P61086
PR
Gene name |
UBE2K (HIP2, LIG) |
Protein name |
Ubiquitin-conjugating enzyme E2 K |
Names |
E2 ubiquitin-conjugating enzyme K, Huntingtin-interacting protein 2, HIP-2, Ubiquitin carrier protein, Ubiquitin-conjugating enzyme E2-25 kDa, Ubiquitin-conjugating enzyme E2(25K), Ubiquitin-conjugating enzyme E2-25K, Ubiquitin-protein ligase |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:3093 |
EC number |
2.3.2.23: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
14 structures for P61086
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1YLA | X-ray | 240 A | A/B | 1-200 | PDB |
| 2O25 | X-ray | 260 A | A/B | 1-200 | PDB |
| 3E46 | X-ray | 186 A | A | 1-200 | PDB |
| 3F92 | X-ray | 223 A | A | 1-200 | PDB |
| 3K9O | X-ray | 180 A | A | 1-200 | PDB |
| 3K9P | X-ray | 280 A | A | 1-200 | PDB |
| 5DFL | X-ray | 210 A | A | 1-200 | PDB |
| 6IF1 | X-ray | 247 A | A/B | 1-199 | PDB |
| 6JB6 | X-ray | 270 A | A | 1-200 | PDB |
| 6JB7 | X-ray | 210 A | A | 1-200 | PDB |
| 7MYF | X-ray | 300 A | A | 2-200 | PDB |
| 7MYH | X-ray | 239 A | A | 2-200 | PDB |
| 7OJX | X-ray | 240 A | B | 1-200 | PDB |
| AF-P61086-F1 | Predicted | AlphaFoldDB |
44 variants for P61086
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA356779911 rs1437662623 |
9 | I>M | No |
ClinGen TOPMed |
|
|
CA356779962 rs1578404849 |
16 | V>G | No |
ClinGen Ensembl |
|
|
rs1319113452 CA356780023 |
22 | T>M | No |
ClinGen gnomAD |
|
|
CA356780025 rs1267882281 |
23 | S>G | No |
ClinGen gnomAD |
|
|
rs1332677043 CA356780029 |
23 | S>N | No |
ClinGen TOPMed |
|
|
rs1253345719 CA356780073 |
29 | V>L | No |
ClinGen gnomAD |
|
|
RCV000890168 rs201140126 CA2895389 |
32 | V>I | No |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
rs113098017 CA96123896 |
33 | D>G | No |
ClinGen gnomAD |
|
|
CA2895390 rs766305230 |
37 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 38 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 49 | T>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA96123898 rs867623067 |
50 | P>T | No |
ClinGen Ensembl |
|
| TCGA novel | 52 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs910149089 CA96124942 |
57 | Q>E | No |
ClinGen TOPMed |
|
|
rs1457468590 CA356780283 |
57 | Q>R | No |
ClinGen gnomAD |
|
|
CA356780306 rs1177076704 |
60 | I>M | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 61 | K>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 70 | P>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1188163024 CA356780424 |
76 | I>V | No |
ClinGen gnomAD |
|
| TCGA novel | 79 | I>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2895424 rs745506061 |
87 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs199792616 COSM1429640 CA96128614 |
107 | R>H | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes NCI-TCGA gnomAD |
| TCGA novel | 116 | L>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2895463 rs767042581 |
136 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA356780886 rs1160140704 |
138 | P>S | No |
ClinGen TOPMed |
|
| TCGA novel | 139 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1332929466 CA356780919 |
142 | K>R | No |
ClinGen gnomAD |
|
|
CA356780943 rs1056467894 |
146 | R>* | No |
ClinGen TOPMed gnomAD |
|
|
CA96128906 rs1056467894 |
146 | R>G | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 146 | R>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2895465 rs760206439 |
150 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA356781033 rs1342224157 |
160 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA356781034 rs1342224157 |
160 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
CA356781058 rs1264854079 |
163 | T>N | No |
ClinGen gnomAD |
|
| TCGA novel | 165 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1345622445 | 166 | I>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 166 | I>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2895470 rs753277761 |
168 | N>K | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 169 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 170 | C>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1355918376 CA356781119 |
172 | M>V | No |
ClinGen TOPMed |
|
|
CA2895471 rs758936193 |
176 | R>S | No |
ClinGen ExAC gnomAD |
|
|
CA356781179 rs1198729323 |
178 | A>G | No |
ClinGen gnomAD |
|
|
rs1450159016 CA356781283 |
194 | T>A | No |
ClinGen gnomAD |
No associated diseases with P61086
3 regional properties for P61086
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | 14-3-3 protein, conserved site | 51 - 61 | IPR023409-1 |
| conserved_site | 14-3-3 protein, conserved site | 223 - 242 | IPR023409-2 |
| domain | 14-3-3 domain | 11 - 254 | IPR023410 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.23 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| filopodium tip | The end of a filopodium distal to the body of the cell. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ubiquitin conjugating enzyme activity | Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
| ubiquitin-ubiquitin ligase activity | Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to interferon-beta | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. |
| free ubiquitin chain polymerization | The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein. |
| positive regulation of peptidyl-threonine phosphorylation | Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
| positive regulation of tumor necrosis factor-mediated signaling pathway | Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway. |
| positive regulation of type I interferon-mediated signaling pathway | Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. |
| proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| protein K48-linked ubiquitination | A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. |
| protein polyubiquitination | Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. |
| regulation of proteasomal ubiquitin-dependent protein catabolic process | Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P21734 | UBC1 | Ubiquitin-conjugating enzyme E2 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P61085 | UBE2K | Ubiquitin-conjugating enzyme E2 K | Bos taurus (Bovine) | PR |
| P52486 | Ubc4 | Ubiquitin-conjugating enzyme E2-22 kDa | Drosophila melanogaster (Fruit fly) | PR |
| Q9H8T0 | AKTIP | AKT-interacting protein | Homo sapiens (Human) | PR |
| Q9Y385 | UBE2J1 | Ubiquitin-conjugating enzyme E2 J1 | Homo sapiens (Human) | PR |
| Q9NPD8 | UBE2T | Ubiquitin-conjugating enzyme E2 T | Homo sapiens (Human) | PR |
| O00762 | UBE2C | Ubiquitin-conjugating enzyme E2 C | Homo sapiens (Human) | PR |
| O14933 | UBE2L6 | Ubiquitin/ISG15-conjugating enzyme E2 L6 | Homo sapiens (Human) | PR |
| Q96LR5 | UBE2E2 | Ubiquitin-conjugating enzyme E2 E2 | Homo sapiens (Human) | PR |
| Q969T4 | UBE2E3 | Ubiquitin-conjugating enzyme E2 E3 | Homo sapiens (Human) | PR |
| Q7Z7E8 | UBE2Q1 | Ubiquitin-conjugating enzyme E2 Q1 | Homo sapiens (Human) | PR |
| A1L167 | UBE2QL1 | Ubiquitin-conjugating enzyme E2Q-like protein 1 | Homo sapiens (Human) | PR |
| Q16763 | UBE2S | Ubiquitin-conjugating enzyme E2 S | Homo sapiens (Human) | EV |
| P61087 | Ube2k | Ubiquitin-conjugating enzyme E2 K | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANIAVQRIK | REFKEVLKSE | ETSKNQIKVD | LVDENFTELR | GEIAGPPDTP | YEGGRYQLEI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KIPETYPFNP | PKVRFITKIW | HPNISSVTGA | ICLDILKDQW | AAAMTLRTVL | LSLQALLAAA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EPDDPQDAVV | ANQYKQNPEM | FKQTARLWAH | VYAGAPVSSP | EYTKKIENLC | AMGFDRNAVI |
| 190 | |||||
| VALSSKSWDV | ETATELLLSN |