P61957
SS
Gene name |
Sumo2 (Smt3b, Smt3h2) |
Protein name |
Small ubiquitin-related modifier 2 |
Names |
SUMO-2 , SMT3 homolog 2 , Ubiquitin-like protein SMT3B , Smt3B |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:170930 |
EC number |
|
Protein Class |
|
Descriptions
The N-terminal region of SUMO1 functions as an autoinhibition domain by blocking its binding to the phosphorylated SIMs of PML and Daxx. This autoinhibition is relieved by zinc, which stabilizes the complex between SUMO1 and a phospho-mimetic form of the SIM of PML, suggesting a paralog specific function of SUMO1 in regulating SUMO1-SIM interactions required for PML-NB formation and function.
Autoinhibitory domains (AIDs)
Target domain |
16-93 (Ubiquitin-like domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
3 structures for P61957
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5TVP | X-ray | 240 A | Q | 10-88 | PDB |
| 5TVQ | X-ray | 235 A | B | 10-93 | PDB |
| AF-P61957-F1 | Predicted | AlphaFoldDB |
2 variants for P61957
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3402144201 | 5 | K>R | No | EVA | |
| rs3389219427 | 93 | G>S | No | EVA |
No associated diseases with P61957
13 regional properties for P61957
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Leucine-rich repeat N-terminal domain | 31 - 63 | IPR000372 |
| domain | Cysteine-rich flanking region, C-terminal | 160 - 208 | IPR000483 |
| domain | Protein kinase domain | 538 - 814 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 539 - 809 | IPR001245 |
| repeat | Leucine-rich repeat | 104 - 160 | IPR001611 |
| conserved_site | Tyrosine-protein kinase, receptor class II, conserved site | 703 - 711 | IPR002011 |
| domain | Immunoglobulin subtype | 216 - 302 | IPR003599 |
| domain | Immunoglobulin-like domain | 210 - 300 | IPR007110 |
| active_site | Tyrosine-protein kinase, active site | 675 - 687 | IPR008266 |
| domain | Immunoglobulin-like beta-sandwich domain | 218 - 296 | IPR013151 |
| binding_site | Protein kinase, ATP binding site | 544 - 572 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 538 - 810 | IPR020635 |
| domain | Growth factor receptor NTRK, leucine rich repeat C-terminal | 163 - 208 | IPR031635 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| PML body | A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| nuclear retinoid X receptor binding | Binding to a nuclear retinoid X receptor. |
| protein tag activity | A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation. |
| SUMO transferase activity | Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
| ubiquitin-like protein ligase binding | Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of protein sumoylation | Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
| protein sumoylation | The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. |
32 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9D1 | SUMO1 | Small ubiquitin-related modifier 1 | Bos taurus (Bovine) | SS |
| Q17QV3 | SUMO3 | Small ubiquitin-related modifier 3 | Bos taurus (Bovine) | SS |
| Q5ZHQ1 | SUMO3 | Small ubiquitin-related modifier 3 | Gallus gallus (Chicken) | SS |
| Q5ZJM9 | SUMO2 | Small ubiquitin-related modifier 2 | Gallus gallus (Chicken) | SS |
| Q8QGH2 | SUMO1 | Small ubiquitin-related modifier 1 | Gallus gallus (Chicken) | SS |
| Q9VCP1 | CG4449 | Uncharacterized protein CG4449 | Drosophila melanogaster (Fruit fly) | PR |
| P63165 | SUMO1 | Small ubiquitin-related modifier 1 | Homo sapiens (Human) | EV |
| Q6EEV6 | SUMO4 | Small ubiquitin-related modifier 4 | Homo sapiens (Human) | SS |
| P61956 | SUMO2 | Small ubiquitin-related modifier 2 | Homo sapiens (Human) | SS |
| P55854 | SUMO3 | Small ubiquitin-related modifier 3 | Homo sapiens (Human) | SS |
| P63166 | Sumo1 | Small ubiquitin-related modifier 1 | Mus musculus (Mouse) | SS |
| Q9Z172 | Sumo3 | Small ubiquitin-related modifier 3 | Mus musculus (Mouse) | SS |
| A7WLH8 | SUMO1 | Small ubiquitin-related modifier 1 | Sus scrofa (Pig) | SS |
| P61958 | SUMO2 | Small ubiquitin-related modifier 2 | Sus scrofa (Pig) | SS |
| Q5I0H3 | Sumo1 | Small ubiquitin-related modifier 1 | Rattus norvegicus (Rat) | SS |
| Q5XIF4 | Sumo3 | Small ubiquitin-related modifier 3 | Rattus norvegicus (Rat) | SS |
| P61959 | Sumo2 | Small ubiquitin-related modifier 2 | Rattus norvegicus (Rat) | SS |
| P55857 | SUMO1 | Small ubiquitin-related modifier 1 | Oryza sativa subsp. japonica (Rice) | SS |
| P55853 | smo-1 | Small ubiquitin-related modifier | Caenorhabditis elegans | SS |
| B3H5R8 | SUMO8 | Putative small ubiquitin-related modifier 8 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P55852 | SUMO1 | Small ubiquitin-related modifier 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8VZI7 | SUMO5 | Small ubiquitin-related modifier 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FKC5 | SUMO4 | Putative small ubiquitin-related modifier 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FLP5 | SUMO3 | Small ubiquitin-related modifier 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8A8 | SUMO7 | Putative small ubiquitin-related modifier 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FLP6 | SUMO2 | Small ubiquitin-related modifier 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q6DEP7 | sumo1 | Small ubiquitin-related modifier 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q28H04 | sumo2 | Small ubiquitin-related modifier 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q6DI05 | sumo3 | Small ubiquitin-related modifier 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6DHL4 | sumo2 | Small ubiquitin-related modifier 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6NV25 | sumo3l | Small ubiquitin-related modifier 3-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7SZR5 | sumo1 | Small ubiquitin-related modifier 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADEKPKEGV | KTENNDHINL | KVAGQDGSVV | QFKIKRHTPL | SKLMKAYCER | QGLSMRQIRF |
| 70 | 80 | 90 | |||
| RFDGQPINET | DTPAQLEMED | EDTIDVFQQQ | TGGVY |