-protein beta/gamma-subunit complex binding Binding to a complex of G-protein beta/gamma subunits.
GDP binding Binding to GDP, guanosine 5'-diphosphate.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction
magnesium ion binding Binding to a magnesium (Mg) ion.

10 GO annotations of biological process

Name Definition
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP).
adenylate cyclase-modulating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP).
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cellular response to forskolin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
positive regulation of protein localization to cell cortex Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex.
regulation of cAMP-mediated signaling Any process which modulates the frequency, rate or extent of cAMP-mediated signaling.
regulation of mitotic spindle organization Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
response to peptide hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.

62 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P0C7Q4 GNAT3 Guanine nucleotide-binding protein G Bos taurus (Bovine) SS
P04696 GNAT2 Guanine nucleotide-binding protein G Bos taurus (Bovine) SS
P04695 GNAT1 Guanine nucleotide-binding protein G Bos taurus (Bovine) SS
P08239 GNAO1 Guanine nucleotide-binding protein G Bos taurus (Bovine) SS
P63097 GNAI1 Guanine nucleotide-binding protein G Bos taurus (Bovine) SS
P50147 GNAI2 Guanine nucleotide-binding protein G Gallus gallus (Chicken) SS
P50146 GNAI1 Guanine nucleotide-binding protein G Gallus gallus (Chicken) SS
P16378 Galphao G protein alpha o subunit Drosophila melanogaster (Fruit fly) SS
P25157 cta Guanine nucleotide-binding protein subunit alpha homolog Drosophila melanogaster (Fruit fly) SS
P20353 Galphai G protein alpha i subunit Drosophila melanogaster (Fruit fly) SS
Q14344 GNA13 Guanine nucleotide-binding protein subunit alpha-13 Homo sapiens (Human) SS
Q03113 GNA12 Guanine nucleotide-binding protein subunit alpha-12 Homo sapiens (Human) SS
P29992 GNA11 Guanine nucleotide-binding protein subunit alpha-11 Homo sapiens (Human) SS
P30679 GNA15 Guanine nucleotide-binding protein subunit alpha-15 Homo sapiens (Human) SS
O95837 GNA14 Guanine nucleotide-binding protein subunit alpha-14 Homo sapiens (Human) SS
P50148 GNAQ Guanine nucleotide-binding protein G Homo sapiens (Human) SS
P38405 GNAL Guanine nucleotide-binding protein G Homo sapiens (Human) SS
A8MTJ3 GNAT3 Guanine nucleotide-binding protein G Homo sapiens (Human) SS
P19087 GNAT2 Guanine nucleotide-binding protein G Homo sapiens (Human) SS
P11488 GNAT1 Guanine nucleotide-binding protein G Homo sapiens (Human) SS
P04899 GNAI2 Guanine nucleotide-binding protein G Homo sapiens (Human) SS
P08754 GNAI3 Guanine nucleotide-binding protein G Homo sapiens (Human) SS
P19086 GNAZ Guanine nucleotide-binding protein G Homo sapiens (Human) SS
P09471 GNAO1 Guanine nucleotide-binding protein G Homo sapiens (Human) SS
Q9DC51 Gnai3 Guanine nucleotide-binding protein G Mus musculus (Mouse) SS
P27600 Gna12 Guanine nucleotide-binding protein subunit alpha-12 Mus musculus (Mouse) SS
P20612 Gnat1 Guanine nucleotide-binding protein G Mus musculus (Mouse) SS
P27601 Gna13 Guanine nucleotide-binding protein subunit alpha-13 Mus musculus (Mouse) SS
Q3V3I2 Gnat3 Guanine nucleotide-binding protein G Mus musculus (Mouse) SS
O70443 Gnaz Guanine nucleotide-binding protein G Mus musculus (Mouse) SS
P50149 Gnat2 Guanine nucleotide-binding protein G Mus musculus (Mouse) SS
P08752 Gnai2 Guanine nucleotide-binding protein G Mus musculus (Mouse) SS
P18872 Gnao1 Guanine nucleotide-binding protein G Mus musculus (Mouse) SS
B2RSH2 Gnai1 Guanine nucleotide-binding protein G Mus musculus (Mouse) SS
P93564 GPA1 Guanine nucleotide-binding protein alpha-1 subunit Solanum tuberosum (Potato) SS
Q63210 Gna12 Guanine nucleotide-binding protein subunit alpha-12 Rattus norvegicus (Rat) SS
P19627 Gnaz Guanine nucleotide-binding protein G Rattus norvegicus (Rat) SS
P29348 Gnat3 Guanine nucleotide-binding protein G Rattus norvegicus (Rat) SS
P04897 Gnai2 Guanine nucleotide-binding protein G Rattus norvegicus (Rat) SS
P59215 Gnao1 Guanine nucleotide-binding protein G Rattus norvegicus (Rat) SS
P08753 Gnai3 Guanine nucleotide-binding protein G Rattus norvegicus (Rat) SS
Q6Q7Y5 Gna13 Guanine nucleotide-binding protein subunit alpha-13 Rattus norvegicus (Rat) SS
P10824 Gnai1 Guanine nucleotide-binding protein G subunit alpha-1 Rattus norvegicus (Rat) EV
Q0DJ33 GPA1 Guanine nucleotide-binding protein alpha-1 subunit Oryza sativa subsp. japonica (Rice) SS
O76584 gpa-11 Guanine nucleotide-binding protein alpha-11 subunit Caenorhabditis elegans SS
P51875 goa-1 Guanine nucleotide-binding protein G Caenorhabditis elegans SS
Q18434 odr-3 Guanine nucleotide-binding protein alpha-17 subunit Caenorhabditis elegans SS
Q9BIG4 gpa-10 Guanine nucleotide-binding protein alpha-10 subunit Caenorhabditis elegans PR
P28052 gpa-3 Guanine nucleotide-binding protein alpha-3 subunit Caenorhabditis elegans SS
Q9XTB2 gpa-13 Guanine nucleotide-binding protein alpha-13 subunit Caenorhabditis elegans SS
Q93743 gpa-6 Guanine nucleotide-binding protein alpha-6 subunit Caenorhabditis elegans SS
Q20907 gpa-8 Guanine nucleotide-binding protein alpha-8 subunit Caenorhabditis elegans PR
P91907 gpa-15 Guanine nucleotide-binding protein alpha-15 subunit Caenorhabditis elegans SS
Q21917 gpa-7 Guanine nucleotide-binding protein alpha-7 subunit Caenorhabditis elegans SS
P28051 gpa-1 Guanine nucleotide-binding protein alpha-1 subunit Caenorhabditis elegans SS
Q9BIG5 gpa-4 Guanine nucleotide-binding protein alpha-4 subunit Caenorhabditis elegans SS
Q9N2V6 gpa-16 Guanine nucleotide-binding protein alpha-16 subunit Caenorhabditis elegans SS
P93163 GPA2 Guanine nucleotide-binding protein alpha-2 subunit Glycine max (Soybean) (Glycine hispida) SS
P49084 GPA1 Guanine nucleotide-binding protein alpha-1 subunit Glycine max (Soybean) (Glycine hispida) SS
O80462 XLG1 Extra-large guanine nucleotide-binding protein 1 Arabidopsis thaliana (Mouse-ear cress) PR
P18064 GPA1 Guanine nucleotide-binding protein alpha-1 subunit Arabidopsis thaliana (Mouse-ear cress) SS
P26981 GPA1 Guanine nucleotide-binding protein alpha-1 subunit Solanum lycopersicum (Tomato) (Lycopersicon esculentum) SS
10 20 30 40 50 60
MGCTLSAEDK AAVERSKMID RNLREDGEKA AREVKLLLLG AGESGKSTIV KQMKIIHEAG
70 80 90 100 110 120
YSEEECKQYK AVVYSNTIQS IIAIIRAMGR LKIDFGDSAR ADDARQLFVL AGAAEEGFMT
130 140 150 160 170 180
AELAGVIKRL WKDSGVQACF NRSREYQLND SAAYYLNDLD RIAQPNYIPT QQDVLRTRVK
190 200 210 220 230 240
TTGIVETHFT FKDLHFKMFD VGGQRSERKK WIHCFEGVTA IIFCVALSDY DLVLAEDEEM
250 260 270 280 290 300
NRMHESMKLF DSICNNKWFT DTSIILFLNK KDLFEEKIKK SPLTICYPEY AGSNTYEEAA
310 320 330 340 350
AYIQCQFEDL NKRKDTKEIY THFTCATDTK NVQFVFDAVT DVIIKNNLKD CGLF