AiPD: Autoinhibited Protein Database

P61006

Gene name	RAB8A (MEL, RAB8)
Protein name	Ras-related protein Rab-8A
Names	Oncogene c-mel
Species	Homo sapiens (Human)
KEGG Pathway	hsa:4218
EC number	3.6.5.2: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

137-207 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

137-207 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

20 structures for P61006

Entry ID	Method	Resolution	Chain	Position	Source
3QBT	X-ray	200 A	A/C/E/G	6-176	PDB
3TNF	X-ray	250 A	A	6-176	PDB
4LHV	X-ray	195 A	A/B/C/D/E	6-176	PDB
4LHW	X-ray	155 A	A/B/C/D/E	6-176	PDB
4LHX	X-ray	305 A	A/B	1-184	PDB
4LHY	X-ray	310 A	A/B	1-184	PDB
4LHZ	X-ray	320 A	A/B	1-184	PDB
4LI0	X-ray	330 A	A/B	1-184	PDB
5SZI	X-ray	285 A	A	1-207	PDB
6RIR	X-ray	177 A	A/B	1-181	PDB
6SQ2	X-ray	168 A	A/B	1-181	PDB
6STF	X-ray	240 A	A/B/C/D/E	5-176	PDB
6STG	X-ray	250 A	A/B	5-176	PDB
6WHE	X-ray	173 A	A/B	1-181	PDB
6YX5	X-ray	214 A	A	6-176	PDB
6ZSI	X-ray	191 A	A/B	1-176	PDB
6ZSJ	X-ray	200 A	A/B	1-176	PDB
7BWT	X-ray	230 A	B	2-183	PDB
7LWB	X-ray	190 A	A	1-181	PDB
AF-P61006-F1	Predicted				AlphaFoldDB

111 variants for P61006

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA404580493 rs1361108248	4	T>S		No	ClinGen gnomAD
TCGA novel	5	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404580498 rs1568317850	5	Y>H		No	ClinGen Ensembl
CA9275585 rs768071919	14	I>M		No	ClinGen ExAC gnomAD
rs1181766596 CA404580577	17	S>T		No	ClinGen TOPMed
CA404580594 rs1599393043	19	V>G		No	ClinGen Ensembl
TCGA novel	26	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751027770 CA9275591	31	D>E		No	ClinGen ExAC gnomAD
CA404580686 rs1568317890	33	F>Y		No	ClinGen Ensembl
rs781047043 CA9275593	34	N>S		No	ClinGen ExAC TOPMed gnomAD
CA9275594 rs745787780	36	T>A		No	ClinGen ExAC gnomAD
CA404580773 rs1208176747	44	D>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1448892419 CA404580814	49	T>I		No	ClinGen gnomAD
CA9275616 rs145971722	50	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs139537285 CA9275617	50	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA9275615 rs145971722	50	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1429377302 CA404580827	52	L>F		No	ClinGen TOPMed
CA404580833 rs1599395321	53	D>N		No	ClinGen Ensembl
CA404580843 rs1419063620	54	G>S		No	ClinGen TOPMed
CA9275619 rs373314086	55	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs890623886 CA305901854	56	R>I		No	ClinGen Ensembl
CA9275620 rs777976720	61	I>M		No	ClinGen ExAC TOPMed gnomAD
CA404580895 rs1383515977	62	W>R		No	ClinGen gnomAD
TCGA novel	63	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9275637 rs753016512	66	G>C		No	ClinGen ExAC gnomAD
TCGA novel	66	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758644794 CA9275638	67	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1213294850 CA404580950	68	E>Q		No	ClinGen gnomAD
CA9275639 rs778028924	69	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1470442545 CA404580958	69	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1482944299 CA404580968	70	F>L		No	ClinGen gnomAD
CA9275640 rs747042137	71	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs771353371 CA9275641	75	T>A		No	ClinGen ExAC gnomAD
rs781750272 CA9275642	75	T>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	76	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	77	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404581011 rs1432439795	78	Y>H		No	ClinGen gnomAD
rs1473869285 CA404581065	84	I>V		No	ClinGen gnomAD
CA404581073 rs1298136718	85	M>L		No	ClinGen gnomAD
CA404581089 rs1308473301	87	V>A		No	ClinGen gnomAD
CA305907834 rs1020965743	89	D>N		No	ClinGen Ensembl
CA9275672 rs775954889	92	N>T		No	ClinGen ExAC gnomAD
rs1049101274 CA305907836	93	E>K		No	ClinGen TOPMed gnomAD
CA9275674 rs765198343	97	D>N		No	ClinGen ExAC TOPMed gnomAD
rs775438230 CA9275675	98	N>S		No	ClinGen ExAC gnomAD
CA305907849 rs887364471	100	R>Q		No	ClinGen TOPMed gnomAD
rs967148175 CA305907846	100	R>W		No	ClinGen Ensembl
rs763790113 CA9275677	103	I>V		No	ClinGen ExAC gnomAD
CA9275678 rs751842773	104	R>H		No	ClinGen ExAC gnomAD
CA9275679 rs757394695	105	N>S		No	ClinGen ExAC gnomAD
rs1004305778 CA305907890	106	I>T		No	ClinGen TOPMed gnomAD
TCGA novel	107	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9275681 rs750406773	108	E>Q		No	ClinGen ExAC
CA9275724 rs758754074	109	H>N		No	ClinGen ExAC TOPMed gnomAD
rs1421471379 CA404581259	110	A>G		No	ClinGen TOPMed
CA9275726 COSM1680771 rs750145818	110	A>T	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA404581270 rs1360547786	112	A>E		No	ClinGen TOPMed
TCGA novel	112	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs949829005 CA305909467	114	V>I		No	ClinGen TOPMed gnomAD
CA305909472 rs1045591736	115	E>K		No	ClinGen TOPMed
CA404581302 rs1424732985	117	M>V		No	ClinGen TOPMed
CA404581311 rs1317165266	118	I>V		No	ClinGen TOPMed gnomAD
rs1324362837 CA404581322	119	L>R		No	ClinGen gnomAD
CA404581336 rs1333993671	121	N>K		No	ClinGen gnomAD
rs1599398800 CA404581346	123	C>R		No	ClinGen Ensembl
CA404581348 rs1275080931	123	C>Y		No	ClinGen gnomAD
rs778785985 CA9275731	126	N>S		No	ClinGen ExAC TOPMed gnomAD
CA9275732 rs748088384	128	K>E		No	ClinGen ExAC TOPMed gnomAD
CA305909509 rs369762374 CA9275733	128	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA305909500 rs748088384	128	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs1474491071 CA404581417	133	K>R		No	ClinGen gnomAD
rs771073154 CA404581431	135	R>L		No	ClinGen ExAC TOPMed gnomAD
CA9275736 rs771073154	135	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs747264307 CA9275735 COSM1391240	135	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA9275737 CA404581452 rs776705625	138	K>N		No	ClinGen ExAC gnomAD
rs768854359 CA9275778	142	D>G		No	ClinGen ExAC gnomAD
CA305909832 rs765205828	142	D>N		No	ClinGen Ensembl
rs775041655 COSM564969 CA9275779	143	Y>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs372254577 CA305909850	146	K>N		No	ClinGen ESP TOPMed gnomAD
CA404581512 rs1267675900	146	K>R		No	ClinGen gnomAD
rs772587714 CA9275781	148	M>I		No	ClinGen ExAC gnomAD
rs1164220285 CA404581554	152	A>T		No	ClinGen gnomAD
CA305909877 rs145305113	155	N>S		No	ClinGen ESP TOPMed
CA404581587 rs1249972414	156	I>M		No	ClinGen gnomAD
rs764886982 CA9275784	157	N>S		No	ClinGen ExAC TOPMed gnomAD
CA404581595 rs1233045102	158	V>M		No	ClinGen TOPMed
rs1380876949 CA404581613	160	N>S		No	ClinGen gnomAD
CA404581643 rs1423406940	163	F>I		No	ClinGen TOPMed
CA9275813 rs747266932	163	F>L		No	ClinGen ExAC gnomAD
rs1160073390 CA404581655	164	T>I		No	ClinGen TOPMed
rs758396964 CA9275816	166	A>S		No	ClinGen ExAC gnomAD
CA9275815 rs758396964	166	A>T		No	ClinGen ExAC gnomAD
rs1434484343 CA404581678	168	D>A		No	ClinGen gnomAD
CA9275817 rs747441158	168	D>E		No	ClinGen ExAC gnomAD
CA305911226 rs201751163	172	K>Q		No	ClinGen Ensembl
rs748965804 CA9275820	173	M>V		No	ClinGen ExAC gnomAD
rs1363132075 CA404581747	176	K>I		No	ClinGen TOPMed
CA9275842 rs747736923	180	N>S		No	ClinGen ExAC TOPMed gnomAD
CA9275844 rs772560627	181	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA404581804 rs1183018562	181	S>R		No	ClinGen gnomAD
CA305913188 rs927338669	188	G>A		No	ClinGen TOPMed
TCGA novel	188	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760666638 CA9275845	189	V>I		No	ClinGen ExAC TOPMed gnomAD
CA305913192 rs558096021	190	K>R		No	ClinGen 1000Genomes gnomAD
rs770935465 CA9275846	191	I>V		No	ClinGen ExAC
CA305913208 rs769827222	192	T>I		No	ClinGen ExAC gnomAD
CA9275847 rs769827222	192	T>K		No	ClinGen ExAC gnomAD
rs765092264 CA9275849	196	Q>H		No	ClinGen ExAC gnomAD
CA404581956 rs1321147098	200	S>G		No	ClinGen gnomAD
rs1175467248 CA404581962	200	S>R		No	ClinGen TOPMed gnomAD
CA404582026 rs1599401002	208	L>G		No	ClinGen Ensembl

No associated diseases with P61006

1 regional properties for P61006

Type	Name	Position	InterPro Accession
domain	Small GTP-binding protein domain	7 - 162	IPR005225

Functions

		Description
EC Number	3.6.5.2	Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization	Cell membrane ; Lipid-anchor ; Cytoplasmic side Golgi apparatus Endosome membrane Recycling endosome membrane Cell projection, cilium Cytoplasmic vesicle, phagosome Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium basal body Midbody Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm	Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane (PubMed:15837803) In the GDP-bound form, present in the perinuclear region (PubMed:12221131) Shows a polarized distribution to distal regions of cell protrusions in the GTP-bound form (PubMed:12221131) Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297) Localizes to tubular recycling endosome (PubMed:19864458) Recruited to phagosomes containing S aureus or M tuberculosis (PubMed:21255211) Non-phosphorylated RAB8A predominantly localized to the cytoplasm whereas phosphorylated RAB8A localized to the membrane (PubMed:26824392, PubMed:29125462, PubMed:30398148) Colocalized with MICAL1, GRAF1/ARHGAP26 and GRAF2/ARHGAP10 on endosomal tubules (PubMed:32344433)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

24 GO annotations of cellular component

Name	Definition
centriole	A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
ciliary basal body	A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
ciliary base	Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.
ciliary membrane	The portion of the plasma membrane surrounding a cilium.
cilium	A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendritic spine	A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
endosome	A vacuole to which materials ingested by endocytosis are delivered.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
non-motile cilium	A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors.
phagocytic vesicle	A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
phagocytic vesicle membrane	The lipid bilayer surrounding a phagocytic vesicle.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
recycling endosome membrane	The lipid bilayer surrounding a recycling endosome.
synaptic vesicle	A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
trans-Golgi network membrane	The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.
trans-Golgi network transport vesicle	A vesicle that mediates transport between the trans-Golgi network and other parts of the cell.

6 GO annotations of molecular function

Name	Definition
GDP binding	Binding to GDP, guanosine 5'-diphosphate.
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
myosin V binding	Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport.
protein tyrosine kinase binding	Binding to protein tyrosine kinase.
small GTPase binding	Binding to a small monomeric GTPase.

18 GO annotations of biological process

Name	Definition
autophagy	The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
axonogenesis	De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
cellular response to insulin stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
cilium assembly	The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
endocytic recycling	The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
Golgi organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
Golgi vesicle fusion to target membrane	The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane.
neurotransmitter receptor transport to postsynaptic membrane	The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles.
neurotransmitter receptor transport, endosome to postsynaptic membrane	The directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.
protein localization to cilium	A process in which a protein is transported to, or maintained in, a location within a cilium.
protein localization to plasma membrane	A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
protein secretion	The controlled release of proteins from a cell.
regulation of autophagy	Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
regulation of exocytosis	Any process that modulates the frequency, rate or extent of exocytosis.
regulation of long-term neuronal synaptic plasticity	A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
regulation of protein transport	Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
vesicle docking involved in exocytosis	The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis.
vesicle-mediated transport in synapse	Any vesicle-mediated transport that occurs in a synapse.

29 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P07560	SEC4	Ras-related protein SEC4	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q2HJI8	RAB8B	Ras-related protein Rab-8B	Bos taurus (Bovine)	PR
Q1RMR4	RAB15	Ras-related protein Rab-15	Bos taurus (Bovine)	PR
A4FV54	RAB8A	Ras-related protein Rab-8A	Bos taurus (Bovine)	PR
Q5F470	RAB8A	Ras-related protein Rab-8A	Gallus gallus (Chicken)	PR
P61007	RAB8A	Ras-related protein Rab-8A	Canis lupus familiaris (Dog) (Canis familiaris)	PR
P0C0E4	RAB40AL	Ras-related protein Rab-40A-like	Homo sapiens (Human)	PR
Q8WXH6	RAB40A	Ras-related protein Rab-40A	Homo sapiens (Human)	PR
Q12829	RAB40B	Ras-related protein Rab-40B	Homo sapiens (Human)	PR
Q96S21	RAB40C	Ras-related protein Rab-40C	Homo sapiens (Human)	PR
Q6IQ22	RAB12	Ras-related protein Rab-12	Homo sapiens (Human)	PR
Q92930	RAB8B	Ras-related protein Rab-8B	Homo sapiens (Human)	PR
P59190	RAB15	Ras-related protein Rab-15	Homo sapiens (Human)	PR
Q8K386	Rab15	Ras-related protein Rab-15	Mus musculus (Mouse)	PR
P61028	Rab8b	Ras-related protein Rab-8B	Mus musculus (Mouse)	PR
P35283	Rab12	Ras-related protein Rab-12	Mus musculus (Mouse)	PR
Q9DD03	Rab13	Ras-related protein Rab-13	Mus musculus (Mouse)	PR
Q8CB87	Rab44	Ras-related protein Rab-44	Mus musculus (Mouse)	PR
Q8VHP8	Rab40b	Ras-related protein Rab-40B	Mus musculus (Mouse)	PR
Q8VHQ4	Rab40c	Ras-related protein Rab-40C	Mus musculus (Mouse)	PR
P55258	Rab8a	Ras-related protein Rab-8A	Mus musculus (Mouse)	PR
P35289	Rab15	Ras-related protein Rab-15	Rattus norvegicus (Rat)	PR
P70550	Rab8b	Ras-related protein Rab-8B	Rattus norvegicus (Rat)	PR
P35284	Rab12	Ras-related protein Rab-12	Rattus norvegicus (Rat)	PR
P35281	Rab10	Ras-related protein Rab-10	Rattus norvegicus (Rat)	PR
P35280	Rab8a	Ras-related protein Rab-8A	Rattus norvegicus (Rat)	PR
O24466	RABE1A	Ras-related protein RABE1a	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SF91	RABE1E	Ras-related protein RABE1e	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LZD4	RABE1D	Ras-related protein RABE1d	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MAKTYDYLFK	LLLIGDSGVG	KTCVLFRFSE	DAFNSTFIST	IGIDFKIRTI	ELDGKRIKLQ
70	80	90	100	110	120
IWDTAGQERF	RTITTAYYRG	AMGIMLVYDI	TNEKSFDNIR	NWIRNIEEHA	SADVEKMILG
130	140	150	160	170	180
NKCDVNDKRQ	VSKERGEKLA	LDYGIKFMET	SAKANINVEN	AFFTLARDIK	AKMDKKLEGN
190	200
SPQGSNQGVK	ITPDQQKRSS	FFRCVLL