P61019
PR
Gene name |
RAB2A |
Protein name |
Ras-related protein Rab-2A |
Names |
|
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:5862 |
EC number |
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P61019
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1Z0A | X-ray | 212 A | A/B/C/D | 2-170 | PDB |
| AF-P61019-F1 | Predicted | AlphaFoldDB |
75 variants for P61019
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1287211224 CA371397929 |
4 | A>T | No |
ClinGen gnomAD |
|
|
rs566681369 CA4759002 |
7 | F>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1382710759 CA371397997 |
13 | G>D | No |
ClinGen gnomAD |
|
| TCGA novel | 16 | G>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 31 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1008246469 CA178160786 |
39 | I>V | No |
ClinGen TOPMed |
|
|
CA371398044 rs781309549 |
42 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1293334726 CA371398047 |
43 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
rs976954172 CA178162221 |
44 | G>S | No |
ClinGen Ensembl |
|
|
CA371398063 rs1218977322 |
45 | A>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1256149525 CA371398077 CA371398078 |
47 | M>I | No |
ClinGen gnomAD |
|
|
rs1474185296 CA371398072 |
47 | M>L | No |
ClinGen TOPMed |
|
|
rs1395142472 CA371398081 |
48 | I>K | No |
ClinGen Ensembl |
|
|
CA178162222 rs1020040727 |
48 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA371398089 rs1205113665 |
49 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA371398090 rs1205113665 |
49 | T>S | No |
ClinGen TOPMed gnomAD |
|
|
CA371398092 rs1260222034 |
50 | I>V | No |
ClinGen gnomAD |
|
|
CA371398104 rs1428961456 |
51 | D>E | No |
ClinGen gnomAD |
|
|
CA371398098 rs1194877505 |
51 | D>N | No |
ClinGen gnomAD |
|
|
rs771183016 CA4759093 |
58 | Q>K | No |
ClinGen ExAC |
|
| TCGA novel | 62 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4759124 rs765864736 |
65 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA371398488 rs1450900828 |
65 | Q>R | No |
ClinGen gnomAD |
|
|
CA371398502 rs1586097496 |
67 | S>T | No |
ClinGen Ensembl |
|
|
rs1451614899 CA371398517 |
69 | R>H | No |
ClinGen gnomAD |
|
|
rs1361749164 CA371398533 |
72 | T>A | No |
ClinGen gnomAD |
|
|
rs1586097508 CA371398547 |
74 | S>A | No |
ClinGen Ensembl |
|
|
CA178163642 rs866530512 |
74 | S>L | No |
ClinGen Ensembl |
|
|
rs1280437406 CA371398559 |
76 | Y>H | No |
ClinGen gnomAD |
|
|
CA371398585 rs1303794346 |
80 | A>S | No |
ClinGen TOPMed |
|
| TCGA novel | 81 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 83 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1378648752 CA371398652 |
90 | R>Q | No |
ClinGen gnomAD |
|
|
rs375530419 CA371398680 |
92 | D>E | No |
ClinGen ESP TOPMed gnomAD |
|
| TCGA novel | 92 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 93 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA371398728 rs770388750 |
99 | T>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770388750 CA4759142 |
99 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 100 | W>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4759145 rs767290685 |
105 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 105 | R>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4759146 rs752329627 |
109 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA178163685 rs1026751706 |
111 | N>T | No |
ClinGen Ensembl |
|
|
CA178163686 rs951987434 |
112 | M>L | No |
ClinGen Ensembl |
|
|
CA4759148 rs760414199 |
113 | V>F | No |
ClinGen ExAC gnomAD |
|
|
CA4759147 rs760414199 |
113 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs763831821 CA4759166 |
129 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA371398275 rs1310015226 |
132 | E>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
| TCGA novel | 132 | E>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs571157583 CA178164528 |
135 | E>D | No |
ClinGen Ensembl |
|
|
COSM343779 CA371398325 rs1243595305 |
139 | R>Q | lung [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
CA178164530 rs199581780 |
144 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA371398377 rs1194924934 CA371398378 |
146 | M>I | No |
ClinGen gnomAD |
|
|
rs761702966 CA4759186 |
162 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 171 | I>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs773184273 CA4759188 |
173 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs762848383 CA4759189 |
175 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA371399038 rs1195382451 |
175 | V>I | No |
ClinGen TOPMed |
|
|
rs1488451844 CA371399065 |
178 | I>V | No |
ClinGen TOPMed |
|
|
CA371399141 rs963087918 |
185 | I>F | No |
ClinGen TOPMed |
|
|
CA178167931 rs963087918 |
185 | I>V | No |
ClinGen TOPMed |
|
| TCGA novel | 189 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA371399176 rs1315046594 |
189 | P>S | No |
ClinGen TOPMed |
|
|
CA371399196 rs1352391334 |
191 | H>R | No |
ClinGen gnomAD |
|
|
rs549995165 CA4759217 |
195 | N>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1334648053 CA371399241 |
196 | A>V | No |
ClinGen gnomAD |
|
|
CA4759218 rs571634003 |
199 | A>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA371399283 rs1217840448 |
201 | N>S | No |
ClinGen gnomAD |
|
|
rs1267298715 CA371399292 |
202 | Q>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
| TCGA novel | 204 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs780644258 CA4759221 |
205 | Q>P | No |
ClinGen ExAC gnomAD |
|
|
rs1293539677 CA371399340 |
208 | G>R | No |
ClinGen gnomAD |
|
| TCGA novel | 209 | G>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 210 | G>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs374486741 CA178167933 |
210 | G>S | No |
ClinGen ESP TOPMed gnomAD |
No associated diseases with P61019
1 regional properties for P61019
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 7 - 161 | IPR005225 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.5.2 | Acting on GTP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| acrosomal vesicle | A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| endoplasmic reticulum-Golgi intermediate compartment membrane | The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system. |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| melanosome | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GDP binding | Binding to GDP, guanosine 5'-diphosphate. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| endoplasmic reticulum to Golgi vesicle-mediated transport | The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. |
| Golgi organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6IMM1 | DNAJC27 | DnaJ homolog subfamily C member 27 | Gallus gallus (Chicken) | PR |
| Q90965 | RAB2A | Ras-related protein Rab-2A | Gallus gallus (Chicken) | PR |
| P61105 | RAB2A | Ras-related protein Rab-2A | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q8WUD1 | RAB2B | Ras-related protein Rab-2B | Homo sapiens (Human) | PR |
| P20338 | RAB4A | Ras-related protein Rab-4A | Homo sapiens (Human) | PR |
| P61018 | RAB4B | Ras-related protein Rab-4B | Homo sapiens (Human) | PR |
| P62491 | RAB11A | Ras-related protein Rab-11A | Homo sapiens (Human) | PR |
| Q15907 | RAB11B | Ras-related protein Rab-11B | Homo sapiens (Human) | PR |
| Q8CFP6 | Dnajc27 | DnaJ homolog subfamily C member 27 | Mus musculus (Mouse) | PR |
| P53994 | Rab2a | Ras-related protein Rab-2A | Mus musculus (Mouse) | PR |
| Q6IML7 | Dnajc27 | DnaJ homolog subfamily C member 27 | Rattus norvegicus (Rat) | PR |
| P05712 | Rab2a | Ras-related protein Rab-2A | Rattus norvegicus (Rat) | PR |
| Q6IMK3 | dnajc27 | DnaJ homolog subfamily C member 27 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAYAYLFKYI | IIGDTGVGKS | CLLLQFTDKR | FQPVHDLTIG | VEFGARMITI | DGKQIKLQIW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DTAGQESFRS | ITRSYYRGAA | GALLVYDITR | RDTFNHLTTW | LEDARQHSNS | NMVIMLIGNK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SDLESRREVK | KEEGEAFARE | HGLIFMETSA | KTASNVEEAF | INTAKEIYEK | IQEGVFDINN |
| 190 | 200 | 210 | |||
| EANGIKIGPQ | HAATNATHAG | NQGGQQAGGG | CC |