Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

8 structures for P61587

Entry ID Method Resolution Chain Position Source
1M7B X-ray 200 A A 19-200 PDB
2V55 X-ray 370 A B/D 1-200 PDB
4BG6 X-ray 230 A Q/R 232-241 PDB
7OBC X-ray 190 A B 231-241 PDB
7OBD X-ray 200 A B 231-241 PDB
8B2K X-ray 140 A B 231-244 PDB
8BFC X-ray 140 A B 231-244 PDB
AF-P61587-F1 Predicted AlphaFoldDB

147 variants for P61587

Variant ID(s) Position Change Description Diseaes Association Provenance
CA348873000
rs1182539573
5 R>K No ClinGen
TOPMed
rs759966800
CA348872992
6 A>G No ClinGen
ExAC
gnomAD
rs772557837
CA1902738
6 A>T No ClinGen
ExAC
gnomAD
rs759966800
CA1902737
6 A>V No ClinGen
ExAC
gnomAD
CA348872985
rs773861698
7 S>R No ClinGen
ExAC
TOPMed
gnomAD
rs1406655640
CA348872961
10 L>F No ClinGen
TOPMed
rs1467092859
CA348872960
11 S>T No ClinGen
gnomAD
rs1455403238
CA348872947
12 S>R No ClinGen
gnomAD
rs147918776
CA1902734
15 I>V No ClinGen
ESP
ExAC
TOPMed
gnomAD
TCGA novel 17 D>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA58436378
rs892934922
18 P>S No ClinGen
Ensembl
rs777448950
CA1902733
20 Q>H No ClinGen
ExAC
TOPMed
gnomAD
rs769524149
CA348872882
21 N>K No ClinGen
ExAC
TOPMed
gnomAD
rs747961527
CA1902731
22 V>M No ClinGen
ExAC
gnomAD
rs754971352
CA1902729
26 I>L No ClinGen
ExAC
gnomAD
CA348872824
rs1337593899
30 G>A No ClinGen
TOPMed
TCGA novel 30 G>E Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1260221848
CA348872815
31 D>E No ClinGen
gnomAD
rs1348555628
CA348872822
31 D>N No ClinGen
gnomAD
CA348872802
rs1473735404
33 Q>R No ClinGen
gnomAD
CA1902727
rs779158844
34 C>Y No ClinGen
ExAC
gnomAD
rs754050173
CA1902725
36 K>N No ClinGen
ExAC
gnomAD
rs1054378795
CA58436377
38 A>S No ClinGen
Ensembl
rs753058821
CA1902722
39 L>Q No ClinGen
ExAC
gnomAD
CA348872754
rs1279002171
41 H>R No ClinGen
TOPMed
rs760054624
CA1902720
47 C>W No ClinGen
ExAC
TOPMed
gnomAD
rs774796736
CA1902719
49 P>S No ClinGen
ExAC
gnomAD
rs772797723
CA1902716
50 E>A No ClinGen
ExAC
TOPMed
gnomAD
CA348872691
rs1474730686
50 E>K Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA348872668
rs1251228402
51 N>K No ClinGen
gnomAD
rs759860450
CA1902699
53 V>I No ClinGen
ExAC
gnomAD
CA348872649
rs1283966249
54 P>L No ClinGen
gnomAD
CA1902698
rs752108217
54 P>S No ClinGen
ExAC
gnomAD
rs974493111
CA58436320
60 Y>H No ClinGen
TOPMed
rs766894438
CA1902697
61 T>K No ClinGen
ExAC
gnomAD
rs766894438
CA58436318
61 T>M No ClinGen
ExAC
gnomAD
CA58436319
rs1008533367
61 T>P No ClinGen
Ensembl
rs1186122682
CA348872594
63 S>C No ClinGen
Ensembl
CA58436317
rs1047476805
64 F>L No ClinGen
Ensembl
rs930357058
CA58436316
65 E>K No ClinGen
Ensembl
CA1902694
rs764594599
67 D>H No ClinGen
ExAC
TOPMed
gnomAD
CA1902692
rs575671552
71 I>T No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs761580913
CA1902693
71 I>V No ClinGen
ExAC
gnomAD
CA348872485
rs1407959561
78 T>S No ClinGen
gnomAD
CA1902666
rs748211534
82 P>S Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs1272642255
CA348872406
88 R>H No ClinGen
Ensembl
CA348872399
rs1222381944
89 P>H No ClinGen
Ensembl
rs755197296
CA1902664
90 L>V No ClinGen
ExAC
gnomAD
COSM175652
CA1902663
rs747141041
95 S>L Variant assessed as Somatic; 0.0 impact. large_intestine breast [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
gnomAD
CA348872354
rs758650254
96 D>E No ClinGen
ExAC
gnomAD
rs1231663472
CA348872349
97 A>D No ClinGen
TOPMed
rs1355458423
CA348872352
97 A>T No ClinGen
TOPMed
CA1902658
rs372548276
105 S>I No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1347986827
CA348872280
107 P>R No ClinGen
TOPMed
rs753396212
CA1902657
107 P>S No ClinGen
ExAC
gnomAD
rs752248279
CA1902654
112 S>T No ClinGen
ExAC
TOPMed
gnomAD
rs367957253
CA1902653
115 K>R No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1178184010
CA348872218
116 K>N No ClinGen
TOPMed
CA348872193
rs1448290511
117 W>C No ClinGen
gnomAD
CA58434716
rs1017439234
119 G>C No ClinGen
Ensembl
CA58434715
rs959552606
119 G>V No ClinGen
TOPMed
CA348872180
rs1411768721
120 E>K No ClinGen
TOPMed
CA58434714
rs1007361820
121 I>T No ClinGen
Ensembl
CA58434713
rs1033868173
122 Q>P No ClinGen
TOPMed
rs777453229
CA1902634
125 C>Y No ClinGen
ExAC
gnomAD
CA1902633
rs755543766
126 P>R No ClinGen
ExAC
TOPMed
gnomAD
CA348872113
rs1272286193
129 K>R No ClinGen
gnomAD
rs142625334
CA58434712
131 L>F Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ESP
NCI-TCGA
TOPMed
gnomAD
TCGA novel 131 L>P Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA348872082
rs1214214463
134 G>S No ClinGen
gnomAD
rs751315149
CA1902629
137 S>F No ClinGen
ExAC
gnomAD
rs1226352833
CA348872042
140 R>G No ClinGen
gnomAD
COSM716445
CA1902628
rs766103665
140 R>Q lung [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
rs540244240
CA1902626
142 D>V No ClinGen
1000Genomes
ExAC
gnomAD
CA348872015
rs1294665313
144 S>N No ClinGen
gnomAD
rs1048150963
CA58434710
145 T>K No ClinGen
TOPMed
gnomAD
CA1902623
rs775841994
147 V>L No ClinGen
ExAC
gnomAD
CA348871986
rs1390242501
149 L>I No ClinGen
gnomAD
CA1902621
rs746037801
151 N>I No ClinGen
ExAC
gnomAD
CA348871971
rs746037801
151 N>T No ClinGen
ExAC
gnomAD
CA348871965
rs1339441930
152 H>Y No ClinGen
TOPMed
CA348871958
rs1266537573
153 R>G No ClinGen
gnomAD
rs779437802
CA1902620
153 R>S No ClinGen
ExAC
gnomAD
CA348871946
rs1489304179
154 Q>H No ClinGen
gnomAD
rs145448904
COSM145874
CA1902619
155 T>M haematopoietic_and_lymphoid_tissue [Cosmic] No ClinGen
cosmic curated
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA1902617
rs778398680
156 P>T No ClinGen
ExAC
CA348871906
rs1223888524
161 Q>E No ClinGen
TOPMed
rs546539467
CA1902604
163 A>E No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA1902603
rs774679742
165 M>T No ClinGen
ExAC
TOPMed
gnomAD
rs749653637
CA1902601
166 A>G No ClinGen
ExAC
gnomAD
rs771468851
CA1902602
166 A>T No ClinGen
ExAC
TOPMed
gnomAD
rs749653637
CA58434573
166 A>V Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
CA1902600
rs773921122
168 Q>E No ClinGen
ExAC
gnomAD
rs200146323
CA1902599
172 A>D No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA348871822
rs1306694910
172 A>P No ClinGen
TOPMed
gnomAD
TCGA novel 172 A>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA348871803
rs1558868730
175 I>V No ClinGen
Ensembl
rs536121901
CA348871796
176 E>* No ClinGen
1000Genomes
TOPMed
gnomAD
CA58434571
COSM3836975
rs536121901
176 E>K Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
1000Genomes
NCI-TCGA
TOPMed
gnomAD
CA1902595
rs746704792
177 C>R No ClinGen
ExAC
CA348871788
rs1400866920
177 C>S No ClinGen
gnomAD
rs1430293512
CA348871766
180 L>F No ClinGen
gnomAD
rs978242755
CA58434570
182 S>L No ClinGen
TOPMed
rs978242755
CA348871752
182 S>W No ClinGen
TOPMed
CA348871723
rs1192595445
186 V>G Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA1902591
rs144867114
186 V>I No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA1902590
rs757158401
187 R>K No ClinGen
ExAC
gnomAD
rs753763478
CA1902589
191 H>R No ClinGen
ExAC
gnomAD
CA1902587
rs765035010
192 V>I No ClinGen
ExAC
TOPMed
gnomAD
rs765035010
CA348871686
192 V>L No ClinGen
ExAC
TOPMed
gnomAD
rs763199337
CA1902584
196 A>T No ClinGen
ExAC
gnomAD
rs1331584919
CA348871649
198 V>I No ClinGen
gnomAD
CA348871636
rs1291894641
199 N>K No ClinGen
gnomAD
rs1242141817
CA348871635
200 K>Q No ClinGen
gnomAD
CA1902581
rs777165494
201 T>I No ClinGen
ExAC
TOPMed
gnomAD
rs777165494
CA1902580
201 T>K No ClinGen
ExAC
TOPMed
gnomAD
rs777165494
CA348871624
201 T>R No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 202 N>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs768101389
CA1902579
202 N>H No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 202 N>K Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA1902577
rs151069801
205 V>I No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs745467973
CA1902575
207 R>Q No ClinGen
ExAC
gnomAD
CA1902576
rs758054007
207 R>W No ClinGen
ExAC
TOPMed
gnomAD
CA1902574
rs778598169
210 S>P No ClinGen
ExAC
TOPMed
gnomAD
CA348871562
rs1369227927
211 Q>E No ClinGen
gnomAD
CA348871550
rs1189903110
212 R>S No ClinGen
gnomAD
rs532782714
CA58434569
213 A>T No ClinGen
1000Genomes
TOPMed
rs777749153
CA1902571
216 R>Q No ClinGen
ExAC
TOPMed
gnomAD
CA348871505
rs1180754677
219 H>Q No ClinGen
TOPMed
CA348871502
rs1466682774
220 M>V No ClinGen
gnomAD
CA348871494
rs1364169705
221 P>A No ClinGen
TOPMed
CA1902570
rs755171874
222 S>N No ClinGen
ExAC
gnomAD
CA348871489
rs1410266235
222 S>R No ClinGen
gnomAD
CA348871478
rs1573951640
223 R>K No ClinGen
Ensembl
CA1902567
rs763288592
224 P>R No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 225 E>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1362395691
CA348871466
225 E>V No ClinGen
gnomAD
CA1902566
rs750617672
226 L>R No ClinGen
ExAC
TOPMed
gnomAD
rs762217114
CA1902564
227 S>L No ClinGen
ExAC
TOPMed
gnomAD
rs1404494909
CA348871433
231 T>A No ClinGen
gnomAD
CA1902561
rs761105485
231 T>M No ClinGen
ExAC
TOPMed
gnomAD
rs771524793
CA1902559
232 D>V No ClinGen
ExAC
gnomAD
rs1389618167
CA348871414
234 R>* No ClinGen
TOPMed
gnomAD
rs745554710
CA1902558
235 K>R No ClinGen
ExAC
gnomAD
TCGA novel 236 D>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA348871386
rs1251632260
238 A>T No ClinGen
gnomAD
CA1902556
rs770685295
238 A>V No ClinGen
ExAC
gnomAD

No associated diseases with P61587

1 regional properties for P61587

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 24 - 167 IPR005225

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus membrane; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

9 GO annotations of biological process

Name Definition
actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cortical cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
establishment or maintenance of cell polarity Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of cell shape Any process that modulates the surface configuration of a cell.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.

37 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q00246 RHO4 GTP-binding protein RHO4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P61585 RHOA Transforming protein RhoA Bos taurus (Bovine) PR
Q1RMJ6 RHOC Rho-related GTP-binding protein RhoC Bos taurus (Bovine) PR
Q17QI8 Rhov Rho-related GTP-binding protein RhoV Bos taurus (Bovine) PR
Q3ZBW5 RHOB Rho-related GTP-binding protein RhoB Bos taurus (Bovine) PR
Q2HJ68 RND1 Rho-related GTP-binding protein Rho6 Bos taurus (Bovine) PR
Q9PSX7 RHOC Rho-related GTP-binding protein RhoC Gallus gallus (Chicken) PR
P48148 Rho1 Ras-like GTP-binding protein Rho1 Drosophila melanogaster (Fruit fly) PR
O94955 RHOBTB3 Rho-related BTB domain-containing protein 3 Homo sapiens (Human) EV
O94844 RHOBTB1 Rho-related BTB domain-containing protein 1 Homo sapiens (Human) PR
P08134 RHOC Rho-related GTP-binding protein RhoC Homo sapiens (Human) PR
P61586 RHOA Transforming protein RhoA Homo sapiens (Human) PR
P62745 RHOB Rho-related GTP-binding protein RhoB Homo sapiens (Human) PR
Q92730 RND1 Rho-related GTP-binding protein Rho6 Homo sapiens (Human) PR
Q96L33 RHOV Rho-related GTP-binding protein RhoV Homo sapiens (Human) PR
Q62159 Rhoc Rho-related GTP-binding protein RhoC Mus musculus (Mouse) PR
Q9QUI0 Rhoa Transforming protein RhoA Mus musculus (Mouse) PR
Q9DAK3 Rhobtb1 Rho-related BTB domain-containing protein 1 Mus musculus (Mouse) PR
Q9CTN4 Rhobtb3 Rho-related BTB domain-containing protein 3 Mus musculus (Mouse) SS
Q8VDU1 Rhov Rho-related GTP-binding protein RhoV Mus musculus (Mouse) PR
P62746 Rhob Rho-related GTP-binding protein RhoB Mus musculus (Mouse) PR
Q8BLR7 Rnd1 Rho-related GTP-binding protein Rho6 Mus musculus (Mouse) PR
P61588 Rnd3 Rho-related GTP-binding protein RhoE Mus musculus (Mouse) PR
O77683 RND3 Rho-related GTP-binding protein RhoE Sus scrofa (Pig) PR
P62747 Rhob Rho-related GTP-binding protein RhoB Rattus norvegicus (Rat) PR
Q9Z1Y0 Rhov Rho-related GTP-binding protein RhoV Rattus norvegicus (Rat) PR
P61589 Rhoa Transforming protein RhoA Rattus norvegicus (Rat) PR
Q6SA80 Rnd3 Rho-related GTP-binding protein RhoE Rattus norvegicus (Rat) PR
Q9SSX0 RAC1 Rac-like GTP-binding protein 1 Oryza sativa subsp japonica (Rice) PR
Q6Z808 RAC3 Rac-like GTP-binding protein 3 Oryza sativa subsp japonica (Rice) PR
Q68Y52 RAC2 Rac-like GTP-binding protein 2 Oryza sativa subsp japonica (Rice) PR
Q67VP4 RAC4 Rac-like GTP-binding protein 4 Oryza sativa subsp japonica (Rice) PR
Q22038 rho-1 Ras-like GTP-binding protein rhoA Caenorhabditis elegans PR
Q9SU67 ARAC8 Rac-like GTP-binding protein ARAC8 Arabidopsis thaliana (Mouse-ear cress) PR
O82480 ARAC7 Rac-like GTP-binding protein ARAC7 Arabidopsis thaliana (Mouse-ear cress) PR
Q38903 ARAC2 Rac-like GTP-binding protein ARAC2 Arabidopsis thaliana (Mouse-ear cress) PR
O82481 ARAC10 Rac-like GTP-binding protein ARAC10 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE NYVPTVFENY
70 80 90 100 110 120
TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI CFDISRPETL DSVLKKWKGE
130 140 150 160 170 180
IQEFCPNTKM LLVGCKSDLR TDVSTLVELS NHRQTPVSYD QGANMAKQIG AATYIECSAL
190 200 210 220 230 240
QSENSVRDIF HVATLACVNK TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS
CTVM