AiPD: Autoinhibited Protein Database

Gene name	Rab6b (D9Bwg0185e)
Protein name	Ras-related protein Rab-6B
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:270192
EC number	3.6.5.2: Acting on GTP; involved in cellular and subcellular movement
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

146-208 (Predicted disordered autoinhibitory region) PR

146-208 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
8IJ9	X-ray	204 A	A/B	8-176	PDB
AF-P61294-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389045561	29	L>M	No	EVA
rs3389059996	78	L>P	No	EVA
rs3389070096	82	Y>D	No	EVA
rs3389070062	125	G>D	No	EVA
rs3400729398	202	S>I	No	EVA
rs3400837284	202	S>R	No	EVA
rs3400265001	203	E>A	No	EVA
rs3400638290	203	E>D	No	EVA

Type	Name	Position	InterPro Accession
domain	Small GTP-binding protein domain	13 - 169	IPR005225

		Description
EC Number	3.6.5.2	Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization	Golgi apparatus membrane ; Lipid-anchor Endoplasmic reticulum-Golgi intermediate compartment Cytoplasmic vesicle	Colocalizes with BICD1 at vesicular structures that align along microtubules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasmic vesicle	A vesicle found in the cytoplasm of a cell.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum-Golgi intermediate compartment	A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
presynapse	The part of a synapse that is part of the presynaptic cell.

Name	Definition
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
myosin V binding	Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport.

Name	Definition
Golgi organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
intra-Golgi vesicle-mediated transport	The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
protein localization to Golgi membrane	A process in which a protein is transported to, or maintained in, a location within a Golgi membrane.
retrograde transport, endosome to Golgi	The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A6QR46	RAB6B	Ras-related protein Rab-6B	Bos taurus (Bovine)	PR
Q1KME6	RAB6A	Ras-related protein Rab-6A	Gallus gallus (Chicken)	PR
O18334	Rab6	Ras-related protein Rab6	Drosophila melanogaster (Fruit fly)	PR
O95755	RAB36	Ras-related protein Rab-36	Homo sapiens (Human)	PR
Q9BZG1	RAB34	Ras-related protein Rab-34	Homo sapiens (Human)	PR
P20340	RAB6A	Ras-related protein Rab-6A	Homo sapiens (Human)	PR
Q5JT25	RAB41	Ras-related protein Rab-41	Homo sapiens (Human)	PR
Q9NRW1	RAB6B	Ras-related protein Rab-6B	Homo sapiens (Human)	PR
Q8CAM5	Rab36	Ras-related protein Rab-36	Mus musculus (Mouse)	PR
P35279	Rab6a	Ras-related protein Rab-6A	Mus musculus (Mouse)	PR
P35293	Rab18	Ras-related protein Rab-18	Mus musculus (Mouse)	PR
P35294	Rab19	Ras-related protein Rab-19	Mus musculus (Mouse)	PR
Q8CFP6	Dnajc27	DnaJ homolog subfamily C member 27	Mus musculus (Mouse)	PR
Q9WVB1	Rab6a	Ras-related protein Rab-6A	Rattus norvegicus (Rat)	PR
P34213	rab-6.1	Ras-related protein rab-6.1	Caenorhabditis elegans	PR
Q22782	rab-6.2	Ras-related protein rab-6.2	Caenorhabditis elegans	PR
O80501	RABH1B	Ras-related protein RABH1b	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LFT9	RABH1E	Ras-related protein RABH1e	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SMR4	RABH1C	Ras-related protein RABH1c	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LV79	RABH1A	Ras-related protein RABH1a	Arabidopsis thaliana (Mouse-ear cress)	PR