P61956
SS
Gene name |
SUMO2 (SMT3B, SMT3H2) |
Protein name |
Small ubiquitin-related modifier 2 |
Names |
SUMO-2 , HSMT3 , SMT3 homolog 2 , SUMO-3 , Sentrin-2 , Ubiquitin-like protein SMT3B , Smt3B |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:6613 |
EC number |
|
Protein Class |
|
Descriptions
The N-terminal region of SUMO1 functions as an autoinhibition domain by blocking its binding to the phosphorylated SIMs of PML and Daxx. This autoinhibition is relieved by zinc, which stabilizes the complex between SUMO1 and a phospho-mimetic form of the SIM of PML, suggesting a paralog specific function of SUMO1 in regulating SUMO1-SIM interactions required for PML-NB formation and function.
Autoinhibitory domains (AIDs)
Target domain |
16-93 (Ubiquitin-like domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
26 structures for P61956
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1WM2 | X-ray | 160 A | A | 12-89 | PDB |
| 1WM3 | X-ray | 120 A | A | 17-88 | PDB |
| 1WZ0 | NMR | - | A | 1-91 | PDB |
| 2AWT | NMR | - | A | 1-95 | PDB |
| 2CKH | X-ray | 320 A | B | 15-93 | PDB |
| 2D07 | X-ray | 210 A | B | 1-93 | PDB |
| 2IO0 | X-ray | 230 A | B | 15-95 | PDB |
| 2IO3 | X-ray | 320 A | B | 15-93 | PDB |
| 2IYD | X-ray | 320 A | B | 15-95 | PDB |
| 2N1W | NMR | - | A | 1-93 | PDB |
| 2N9E | NMR | - | B | 1-95 | PDB |
| 2RPQ | NMR | - | A | 1-93 | PDB |
| 3UIN | X-ray | 260 A | B | 14-93 | PDB |
| 3UIO | X-ray | 260 A | B | 14-93 | PDB |
| 3ZO5 | X-ray | 215 A | B | 16-95 | PDB |
| 4BKG | X-ray | 211 A | A | 12-93 | PDB |
| 4NPN | X-ray | 163 A | A | 12-93 | PDB |
| 5D2M | X-ray | 240 A | B/E | 15-93 | PDB |
| 5ELU | X-ray | 235 A | B | 14-89 | PDB |
| 5EQL | X-ray | 249 A | B | 14-89 | PDB |
| 5GHB | NMR | - | A | 1-93 | PDB |
| 5GHC | NMR | - | A | 1-93 | PDB |
| 6JXW | NMR | - | A | 1-95 | PDB |
| 6JXX | NMR | - | A | 1-95 | PDB |
| 7ZJV | X-ray | 240 A | B | 18-92 | PDB |
| AF-P61956-F1 | Predicted | AlphaFoldDB |
35 variants for P61956
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs1180720421 | 2 | A>V | No | gnomAD | |
| rs2074840439 | 3 | D>E | No | TOPMed | |
| TCGA novel | 4 | E>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1204157058 | 5 | K>M | No | Ensembl | |
| rs746155821 | 5 | K>N | No |
ExAC gnomAD |
|
| rs1368991070 | 9 | G>E | No | TOPMed | |
| rs1213663390 | 9 | G>R | No | gnomAD | |
| TCGA novel | 14 | N>Q | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs749365427 | 15 | N>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
|
rs17850328 VAR_047508 |
16 | D>N | No |
UniProt ExAC dbSNP gnomAD |
|
| rs2145227434 | 18 | I>V | No | Ensembl | |
| rs2145227428 | 19 | N>T | No | Ensembl | |
| COSM6147959 | 24 | G>W | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs2074825482 | 31 | Q>H | No | TOPMed | |
| TCGA novel | 31 | Q>P | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs2145227400 | 33 | K>N | No | 1000Genomes | |
| rs1284554895 | 36 | R>K | No | TOPMed | |
| rs2074825413 | 37 | H>N | No | gnomAD | |
| COSM984282 | 49 | E>A | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1044073724 | 52 | G>* | No | TOPMed | |
| rs1389138401 | 55 | M>I | No |
TOPMed gnomAD |
|
| rs760160309 | 55 | M>V | No |
ExAC gnomAD |
|
| rs930950247 | 67 | I>V | No |
TOPMed gnomAD |
|
| rs763179877 | 68 | N>S | No |
ExAC TOPMed gnomAD |
|
| TCGA novel | 68 | N>T | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs773308710 | 70 | T>A | No |
ExAC TOPMed gnomAD |
|
| TCGA novel | 77 | E>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 79 | E>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1391565643 | 80 | D>N | No | gnomAD | |
| COSM3522045 | 87 | F>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1204753119 | 91 | T>M | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| COSM1318456 | 93 | G>D | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1451711605 | 94 | V>A | No |
TOPMed gnomAD |
|
| rs750609260 | 94 | V>I | No |
ExAC gnomAD |
|
| rs1192064814 | 96 | Y>C | No | TOPMed |
No associated diseases with P61956
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| PML body | A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein tag activity | A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
| ubiquitin-like protein ligase binding | Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| protein sumoylation | The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. |
33 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q17QV3 | SUMO3 | Small ubiquitin-related modifier 3 | Bos taurus (Bovine) | SS |
| Q5E9D1 | SUMO1 | Small ubiquitin-related modifier 1 | Bos taurus (Bovine) | SS |
| Q5ZHQ1 | SUMO3 | Small ubiquitin-related modifier 3 | Gallus gallus (Chicken) | SS |
| Q8QGH2 | SUMO1 | Small ubiquitin-related modifier 1 | Gallus gallus (Chicken) | SS |
| Q5ZJM9 | SUMO2 | Small ubiquitin-related modifier 2 | Gallus gallus (Chicken) | SS |
| Q9VCP1 | CG4449 | Uncharacterized protein CG4449 | Drosophila melanogaster (Fruit fly) | PR |
| Q6EEV6 | SUMO4 | Small ubiquitin-related modifier 4 | Homo sapiens (Human) | SS |
| P55854 | SUMO3 | Small ubiquitin-related modifier 3 | Homo sapiens (Human) | SS |
| P63165 | SUMO1 | Small ubiquitin-related modifier 1 | Homo sapiens (Human) | EV |
| G2XKQ0 | SUMO1P1 | Small ubiquitin-related modifier 5 | Homo sapiens (Human) | SS |
| P63166 | Sumo1 | Small ubiquitin-related modifier 1 | Mus musculus (Mouse) | SS |
| Q9Z172 | Sumo3 | Small ubiquitin-related modifier 3 | Mus musculus (Mouse) | SS |
| P61957 | Sumo2 | Small ubiquitin-related modifier 2 | Mus musculus (Mouse) | SS |
| A7WLH8 | SUMO1 | Small ubiquitin-related modifier 1 | Sus scrofa (Pig) | SS |
| P61958 | SUMO2 | Small ubiquitin-related modifier 2 | Sus scrofa (Pig) | SS |
| Q5I0H3 | Sumo1 | Small ubiquitin-related modifier 1 | Rattus norvegicus (Rat) | SS |
| Q5XIF4 | Sumo3 | Small ubiquitin-related modifier 3 | Rattus norvegicus (Rat) | SS |
| P61959 | Sumo2 | Small ubiquitin-related modifier 2 | Rattus norvegicus (Rat) | SS |
| P55857 | SUMO1 | Small ubiquitin-related modifier 1 | Oryza sativa subsp. japonica (Rice) | SS |
| P55853 | smo-1 | Small ubiquitin-related modifier | Caenorhabditis elegans | SS |
| Q9FKC5 | SUMO4 | Putative small ubiquitin-related modifier 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FLP5 | SUMO3 | Small ubiquitin-related modifier 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P55852 | SUMO1 | Small ubiquitin-related modifier 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8VZI7 | SUMO5 | Small ubiquitin-related modifier 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| B3H5R8 | SUMO8 | Putative small ubiquitin-related modifier 8 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8A8 | SUMO7 | Putative small ubiquitin-related modifier 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FLP6 | SUMO2 | Small ubiquitin-related modifier 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q6DEP7 | sumo1 | Small ubiquitin-related modifier 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q28H04 | sumo2 | Small ubiquitin-related modifier 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q6DI05 | sumo3 | Small ubiquitin-related modifier 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6NV25 | sumo3l | Small ubiquitin-related modifier 3-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7SZR5 | sumo1 | Small ubiquitin-related modifier 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6DHL4 | sumo2 | Small ubiquitin-related modifier 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADEKPKEGV | KTENNDHINL | KVAGQDGSVV | QFKIKRHTPL | SKLMKAYCER | QGLSMRQIRF |
| 70 | 80 | 90 | |||
| RFDGQPINET | DTPAQLEMED | EDTIDVFQQQ | TGGVY |