P62491

PR
Gene name
RAB11A
Protein name
Ras-related protein Rab-11A
Names
Rab-11, YL8
Species
Homo sapiens (Human)
KEGG Pathway
hsa:8766
EC number
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

146-216 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

29 structures for P62491

Entry ID Method Resolution Chain Position Source
1OIV X-ray 198 A A/B 1-173 PDB
1OIW X-ray 205 A A 1-173 PDB
1OIX X-ray 170 A A 1-173 PDB
1YZK X-ray 200 A A 8-175 PDB
2D7C X-ray 175 A A/B 7-173 PDB
2GZD X-ray 244 A A/B 2-173 PDB
2GZH X-ray 247 A A 2-173 PDB
2HV8 X-ray 186 A A/B/C 6-175 PDB
4C4P X-ray 200 A A 1-173 PDB
4D0L X-ray 294 A B/D/F 1-216 PDB
4D0M X-ray 600 A B/D/H/J/N/P/R/T/X/Z/d/h 1-216 PDB
4LWZ X-ray 255 A A/C 1-177 PDB
4LX0 X-ray 219 A A/C 1-177 PDB
4UJ3 X-ray 300 A A/D/G/J/M/P/S/V 4-186 PDB
4UJ4 X-ray 420 A A/D/G/J 4-186 PDB
4UJ5 X-ray 260 A A/B 6-186 PDB
5C46 X-ray 265 A F 1-216 PDB
5C4G X-ray 320 A B 1-216 PDB
5EUQ X-ray 320 A B 1-216 PDB
5EZ5 X-ray 240 A A/B 8-175 PDB
5FBL X-ray 337 A B 1-216 PDB
5FBQ X-ray 379 A B 1-216 PDB
5FBR X-ray 328 A B 1-216 PDB
5FBV X-ray 329 A B 1-216 PDB
5FBW X-ray 349 A B 1-216 PDB
5JCZ X-ray 206 A A/D/I 1-177 PDB
6DJL X-ray 310 A A/F/G/H 1-216 PDB
6IXV X-ray 380 A E/F/G/H 1-173 PDB
AF-P62491-F1 Predicted AlphaFoldDB

66 variants for P62491

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1263754517
CA392918973
 5 D>G No ClinGen
gnomAD
rs1224127056
CA392918957
 5 D>N Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
rs892660603
CA271610661
 8 Y>C Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
CA392919058
rs1240528470
 9 D>Y No ClinGen
gnomAD
TCGA novel 24 K>Q Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA271613491
rs201712940
 28 L>P No ClinGen
1000Genomes
TCGA novel 29 S>Y Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA392919871
rs1449908676
 30 R>Q No ClinGen
TOPMed
gnomAD
CA392919924
rs763409430
 33 R>* No ClinGen
ExAC
TOPMed
gnomAD
rs374592220
CA271613540
 34 N>K No ClinGen
ESP
TOPMed
CA392920365
rs1177010794
 51 R>T No ClinGen
TOPMed
CA392920551
rs1324821460
 60 I>V No ClinGen
TOPMed
gnomAD
TCGA novel 62 A>E Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 82 R>C Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 82 R>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA392921071
rs1478967473
 83 G>A No ClinGen
gnomAD
rs190571382
CA7621572
 91 Y>F No ClinGen
1000Genomes
ExAC
gnomAD
rs1324263835
CA392921437
 100 E>G No ClinGen
gnomAD
CA392921583
rs1240762441
 107 K>T No ClinGen
TOPMed
TCGA novel 108 E>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1434404164
CA392921661
 111 D>N No ClinGen
gnomAD
rs772613563
CA7621579
 112 H>L No ClinGen
ExAC
gnomAD
rs1567137438
CA392921709
 113 A>G No ClinGen
Ensembl
rs1190052210
CA392921819
 117 I>V No ClinGen
TOPMed
TCGA novel 123 G>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 124 N>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA392922104
rs1567137460
 137 D>H No ClinGen
Ensembl
rs776183548
CA7621582
 138 E>K No ClinGen
ExAC
gnomAD
TCGA novel 140 R>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA271613775
rs766250277
 142 F>L No ClinGen
Ensembl
CA392923212
rs1412602889
 150 F>S No ClinGen
gnomAD
rs1292123777
CA392923220
 151 I>V No ClinGen
gnomAD
rs1249496263
CA618663330
 157 D>C No ClinGen
gnomAD
CA392923297
rs1338701122
 157 D>V No ClinGen
gnomAD
rs375521278
CA7621611
 159 T>K No ClinGen
ESP
ExAC
gnomAD
CA7621613
rs201908439
 163 A>G No ClinGen
ExAC
TOPMed
gnomAD
rs1241849519
CA392923373
 163 A>T No ClinGen
TOPMed
CA392923469
rs1478817063
 170 T>A No ClinGen
TOPMed
gnomAD
TCGA novel 171 E>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA392924861
rs1429663909
 172 I>M No ClinGen
TOPMed
rs1457090212
CA392924882
 174 R>C No ClinGen
gnomAD
CA7621632
COSM1374151
rs759435629
 174 R>H Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
CA392924894
rs1476977752
 175 I>V No ClinGen
TOPMed
CA7621635
rs760325951
 181 M>I No ClinGen
ExAC
gnomAD
rs752698600
CA7621634
 181 M>V No ClinGen
ExAC
gnomAD
CA271618250
rs1054774828
 184 R>G No ClinGen
TOPMed
rs764020784
CA7621636
 185 R>C No ClinGen
ExAC
TOPMed
gnomAD
rs764020784
CA392925022
 185 R>G No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 187 N>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA392925101
rs1237234616
 190 S>P No ClinGen
gnomAD
CA7621639
rs778537719
 192 S>N No ClinGen
ExAC
TOPMed
gnomAD
rs375723446
CA392925165
 194 N>I No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA7621640
rs375723446
 194 N>S No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1251632357
CA392925204
 197 P>L No ClinGen
gnomAD
CA7621643
rs748693318
 199 H>R No ClinGen
ExAC
gnomAD
CA271618270
rs1015728032
 200 V>I No ClinGen
TOPMed
CA392925274
rs1376052565
 202 P>S No ClinGen
TOPMed
CA392925307
rs1280621310
 204 T>A No ClinGen
TOPMed
CA271618273
rs11556461
 205 E>K No ClinGen
Ensembl
rs770049340
CA7621644
 206 N>S No ClinGen
ExAC
gnomAD
CA271618281
rs4920
 207 K>N No ClinGen
Ensembl
rs778257251
CA392925437
 210 V>A No ClinGen
ExAC
gnomAD
rs778257251
CA7621645
 210 V>G No ClinGen
ExAC
gnomAD
rs1442206199
CA392925426
 210 V>M No ClinGen
TOPMed
rs749489126
CA7621646
 215 N>I No ClinGen
ExAC
gnomAD
rs749489126
CA271618292
 215 N>S No ClinGen
ExAC
gnomAD

No associated diseases with P62491

1 regional properties for P62491

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 10 - 168 IPR005225

Functions

Description
EC Number 3.6.5.2 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
  • Cell membrane ; Lipid-anchor
  • Endosome membrane
  • Recycling endosome membrane ; Lipid-anchor
  • Cleavage furrow
  • Cytoplasmic vesicle, phagosome
  • Cytoplasmic vesicle membrane
  • Golgi apparatus
  • Golgi apparatus, trans-Golgi network
  • Localized to WDR44-positive endosomes and tubules (PubMed:32344433)
  • Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:11994279)
  • During interphase, localized in vesicles continuously moving from peripheral sorting endosomes towards the pericentrosomal ERC (PubMed:20026645)
  • Localizes to the cleavage furrow (PubMed:15601896)
  • Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297)
  • Recruited to phagosomes containing S
  • aureus or M
  • tuberculosis (PubMed:21255211)
  • Localized to rhodopsin transport carriers when interacting with RAB11AFIP3 and ASAP1 in photoreceptors (PubMed:25673879)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

23 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
centriolar satellite A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome.
centriole A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cleavage furrow The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endosome A vacuole to which materials ingested by endocytosis are delivered.
extracellular exosome A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
multivesicular body A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
postsynaptic recycling endosome A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signalling and so can play a role in long term potentiation.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
recycling endosome membrane The lipid bilayer surrounding a recycling endosome.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
trans-Golgi network The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
transport vesicle Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
vesicle Any small, fluid-filled, spherical organelle enclosed by membrane.

6 GO annotations of molecular function

Name Definition
G protein activity A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
myosin V binding Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport.
syntaxin binding Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.

22 GO annotations of biological process

Name Definition
amyloid-beta clearance by transcytosis The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by transcytosis across the blood-brain barrier.
astral microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles.
establishment of protein localization to membrane The directed movement of a protein to a specific location in a membrane.
establishment of protein localization to organelle The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.
establishment of vesicle localization The directed movement of a vesicle to a specific location.
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
exosomal secretion The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.
melanosome transport The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
mitotic metaphase plate congression The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.
mitotic spindle assembly Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied.
multivesicular body assembly The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
neuron projection development The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
neurotransmitter receptor transport, endosome to postsynaptic membrane The directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.
plasma membrane to endosome transport Transport of a vesicle from the plasma membrane to the endosome.
positive regulation of epithelial cell migration Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
positive regulation of G2/M transition of mitotic cell cycle Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
protein localization to cell surface A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.
protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
regulation of cytokinesis Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
regulation of multivesicular body size Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles.
regulation of vesicle-mediated transport Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3MHP2 RAB11B Ras-related protein Rab-11B Bos taurus (Bovine) PR
Q2TA29 RAB11A Ras-related protein Rab-11A Bos taurus (Bovine) PR
Q5ZJN2 RAB11A Ras-related protein Rab-11A Gallus gallus (Chicken) PR
P62490 RAB11A Ras-related protein Rab-11A Canis lupus familiaris (Dog) (Canis familiaris) PR
Q8WUD1 RAB2B Ras-related protein Rab-2B Homo sapiens (Human) PR
P61019 RAB2A Ras-related protein Rab-2A Homo sapiens (Human) PR
P20338 RAB4A Ras-related protein Rab-4A Homo sapiens (Human) PR
P61018 RAB4B Ras-related protein Rab-4B Homo sapiens (Human) PR
Q15907 RAB11B Ras-related protein Rab-11B Homo sapiens (Human) PR
P46638 Rab11b Ras-related protein Rab-11B Mus musculus (Mouse) PR
P62492 Rab11a Ras-related protein Rab-11A Mus musculus (Mouse) PR
Q52NJ1 RAB11A Ras-related protein Rab-11A Sus scrofa (Pig) PR
O35509 Rab11b Ras-related protein Rab-11B Rattus norvegicus (Rat) PR
P62494 Rab11a Ras-related protein Rab-11A Rattus norvegicus (Rat) PR
O04486 RABA2A Ras-related protein RABA2a Arabidopsis thaliana (Mouse-ear cress) PR
Q9FE79 RABA4C Ras-related protein RABA4c Arabidopsis thaliana (Mouse-ear cress) PR
Q9LH50 RABA4D Ras-related protein RABA4d Arabidopsis thaliana (Mouse-ear cress) PR
Q9LNK1 RABA3 Ras-related protein RABA3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LNW1 RABA2B Ras-related protein RABA2b Arabidopsis thaliana (Mouse-ear cress) PR
O49513 RABA1E Ras-related protein RABA1e Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT RSIQVDGKTI
70 80 90 100 110 120
KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE NVERWLKELR DHADSNIVIM
130 140 150 160 170 180
LVGNKSDLRH LRAVPTDEAR AFAEKNGLSF IETSALDSTN VEAAFQTILT EIYRIVSQKQ
190 200 210
MSDRRENDMS PSNNVVPIHV PPTTENKPKV QCCQNI